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The Qinghai-Tibet Plateau (QTP) is an area with highly distinctive natural and socio-cultural characteristics. In recent years, the pastoral areas of northern Tibet have undergone a phase transition from nomadic to settled grazing, and the settlement system is in a stage of formation and evolution. Against the backdrop of China's new strategy of rural revitalization, conducting associated research on the evolution of the settlement system and the prospect of rural revitalization is of great significance for improving the living and working conditions of herdsmen in alpine pastoral areas and promoting sustainable development on the QTP. Using settlement patch data obtained by visual interpretation of high-definition remote sensing images, combined with field investigations, this paper explores the temporal and spatial evolution characteristics of the settlement system in Nagqu County, northern Tibet, summarizing its development status and existing problems from the perspective of factor-structure-function, and details the paths for rural revitalization on this basis. The results show the following: (1) Since 2005, the settlement system of Nagqu County has undergone a phase transition from concentrated settlement to functional expansion, with the continuous enrichment of development elements and the enhancement of functions. The density distribution of settlements shows strong adaptability to the natural geographical environment. The pattern of settlement has gradually changed from resource-dependent to facility-dependent. Transportation and public service facilities play an important role in guiding the speed and direction of settlement evolution. (2) There are still various problems in the settlement system of Nagqu County, including a weak industrial foundation; some occupation of important ecological spaces and ecologically fragile areas by settlements; insufficient attention to the cultural aspect of the Tibetan settlement system; a scattered settlement layout, which makes grassroots governance difficult; a large talent gap; and weak spatial support system of settlements. (3) From the perspective of enriching and integrating the development factors of rural settlements, reorganizing the diversified structure of rural settlements, and improving and expanding the functions of rural settlements, this paper explains the correlation mechanism between optimization of the rural settlement system and rural revitalization, and puts forward the implementation paths for rural revitalization in alpine pastoral areas of the QTP. The study expands our understanding of the characteristics of settlements in sparsely populated alpine pastoral areas, and provides valuable, up-to-date policy guidance for the promotion of rural revitalization in alpine pastoral areas on the QTP. [ABSTRACT FROM AUTHOR]

A large amount of distal skarn Pb–Zn deposits without any causative intrusions exposed have been discovered along the eastern Nyainqêntanglha metallogenic belt (NMB) in the Gangdese region, Tibet, China. As a typical distal skarn Pb–Zn deposit in the east of NMB, the Mengya'a deposit is adjacent to the Longmala Pb–Zn ± Cu ± Fe deposit. However, the linkage between these two deposits is not unclear due to the chaotic dating results. In situ Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA‐ICP‐MS) U–Pb dating of reddish‐brown and yellow‐green garnet from Mengya'a yielded lower intersect ages of 53.6 ± 3.1 and 52.4 ± 4.4 Ma, respectively, indicating that Pb–Zn mineralization took place during the main collision stage of the India–Asia plates. The δDSMOW values of garnet, quartz and calcite vary from −148.4‰ to −140.4‰, −123.5‰ to −115.3‰ and −127.9‰ to −121.3‰, with the δ18OH2O values ranging from 5.8‰ to 6.6‰, 0.4‰ to 3.7‰ and 1.0‰ to 1.7‰, respectively. The δ13CV‐PDB and δ18OSMOW values of calcite range from −8.2‰ to −4.7‰ and 9.8‰ to 18.6‰, respectively. These C–H–O isotopic compositions of hydrothermal minerals indicate that the ore‐forming fluids were initially derived from the magmatic water with progressive input of meteoric water from the prograde stage to the retrograde stage. The 87Sr/86Sr(53 Ma) ratios of sphalerite (0.72321–0.73474) are consistent with those of Ando gneiss in the Lhasa‐Golmud area, indicating that the basement gneiss makes a great contribution for the source of ore‐forming materials. The newly obtained garnet U–Pb ages at Mengya'a are consistent with those of mineralization and causative intrusion in the Longmala Pb–Zn ± Fe ± Cu deposit, suggesting that the Mengya'a and Longmala deposits constitute an integrated distal skarn‐type system. This proposed hypothesis suggests that the Fe–Cu ± Pb ± Zn mineralization within the contact zone should focus on the locations beneath the identified Pb–Zn orebodies at Longmala and Pb‐21 orebody at Mengya'a. [ABSTRACT FROM AUTHOR]

Background. The prevalence of chronic kidney disease (CKD) at high altitude is not known. We conducted a population-based survey in Tibet to identify the prevalence and associated risk factors of CKD in subjects living at altitudes of > 3500 m.Methods. One thousand two hundred and eighty-nine Tibetans (≥ 18 years) from four districts of Lhasa city (altitude 3658 m) and eight villages of Dangxiong County (altitude 4200 m) were interviewed and tested for haematuria, albuminuria and estimated glomerular filtration rate (eGFR).Results. The adjusted prevalence of hypertension, albuminuria, haematuria and reduced eGFR were 38.8% (95% CI: 36.2–41.5%), 16.2% (95% CI: 14.1–18.2%), 3.9% (95% CI: 2.8–4.9%) and 2.1% (95% CI: 1.3–2.9%), respectively. Both the presence of hypertension and the presence of albuminuria were strongly and independently associated with hyperuricaemia and elevated haematocrit.Conclusions. This is the first population-based epidemiological study of CKD in the Tibetan population. We found a higher prevalence of CKD and associated high prevalence of albuminuria, hypertension, hyperuricaemia and high haematocrit in the Tibetan population. The present study indicates the urgent need to develop comprehensive strategies targeted at reducing the CKD burden in this area and may lead to a better understanding of CKD in high-altitude populations. [ABSTRACT FROM AUTHOR]

The Bangongco–Nujiang metallogenic belt of Tibet is a main suture zone in the Qinghai–Tibet Plateau, which is known as an important porphyry–epithermal–skarn Cu-polymetallic mineralization zone in China. The western part of the Bangongco–Nujiang metallogenic belt exposes several medium high-silica terrestrial alkaline volcanic rocks with strong alteration influenced by collision orogeny. Some research has shown that clues to mineralization such as malachite and gossan are found on the surface. However, volcanic rock areas with varied topography place a huge burden on geological investigation, and the existing research on predicting mineralization is relatively scarce. This paper describes the extraction of alteration mineral information based on medium spatial resolution and hyperspectral resolution images, establishing a spectral library of alteration minerals in this area. By analyzing radar data, digital elevation, and synthesis results of different spectral bands, we combine remote sensing with geographic information technology to establish crater markers. The extraction results from multisource and chemical exploration data are superimposed onto the analysis of mineralization characteristics and geological conditions so as to establish the mineralization signatures for terrestrial volcanic rock areas. Eighteen mineralization prospect areas were identified, which can provide technical support for future mineralization research in this belt. [ABSTRACT FROM AUTHOR]

Low air pressure and low oxygen partial pressure at high altitude seriously affect the survival and development of human beings and animals. ECE1 is a recently discovered gene that is involved in anti-hypoxia, but the full-length cDNA sequence has not been obtained. For a better understanding of the structure and function of the ECE1 gene and to study its effect in Tibetan pig, the cDNA of the ECE1 gene from the muscle of Tibetan pig was cloned, sequenced and characterized. The ECE1 full-length cDNA sequence consists of 2262 bp coding sequence (CDS) that encodes 753 amino acids with a molecular mass of 85,449 kD, 2 bp 5′UTR and 1507 bp 3′UTR. In addition, the phylogenetic tree analysis revealed that the Tibetan pig ECE1 has a closer genetic relationship and evolution distance with the land mammals ECE1 . Furthermore, analysis by qPCR showed that the ECE1 transcript is constitutively expressed in the 10 tissues tested: the liver, subcutaneous fat, kidney, muscle, stomach, heart, brain, spleen, pancreas, and lung. These results serve as a foundation for further insight into the Tibetan pig ECE1 gene. [ABSTRACT FROM AUTHOR]