1. Simultaneous Determination of Sodium Pentachlorophenolate and Its Metabolites in Swine Samples.
- Author
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Jia, Qi, Cui, Miao, Li, Meiling, Li, Yuncheng, Meng, Fanbing, Xu, Yanyang, Qian, Yongzhong, Yan, Xue, and Qiu, Jing
- Subjects
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LIQUID chromatography-mass spectrometry , *GAS chromatography , *SWINE , *PERSISTENT pollutants , *SODIUM channels , *METABOLITES , *FOOD of animal origin , *LUNGS , *HEART - Abstract
Pentachlorophenol (PCP) is a persistent organic pollutant usually present in the form of sodium salts (PCP-Na) that has been banned for many years, but it can still be detected in animal food. The present study established a method of detecting PCP-Na and its metabolites—tetrachlorocatechol (TCC), pentachlorophenol acetate (PCP-acetate), and pentachloroanisole (PCA)—in swine samples (pork, fat, liver, heart, lungs and kidney), simultaneously using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and gas chromatography-tandem mass spectrometry (GC-MS/MS) based on the modified QuEChERS pre-treatment method. The validation results exhibited a good sensitivity with limits of quantitation (LOQs) of 1 μg/kg–2 μg/kg. The recoveries of spiked samples were in the range of 60.5–119.9%, with a relative standard deviation (RSD) between replicates (n = 5) of between 0.70% and 12.06%. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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