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Background: The main obstacle encountered in microarray technology is how to mine the valuable information under the profiles and study the genes function.Objective: Maximal information coefficient (MIC) is a novel, non-parametric statistic that has been successfully applied to genome-wide association studies and differentially gene and miRNA expression analysis. However, the data used in these applications are not gold standard but real data.Methods: Therefore, this study attempts to test the feasibility of MIC for differentially expressed gene identification with simulation data.Results: Our experiments indicate that, MIC perfermance is better than Limma always, which is almost the same level of SAM, ROTS or DESeq2. However, the count of AUC < 0.5 of MIC is significantly smaller than the three methods, and MIC does not exhibit an abnormal phenomenon in which the AUC increases as the noise increases.Conclusions: Compared to the existing methods, our experiments show that MIC is not only in the first tier in identifying differentially expressed genes and noise immunity, but also shows better robustness and stronger data/environment adaptability. [ABSTRACT FROM AUTHOR]