The fundamental aim of this research is to analyze the configuration of 픽4R submodules, skew cyclic codes over 픽4R and establish their connection with DNA codes, where 픽4 is a field of order 4 and R = 픽4 + u픽4 + v픽4 + w픽4 with u2 = u, v2 = v, w2 = w, uv = vu = 0, vw = wv = 0, wu = uw = 0 is a finite ring. This is achieved by examining particular subclasses like reversible codes. Ultimately, this study aims to utilize Gray maps to derive codes that possess the characteristics of DNA structures. At the end of this paper, we have provided the necessary and sufficient condition for skew cyclic codes to be reversible complement. [ABSTRACT FROM AUTHOR]