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1. Defective Phosphorylation of Interleukin-18 Receptor β Causes Impaired Natural Killer Cell Function in Systemic-Onset Juvenile Idiopathic Arthritis.

Author

de Jager, Wilco, Vastert, Sebastiaan J., Beekman, Jeffrey M., Wulffraat, Nico M., Kuis, Wietse, Coffer, Paul J., and Prakken, Berent J.

Subjects
*INTERLEUKINS, *KILLER cells, *ARTHRITIS, *CELL physiology, *FIRE assay, *PHOSPHORYLATION, *PHENOTYPES
Abstract

The article explores the association of high plasma levels of interleukin-18 (IL-18) with the documented natural killer (NK) cell failure in systemic-onset juvenile idiopathic arthritis (JIA). It notes the characterization of the phenotype and function of NK cells by staining and functional assays in vitro. According to the article, impaired NK cell function in systemic-onset JIA features a defect in the phosphorylation of IL-18RB.

Published
2009
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