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The teaching-learning-based optimization (TLBO) algorithm is a population-based optimization algorithm which is based on the effect of the influence of a teacher on the output of learners in a class. A variant of teaching-learning-based optimization (TLBO) algorithm with differential learning (DLTLBO) is proposed in the paper. In this method, DLTLBO utilizes a learning strategy based on neighborhood search of teacher phase in the standard TLBO to generate a new mutation vector, while utilizing a differential learning to generate another new mutation vector. Then DLTLBO employs the crossover operation to generate new solutions so as to increase the diversity of the population. By the integration of the local search and the global search, DLTLBO achieves a tradeoff between exploration and exploitation. To demonstrate the effectiveness of our approaches, 24 benchmark functions are used for simulating and testing. Moreover, DLTLBO is used for parameter estimation of digital IIR filter and experimental results show that DLTLBO is superior or comparable to other given algorithms for the employed examples. [ABSTRACT FROM AUTHOR]