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A mixed ligand-nickel complex of formula [Ni(DBMA)(en)(H2O)3]·3H2O, where DBMA = 2,2-dibenzyl malonic acid, en = ethylenediamine, has been synthesized and characterized by elemental analysis, IR, and single-crystal X-ray diffraction. The unit cell parameters for the complex area = 16.0214(16) Å,b = 10.0801(10) Å,c = 15.4024(15) Å,β = 108.488(2)°,V = 2359.074(40) Å3,Z = 4, space groupP2(1)/c. The crystal system of the complex is monoclinic. Thermal stability of the water cluster by thermogravimetric analysis has been studied. Gel electrophoresis assay demonstrated the ability of the complex to cleave pBR322 plasmid DNA. The binding of the complex with HeLa cell DNA (HC-DNA) has been investigated by fluorescence spectra. Value of IC50calculated for the complex shows that the complex exhibits good cytotoxicity against HeLa and KB cell lines. [ABSTRACT FROM AUTHOR]

Two manganese complexes, [Mn(L1)2(dibe)2](L1) (1) and [Mn(L2)2(dibe)2] (2) (where L1 = 2,2′-bipyridine (bipy), L2 = 1,10-phenanthroline (phen)), were synthesized by using a carboxylic acid ligand (dibe = 2,2-dibenzylmalonate acid). The two complexes were characterized using IR, elemental analysis, and X-ray crystallography. Fluorescence analysis indicates that the two complexes can bind to HeLa cell DNA (HC-DNA), and gel electrophoresis assay demonstrates the ability of the complexes to cleave the HC-DNA. The two complexes exhibit cytotoxic specificity and significant cancer cell inhibitory rate. Furthermore, apoptotic tests demonstrate that these two complexes have apoptotic effects on HeLa cells. [ABSTRACT FROM AUTHOR]