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BACKGROUND: HMIS will incorporate a paradigm shift in health such as removing manual records and transformation of data through the complex structure of health departments in Tamilnadu. Thus developing a model of technology acceptance in HMIS contest is important and necessary in order to promote usage of the HMIS in rural health care system.OBJECTIVE: The papers purpose is to formulate a model of technology acceptance of Health Management Information System (HMIS) by generating and validating a research model that best describes rural health care workers usage behavior and behavior intention. METHODS: This research proposes a theoretical framework which is comprised of key determinants that influence usage behavior of HMIS together with moderator. It has been tested through different parametric test and confirmatory factor analysis. RESULTS: Data analysis shows that health workers innovativeness and voluntariness have a direct and positive influence on Technology Acceptance level and that the basic TAM hypotheses are fulfilled. HMIS usage behavior and behavior intention can be increased with factors that are effecting the successful implementation of HMIS when it remains high. CONCLUSIONS: This research enables health departments to know which aspects of their HMIS components and variables to improve. This shows that HMIS usage and health workers/staffs acceptance level are key tools in the success of HMIS. This research has seemed to be done at the right time and in the right place to the best of its kind. [ABSTRACT FROM AUTHOR]