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Treatment for endometrial cancer (EC) is increasingly guided by molecular risk classifications. Here, we aimed at using machine learning (ML) to incorporate clinical and molecular risk factors to optimize risk assessment. The Cancer Genome Atlas-Uterine Corpus Endometrial Carcinoma (n = 596), Memorial Sloan Kettering-Metastatic Events and Tropisms (n = 1315) and the American Association for Cancer Research Project Genomics Evidence Neoplasia Information Exchange (n = 4561) datasets were used to identify genetic alterations and clinicopathological features. Software packages including Keras, Pytorch, and Scikit Learn were tested to build artificial neural networks (ANNs) with a binary output as either intra-abdominal metastatic progression ('1') vs. non-metastatic ('0'). Black patients with EC have worse prognosis than White patients, adjusting for TP53 or POLE mutation status. Over 75% of Black patients carry TP53 mutations as compared to approximately 40% of White patients. Older age is associated with an increasing likelihood of TP53 mutation, high risk histology, and distant metastasis. For patients above age 70, 91% of Black and 60% of White EC patients carry TP53 mutations. A ML-based New Unified classifiCATion Score (NU-CATS) that incorporates age, race, histology, mismatch repair status, and TP53 mutation status showed 75% accuracy in prognosticating intra-abdominal progression. A higher NU-CATS is associated with an increasing risk of having positive pelvic or para-aortic lymph nodes and distant metastasis. NU-CATS was shown to outperform Leiden/TransPORTEC model for estimating risk of FIGO Stage I/II disease progression and survival in Black EC patients. The NU-CATS, a ML-based, cost-effective algorithm, incorporates diverse clinicopathologic and molecular variables of EC and yields superior prognostication of the risk of nodal involvement, distant metastasis, disease progression, and overall survival. [Display omitted] • Race is an independent risk factor for endometrial cancer (EC) prognosis. • Over 75% of Black EC patients have TP53 mutations as compared to 40% of White patients. • A machine learning (ML)-based algorithm NU-CATS predicts early-stage and Black EC patients' progression. [ABSTRACT FROM AUTHOR]

Dual-imprinted GO/TiO 2 -loaded nanocomposite membranes based on polydopamine-based and sol–gel imprinting methods were prepared for selective separation of tetracycline. [Display omitted] Molecularly imprinted membranes (MIMs) with sufficient and even-distributed recognition sites that can break the permeability-selectivity trade-off phenomenon are desirable in chemical field of selective separation. Herein graphene oxide (GO)/TiO 2 -loaded nanocomposite fibrous membranes were prepared by developing two kinds of tetracycline (TC)-imprinted systems in the same MIMs-based material. Thereinto, polydopamine-based and sol–gel-based imprinting processes were applied to the synthesis of GO/TiO 2 -loaded dual-imprinted mixed matrix membranes (GT-DIMs). The as-prepared GT-DIMs encompassed innovative GO/TiO 2 -based nanocomposite fibrous channels and two kinds of TC-imprinted systems, and critical comparisons regarding the fluxes, rebinding capacities and permselectivity were provided and studied. Importantly, dual-imprinted system of GT-DIMs could not only allow for largely enhanced rebinding result (70.63 mg/g) and fast adsorption equilibrium rate within 30 min, but also facilitate the high permselectivity of TC in complex separation systems and lab-simulated wastewater samples. The permselectivity factors were all around 5.0, which strongly demonstrated the efficiently selective recognition and separation performance of GT-DIMs. Overall, based on testing results of practical separation and scalability, excellent structural stability and separation continuity had been successfully obtained for selective separation applications of pollutants. [ABSTRACT FROM AUTHOR]

Porous&permselective dual-tetracycline-imprinted nanocomposite membranes based on twice-polymerization-based imprinting process were prepared for selective separation of tetracycline. [Display omitted] • Twice-PDA-based dual-TC-imprinted membrane was first proposed. • Dual-imprinted membrane with GO/SiO 2 -loaded structure was successfully constructed. • Well-designed TC-imprinted membrane was applied as selective separation device. • High-performance flux and permselectivity of MIMs were obtained simultaneously. Here, the graphene oxide (GO)/SiO 2 -loaded dual-imprinted membranes (GS-DIMs) were constructed based on the self-polymerization imprinting technique of dopamine, in which a twice polydopamine (PDA)-based imprinting strategy had been successfully developed to obtain the three-dimensional nanocomposite membrane-based separation system. Meanwhile, the pollution-intensive antibiotics of tetracycline (TC) was used as template molecule throughout the GS-DIMs synthesis, and the dopamine molecules were simultaneously used as functional monomer and cross-linking agent during the twice polydopamine (PDA)-based imprinting processes. Therefore, dual-TC-imprinted sites had been prepared based on the as-designed dual imprinting processes, the as-prepared GS-DIMs-based separation system with dual-TC-imprinted structures could not only allow for the largely enhanced rebinding result of 65.61 mg/g and faster adsorption equilibrium rate within 20 min, but also facilitate the permselectivity performance from TC-based complex separation system and mimetic water sample. Importantly, we demonstrated the applications and effects of the dual-imprinted membrane-based separation materials to selective rebinding and separation of TC from complex solution systems and mimetic water samples. The as-obtained permselectivity factors (β) around 4.0 strongly illustrated the efficiently selective separation ability and high-intensitive recognizability of TC than any other non-template molecules based on our GS-DIMs-based separation system. Overall, the as-designed GS-DIMs had great potential for selective separation applications and provided critical comparisons based on the as-achieved excellent rebinding and permselectivity performance, which encompassed innovative GO/SiO 2 -loaded nanocomposite and PDA-based dual-TC-imprinted system. [ABSTRACT FROM AUTHOR]

3D wood-based Nd3+-imprinted membranes with high permselectivity performance were successfully synthesized by developing a PDA@basswood-based multilevel membrane structure. • Basswood was used as the supporting membrane for the preparation of imprinting materials. • 3D wood-based Nd3+-imprinted multilevel structure was designed and prepared. • Well-designed multilevel/hierarchical 3DW-IIMs were first proposed and applied as selective separation membranes. • The PDA@basswood structure was first proposed and applied as imprinting-initiated factors. • High rebinding capacity and permselectivity performance could be simultaneously obtained. Three-dimensional (3D) basswood materials, for the first time, were successfully used for the construction of rare-earth Nd(III)-imprinted nanocomposite membranes. Herein, polydopamine (PDA)-modified layers could be initially synthesized on basswood surfaces. After the double-bonded modification procedure, the 3D wood-based ionic imprinted membranes (3DW-IIMs) system was finally accomplished by developing a re-modified two-step-temperature free radical polymerization process. The as-design PDA@basswood surface structure was first proposed and applied as imprinting-initiated factors for the preparation of Nd(III)-imprinted sites. Importantly, excellent rebinding capacity (120.87 mg g−1), adsorption kinetics and permselectivity coefficients (more than 10) were achieved successfully. Furthermore, an important research result had also been found that the PDA-modified layers caused significant promotions to the rebinding capacities of the as-prepared 3DW-IIMs, that is to say, more and more Nd(III)-imprinted sites could be synthesized because of the PDA-modified surfaces. The as-obtained selective rebinding and separation results together with the green natural wood-based materials strongly demonstrated that our synthesis methodology of 3DW-IIMs had great potential for applications in various fields of rare earth separation, chemical industry, and environment protection. [ABSTRACT FROM AUTHOR]

Au/SiO 2 -pDA-based nanocomposite ovalbumin-imprinted membranes with controllable biocompatibility/selectivity were first proposed and developed for the achievements of thermo-responsive recognition ability and reversible cell adhesion/detachment. Inspired by the biomimetic modification strategy of dopamine self-polymerization technique, molecularly imprinted nanocomposite membranes (MINCMs) with thermo-responsive rebinding and separation performance were synthesized and evaluated. Herein, the Au/SiO 2 -based multilevel structure had been successfully obtained onto the polydopamine (pDA) modified membrane surfaces. Afterward, the poly(N -isopropylacrylamide)-based biomolecule-imprinted sites were adequately constructed by developing a photoinitiated atom transfer radical polymerization (pATRP) imprinting strategy using the high-biocompatible ovalbumin (Ova, pI 4.6) as template molecule. Therefore, thermo-responsive 'specific recognition sites' toward Ova were then achieved on the as-prepared MINCMs after the well-designed imprinting process. When the external temperature was set at 37 °C, excellent ovalbumin rebinding capacity (33.26 mg/g), selectivity factor (3.06) and structural stability were obtained. Importantly, as to the controllable biocompatibility research of this work, the bare glass and Ova-bound-MINCMs (the MINCMs were bound with Ova) showed basically the same cell adhesion behaviors and viability, indicating the excellent biocompatibility of the Ova-bound-MINCMs. Additionally, efficient and rapid regulation of cell adhesion/detachment on ovalbumin-bound MINCMs could be still obtained even after 10 cycles of temperature-switch process, which indicated that the as-prepared MINCMs had strong ability to work under high intensity and long continuous operation. [ABSTRACT FROM AUTHOR]

PDA/CaCO 3 -based imprinted nanocomposite membranes with high rebinding capacity and permselectivity performance were first proposed and developed for the selective recognition and separation of m-cresol. In spite of the intense efforts in selective separation field, the utilization and preparation of membrane-associated molecularly imprinted membranes with both enhanced rebinding capacities and high permselectivity performance still remain strong challenges. Herein, the bioinspired PDA-modified porous regenerated cellulose membrane (pRCMs) with mineral-coated multilevel structure was first proposed for the preparation of PDA/CaCO 3 -based imprinted nanocomposite membranes (PCIMs), m-cresol was chosen as the template molecule. Importantly, this bioinspired methodology was redeveloped and optimized to obtain abundant and uniformly distributed CaCO 3 nanocomposite on the surfaces of PDA@pRCMs. The as-designed sandwich-like imprinting structure were then constructed on PDA/CaCO 3 -based surfaces by developing a simple sol-gel imprinting process. Attributing to the design of the uniform CaCO 3 /PDA@pRCMs surfaces, amount of m-cresol-imprinted sites and permeation selectivity could be both optimized, it was no surprise that more excellent rebinding capacity (97.4 mg g−1), fast adsorption kinetics and high permselectivity coefficients (more than 13) were successfully achieved. Importantly, the whole synthesis process was conducted without complicated procedures and polluting the environment. Finally, the experimental results mentioned above, together with the green synthesis processes strongly demonstrated that our synthesis methodology of PCIMs had great potential for applications in various fields of selective separation, chemical industry, environment, biological medicine and so on. [ABSTRACT FROM AUTHOR]

A tremendous effort has been made for the synthesis and multifunction of environmentally responsive and selective separation membranes. With the bioinspired design of polydopamine (pDA)-assisted inorganic film, we proposed a simple, yet efficient, thermo-responsive cell culture substrate. Herein, a Ag/TiO 2 /pDA-based nanocomposite structure was initially obtained, and the ciprofloxacin-imprinted membranes (MINCMs) with thermo-responsive recognition sites were then synthesized by using NIPAm as backbone monomer. The opto-thermally responsive molecularly imprinted membranes (OT-MIMs) were obtained through in situ reduction of HAuCl 4 on membrane surfaces, Au nanoparticles were used as the light-heat converters. The light-switching principle was elaborated as well as the energy conversions that took place in this system. These conformational changes finally allowed the constructions or destructions of ciprofloxacin-imprinted sites. Due to the formation of the opto-thermally responsive ciprofloxacin-imprinted sites, rapid adsorption dynamics and opto-thermally responsive perm-selectivity toward templates were both achieved. Therefore, 58.65 mg/g of adsorption capacity and 4.91 of permselectivity factor from OT-MIMs were successfully obtained. Importantly, the as-designed bioinspired strategy led to a state-of-the-art design that was capable of reversibly controlling the flow rate ( J ) of ciprofloxacin from 12.10 to 4.93 mg min −1  cm −2 in less than a few minutes using light. [ABSTRACT FROM AUTHOR]

Cluster categories were introduced in 2006 by Buan-Marsh-Reineke-Reiten-Todorov in order to categorify acyclic cluster algebras without coefficients. Their construction was generalized by Amiot (2009) [3] and Plamondon (2011) [50] to arbitrary cluster algebras associated with quivers. A higher dimensional generalization is due to Guo (2011) [17]. Cluster algebras with coefficients are important since they appear in nature as coordinate algebras of varieties like Grassmannians, double Bruhat cells, unipotent cells, etc. The work of Geiss-Leclerc-Schröer often yields Frobenius exact categories which allow us to categorify such cluster algebras. In this paper, we generalize the construction of (higher) cluster categories by Claire Amiot and by Lingyan Guo to the relative context. We prove the existence of an n -cluster tilting object in a Frobenius extriangulated category, namely the Higgs category (generalizing the Frobenius categories of Geiss-Leclerc-Schröer), which is stably n -Calabi–Yau and Hom-finite, arising from a left (n + 1) -Calabi–Yau morphism. Our results apply in particular to relative Ginzburg dg algebras coming from ice quivers with potential and higher Auslander algebras associated to n -representation-finite algebras. [ABSTRACT FROM AUTHOR]

Click-Chemistry synergic MXene-functionalized flexible skeleton membranes achieved high-efficiency selective separation to artemisinin. [Display omitted] • Transport to specific molecule was achieved assisted by MXene laminated structure. • High stability for perm-selectivity of MIMs in mobile phase was achieved. • Click-chemistry drove to build dot-matrix imprinting units. • MIMs showed excellent antibacterial properties and sustainable reusability. Membrane-based technology with accurate-recognition and specific-transmission has been regarded as one of the most promising strategies in environmental protection and energy conservation. However, membrane technique still faces challenges of "trade-off effect" between high selectivity and permeation flux within organic-aqueous mixed matrix. Here, well-intergrown click-chemistry synergic MXene-functionalized flexible skeleton membranes has been prepared in this strategy, enabling size-exclusion&structure selectivity by uniform location array imprinting unit and transport performance towards specific medicinal molecules of artemisinin (Ars). The well-assembled ultrathin cascade-type MXene layer guarantees the narrow interlayer nanochannels and the flexible skeleton modified mesoporous SiO 2 nanoparticles provide active reaction platform for the construction of selective recognition space. The resulting membranes demonstrated outstanding selective separation performance with permeability factor that artesunate (Aru) /Ars and dihydro-artemisinin (d -Ars) / Ars of 3.17 and 2.89 and permeation flux of 1173.25 L·m−2·h−1·bar−1. Besides, combined with antibacterial durability, recycling performance, high separation performance in mobile phase stability of CMFMs, it is anticipated that this work hopefully opens a new avenue for efficient chiral separation to medicinal molecules, exhibiting broad potential for practical application. [ABSTRACT FROM AUTHOR]

In order to achieve the disturbance rejection and vibration abatement of a flexible marine riser system, this article discusses the design of disturbance observers and controller. The riser system subjected to external disturbances is a distributed parameter system in essence and represented by infinite-dimensional equation coupled with finite-dimensional equations. In addition to designing a basic boundary disturbance observer to deal with the time-varying boundary disturbance in this paper, an innovative infinite dimensional disturbance observer is also designed to compensate for the spatially distributed disturbance. Applying these two observers as feedforward compensators, an observer-based boundary controller is formulated by means of combining backstepping technique with boundary control method. Moreover, the well-posedness of the closed-loop riser system is discussed, and simulations are presented to display the effectiveness of formulated control approach. [ABSTRACT FROM AUTHOR]

A MXene-based SA-imprinted membrane using cooperative dual-imprinting strategy has been rationally developed to obtain high-selectivity double-layer-based SA-imprinted sites for selective recognition and separation of SA. [Display omitted] Ti 3 C 2 T x (MXene) has attracted extensive attention from scholars at home and abroad due to its rich surface termination functional groups and two-dimensional multilayer structure. In this work, MXene was introduced to the membrane by vacuum-assisted filtration processes, and the formed interlayer channel facilitated the construction of recognition sites and molecular transmission. In this paper, PDA@MXene@PDA@SiO 2 -PVDF dual-imprinted mixed matrix membrane (PMS-DIMs) were developed by the cooperative dual-imprinting strategy, which was used for the adsorption of shikimic acid (SA). Firstly, SiO 2 -PVDF nanofiber basement membrane were prepared by electrospinning method and the first Polydopamine (PDA)-based imprinted layer was constructed on the membrane. PDA not only realized the imprinting process, PDA modification was used to give MXene nanosheets better antioxidant properties and to confer the SiO 2 -PVDF nanofiber membrane the interface stability. After that, the second-imprinted sites were constructed on the stacked MXene nanosheets surface as well as between the layers. The SA dual-imprinted sites significantly increased the efficiency of the selective adsorption efficiency, when the template molecule passed through the membrane, the cooperative dual-imprinting strategy enabled multiplex recognition and adsorption of template molecules. As a consequence, which greatly improving the rebinding ability(262.17 g m−2), and mselectivity factors (β Catechol/SA , β P-HB/SA , β P-NP/SA were 2.34, 4.50 and 5.68). High stability proved the potentials of the PMS-DIMs for practical application. Precise SA-recognition sites were constructed on the PMS-DIMs, PMS-DIMs not only exhibit excellent selective rebinding properties but also have high permeability. [ABSTRACT FROM AUTHOR]

Primary Sjögren's Disease (pSjD) is considered a B cell-mediated disease. Toll-like receptor 10 (TLR10) is highly expressed in human B cells, indicating that TLR10 probably plays a vital role in pSjD. We examined TLR10 expression in peripheral B subsets of pSjD patients and analyzed their association with disease activity. We observed that TLR10 expression in total, naïve, memory, and switched memory B cells was significantly increased in low-activity pSjD patients as compared with healthy controls and high-activity patients. TLR10 expression in the above mentioned B subsets (except naïve B) was negatively correlated with serum levels of anti-SSA antibody and BAFF, respectively. Moreover, a higher proportion of high-activity pSjD patients was observed in TLR10 low- than high-expressed patients. Our study concluded that TLR10 expression in CD19+ B and memory B was negatively correlated with pSjD disease activity, suggesting that TLR10 might take part in the progression of pSjD. • Upregulated expression of TLR10 in switched memory B in pSjD patients. • TLR10 expression is reduced in B subsets in high-activity pSjD patients. • Expression of TLR10 in B subsets is negatively correlated with anti-SSA and BAFF. [ABSTRACT FROM AUTHOR]

PDA-induced molecularly imprinted nanocomposite membranes with three-dimensional MOFs-based imprinting structure, in which propranolol was template molecule, was constructed based on our newly-developed synergetic synthesis strategy of the sol-gel imprinting-initiated system. [Display omitted] Molecularly imprinted nanocomposite membranes with three-dimensional metal–organic frameworks (MOFs)-based structure (MINMs-TM) were successfully prepared by using propranolol as template molecule. Importantly, for the first time, polycarbonate track etch membranes had been used as the supporting surfaces to construct the polydopamine (PDA)-induced MOFs composite structure, in which the as-prepared PDA-modified surface would promote the crystallization and nucleation of ZIF-8-based composite layer. Based on the entire preparation processes of our design, the as-prepared PDA-induced ZIF-8-modified surfaces could be regarded as the imprinted-initiated units of sol–gel imprinting polymerization. Abundant recognition sits of propranolol were achieved in MINMs-TM, which showed characteristic properties of permeability and selectivity. Therefore, high adsorption capacity (41.31 mg/g) and fast adsorption equilibrium rate (within 30 min) had been successfully achieved. Meanwhile, excellent permselectivity rates (β) of MINMs-TM toward propranolol were also obtained as 5.04, 4.79 and 5.14, which MINMs-TM the successful synthesis of high-affinity and high-density propranolol-imprinted sites. Overall, for the practical selective separation and scalability, we had successfully MINMs-TM the preparation of MINMs-TM-based to selective rebinding and separation of propranolol from complex solution system and mimetic water sample, which had further confirmed the desired and potential applications of many environmental pollutants. [ABSTRACT FROM AUTHOR]

Lithium ion (Li+) is one of the important sustainable resource and it's urgently demanded to develop high-selectivity and high-efficient method to extract of Li+ from seawater. Hence, we propose the ester-functionalized ion-imprinted membrane (IIMs) with high selectivity and stability for the rebinding and separation of Li+ in aqueous medium via ion imprinted technology and membrane separation technology. In this work, the hydrophilic polydimethylsiloxane membranes (PDMS) are synthesized by self-polymerization of dopamine (DA) in aqueous solution, resulting in the fabrication of dense poly-dopamine (PDA) layer on the surface of PDMS (PDMS-PDA). In view of weak bonding forces (such as hydrogen bond, ionic bond and Van der Waals' force) between traditional imprinted polymer and ligand, the ester groups are formed between modified PDMS-PDA and ligand by surface grafting. The obtained Li+ imprinted membranes (Li-IIMs) have a suitable cavity and high adsorption capacity toward Li+ which reveal a high rebinding capacity (50.872 mg g−1) toward Li+ based on ample rebinding sites and strong affinity force. The superior relative selectivity coefficients (α Na/Li , α K/Li and α Rb/Li are 1.71, 4.56 and 3.80, respectively) can be also achieved. The selectivity factors of Li-IIMs for Na+, K+ and Rb+ are estimated to be 2.52, 2.8 and 3.03 times larger than Li+ non-imprinted membranes (Li-NIMs), which imply the superior selectivity of Li-IIMs toward Li+. The regeneration ability of Li-IIMs is observed by systematic batch experiments. In summary, it can be concluded that the rebinding capacities of Li-IIMs is slightly decrease after eluting process, owing to the Li-IIMs with outstanding stability performance. Presentation of the method pave a fine prospect for coming true the long-term use of imprinted membrane. [ABSTRACT FROM AUTHOR]

Graphical abstract Schematic illustration of the superhydrophilicity/underwater superoleophilicity mechanism for composite membrane and images of oil-water emulsion separation. Abstract Development of superhydrophilic, stable and cost-effective composite membranes for efficient oil-water emulsion separation is highly desirable. Herein, an irregular rod-like composite membrane was prepared through 3-aminopropyltriethoxysilane (APTES) modification, followed by acrylamide polymerization with atomic transfer radical polymerization (ATRP). The as-prepared membrane exhibits superhydrophilicity/underwater superoleophobicity due to its irregular rod-like structure and pores-induced capillary actions. The composite membrane has demonstrated sufficient stability in acidic, alkaline and salty environments due to the polymerization of acrylamide. Moreover, the as-prepared composite membrane has effectively separated various oil-water emulsions and demonstrated high permeation and superior flux recovery. The present work demonstrates that the ATRP-assisted composite membrane is a promising material in a wide range of applications, such as industrial wastewater recovery and drinking water treatment. [ABSTRACT FROM AUTHOR]