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The coarctation of the aorta (CoA) combined with heart defects or cerebral artery aneurysms is more prevalent in clinical practice. However, cases of concurrent bilateral iliac artery dissection (IAD) are extremely rare and have not been reported. Here, we described a case with CoA combined with bilateral IAD. The patient, a 62‐year‐old male, presented with acute intermittent claudication accompanied by pain and aching in both lower limbs after walking. Following a thorough medical history inquiry and examination, the patient was diagnosed with acute bilateral IAD combined with CoA. The patient underwent endovascular treatment. Postoperatively, the aortic diameter recovered, and the bilateral IAD disappeared, yielding satisfactory therapeutic results. Conclusively, endovascular treatment of aortic coarctation combined with IAD is an effective therapeutic approach, enhancing patient survival and improving their quality of life. [ABSTRACT FROM AUTHOR]

Highlights Nature has evolved a myriad of dedicate‐designed structures that assist in prey capture. Spiders employ their web structures for vibrational sensing and prey capture, analogous to a component of a neurosensory system. Here, we propose a spider web‐inspired sensor with integrated energy‐absorption and force perception capabilities by 3D printing. The conductive carbon black/TPU composite made from TPU granules and carbon black particles are employed for 3D printing. We analyze the underlying sensing mechanism of conductive CB/TPU composites stemming from the enhanced dispersion of the CB particles. Through 3D printing method, we are allowed to regulate the structure's form, filling density, arrangement, and printing path to tailor the static mechanical properties, initial resistance, and force sensitivity of the spider‐web inspired structure. The static mechanical model for single silk of the spider‐web inspired structure is constructed. We explore the energy absorption capability of spider‐web inspired structures with different structural parameters, and demonstrate its impact perceiving characteristics at different falling height. Additionally, we assembled a circuit to visually reflect the falling height of the impacting ball through the brightness of the LED light. This study provides insights to endowing structural materials with intelligent characteristics, contributing to their practical applications in the fields of biomedical, soft robotics, and artificial skin, etc. A spider web‐inspired sensor is 3D printed with CB/TPU composites. The sensor has integrated force perception and energy‐absorption capabilities. The sensitivity capabilities can be regulated by parameter design. The mechanical model of the bioinspired structure is constructed. Its impact perceiving characteristics are demonstrated by two applications. [ABSTRACT FROM AUTHOR]

Objective: The purpose of the systematic review is to verify the presence of PANoptosis in periodontitis based on the published literatures studying cell death in periodontitis. Materials and Methods: We conducted a comprehensive review of literature studying the types of cell death in vitro cellular experiments, in vivo rodent studies and clinical studies from three major databases: PubMed, Scopus, and Web of Science. The present systematic review was recorded in the PROSPERO database, under registration number CRD42022383456. Results: In total, 51 articles were included in this study. Our analysis of in vitro cell models revealed that pyroptosis, necroptosis, and apoptosis could be induced by periodontal pathogens in macrophages, fibroblasts, stem cells, and periodontal ligament cells. Furthermore, three types of cell death were detected in in vivo rodent periodontitis models. Clinical studies on human periodontitis tissue specimens and gingival crevicular fluid (GCF) showed that some key proteins related to pyroptosis, necroptosis, and apoptosis were elevated in periodontitis. Conclusions: Various studies have established similar in vivo and in vitro models with three modes of death detected under the same conditions, revealing complex interactions between different types of cell death pathways in periodontitis and the potential for PANoptosis to occur in periodontitis. [ABSTRACT FROM AUTHOR]

Background and purpose Methods Results Conclusion Human motor planning and control depend highly on optimal feedback control systems, such as the neocortex–cerebellum circuit. Here, diffusion tensor imaging was used to verify the disruption of the neocortex–cerebellum circuit in spinocerebellar ataxia type 3 (SCA3), and the circuit's disruption correlation with SCA3 motor dysfunction was investigated.This study included 45 patients with familial SCA3, aged 17–67 years, and 49 age‐ and sex‐matched healthy controls, aged 21–64 years. Tract‐based spatial statistics and probabilistic tractography was conducted using magnetic resonance images of the patients and controls. The correlation between the local probability of probabilistic tractography traced from the cerebellum and clinical symptoms measured using specified symptom scales was also calculated.The cerebellum‐originated probabilistic tractography analysis showed that structural connectivity, mainly in the subcortical cerebellar–thalamo–cortical tract, was significantly reduced and the cortico–ponto–cerebellar tract was significantly stronger in the SCA3 group than in the control group. The enhanced tract was extended to the right lateral parietal region and the right primary motor cortex. The enhanced neocortex–cerebellum connections were highly associated with disease progression, including duration and symptomatic deterioration. Tractography probabilities from the cerebellar to parietal and sensorimotor areas were significantly negatively correlated with motor abilities in patients with SCA3.To our knowledge, this study is the first to reveal that disrupting the neocortex–cerebellum loop can cause SCA3‐induced motor dysfunctions. The specific interaction between the cerebellar–thalamo–cortical and cortico–ponto–cerebellar pathways in patients with SCA3 and its relationship with ataxia symptoms provides a new direction for future research. [ABSTRACT FROM AUTHOR]

Spinocerebellar ataxia type 3 (SCA3) is an inherited movement disorder characterized by a progressive decline in motor coordination. Despite the extensive functional connectivity (FC) alterations reported in previous SCA3 studies in the cerebellum and cerebellar‐cerebral pathways, the influence of these FC disturbances on the hierarchical organization of cerebellar functional regions remains unclear. Here, we compared 35 SCA3 patients with 48 age‐ and sex‐matched healthy controls using a combination of voxel‐based morphometry and resting‐state functional magnetic resonance imaging to investigate whether cerebellar hierarchical organization is altered in SCA3. Utilizing connectome gradients, we identified the gradient axis of cerebellar hierarchical organization, spanning sensorimotor to transmodal (task‐unfocused) regions. Compared to healthy controls, SCA3 patients showed a compressed hierarchical organization in the cerebellum at both voxel‐level (p <.05, TFCE corrected) and network‐level (p <.05, FDR corrected). This pattern was observed in both intra‐cerebellar and cerebellar‐cerebral gradients. We observed that decreased intra‐cerebellar gradient scores in bilateral Crus I/II both negatively correlated with SARA scores (left/right Crus I/II: r = −.48/−.50, p =.04/.04, FDR corrected), while increased cerebellar‐cerebral gradients scores in the vermis showed a positive correlation with disease duration (r =.48, p =.04, FDR corrected). Control analyses of cerebellar gray matter atrophy revealed that gradient alterations were associated with cerebellar volume loss. Further FC analysis showed increased functional connectivity in both unimodal and transmodal areas, potentially supporting the disrupted cerebellar functional hierarchy uncovered by the gradients. Our findings provide novel evidence regarding alterations in the cerebellar functional hierarchy in SCA3. [ABSTRACT FROM AUTHOR]