1. Engineering light-controllable CAR T cells for cancer immunotherapy.
- Author
-
Ziliang Huang, Yiqian Wu, Allen, Molly E., Yijia Pan, Kyriakakis, Phillip, Shaoying Lu, Ya-Ju Chang, Xin Wang, Shu Chien, and Yingxiao Wang
- Subjects
- *
CYTOTOXIC T cells , *CANCER cells , *T cells , *BIOENGINEERING , *T helper cells - Abstract
The article focuses on a light-inducible nuclear translocation and dimerization (LINTAD) system for gene regulation to control CAR T activation. It mentions that pulsed light stimulations can activate LINTAD CAR T cells with strong cytotoxicity against target cancer cells, both in vitro and in vivo; and also mentions that LINTAD system can serve as an efficient tool to noninvasively control gene activation and activate inducible CAR T cells for precision cancer immunotherapy.
- Published
- 2020
- Full Text
- View/download PDF