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An extensive and coherent body of social and psychological research has identified social ties and supportive relationships as important predictors of well-being and quality of life. This paper examines the relationships between structural and functional indicators of supportive relations and well-being in Greece at different levels of analysis based on results from three studies: (a) the European Social Survey (Study 1); (b) a cross sectional community study in Greece (Study 2); and (c) a social interactions study in Greece and the UK using an event sampling methodology (Study 3). Structural indicators of social support and life satisfaction and happiness in the first study were moderately associated. This finding was partly supported by results from the second study which revealed connections between some structural aspects of social support and well-being (happiness, anxiety, irritability) but not others. Functional aspects of social support and psychological indicators of well-being (happiness, anxiety, mental health) at the individual (Study 2) and social interaction (Study 3) levels were not associated. Cross-cultural comparisons of structural indicators of social support in Studies 1 and 3 revealed low frequency of social interactions. Also functional aspects of social support in everyday social interactions in Greece showed significantly lower levels in comparison to the UK. These findings suggest that structural and functional aspects of social support in Greece may not have the same palliative role as usually observed in the international literature and are discussed with particular attention to the level of analysis, the method, and the aspect of well-being being assessed. [ABSTRACT FROM AUTHOR]