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1. The Incidence of Spontaneously Occurring Anti-Liver Antibodies in New Zealand Black Mice.

Author

Elson, C.J. and Naysmith, J.D.

Subjects
*IMMUNOGLOBULINS, *ANTIGENS, *MICE, *RODENTS, *IMMUNITY
Abstract

The sera of NZB/BL mice have been found to be active in the complement fixation test against isogeneic liver antigens to a higher titre than the sera of CBA, C57BL and DBA/2 mice. Six sera from NZB mice were fractionated by zone ultracentrifugation in sucrose density gradients and the anti-liver activity was found to sediment with the high molecular weight immunoglobulin. No correlation was found between complement-fixing activity against liver antigens and the presence of globulin on red cells (positive direct Coombs test). [ABSTRACT FROM AUTHOR]

Published
1969

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