1. Effect of ropivacaine, mepivacaine or the combination of ropivacaine and mepivacaine for epidural anaesthesia on the postoperative recovery in patients undergoing caesarean section: a randomized, prospective, double-blind study.
- Author
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Wang, Muye, Liao, Chen, Li, Xiaocui, Chen, Weiming, Li, Yujie, Zhang, Wei, and Wang, Shouping
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MATERNAL health services , *ELECTIVE surgery , *ROPIVACAINE , *ANALGESIA , *COMBINATION drug therapy , *EPIDURAL anesthesia , *CONVALESCENCE , *TIME , *WOMEN , *VISUAL analog scale , *PIPERIDINE , *RANDOMIZED controlled trials , *RELAXATION for health , *EARLY ambulation (Rehabilitation) , *BLIND experiment , *BODY movement , *DESCRIPTIVE statistics , *RESEARCH funding , *CESAREAN section , *STATISTICAL sampling , *LONGITUDINAL method , *EPIDURAL catheters - Abstract
Background: Anaesthetic methods and drugs with rapid onset, rapid recovery and better postoperative analgesia are more suitable for rapid recovery in obstetric anaesthesia. We formulated the following hypothesis: a combination of mepivacaine and ropivacaine could provide a longer analgesic effect and have more advantages in terms of rapid-recovery indicators. Methods: A total of 180 pregnant women scheduled to undergo elective caesarean sections were randomly assigned to three surgical groups, which received 2% mepivacaine (Group M), 2% mepivacaine + 0.75% ropivacaine (Group MR) (Volume 1:1) or 0.75% ropivacaine (Group R) through an epidural catheter. The situation of postoperative analgesia and other indicators of rapid recovery were recorded. Results: One hundred and fifty patients were included in the final analysis. Their demographic data were similar. The visual analogue scale (VAS) scores of Group MR and Group R were lower than Group M at 1 and 2 h after surgery both at rest and with movement (P < 0.05), and the time to first ambulation in Group MR (17.38 ± 2.06 h) and Group M (17.20 ± 2.09 h) was shorter than that in Group R (22.18 ± 1.74 h) (P < 0.05). Conclusion: Application of 2% mepivacaine combined with 0.75% ropivacaine for epidural anaesthesia can provide longer postoperative analgesia and earlier ambulation, these effect may be more suitable than that of 2% mepivacaine or 0.75% ropivacaine alone for caesarean section. Trial registration: This study was registered at Chinese Clinical Trial Registry (Registration number: ChiCTR 2300078288; date of registration: 04/12/2023). [ABSTRACT FROM AUTHOR]
- Published
- 2024
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