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Bioconvection is a fascinating phenomenon observed in various biological systems, where the motion of motile microorganisms generates fluid flow patterns. This article explores the occurrence and characteristics of bioconvection within the context of a jet flow. The study of bioconvection in jet flow involves the interaction between motile microorganisms and the fluid dynamics of the surrounding medium. Microorganisms such as bacteria and algae are known to exhibit directed swimming behavior, which can lead to the formation of dynamic flow structures. Investigating the mechanisms underlying bioconvection in jet flow requires a multidisciplinary approach encompassing fluid dynamics, microbial ecology, and mathematical modeling. Experimental techniques, such as microscopy and particle image velocimetry, along with computational simulations, are employed to analyze the complex interactions between microorganisms and the fluid flow. In this regard, a supportive mathematical model is designed using partial differential equations (PDEs) which are later transformed into ordinary differential equations using similarity transformations. The resulting system of equations is solved using the RKF-45 method and the outcomes are recorded in tables and graphs. The consideration of thermophoresis has shown a significant impact on the heat and mass transfer of the jet flow and both these profiles are observed to increase with thermophoresis. Meanwhile, the Schmidt number decrease their respective mass profiles. Furthermore, the porosity is found to create a drag force which tends to oppose the fluid flow. [ABSTRACT FROM AUTHOR]

In this article, the two-dimensional, steady flow, and incompressible flow of Powell–Eyring fluid (non-Newtonian fluid) is considered toward a stretching surface. Applications of this emerging challenge include heating meals, grilling, baking, roasting, treating wounds, inflammation, and injuries with thermotherapy and cryotherapy, as well as steam turbines, industrial operations, casting, smelting, cooling aviation engines, and other things. Motion of particles is induced using variable wall velocity involving constant magnetic field. The characteristics of Lorentz force (magnetic field) and stagnation point flow are analyzed while direction of Lorentz is implemented toward y-direction of a bidirectional stretching surface under consideration of low magnetic Reynolds parameter. The phenomena regarding transfer of thermal energy have been addressed subject to thermal radiation, non-Fourier's law and Joule heating. The PD-equations (partial differential equations) associated with heat transfer and flow are re-framed in forms of OD-equations (ordinary differential equations) using similarity variables. The influences based on various parameters against variation of motion and temperature field are analyzed in tables and graphical forms. The features of divergent velocity and temperature gradient are tabulated in Table 1. It is noted that temperature field is decreased against argument values of the Prandtl number whereas the same impact is noticed in thickness regarding thermal layers. The fluid parameter brings maximum acceleration into motion of fluid particles but the opposite trend is noticed in motion of fluid particles versus enhancement of Ratio of expansion rates number and Powell–Eyring fluid parameter. [ABSTRACT FROM AUTHOR]

Aim: We aimed to investigate the long‐term influence of a diet and/or exercise intervention on long‐term mortality and cardiovascular disease (CVD) events. Methods: The Da Qing Diabetes Prevention Study had 576 participants with impaired glucose tolerance (IGT) randomized to diet‐only, exercise‐only and diet‐plus‐exercise intervention group and control group. The participants underwent lifestyle interventions for 6 years. The subsequent Da Qing Diabetes Prevention Outcome Study was a prospective cohort study to follow‐up the participants for up to 24 years after the end of 6‐year intervention. In total, 540 participants completed the follow‐up, while 36 subjects lost in follow‐up. Cox proportional hazards analysis was applied to assess the influence of lifestyle interventions on targeted outcomes. Results: Compared with controls, the diet‐only intervention in people with IGT was significantly associated with a reduced risk of all‐cause death [hazard ratio (HR) 0.77, 95% confidence interval (CI) (0.61‐0.97)], CVD death [HR 0.67, 95% CI (0.46‐0.97)] and CVD events [HR 0.72, 95% CI (0.54‐0.96)]. The diet‐plus‐exercise intervention was significantly associated with a decreased risk of all‐cause death [HR 0.64, 95% CI (0.48‐0.84)], CVD death [HR 0.54, 95% CI (0.30‐0.97)] and CVD events [HR 0.68, 95% CI (0.52‐0.90)]. Unexpectedly, the exercise‐only intervention was not significantly associated with the reduction of any of these outcomes, although there was a consistent trend towards reduction. Conclusions: A diet‐only intervention and a diet‐plus‐exercise intervention in people with IGT were significantly associated with a reduced risk of all‐cause death, CVD death and CVD events, while an exercise‐only intervention was not. It suggests that diet‐related interventions may have a potentially more reliable influence on long‐term vascular complications and mortality. [ABSTRACT FROM AUTHOR]

Background: This study investigated the effects of early‐onset type 2 diabetes (EOD) vs late‐onset type 2 diabetes (LOD) on nonfatal cardiovascular diseases (CVD) in China. Methods: We conducted a cross‐sectional survey of 46 239 participants from 14 provinces in China from 2007 to 2008, selecting 4949 participants with type 2 diabetes for analysis. Participants were categorized as EOD (<40 years) or LOD (≥40 years) based on age at diabetes diagnosis. Sociodemographic and nonfatal CVD information was collected through an interviewer‐assisted questionnaire and clinical examination. Logistic regression analysis was used to investigate the nonfatal CVD risk. Results: Out of 4949 participants with type 2 diabetes, 390 (7.88%) had nonfatal CVD. Participants with EOD had a higher age‐standardized prevalence of nonfatal CVD than those with LOD (11.4% vs 4.4%). Compared to LOD patients, EOD patients tended to be males and had a higher family history of diabetes, unhealthy lifestyle behaviors, and lower blood pressure levels. After adjustment for age and sex, EOD patients had a higher risk of nonfatal CVD than LOD patients (odds ratio [OR] 2.3, 95% CI 1.5–3.5). After further adjustment for diabetes duration, use of drugs, and other risk factors, the OR of nonfatal CVD was reduced but significant (OR 1.8, 95% CI 1.1–2.9). Sensitivity analysis revealed that EOD patients with metabolic syndrome had an increased nonfatal CVD risk compared to LOD patients (OR 2.0, 95% CI 1.2–3.5). Conclusions: EOD patients are at increased risk of nonfatal CVD. Individualized intervention and management measures for EOD patients are necessary. [ABSTRACT FROM AUTHOR]

P-glycoprotein (Pgp) modulators are promising agents for overcoming multidrug resistance (MDR) in cancer chemotherapy. In this study, via structural optimization of our lead compound S54 (nonsubstrate allosteric inhibitor of Pgp), 29 novel pyxinol amide derivatives bearing an aliphatic heterocycle were designed, synthesized, and screened for MDR reversal activity in KBV cells. Unlike S54 , these active derivatives were shown to transport substrates of Pgp. The most potent derivative 4c exhibited promising MDR reversal activity (IC 50 of paclitaxel = 8.80 ± 0.56 nM, reversal fold = 211.8), which was slightly better than that of third-generation Pgp modulator tariquidar (IC 50 of paclitaxel = 9.02 ± 0.35 nM, reversal fold = 206.6). Moreover, the cytotoxicity of this derivative was 8-fold lower than that of tariquidar in human normal HK-2 cells. Furthermore, 4c blocked the efflux function of Pgp and displayed high selectivity for Pgp but had no effect on its expression and distribution. Molecular docking revealed that 4c bound preferentially to the drug-binding domain of Pgp. Overall, 4c is a promising lead compound for developing Pgp modulators. [Display omitted] • Twenty-nine novel pyxinol amide derivatives were designed and synthesized. • The structure-activity relationships of the MDR reversal activity were described. • Analog 4c showed better MDR reversal activity than tariquidar with less cytotoxicity. • Analog 4c inhibited the efflux function of P-glycoprotein with high selectivity. • Analog 4c was present in an L-shaped conformation in the access channel of Pgp. [ABSTRACT FROM AUTHOR]

Oats are recognized to provide many health benefits that are mainly associated with its dietary fibre, β-glucan. However, the protein derived from oats is largely understudied with respect to its ability to maintain health and attenuate risk factors of chronic diseases. The goal of the current study was to investigate the metabolic effects of oat protein consumption in lieu of casein as the protein source in high fat, high sucrose (HF/HS) fed Wistar rats. Four-week-old rats were divided into three groups and were fed three different experimental diets: a control diet with casein as the protein source, an HF/HS diet with casein, or an HF/HS diet with oat protein for 16 weeks. Heart structure and function were determined by echocardiography. Blood pressure measurements, an oral glucose tolerance test, and markers of cholesterol metabolism, oxidative stress, inflammation, and liver and kidney damage were also performed. Our study results show that incorporation of oat protein in the diet was effective in preserving systolic heart function in HF/HS fed rats. Oat protein significantly reduced serum total and low-density lipoprotein cholesterol levels. Furthermore, oat protein normalized liver HMG-CoAR activity, which, to our knowledge, is the first time this has been reported in the literature. Therefore, our research suggests that oat protein can provide hypocholesterolemic and cardioprotective benefits in a diet-induced model of metabolic syndrome. [ABSTRACT FROM AUTHOR]

We previously showed that the transaminase inhibitor, aminooxyacetic acid, reduced respiration energized at complex II (succinate dehydrogenase, SDH) in mitochondria isolated from mouse hindlimb muscle. The effect required a reduction in membrane potential with resultant accumulation of oxaloacetate (OAA), a potent inhibitor of SDH. To specifically assess the effect of the mitochondrial transaminase, glutamic oxaloacetic transaminase (GOT2) on complex II respiration, and to determine the effect in intact cells as well as isolated mitochondria, we performed respiratory and metabolic studies in wildtype (WT) and CRISPR-generated GOT2 knockdown (KD) C2C12 myocytes. Intact cell respiration by GOT2KD cells versus WT was reduced by adding carbonyl cyanide-p-trifluoromethoxyphenylhydrazone (FCCP) to lower potential. In mitochondria of C2C12 KD cells, respiration at low potential generated by 1 µM FCCP and energized at complex II by 10 mM succinate + 0.5 mM glutamate (but not by complex I substrates) was reduced versus WT mitochondria. Although we could not detect OAA, metabolite data suggested that OAA inhibition of SDH may have contributed to the FCCP effect. C2C12 mitochondria differed from skeletal muscle mitochondria in that the effect of FCCP on complex II respiration was not evident with ADP addition. We also observed that C2C12 cells, unlike skeletal muscle, expressed glutamate dehydrogenase, which competes with GOT2 for glutamate metabolism. In summary, GOT2 KD reduced C2C12 respiration in intact cells at low potential. From differential substrate effects, this occurred largely at complex II. Moreover, C2C12 versus muscle mitochondria differ in complex II sensitivity to ADP and differ markedly in expression of glutamate dehydrogenase. NEW & NOTEWORTHY: Impairment of the mitochondrial transaminase, GOT2, reduces complex II (succinate dehydrogenase, SDH)-energized respiration in C2C12 myocytes. This occurs only at low inner membrane potential and is consistent with inhibition of SDH. Incidentally, we observed that C2C12 mitochondria compared with muscle tissue mitochondria differ in sensitivity of complex II respiration to ADP and in the expression of glutamate dehydrogenase. [ABSTRACT FROM AUTHOR]

Background: Self-regulation is crucial for nurses who engage in in-depth end-of-life conversations with advanced cancer patients, especially in cultural contexts featuring death taboos. An improved understanding of the self-regulation process of nurses can help them address negative emotions and promote self-growth more effectively. Therefore, this study aimed to explore nurses' self-regulation process after end-of-life conversations with advanced cancer patients. Methods: This study employed a descriptive, qualitative approach. Seventeen nurses from four hospitals and a hospice unit in mainland China were interviewed between September 2022 and June 2023. Data were collected through face-to-face semistructured interviews. A thematic analysis method was used to analyse the data following the guidance of regulatory focus theory. Results: Three main themes were developed: self-regulation antecedents include personality, experience, and support; promotion or prevention is a possible self-regulation process for nurses; both self-exhaustion and self-growth may be the outcomes of self-regulation, as did seven subthemes. Personality tendencies, life experience, and perceived support may affect nurses' self-regulation, thereby affecting their self-regulation outcomes. Conclusions: Nurses exhibit different self-regulatory tendencies and self-regulation outcomes. The provision of peer support and counselling support to nurses is highly important with regard to achieving good self-regulation outcomes. [ABSTRACT FROM AUTHOR]

Induced magnetic order in a topological insulator (TI) can be realized either by depositing magnetic adatoms on the surface of a TI or engineering the interface with epitaxial thin film or stacked assembly of 2D van der Waals (vdW) materials. Herein, the observation of spin‐phonon coupling in the otherwise non‐magnetic TI Bi2Te3 is reported, due to the proximity of FePS3 (an antiferromagnet (AFM), TN ≈ 120 K), in a vdW heterostructure framework. Temperature‐dependent Raman spectroscopic studies reveal deviation from the usual phonon anharmonicity originated from spin‐lattice coupling at the Bi2Te3/FePS3 interface at/below 60 K in the peak position (self‐energy) and linewidth (lifetime) of the characteristic phonon modes of Bi2Te3 (106 and 138 cm−1) in the stacked heterostructure. The Ginzburg‐Landau (GL) formalism, where the respective phonon frequencies of Bi2Te3 couple to phonons of similar frequencies of FePS3 in the AFM phase, is adopted to understand the origin of the hybrid magneto‐elastic modes. At the same time, the reduction of characteristic TN of FePS3 from 120 K in isolated flakes to 65 K in the heterostructure, possibly due to the interfacial strain, which leads to smaller Fe‐S‐Fe bond angles as corroborated by computational studies using density functional theory (DFT). Besides, inserting hexagonal boron nitride within Bi2Te3/FePS3 stacking regains the anharmonicity in Bi2Te3. Controlling interfacial spin‐phonon coupling in stacked heterostructure can have potential application in surface code spin logic devices. [ABSTRACT FROM AUTHOR]

Type 1 diabetes (T1D) is an autoimmune disease in which pathogenic lymphocytes target autoantigens expressed in pancreatic islets, leading to the destruction of insulin-producing β-cells. Zinc transporter 8 (ZnT8) is a major autoantigen abundantly present on the β-cell surface. This unique molecular target offers the potential to shield β-cells against autoimmune attacks in T1D. Our previous work showed that a monoclonal antibody (mAb43) against cell-surface ZnT8 could home in on pancreatic islets and prevent autoantibodies from recognizing β-cells. This study demonstrates that mAb43 binds to exocytotic sites on the β-cell surface, masking the antigenic exposure of ZnT8 and insulin after glucose-stimulated insulin secretion. In vivo administration of mAb43 to NOD mice selectively increased the proportion of regulatory T cells in the islet, resulting in complete and sustained protection against T1D onset as well as reversal of new-onset diabetes. The mAb43-induced self-tolerance was reversible after treatment cessation, and no adverse effects were exhibited during long-term monitoring. Our findings suggest that mAb43 masking of the antigenic exposure of β-cells suppresses the immunological cascade from B-cell antigen presentation to T cell–mediated β-cell destruction, providing a novel islet-targeted and antigen-specific immunotherapy to prevent and reverse clinical T1D. Article Highlights: mAb43, a zinc transporter 8 (ZnT8)–specific monoclonal antibody, provides lasting protection against autoimmune diabetes in NOD mice. The in vivo islet specificity of mAb43 enables targeted therapy to enhance safety. High-affinity binding of mAb43 to the extracellular surface of ZnT8 shields β-cells from antigenic exposure. β-Cell masking results in a localized increase in regulatory T cells in the pancreatic islet. Prolonged mAb43 treatment clears destructive insulitis, preserves β-cell mass, and reverses seroconversion of insulin autoantibodies in NOD mice. The immunological processes bridging the masking of specific cell-surface autoantigens and the broad suppression of polyspecific T-cell autoimmunity are still unclear. [ABSTRACT FROM AUTHOR]

In this paper, we consider a predator–prey model with Cosner type functional response and combined harvesting. First, we explore the existence and stability of the equilibria. Then using the center manifold theorem and normal form theory, we investigate codimension one and codimension two bifurcations of the model. The analysis shows that the system has a variety of bifurcation phenomena including transcritical bifurcation, saddle‐node bifurcation, Hopf bifurcation, Bogdanov–Takens bifurcation and homoclinic bifurcation. Our findings indicate that the dynamics with harvesting are significantly richer than the system without harvesting. Finally, numerical simulations are provided to support the analytical results. [ABSTRACT FROM AUTHOR]

Background: Despite the growing interest in hospital rehabilitation services for communities, studies on existing community-based rehabilitation (CBR) services remain scarce owing to limitations in the development of community health services and regional cultural diversity. As a guaranteed measure for ensuring the quality of rehabilitation services and achieving the desired service outcomes, clear roles and responsibilities in multidisciplinary teams and effective service delivery are particularly important. Objective: This scoping review aimed to determine the scope of community stroke rehabilitation programs involving existing multidisciplinary teams and to analyze the implementation content and implementers' functional roles to provide guidance for future CBR programs. Methods: The scoping review design followed the methodology of the Joanna Briggs Institute and was based on the normative scoping review framework proposed by Arksey and O'Malley. The comprehensive CBR framework was proposed by World Health Organization-guided data charting and analysis. Results: Of the 22,849 identified citations, 74 studies were included, consisting of 6,809 patients with stroke and 49 primary caregivers, most of whom were from China. The most common working mode in CBR programs was a dual approach involving both healthcare professionals in medical institutions and community healthcare professionals. The number of programs in each discipline was in the following descending order: nursing, medical care, rehabilitation, psychology, nutrition, and public health. Among these, multidisciplinary teams comprising medical, nursing, and rehabilitation disciplines were the most common, with a total of 29 programs. Disciplinary members were mainly responsible for implementing their respective disciplinary content, with physicians providing guidance for the programs. More than 82.4% of the studies reported 2–4 intervention strategies. The intervention forms of rehabilitation content were the most diverse, whereas preventive interventions were more homogeneous than others. Physical function and socio-psychological measurements were the most commonly reported outcomes. Conclusion: CBR services implemented by multidisciplinary teams can effectively achieve functional and emotional improvement in patients with stroke, and nurses are the most involved in implementation, especially in community settings. The results further emphasize the importance of strengthening the exploration of nurses' maximum potential to implement CBR plans in future practice. Trial registration: The registration information for this scoping review can be found at osf.io/pv7tg. [ABSTRACT FROM AUTHOR]

Potato is an important food crop. After harvest, these tubers will undergo a period of dormancy. Brassinosteroids (BRs) are a new class of plant hormones that regulate plant growth and seed germination. In this study, 500 nM of BR was able to break the dormancy of tubers. Additionally, exogenous BR also upregulated BR signal transduction genes, except for StBIN2. StBIN2 is a negative regulator of BR, but its specific role in tuber dormancy remains unclear. Transgenic methods were used to regulate the expression level of StBIN2 in tubers. It was demonstrated that the overexpression of StBIN2 significantly prolonged tuber dormancy while silencing StBIN2 led to premature sprouting. To further investigate the effect of StBIN2 on tuber dormancy, RNA-Seq was used to analyze the differentially expressed genes in OE-StBIN2, RNAi-StBIN2, and WT tubers. The results showed that StBIN2 upregulated the expression of ABA signal transduction genes but inhibited the expression of lignin synthesis key genes. Meanwhile, it was also found that StBIN2 physically interacted with StSnRK2.2 and StCCJ9. These results indicate that StBIN2 maintains tuber dormancy by mediating ABA signal transduction and lignin synthesis. The findings of this study will help us better understand the molecular mechanisms underlying potato tuber dormancy and provide theoretical support for the development of new varieties using related genes. [ABSTRACT FROM AUTHOR]

Background: Population screening for risk of type 1 diabetes (T1D) has been proposed to identify those with islet autoimmunity (presence of islet autoantibodies). As islet autoantibodies can be transient, screening with a genetic risk score has been proposed as an entry into autoantibody testing. Methods: Children were recruited from eight general pediatric and specialty clinics across Virginia with diverse community settings. Recruiters in each clinic obtained informed consent/assent, a medical history, and a saliva sample for DNA extraction in children with and without a history of T1D. A custom genotyping panel was used to define T1D genetic risk based upon associated SNPs in European- and African-genetic ancestry. Subjects at "high genetic risk" were offered a separate blood collection for screening four islet autoantibodies. A follow-up contact (email, mail, and telephone) in one half of the participants determined interest and occurrence of subsequent T1D. Results: A total of 3818 children aged 2–16 years were recruited, with 14.2% (n = 542) having a "high genetic risk." Of children with "high genetic risk" and without pre-existing T1D (n = 494), 7.0% (34/494) consented for autoantibody screening; 82.4% (28/34) who consented also completed the blood collection, and 7.1% (2/28) of them tested positive for multiple autoantibodies. Among children with pre-existing T1D (n = 91), 52% (n = 48) had a "high genetic risk." In the sample of children with existing T1D, there was no relationship between genetic risk and age at T1D onset. A major factor in obtaining islet autoantibody testing was concern over SARS-CoV-2 exposure. Conclusions: Minimally invasive saliva sampling implemented using a genetic risk score can identify children at genetic risk of T1D. Consent for autoantibody screening, however, was limited largely due to the SARS-CoV-2 pandemic and need for blood collection. [ABSTRACT FROM AUTHOR]

• The decorrelation problem degrades the accuracy of DIC matching or even destroys the measurement. • An improved calculation scheme was proposed to address the decorrelation problem of laser speckle DIC. • Incremental DIC scheme with the nearest integer pixel offset eliminate the additional intensity interpolation error. • Real tests demonstrated the effectiveness of this scheme in eliminating the decorrelation issue in laser speckle DIC. Laser speckles have served as an alternative to artificial speckles for digital image correlation (DIC) measurement in some cases due to the advantages of non-invasive measurement, simplicity and high efficiency in preparation. Regrettably, in using laser speckle DIC, it unavoidably encounters the notorious decorrelation problem when the object surface undergoes a relatively large motion and deformation, which will degrade the accuracy of DIC matching or even destroy the measurement. To realize large deformation measurements, the approach of updating reference image (also termed as incremental DIC) is usually adopted to mitigate the decorrelation problem of laser speckle. However, once the reference image is updated frequently during the incremental DIC calculation, additional errors due to intensity interpolation at the subpixel positions in updated reference images will accumulate over the updating times. To address this issue, an improved calculation scheme composed of incremental DIC with the nearest integer pixel offset and Gaussian pre-filtering is proposed for laser speckle DIC measurement. This involves processing the speckle images with a Gaussian low-pass filter before correlation analysis, and shifting the reference subsets in updated reference images to the nearest integer pixel positions instead of interpolating at subpixel positions during DIC calculation. Simulation tests have confirmed that this scheme effectively mitigates accumulated interpolation errors. Several real tests, including in-plane translation, uniaxial tensile, and high-temperature tests, also demonstrated the effectiveness of this scheme in eliminating the decorrelation issue in laser speckle DIC. [ABSTRACT FROM AUTHOR]

Endovascular therapy (EVT) is effective in the treatment of large vascular occlusive stroke. However, many factors are associated with the outcomes of acute ischemic stroke (AIS) after EVT. This study aimed to identify the main factors related to the prognosis of AIS patients after EVT. We analyzed the clinical data of AIS patients in the neurology department of our medical center from June 2017 to August 2021 following treatment with EVT. The data included the patients' blood pressure upon admission, blood glucose concentration, National Institutes of Health Stroke Scale (NIHSS) score, 90-day modified Rankin scale (mRs) score follow-up data, and time from LKN to the successful groin puncture (GP). A good outcome was defined as a 90-day mRs score of 0–2, and a poor outcome was defined as a 90-day mRs score of 3–6. A total of 144 patients were included in the study. Admission, smoking, and LKN-to-GP time, NIHSS score of 6–12 was found to be relevant to the prognosis. The results of multivariate analysis showed that prognosis was significantly influenced by baseline NIHSS (odds ratio = 3.02; 95% confidence interval, 2.878–4.252; P = 0.001), LKN-to-GP time (odds ratio = 2.17; 95% confidence interval, 1.341–2.625; P = 0.003), and time stratification (6–12 h) (odds ratio = 4.22; 95% confidence interval, 2.519–5.561; P = 0.001). Our study indicated that smoking, baseline NIHSS score, and LKN-to-GP time were the risk factors for a poor outcome in stroke patients following an EVT. Quitting smoking and shortening LKN time to GP should improve the outcome of AIS after EVT. [ABSTRACT FROM AUTHOR]

This document is a correction notice for an article titled "Clinical predictors of prognosis in stroke patients after endovascular therapy" published in Scientific Reports. The correction addresses an error in Figure 2 labelling, specifically the incorrect number of patients. The original Figure 2 and accompanying legend are provided in the correction notice. The authors of the article are Yugang Wang, Xingyun Yuan, Yonggang Kang, Liping Yu, Wanhong Chen, and Gang Fan. [Extracted from the article]

The Motor tic, Obsessions and Compulsions, Vocal tic Evaluation Survey (MOVES) is a widely used screening tool for Tourette syndrome (TS) and associated comorbidities. This study evaluated its applicability for children in China using 7,125 participants from the National Center for Children’s Health (Beijing). Psychometric evaluations included exploratory and confirmatory factor analysis, yielding a 16-item, four-factor model that explained 55.11% of the variance and demonstrated good internal consistency (Cronbach’s alpha = 0.88) and test-retest reliability (ICC = 0.86). The scale showed strong convergent, discriminant, and criterion-related validity and was significantly correlated with other established TS scales. The results affirm the reliability and validity of the MOVES for screening TS in Asian contexts, addressing a crucial gap in the region’s TS assessment tools. [ABSTRACT FROM AUTHOR]