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Despite notable progress in human development and gender equality indicators, mental health issues and gender disparities persist due to various socio-ecological factors in the southern state of Kerala, India. This study aims to identify the psychosocial factors of resilience that enabled rural and urban women to cope with during the challenging COVID-19 pandemic, while also comparing the experiences of resilience among women in rural and urban areas of Malappuram district. A demographic profiler and semi-structured interview questions were employed to assess resilience in a cohort of 44 women in rural and urban settings and within the age range of 21-60 years. Interview questions were specifically based on the definition of resilience, resilience factors specific to women, resilience-boosting elements, and obstacles during COVID-19. Qualitative analysis of the participants' responses revealed five key psychosocial factors (psychological factors, support, life experience, external factors, and gender) influencing women's resilience. Similar factors (support, psychological, and external factors) are critical in strengthening women's resilience during the COVID-19 pandemic. The research also sheds light on subtle gender inequalities, underscoring the need for comprehensive initiatives to promote gender equity and improve men's attitudes towards women. The limitation of the study lies in the regional specificity, which affects its generalizability. The study highlights the importance of designing psychosocial interventions to promote resilience in women across diverse geographical contexts, presenting opportunities for empowering women through comprehensive strategies. These findings offer valuable insights for policymakers, practitioners, and researchers, enabling the development of effective measures to uplift women and create a more equitable and resilient society. Further research is recommended to bridge knowledge gaps and formulate comprehensive strategies to enhance women's empowerment. [ABSTRACT FROM AUTHOR]