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Introduction: The world is facing a formidable challenge to prevent the COVID-19 global outbreak, and health care systems are under pressure globally. The governments alone cannot prevent the spread of this pandemic without creating a sensitive public opinion and cooperation. Therefore, this study analyzed the knowledge, behavior, and precautionary measures taken by the general public to protect themselves from COVID-19 pandemic. Methodology: For this purpose, snowball sampling technique was used to collect data from 401 respondents through an online survey in the Punjab province of Pakistan. A Multivariate Probit Model was used to determine the factors affecting the choice of precautionary measures to avoid COVID-19 infection. Results: Majority of the respondents (58.1%) belonged to urban areas in this study. The urban respondents had higher knowledge about Coronavirus disease as compared to rural respondents. Similarly, the hygienic behavior of urban respondents was better than rural respondents. But unavailability of hygienic material (mask and hand sanitizer) was the main problem faced by the general public. Public transportation was considered the most risk-prone place to COVID-19 by the respondents. Majority of the respondents perceived medium to highest risk from COVID-19, and it was found one of the most influential factors affecting the adoption of precautionary measures along with knowledge of this pandemic. Conclusions: Government needs to start a comprehensive awareness campaign on social media along with the mainstream media create awareness about the importance of social distancing, washing hands and wearing masks among the general public to enhance knowledge and improve the behavior of the general public about COVID-19. [ABSTRACT FROM AUTHOR]