17 results on '"Oepkes, D."'
Search Results
2. Counseling for non-invasive prenatal testing ( NIPT): what pregnant women may want to know.
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Oepkes, D., Yaron, Y., Kozlowski, P., Rego de Sousa, M. J., Bartha, J. L., van den Akker, E. S., Dornan, S. M., Krampl‐Bettelheim, E., Schmid, M., Wielgos, M., Cirigliano, V., Di Renzo, G. C., Cameron, A., Calda, P., and Tabor, A.
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PREGNANT women , *PRENATAL diagnosis , *TRISOMY , *PHYSIOLOGY , *CHROMOSOME abnormalities - Abstract
The article presents the author's views on the non-invasive prenatal testing (NIPT) for pregnant women who want to detect trisomy 21 in their unborn child. It states that NIPT improve the quality of prenatal testing for fetal abnormalities. It further discusses aneuploidy screening, chromosomal microarray analysis and testing in pregnancy.
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- 2014
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3. Non-invasive prenatal testing for trisomy 13: more harm than good?
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Verweij, E. J., de Boer, M. A., and Oepkes, D.
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TRISOMY , *PRENATAL diagnosis , *POLYMERASE chain reaction , *OBSTETRICS surgery - Abstract
ABSTRACT A 35-year-old primigravida, pregnant after in-vitro fertilization, was seen because of a trisomy 13/trisomy 18 ( T13/ T18) risk of 1:55, based on the result of her first-trimester combined test. She elected for non-invasive prenatal testing ( NIPT) at 14 + 5 weeks' gestation, which was positive for T13. After counseling, the patient elected to undergo amniocentesis. Quantitative fluorescence polymerase chain reaction ( QF-PCR) showed no signs of trisomy, and full karyotyping confirmed a normal 46,XY result. Analysis of the published literature on NIPT for T13 gives an overall detection rate of 91.6%, with a false-positive rate of 0.097%. Based on this detection rate, hypothetical calculations show that the positive predictive value is highly dependent on the prevalence of the disease, resulting in an unfavorable balance between benefit and harm in a general population. Copyright © 2014 ISUOG. Published by John Wiley & Sons Ltd. [ABSTRACT FROM AUTHOR]
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- 2014
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4. Consensus diagnostic criteria and monitoring of twin anemia-polycythemia sequence: Delphi procedure.
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Khalil, A., Gordijn, S., Ganzevoort, W., Thilaganathan, B., Johnson, A., Baschat, A. A., Hecher, K., Reed, K., Lewi, L., Deprest, J., Oepkes, D., and Lopriore, E.
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PRENATAL diagnosis , *LIKERT scale , *PERINATAL death , *MULTIPLE pregnancy , *CEREBRAL arteries , *FETOFETAL transfusion , *ANEMIA diagnosis , *POLYCYTHEMIA , *GESTATIONAL age , *DELPHI method , *DIAGNOSIS - Abstract
Objectives: Twin anemia-polycythemia sequence (TAPS) is associated with increased perinatal morbidity and mortality. Inconsistencies in the diagnostic criteria for TAPS exist, which hinder the ability to establish robust evidence-based management or monitoring protocols. The main aim of this study was to determine, by expert consensus using a Delphi procedure, the key diagnostic features and optimal monitoring approach for TAPS.Methods: A Delphi process was conducted among an international panel of experts on TAPS. Panel members were provided with a list of literature-based parameters for diagnosing and monitoring TAPS. They were asked to rate the importance of the parameters on a five-point Likert scale. Consensus was sought to determine the cut-off values for accepted parameters, as well as parameters used in the monitoring of and assessment of outcome in twin pregnancy complicated by TAPS.Results: A total of 132 experts were approached. Fifty experts joined the first round, of whom 33 (66%) completed all three rounds. There was agreement that the monitoring interval for the development of TAPS should be every 2 weeks and that the severity should be assessed antenatally using a classification system based on middle cerebral artery (MCA) peak systolic velocity (PSV), but there was no agreement on the gestational age at which to start monitoring. Once the diagnosis of TAPS is made, monitoring should be scheduled weekly. For the antenatal diagnosis of TAPS, the combination of MCA-PSV ≥ 1.5 MoM in the anemic twin and ≤ 0.8 MoM in the polycythemic twin was agreed. Alternatively, MCA-PSV discordance ≥ 1 MoM can be used to diagnose TAPS. Postnatally, hemoglobin difference ≥ 8 g/dL and intertwin reticulocyte ratio ≥ 1.7 were agreed criteria for diagnosis of TAPS. There was no agreement on the cut-off of MCA-PSV or its discordance for prenatal intervention. The panel agreed on prioritizing perinatal and long-term survival outcomes in follow-up studies.Conclusions: Consensus-based diagnostic features of TAPS, as well as cut-off values for the parameters involved, were agreed upon by a panel of experts. Future studies are needed to validate these diagnostic features before they can be used in clinical trials of interventions. Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd. [ABSTRACT FROM AUTHOR]- Published
- 2020
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5. Consensus definition and essential reporting parameters of selective fetal growth restriction in twin pregnancy: a Delphi procedure.
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Khalil, A., Beune, I., Hecher, K., Wynia, K., Ganzevoort, W., Reed, K., Lewi, L., Oepkes, D., Gratacos, E., Thilaganathan, B., Gordijn, S. J., Khalil, Asma, Beune, Irene, Hecher, Kurt, Wynia, Klaske, Ganzevoort, Wessel, Reed, Keith, Lewi, Liesbeth, Oepkes, Dick, and Gratacos, Eduardo
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FETAL growth retardation , *CONSENSUS (Social sciences) , *DELPHI method , *FETAL ultrasonic imaging , *MEDICAL protocols , *MULTIPLE pregnancy , *PHYSICS , *PRENATAL diagnosis , *TWINS , *UMBILICAL arteries , *DIAGNOSIS - Abstract
Objectives: Twin pregnancy complicated by selective fetal growth restriction (sFGR) is associated with increased perinatal mortality and morbidity. Inconsistencies in the diagnostic criteria for sFGR employed in existing studies hinder the ability to compare or combine their findings. It is therefore challenging to establish robust evidence-based management or monitoring pathways for these pregnancies. The main aim of this study was to determine, by expert consensus using a Delphi procedure, the key diagnostic features of and the essential reporting parameters in sFGR.Methods: A Delphi process was conducted among an international panel of experts in sFGR in twin pregnancy. Panel members were provided with a list of literature-based parameters for diagnosing sFGR and were asked to rate their importance on a five-point Likert scale. Parameters were described as solitary (sufficient to diagnose sFGR, even if all other parameters are normal) or contributory (those that require other abnormal parameter(s) to be present for the diagnosis of sFGR). Consensus was sought to determine the cut-off values for accepted parameters, as well as parameters used in the monitoring, management and assessment of outcome of twin pregnancy complicated by sFGR. The questions were presented in two separate categories according to chorionicity.Results: A total of 72 experts were approached, of whom 60 agreed to participate and entered the first round; 48 (80%) completed all four rounds. For the definition of sFGR irrespective of chorionicity, one solitary parameter (estimated fetal weight (EFW) of one twin < 3rd centile) was agreed. For monochorionic twin pregnancy, at least two out of four contributory parameters (EFW of one twin < 10th centile, abdominal circumference of one twin < 10th centile, EFW discordance of ≥ 25%, and umbilical artery pulsatility index of the smaller twin > 95th centile) were agreed. For sFGR in dichorionic twin pregnancy, at least two out of three contributory parameters (EFW of one twin < 10th centile, EFW discordance of ≥ 25%, and umbilical artery pulsatility index of the smaller twin > 95th centile) were agreed.Conclusions: Consensus-based diagnostic features of sFGR in both monochorionic and dichorionic twin pregnancies, as well as cut-off values for the parameters involved, were agreed upon by a panel of experts. Future studies are needed to validate these diagnostic features before they can be used in clinical trials of interventions. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd. [ABSTRACT FROM AUTHOR]- Published
- 2019
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6. Prenatal diagnosis of LUTO: improving diagnostic accuracy.
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Fontanella, F., Duin, L. K., Adama van Scheltema, P. N., Cohen‐Overbeek, T. E., Pajkrt, E., Bekker, M., Willekes, C., Bax, C. J., Gracchi, V., Oepkes, D., Bilardo, C. M., and Cohen-Overbeek, T E
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PRENATAL diagnosis , *FETAL ultrasonic imaging , *HYDRONEPHROSIS , *HOLOCYSTITES , *PUERPERIUM , *BLADDER abnormalities , *DIAGNOSIS of fetal diseases , *GESTATIONAL age , *FIRST trimester of pregnancy , *SECOND trimester of pregnancy , *RETROSPECTIVE studies ,DUODENUM abnormalities - Abstract
Objective: To propose a clinical score for the optimal antenatal diagnosis of fetal lower urinary tract obstruction (LUTO) in the second and third trimesters of pregnancy, as an alternative to the commonly used ultrasound triad of megacystis, keyhole sign and hydronephrosis.Methods: This was a national retrospective study carried out at the eight tertiary fetal medicine units (FMUs) in The Netherlands. Only cases referred for megacystis from the second trimester onwards and with a clear postnatal diagnosis were included in the study. At referral, data were collected on amniotic fluid volume, renal cortical appearance, bladder volume, hydronephrosis, fetal ascites, ureteral size, keyhole sign, fetal sex and gestational age. Multivariate analysis was performed, starting by including all antenatal variables, and then excluding the weakest predictors using the backward stepwise strategy.Results: Over a 7-year period, 312 fetuses with a diagnosis of megacystis were referred to the eight Dutch tertiary FMUs. A final diagnosis was achieved in 143 cases, including 124 of LUTO and 19 reclassified after birth as non-obstructive megacystis. The optimal bladder volume cut-off for prediction of LUTO was 35 cm3 (area under the curve (AUC) = 0.7, P = 0.03). The clinical score formulated on the basis of the multivariate analysis included fetal sex, degree of bladder distension, ureteral size, oligo- or anhydramnios and gestational age at referral. The combination of these five variables demonstrated good accuracy in discriminating LUTO from non-obstructive megacystis (AUC = 0.84, P < 0.001), compared with the poor performance of the ultrasound triad (AUC = 0.63, P = 0.07).Conclusions: We propose a clinical score that combines five antenatal variables for the prospective diagnosis of congenital LUTO. This score showed good discriminative capacity in predicting LUTO, and better diagnostic accuracy compared with that of the classic ultrasound triad. Future studies to validate these results should be carried out in order to refine antenatal management of LUTO and prevent inappropriate fetal interventions. © 2017 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of the International Society of Ultrasound in Obstetrics and Gynecology. [ABSTRACT FROM AUTHOR]- Published
- 2018
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7. Non-invasive prenatal diagnosis for Down syndrome: no paradigm shift, just better testing... and it is already here!
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Verweij, E. J., de Boer, M. A., and Oepkes, D.
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LETTERS to the editor , *PRENATAL diagnosis , *DOWN syndrome - Abstract
A letter to the editor is presented in response to the article "Non-invasive prenatal diagnosis for Down syndrome: the paradigm will shift, but slowly," by P. Benn, H. Cuckle, and E. Pergament in the 2012 issue.
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- 2012
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8. Diagnostic Accuracy of Noninvasive Detection of Fetal Trisomy 21 in Maternal Blood: A Systematic Review.
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Verweij, E.J., van den Oever, J.M.E., de Boer, M.A., Boon, E.M.J., and Oepkes, D.
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NONINVASIVE diagnostic tests , *PRENATAL diagnosis , *TRISOMY , *DOWN syndrome , *PREGNANT women , *BLOOD plasma , *BLOOD testing , *SYSTEMATIC reviews - Abstract
Background: Both pregnant women and providers of obstetric care are aware of the rapid advances in noninvasive prenatal diagnosis (NIPD) of fetal trisomies, and appear to look forward to its clinical introduction. Objectives: To review and critically assess the published literature on diagnostic accuracy of NIPD using cell-free fetal DNA or RNA in maternal blood to detect fetal trisomy 21. Method: An electronic search was performed in MEDLINE, EMBASE and the Cochrane library (1997 to April 2011). Of a total of 201 citations, 9 studies were eligible for full-text analysis by 2 independent reviewers, using the QUADAS tool. Results: Two of the 9 analyzed studies complied with the criteria of the QUADAS tool. Combining the selected 2 studies, with a total of 681 pregnancies included, overall sensitivity was 125/125 (100%, 95% CI 97.5-100%) and specificity 552/556 (99.3%, 95% CI 98.7-99.3%). Conclusions: NIPD of fetal trisomy 21, using fetal nucleic acids in maternal plasma, appears to have a high diagnostic accuracy. Large-scale prospective studies are awaited before implementation in clinical practice. Copyright © 2011 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
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- 2012
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9. Interobserver agreement in detailed prenatal diagnosis of congenital heart disease by telemedicine using four-dimensional ultrasound with spatiotemporal image correlation.
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Adriaanse, B. M. E., Tromp, C. H. N., Simpson, J. M., Van Mieghem, T., Kist, W. J., Kuik, D. J., Oepkes, D., Van Vugt, J. M. G., and Haak, M. C.
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PRENATAL diagnosis , *CONGENITAL heart disease diagnosis , *TELEMEDICINE , *FETAL echocardiography , *ABORTION - Abstract
Objective To evaluate the clinical accuracy of four-dimensional (4D) echocardiography in the detailed prenatal diagnosis of congenital heart disease (CHD) in a telemedicine setting. Methods Ten second-trimester spatiotemporal image correlation (STIC) volumes were sent to three observers in different tertiary care centers with expertise in 4D echocardiography. The 10 volumes were selected based on the type of diagnosis to cover a wide spectrum of CHD anomalies, and also included one normal fetal heart. Observers were asked to provide the diagnosis, the postprocessing modalities used and the time spent on examination, and to give a rating of the confidence for the diagnosis on a 5-point Likert scale. They were free to consult other colleagues, including pediatric cardiologists, but were blinded to the prenatal diagnosis and the neonatal outcome. A diagnostic scoring system was used to evaluate different aspects of the heart defects. The results were compared with neonatal echocardiography or postmortem findings ('gold standard'). Results In two cases all observers correctly diagnosed all details of the volume datasets. The observer with the best performance reached perfect agreement in six cases and nearly perfect agreement in three. The volumes were most frequently studied by sectional planes and were analyzed in a median time of 11.0 (range, 2.5-30.0) min. The median confidence score was 4.0 (range, 1.0-5.0). Conclusions In a telemedicine setting using STIC volumes, fetal cardiac anomalies can be diagnosed correctly by an expert. However, details required for adequate counseling and planning of postnatal care may be missed. STIC by telemedicine is a promising modality, although not accurate enough for exclusive use in clinical decision making regarding treatment, prognosis or termination of pregnancy. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
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- 2012
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10. Karyotyping or rapid aneuploidy detection in prenatal diagnosis? The different views of users and providers of prenatal care.
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Boormans, E. M. A., Birnie, E., Bilardo, C. M., Oepkes, D., Bonsel, G. J., and Van Lith, J. M. M.
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PRENATAL genetic testing , *ANEUPLOIDY , *PREGNANT women , *PRENATAL care , *CAREGIVERS - Abstract
Developments in prenatal diagnosis raise the question which test strategy should be implemented. However, preferences of women and caregivers are underexposed. This study investigates what kind of prenatal test pregnant women and caregivers prefer and if differences between the groups exist, using self-report questionnaires. Women preferred either karyotyping (50%) or rapid aneuploidy detection (43%). Caregivers opted for the latter (78%). A test targeted on Down syndrome was the least preferred in both groups. We recommend the use of individualised choice for genetic test in prenatal diagnosis, overcoming the existing differences in preferences between women and caregivers. [ABSTRACT FROM AUTHOR]
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- 2009
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11. Fetoscopic Laser Surgery in 100 Pregnancies with Severe Twin-to-Twin Transfusion Syndrome in the Netherlands.
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Middeldorp, J. M., Susters, M., Lopriore, E., Klumper, F. J. C. M., Oepkes, D., Devlieger, R., Kanhai, H. H. H., and Vandenbussche, F. P. H. A
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FETAL diseases , *PRENATAL diagnosis , *LASER surgery , *FETOSCOPY , *SECOND trimester of pregnancy - Abstract
Objective: In this prospective cohort study, we evaluated the initial results of fetoscopic laser surgery for severe second trimester twin-to-twin transfusion syndrome (TTTS) treated at our centre. Method: A total of 100 consecutive pregnancies with severe second trimester TTTS treated at our centre with selective fetoscopic laser coagulation of vascular anastomoses on the placental surface between August 2000 and November 2004 were included in the study. Perinatal survival was analysed in relation to Quintero stage. Results: Median gestational age was 20 weeks at fetoscopy (range: 16–26) and 33 weeks at delivery (range: 18–40). Perinatal survival rate was 70% (139/200). The treatment resulted in at least one survivor at the age of 4 weeks in 81% of pregnancies. Perinatal survival was significantly higher when treatment was performed in the early Quintero stages (95% in stage 1, 76% in stage 2, 70% in stage 3, 50% in stage 4) (p = 0.02). Conclusion: Results of fetoscopic laser surgery for TTTS in our centre are similar to those in specialised centres in other countries. Diagnosis and treatment in the early Quintero stages resulted in significantly higher perinatal survival. Copyright © 2007 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
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- 2007
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12. Timely diagnosis of twin-to-twin transfusion syndrome in monochorionic twin pregnancies by biweekly sonography combined with patient instruction to report onset of symptoms.
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Sueters, M., Middeldorp, J. M., Lopriore, E., Oepkes, D., Kanhai, H. H. H., and Vandenbussche, F. P. H. A.
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DISEASES in twins , *DIAGNOSTIC ultrasonic imaging , *PREGNANCY complications , *FETAL death , *EDEMA , *DOPPLER ultrasonography , *FETAL monitoring , *PRENATAL diagnosis - Abstract
Objectives: To assess the value of serial ultrasound examinations together with patient instructions to report the onset of symptoms in achieving timely detection of twin-to-twin transfusion syndrome (TTTS) in a cohort of monochorionic diamniotic twin pregnancies, and to evaluate sonographic TTTS predictors.Methods: Timely detection of TTTS was defined as diagnosis before severe complications of TTTS occurred, such as preterm prelabor rupture of membranes, very preterm delivery (24-32 weeks of pregnancy), fetal hydrops, or intrauterine fetal death. During a 2-year period, a prospective series of 23 monochorionic twin pregnancies was monitored from the first trimester until delivery. At least every 2 weeks we performed ultrasound and Doppler measurements (nuchal translucency thickness, presence of membrane folding, estimated fetal weight, deepest vertical pocket, bladder filling, and Doppler waveforms of the umbilical artery, ductus venosus and umbilical vein). Measurements of TTTS cases were compared with those of non-TTTS cases matched for gestational age. Furthermore, patients were informed about the symptoms caused by TTTS, and instructed to consult us immediately in case of rapidly increasing abdominal size or premature contractions.Results: In all four TTTS cases, the diagnosis was timely. At the time of diagnosis, one case was at Quintero Stage 1, two at Quintero Stage 2, and one at Quintero Stage 3. Two of the TTTS cases became apparent after the patients' feeling of rapidly increasing girth. The identification of TTTS predictors was successful with respect to one parameter: isolated polyhydramnios in one sac, without oligohydramnios in the other, preceded the ultimate diagnosis of TTTS in two of the four TTTS cases. All other ultrasound measurements of TTTS cases, prior to the diagnosis of TTTS, were within the range of measurements of non-TTTS cases.Conclusion: Biweekly ultrasound examinations, with special attention to the amniotic fluid compartments of both fetuses, combined with detailed patient instructions to report the onset of symptoms resulted in timely diagnosis of all TTTS cases and appears to be a safe program for monitoring monochorionic twin pregnancies. [ABSTRACT FROM AUTHOR]- Published
- 2006
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13. Pathophysiology and treatment of fetal anemia due to placental chorioangioma.
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Haak, M. C., Oosterhof, H., Mouw, R. J., Oepkes, D., Vandenbussche, F. P. H. A., and Vandenbussche, F P
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ANEMIA , *CHORIOCARCINOMA , *FETAL diseases , *PRENATAL diagnosis - Abstract
Placental chorioangiomas occur in 1% of pregnancies. Large chorioangiomas may cause serious complications such as fetal anemia, hydrops and fetal death. In this case report, a pregnancy complicated by a large placental chorioangioma is described. Severe fetal anemia without the occurrence of hydrops fetalis was suspected using ultrasound and Doppler examinations. Successful intrauterine blood transfusion was performed, with an unusually large amount of blood needed to obtain an adequate rise in fetal hematocrit. Two weeks later, at 32 weeks, the infant was born in good condition. In pregnancies with large chorioangiomas, we advise regular ultrasound and Doppler examinations, with the aim of detecting fetal anemia before hydrops develops. When anemia is suspected, fetal blood sampling is indicated and intrauterine transfusion therapy may be beneficial to preserve fetal health until maturity is reached. [ABSTRACT FROM AUTHOR]
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- 1999
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14. P15.03: Antenatal diagnosis of lower urinary tract obstructions (LUTO): a prediction model to improve the diagnostic accuracy.
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Fontanella, F., Duin, L., Adama Van Scheltema, P., Cohen-Overbeek, T.E., Pajkrt, E., Bekker, M.N., Willekes, C., Bax, C., Gracchi, V., Oepkes, D., and Bilardo, C.M.
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PRENATAL diagnosis , *URINARY tract infection diagnosis - Published
- 2017
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15. EP21.04: BOOSTB4: a clinical study to determine safety and efficacy of pre- and/or postnatal stem cell transplantation for treatment of osteogenesis imperfecta.
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Chitty, L.S., David, A.L., Gottschalk, I., Oepkes, D., Westgren, M., Götherström, C., Consortium, O., and Götherström, C
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STEM cell transplantation , *OSTEOGENESIS imperfecta , *PRENATAL diagnosis - Abstract
An abstract of the article "BOOSTB4: a clinical study to determine safety and efficacy of pre- and/or postnatal stem cell transplantation for treatment of osteogenesis imperfecta," by L. S. Chitty and colleagues is presented.
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- 2016
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16. Right ventricular outflow tract obstruction in complicated monochorionic twin pregnancy.
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Eschbach, S J, Boons, L S T M, Van Zwet, E, Middeldorp, J M, Klumper, F J C M, Lopriore, E, Teunissen, A K K, Rijlaarsdam, M E, Oepkes, D, Ten Harkel, A D J, and Haak, M C
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LONGITUDINAL method , *PRENATAL diagnosis , *TWINS , *DISEASE incidence , *RECEIVER operating characteristic curves , *FETOFETAL transfusion , *VENTRICULAR outflow obstruction , *DIAGNOSIS - Abstract
Objectives: Severe right ventricular outflow tract obstruction (RVOTO) is a potential complication in recipient twins of twin-to-twin transfusion syndrome (TTTS) that requires postnatal follow-up or treatment. We aimed to evaluate pregnancy characteristics of neonates with RVOTO from complicated monochorionic twin pregnancies, determine the incidence of RVOTO in TTTS cases and construct a prediction model for its development.Methods: This was an observational cohort study of all complicated monochorionic twin pregnancies with a postnatal diagnosis of RVOTO examined at our center. Cases were referred for evaluation of the need for fetal therapy or intervention because of TTTS, selective intrauterine growth restriction (sIUGR) or multiple congenital malformations in one of the twins. Ultrasound data were retrieved from our monochorionic twin database. Among liveborn TTTS recipients treated prenatally with laser therapy, those with RVOTO were compared with those without RVOTO (controls). We describe four additional cases with RVOTO that were not TTTS recipients.Results: A total of 485 twin pregnancies received laser therapy for TTTS during the study period. RVOTO was diagnosed in 3% (11/368) of liveborn TTTS recipients, of whom two showed mild Ebstein's anomaly. Before laser therapy, pericardial effusion was seen in 45% (5/11) of RVOTO cases (P < 0.01) and abnormal A-wave in the ductus venosus (DV) in 73% (8/11) (P = 0.03), significantly higher proportions than in controls. Mean gestational age at laser therapy was 17 + 3 weeks in RVOTO cases compared with 20 + 3 weeks in controls (P = 0.03). A prediction model for RVOTO was constructed incorporating these three significant variables. One TTTS donor had RVOTO after the development of transient hydrops following laser therapy. Three larger twins in pregnancies complicated by sIUGR developed RVOTO, the onset of which was detectable early in the second trimester.Conclusions: RVOTO occurs in TTTS recipient twins but can also develop in TTTS donors and larger twins of pregnancies complicated by sIUGR. Abnormal flow in the DV, pericardial effusion and early gestational age at onset of TTTS are predictors of RVOTO in TTTS recipients, which suggests increased vulnerability to hemodynamic imbalances in the fetal heart in early pregnancy. These findings could guide diagnostic follow-up protocols after TTTS treatment. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd. [ABSTRACT FROM AUTHOR]- Published
- 2016
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17. OP15.01: Inter-observer agreement in detailed prenatal diagnosis of congenital heart disease by telemedicine using four-dimensional ultrasound.
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Adriaanse, B., Tromp, C., Simpson, J., Van Mieghem, T., Kist, J., Kuik, J., Oepkes, D., Van Vugt, J., and Haak, M.
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PRENATAL diagnosis , *CONGENITAL heart disease ,ABSTRACTS - Abstract
An abstract of the article "Inter-observer agreement in detailed prenatal diagnosis of congenital heart disease by telemedicine using four-dimensional ultrasound," by B. Adriaanse and colleagues is presented.
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- 2011
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