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The recently proposed q-rung picture fuzzy set (q-RPFSs) can describe complex fuzzy and uncertain information effectively. The Hamy mean (HM) operator gets good performance in the process of information aggregation due to its ability to capturing the interrelationships among aggregated values. In this study, we extend HM to q-rung picture fuzzy environment, propose novel q-rung picture fuzzy aggregation operators, and demonstrate their application to multi-attribute group decision-making (MAGDM). First of all, on the basis of Dombi t-norm and t-conorm (DTT), we propose novel operational rules of q-rung picture fuzzy numbers (q-RPFNs). Second, we propose some new aggregation operators of q-RPFNs based on the newly-developed operations, i.e., the q-rung picture fuzzy Dombi Hamy mean (q-RPFDHM) operator, the q-rung picture fuzzy Dombi weighted Hamy mean (q-RPFDWHM) operator, the q-rung picture fuzzy Dombi dual Hamy mean (q-RPFDDHM) operator, and the q-rung picture fuzzy Dombi weighted dual Hamy mean (q-RPFDWDHM) operator. Properties of these operators are also discussed. Third, a new q-rung picture fuzzy MAGDM method is proposed with the help of the proposed operators. Finally, a best project selection example is provided to demonstrate the practicality and effectiveness of the new method. The superiorities of the proposed method are illustrated through comparative analysis. [ABSTRACT FROM AUTHOR]

Uncontrolled inflammation is a pathological state that underlies many diseases. Despite the development of numerous anti-inflammatory agents, the treatment of uncontrolled inflammation remains a challenging task. We developed a targeted delivery system for [5-(p-fluorophenyl)-2-ureido]thiophene-3-carboxamide (TPCA-1), a potent inhibitor of the NF-κB signaling pathway. The system comprises TPCA-1-loaded nanoparticles (NPs) functionalized with a monoclonal antibody (mAb) that specifically binds to the break point of the IgD6 region of the platelet/endothelial cell adhesion molecule-1 (PECAM-1) extracellular segment that is overexposed on the injured endothelium and activated macrophages during the pathogenesis of inflammation. In vitro binding and cellular uptake experiments revealed that the mAb modification on NPs could significantly enhance uptake by both Raw264.7 and HUVEC compared with unmodified NPs. In studies conducted at the cellular level focusing on anti-inflammatory and antioxidant effects, this formulation was found to effectively inhibit M1 polarization of macrophages, downregulate the secretion of pro-inflammatory cytokines, and reduce the production of reactive oxygen species (ROS) and nitric oxide (NO). In an animal model of vascular endothelial injury with acute inflammation, these NPs were capable of delivering TPCA-1 to inflammatory lesions in a targeted manner. Compared with the free agent-treated group, the NP-treated group exhibited reduced infiltration of inflammatory cells. In conclusion, our study demonstrates that this targeted delivery of TPCA-1-loaded NPs represents a promising strategy for improved mitigation of uncontrolled inflammation. [ABSTRACT FROM AUTHOR]