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Seamless phase 2/3 design has become increasingly popular in clinical trials with a single endpoint. Trials that define success based on the achievement of all co-primary endpoints (CPEs) encounter the challenge of inflated type 2 error rates, often leading to an overly large sample size. To tackle this challenge, we introduced a seamless phase 2/3 design strategy that employs Bayesian predictive power (BPP) for futility monitoring and sample size re-estimation at interim analysis. The correlations among multiple CPEs are incorporated using a Dirichlet-multinomial distribution. An alternative approach based on conditional power (CP) was also discussed for comparison. A seamless phase 2/3 vaccine trial employing four binary endpoints under the non-inferior hypothesis serves as an example. Our results spotlight that, in scenarios with relatively small phase 2 sample sizes (e.g., 50 or 100 subjects), the BPP approach either outperforms or matches the CP approach in terms of overall power. Particularly, with n1 = 50 and ρ = 0, BPP showcases an overall power advantage over CP by as much as 8.54%. Furthermore, when the phase 2 stage enrolled more subjects (e.g., 150 or 200), especially with a phase 2 sample size of 200 and ρ = 0, the BPP approach evidences a peak difference of 5.76% in early stop probability over the CP approach, emphasizing its better efficiency in terminating futile trials. It's noteworthy that both BPP and CP methodologies maintained type 1 error rates under 2.5%. In conclusion, the integration of the Dirichlet-Multinominal model with the BPP approach offers improvement in certain scenarios over the CP approach for seamless phase 2/3 trials with multiple CPEs. [ABSTRACT FROM AUTHOR]

Irrigation is a common practice in agriculture to increase crop yield. However, the impacts of irrigation on microbial-mediated processes that influence soil carbon (C) pools and crop yield remains largely unknown. Therefore, we conducted a 2-year field experiment to investigate the effects of low (I1, 80% field capacity, 80%FC), medium (I2, 90%FC), and high (I3, 100%FC) irrigation upper limits on rhizosphere soil bacterial community, soil organic carbon (SOC) content, and wheat yield. The results showed that as the irrigation upper limit increased, the α-diversity of the bacterial community decreased. The bacterial community structure significantly differed across various irrigation upper limits. As the irrigation upper limit increased from low (80%FC) to medium (90%FC) or high (100%FC), the abundance of copiotrophic taxa (Proteobacteria, Actinobacteria, Bacteroidetes) decreased, and oligotrophic taxa (Acidobacteria) increased, enhancing the decomposition of persistent C pools. In the second year of the irrigation experiment, the I2 and I3 treatments significantly decreased microbial biomass carbon (MBC), SOC content (by 4.62–7.30%), and the microbial quotient (MQ) compared to I1. Wheat straw biomass and grain yield also decreased as the irrigation upper limit increased from 80%FC to 100%FC, with key bacterial taxa (Proteobacteria, Actinobacteria, and Chloroflexi) and functional processes (glycan biosynthesis and metabolism; folding, sorting, and degradation; translation; transport, and catabolism) playing key roles in wheat grain formation. Our findings indicate that adjusting irrigation levels affects the rhizosphere soil bacterial communities, and that the lowest upper limit of irrigation application (80%FC) is associated with maximum crop yield and microbial diversity. • As the irrigation upper limit increased, the α-diversity of the bacterial community decreased. • Increasing the irrigation upper limit (80–100%FC) shifted the bacteria from copiotrophic taxa to more oligotrophic taxa. • Bacterial community composition and metabolic function affected wheat yield. • Irrigation could alter the abundance of microbial metabolic functions associated with soil C. [ABSTRACT FROM AUTHOR]

The cathode in lithium-selenium (Li-Se) batteries has garnered extensive attention owing to its superior specific capacity and enhanced conductivity compared to sulfur. Nonetheless, the adoption and advancement of Li-Se batteries face significant challenges due to selenium's low reactivity, substantial volume fluctuations, and the shuttle effect associated with polyselenides. Single-atom catalysts (SACs) are under the spotlight for their outstanding catalytic efficiency and optimal atomic utilization. To address the challenges of selenium's low chemical activity and volume expansion in Li-Se batteries, through electrospun, we have developed a lotus root-inspired carbon nanofiber (CNF) material, featured internal multi-channels and anchored with molybdenum (Mo) single atoms (Mo@CNFs). Mo single atoms significantly enhance the conversion kinetics of selenium (Se), facilitating rapid formation of Li2Se. The internally structured multi-channel CNF serves as an effective host matrix for Se, mitigating its volume expansion during the electrochemical process. The resulting cathode, Se/Mo@CNF composite, exhibits a high discharge specific capacity, superior rate performance, and impressive cycle stability in Li-Se batteries. After 500 cycles at a current density of 1 C, it maintains a capacity retention rate of 82% and nearly 100% coulombic efficiency (CE). This research offers a new avenue for the application of single-atom materials in enhancing advanced Li-Se battery performance. [ABSTRACT FROM AUTHOR]

Highlights: Si/C Composite and Nanostructure Engineering: Advanced Si/C composites and multidimensional nanostructures address key challenges in silicon anodes, like volume expansion and unstable SEI, enhancing LIBs performance. Artificial SEI, Prelithiation, and Binders: Focus on stable artificial SEI layers, efficient prelithiation, and cutting-edge binders to improve Coulombic efficiency and reduce capacity loss, enhancing Si anode durability and efficiency. Real-World Application and Scalability: Analysis of these strategies highlights scalability and commercial viability, transitioning Si-anode technologies to practical, high-performance LIBs applications. Silicon (Si) has emerged as a potent anode material for lithium-ion batteries (LIBs), but faces challenges like low electrical conductivity and significant volume changes during lithiation/delithiation, leading to material pulverization and capacity degradation. Recent research on nanostructured Si aims to mitigate volume expansion and enhance electrochemical performance, yet still grapples with issues like pulverization, unstable solid electrolyte interface (SEI) growth, and interparticle resistance. This review delves into innovative strategies for optimizing Si anodes' electrochemical performance via structural engineering, focusing on the synthesis of Si/C composites, engineering multidimensional nanostructures, and applying non-carbonaceous coatings. Forming a stable SEI is vital to prevent electrolyte decomposition and enhance Li+ transport, thereby stabilizing the Si anode interface and boosting cycling Coulombic efficiency. We also examine groundbreaking advancements such as self-healing polymers and advanced prelithiation methods to improve initial Coulombic efficiency and combat capacity loss. Our review uniquely provides a detailed examination of these strategies in real-world applications, moving beyond theoretical discussions. It offers a critical analysis of these approaches in terms of performance enhancement, scalability, and commercial feasibility. In conclusion, this review presents a comprehensive view and a forward-looking perspective on designing robust, high-performance Si-based anodes the next generation of LIBs. [ABSTRACT FROM AUTHOR]

This paper explores the potential of Longan peel waste (LPw) as a sustainable and cost-effective matrix for selenium-based cathodes in Li-Se and Na-Se batteries. Following activation, we created LP 2 —a designation for the carbon precursor derived from LPw, activated at a 1:2 ratio of carbonized LPw to KOH. This nomenclature, where 'LP' stands for 'Longan peel' and '2′ reflects the optimization of this ratio, led to a hierarchical porous structure with an average pore size of 3.0307 ​nm and a significant BET surface area of 111.9386 ​m2 ​g-1. Selenium was incorporated into the LP 2 matrix using a simple melt diffusion technique, yielding the composite Se@LP 2. In Li-Se batteries, Se@LP 2 exhibited an initial discharge capacity of 1033.75 mAh g⁻1 ​at 0.1C. At a 1C rate, the composite demonstrated a capacity retention of 301.14 mAh g⁻1 after 550 cycles and 380.91 mAh g⁻1 after 100 cycles. Moreover, for Na-Se batteries, the composite showcased a capacity retention of 347.18 mAh g⁻1 after 100 cycles at 0.1C. These findings underscore LP 2 's potential as a viable and efficient matrix for selenium-based cathodes, revealing promising prospects for the advancement of highly efficient Li-Se and Na-Se batteries. [Display omitted] [ABSTRACT FROM AUTHOR]

[Display omitted] • Bi 2 Se 3 nanosheets were synthesized using a straightforward solvothermal process. • The thickness of Bi 2 Se 3 nanosheets was refined with ethylenediamine addition. • The optimized Bi 2 Se 3 cathode demonstrated impressive electrochemical performance. • Phase transition and multiple-electron redox reactions resulted in high capacity. Bi 2 Se 3 is considered a suitable cathode material for zinc-ion batteries (ZIBs) because of its high conductivity and large layer spacing. Herein, Bi 2 Se 3 nanosheets with varying thicknesses are successfully synthesized using a one-step solvothermal process with adding different amounts of ethylenediamine. The introduction of ethylenediamine reduces the thickness of Bi 2 Se 3 from 250 nm to 22.7 nm. The thin structure exposes more active sites and shortens ion transport paths. Therefore, the optimized Bi 2 Se 3 nanosheet exhibits outstanding specific capacity (410 mA h g−1 at 0.2 A/g), high-rate performance (230 mA h g−1 at 5 A/g), and remarkable cycling stability (82.3 % capacity retention after 1200 cycles at 5 A/g). Furthermore, an in-depth exploration of cathodes during cycling is conducted to investigate the charge/discharge mechanism. A dynamic phase transition from Bi 2 Se 3 to BiSe, accompanied by nanosheet exfoliation, is observed during the initial few cycles, designating BiSe as the primary active material. Moreover, an additional redox reaction involving multiple electrons has been proposed. This study offers a valuable guidance for utilizing Bi 2 Se 3 as a cathode in ZIBs. [ABSTRACT FROM AUTHOR]

Xijiao Dihuang decoction (XDT), a famous formula, was usually used to improve the prognosis of patients with blood-heat and blood-stasis syndrome-related diseases. There were some mutual promotion and mutual assistance herb pairs in XDT. However, the exact functions of these herb pairs in the compatibility of XDT were not elucidated due to the lack of appropriate methodologies. Based on the theory of serum pharmacochemistry, a systematic method was established for the qualitative and quantitative analysis of characteristic components in the extracts and drug-containing plasma samples of XDT and its relational mutual promotion/assistance herb pairs. For qualitative analysis, 85 characteristic components were identified using the liquid chromatography with triple time-of-flight mass/mass spectrometry (LC-Triple QTOF-MS/MS) based on the mass defect filtering, product ion filtering, neutral loss filtering and isotope pattern filtering techniques. For quantitative detection, a relative quantitation assay using an extract ion chromatogram (EIC) of the full scan MS experiment was validated and employed to assess the quantity of the 85 identified compounds in the test samples of single herb, herb pairs and XDT. The results of multivariate statistical analyses indicated that both the assistant and guide herbs could improve the solubilization of active compounds from the sovereign and minister herbs in XDT in vitro , might change the trans-membrane transportation, and regulate metabolism in vivo. The methods used in present study might be also valuable for the investigation of multiple components from other classic TCM formulas for the purpose of compatibility feature study. • LC-QTOF-MS/MS for holistic evaluation of TCM formula and drug-containing plasma. • Multiple filtering method was used to classify and screen multi-components. • A total of 85 compounds were identified in the test samples. • The quantity of the 85 identified compounds using a relative quantitation assay. • Serum pharmacochemistry was used to study the compatibility feature of TCM formula. [ABSTRACT FROM AUTHOR]

[Display omitted] • CoN-Mo 2 N heterostructure is synthesized by nitriding the CoMoO 4 nanorods; • CoN-Mo 2 N heterostructure has strong adsorption/bidirectional catalytic capacity for polysulfides; • Li-S cells assembled with CoN-Mo 2 N modified separators show excellent electrochemical performance. A single functional material can hardly simultaneously overcome the problems of poor conductivity of active sulfur, shuttle effect and slow redox reaction kinetics of lithium polysulfides (LiPSs) in rechargeable lithium-sulfur batteries. Herein, a multi-functional CoN-Mo 2 N heterostructure nanorods with excellent adsorption capability and bidirectional catalytic ability is introduced. It is found that the CoN-Mo 2 N heterostructure has a significant interaction with LiPSs, and its chemical affinity can promote the adsorption of LiPSs; The Li 2 S nucleation and electrochemical testing results show that the CoN-Mo 2 N heterostructure can promote the uniform nucleation and rapid growth of Li 2 S, where CoN tends to promote the oxidation reaction kinetics, and Mo 2 N promotes the reduction reaction kinetics. The assembled Li-S cells with CoN-Mo 2 N modified separators can deliver outstanding rate performance and long-cycling stability, with a high initial reversible discharge capacity of 1605.8 mAh g−1 at 0.1C, and capacity decay rate per cycle of 0.198 % after 200 cycles at 0.2C. [ABSTRACT FROM AUTHOR]

The frequency of droughts and floods has increased due to climate change and human activities, leading to adverse impacts on agricultural production. Conventional tillage exacerbates the vulnerability of crops to extreme weather. Optimized tillage practices can maintain crop yield stability by increasing soil water-holding capacity during dry seasons and improving crop lodging resistance during heavy rainfall events. The effects of tillage practice under different rainfall types on the productivity of summer maize were studied by combining a five-year field experiment and a meta-analysis. The study tested four tillage treatments: conventional tillage (CT), no-tillage (NT), ridge cultivation with no-tillage (RNT), and winter wheat conventional tillage followed by summer maize no-tillage (NC). Normal rainfall years (2018, 2019 and 2021), a wet year (2020), and a drought year (2022) were experienced during the experiment. Compared to CT, NC significantly increased available soil water storage during the dry season by an average of 19.7 % (P < 0.05). NC and RNT had lower lodging rates during the wet year than CT, and over the five years, NC had a higher average maize yield (9.8 t ha−1) than RNT, while RNT had a higher yield during the wet year (10.7 t ha−1). NC also had significantly higher yield stability than CT. Furthermore, NC and RNT had higher rainwater use efficiencies (RUE) (23.9 and 23.0 kg ha−1 mm−1, respectively) than NT and CT (22.9 and 21.6 kg ha−1 mm−1, respectively). A meta-analysis showed that the crop yield under combined tillage (COT) was significantly higher than CT and NT by 6.7 % and 7.1 %, respectively, confirming the reliability and universality of the field experiment results. Overall, NC rotation is recommended as the best tillage system for sustainable crop production under semi-arid conditions, while RNT can be used in areas with abundant rainfall and prone to flooding. Our research findings offer evidence-based insights into management strategies that can enhance agricultural ecosystem resilience and production stability under extreme climate conditions. • The combined method of field experiment and meta-analysis was used in this study. • Combined tillage (NC and RNT) improves crop yield and yield stability. • Intermittent tillage (NC) improves the resistance of crops to extreme drought. • Ridge cultivation with no-tillage (RNT) improves waterlogging resistance. • The meta-analysis demonstrated the generality of combined tillage to improve yield stability. [ABSTRACT FROM AUTHOR]