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The purpose of this study was to investigate the effects of the active ingredients of barley lees on the physiological indexes, intestinal flora, and liver transcriptome of mice fed a high‐fat diet. Twenty‐four male C57BL/6J mice were randomly divided into 4 groups and fed the experimental diets for 5 weeks. The results showed that the fat‐soluble components of distillers' grains significantly reduced body weight, abdominal fat, perirenal fat, blood glucose, low‐density lipoprotein cholesterol, triglycerides, and total cholesterol in the high‐fat diet‐fed mice (p <.05), significantly decreased alanine aminotransferase and malondialdehyde levels, and significantly increased total superoxide dismutase, catalase, reduced glutathione and glutathione peroxidase levels (p <.05). At the phylum level, lipid‐soluble components significantly increased the abundance of Bacteroidetes and decreased the Firmicutes/Bacteroidetes ratio. At the genus level, the relative abundances of Bacteroidetes and Clostridium were increased. Transcriptomic analysis showed that lipid‐soluble components of spent grains reduced the mRNA expression of ANGPTL8, CD36, PLTP, and SOAT1 and increased the mRNA expression of CYP7A1 and ABCA1 in the cholesterol metabolism pathway, promoted the transport of cholesterol, and inhibited the absorption of cholesterol, which can decrease cholesterol levels by speeding up the conversion of cholesterol into bile acids. [ABSTRACT FROM AUTHOR]

Tensor completion has gained considerable research interest in recent years and has been frequently applied to image restoration. This type of method basically employs the low‐rank nature of images, implicitly requiring that the whole picture is of globally consistent features. As a result, existing tensor completion algorithms often give reasonably good performance if the target image has only random pixel‐level missing. Unfortunately, pixel‐level missing is very rare in practice and it is often wanted to restore an image with irregular hole‐shaped missing, such as removing electricity poles from landscape photos or irrelevant people from tourist photos. This task is extremely difficult for traditional low‐rank based tensor completion methods. To overcome this drawback, a Contour Information regularized Tensor RIng Completion (CITRIC) method is proposed for practical image restoration. Meanwhile, the contour information regularization is used to capture significant local features, whereas the low‐rank tensor ring structure is utilized to capture as much global information as possible. The alternating direction method of multipliers (ADMM) is adopted to optimize the cost function. Extensive experimental results using real‐world images show that CITRIC is more practical than existing methods and can restore real‐world images with irregular hole‐shaped missing. [ABSTRACT FROM AUTHOR]

Ischemic stroke is the most common stroke and the leading cause of disability and death in the world. Computed tomography (CT) is a popular and economical diagnostic device for the stroke, However the ischemic stroke lesions are not evident on CT images and the diagnostic result relies on the visual observation of neurologists, which may vary from doctor to doctor. To facilitate the treatment, a computer‐aided detection algorithm on CT images is proposed to help clinician for the ischemic stroke screening. In order to obtain accurate lesion annotation on CT images, novel automatic algorithms are developed to achieve image pairing, calibration, and registration. Then, a new framework with the symmetric feature extraction and comparison is proposed to identify and locate the ischemic stroke lesion. Experimental results show that this method achieves 75% of DICE in the detection of ischemic stroke lesions, which is higher than other methods by 4%. Its competitive results compared with seven latest methods is shown in terms of extensive qualitative and quantitative evaluation. This method can accurately detect the lesion in the CT images through the comparison of symmetric regional features, which has contributed to the clinical diagnosis of ischemic stroke. [ABSTRACT FROM AUTHOR]