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In recent years, conditioned particle image velocimetry (CPIV) has attracted much attention for flame front extraction. It is an economical and straightforward technique because the flame front can be obtained simply from Mie-scattering images. In the current work, Mie-scattering and hydroxyl planar laser-induced fluorescence (OH-PLIF) measurements were taken simultaneously to study the applicability of CPIV under conditions with varying equivalence ratios, and the reliable working range of the CPIV method and the source of bias were clarified quantitatively. The premixed dimethyl ether (DME)/air flames stabilized on a two-dimensional bluff body were tested. It is found that the accuracy of the CPIV method worsens as the equivalence ratio decreases. The bias of CPIV is supposed to be related to the flame structure and aerodynamics. The extraction deviation in the upstream region for the stable flames is more significant than that in the downstream area due to the intensified interaction between the shear layer and flame near the bluff body. However, for the flames approaching the lean blow-off (LBO), the bias in the upstream part is smaller than that in the downstream area, which is related to the "back-support" of the hot recirculation zone (RZ). In addition, the difference between the results obtained by CPIV and OH-PLIF is usually the preheat layer of flame and concave-wrinkled location of OH-PLIF filled with CH2O radicals, especially under conditions close to the LBO, which can be used to estimate the spatial distribution of CH2O. [ABSTRACT FROM AUTHOR]

Associations between leisure sedentary behavior (especially leisure screen time, LST) and irritable bowel syndrome (IBS) have been reported, but causality is unclear. Here, the two-sample Mendelian randomization was performed to investigate the causal association between LST and IBS. Two recently published genome-wide association studies (GWASs) including a total of 1,190,502 people from Europe were used as our data source. Inverse variance weighting (OR = 1.120, 95% CI 1.029–1.219) and weighted median (OR = 1.112, 95% CI 1.000–1.236) analyses revealed a causal effect between LST and IBS. There was no evidence of pleiotropy in the sensitive analysis (MR-Egger, p = 0.139). After removing potentially confounding single nucleotide polymorphisms (SNPs), similar results were found using inverse variance weighting (OR = 1.131, 95% CI 1.025–1.248) and weighted median (OR = 1.151, 95% CI 1.020–1.299), as well as in the validation analyses using inverse variance weighting (OR = 1.287, 95% CI 0.996–1.662). This study provided support for a possible causal relationship between leisure screen time and IBS. [ABSTRACT FROM AUTHOR]

Associations between leisure sedentary behavior (especially leisure screen time, LST) and irritable bowel syndrome (IBS) have been reported, but causality is unclear. Here, the two-sample Mendelian randomization was performed to investigate the causal association between LST and IBS. Two recently published genome-wide association studies (GWASs) including a total of 1,190,502 people from Europe were used as our data source. Inverse variance weighting (OR = 1.120, 95% CI 1.029–1.219) and weighted median (OR = 1.112, 95% CI 1.000–1.236) analyses revealed a causal effect between LST and IBS. There was no evidence of pleiotropy in the sensitive analysis (MR-Egger, p = 0.139). After removing potentially confounding single nucleotide polymorphisms (SNPs), similar results were found using inverse variance weighting (OR = 1.131, 95% CI 1.025–1.248) and weighted median (OR = 1.151, 95% CI 1.020–1.299), as well as in the validation analyses using inverse variance weighting (OR = 1.287, 95% CI 0.996–1.662). This study provided support for a possible causal relationship between leisure screen time and IBS. [ABSTRACT FROM AUTHOR]