85 results on '"Kronbichler, Andreas"'
Search Results
2. Using a Network-Based Analysis Approach to Investigate the Involvement of S. aureus in the Pathogenesis of Granulomatosis with Polyangiitis.
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Rowland, Gregory, Kronbichler, Andreas, Smith, Rona, Jayne, David, van der Graaf, Piet H., and Chelliah, Vijayalakshmi
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GRANULOMATOSIS with polyangiitis , *DISEASE relapse , *PATHOGENESIS , *SYMPTOMS , *STAPHYLOCOCCUS aureus , *MUPIROCIN - Abstract
Chronic nasal carriage of Staphylococcus aureus (SA) has been shown to be significantly higher in GPA patients when compared to healthy subjects, as well as being associated with increased endonasal activity and disease relapse. The aim of this study was to investigate SA involvement in GPA by applying a network-based analysis (NBA) approach to publicly available nasal transcriptomic data. Using these data, our NBA pipeline generated a proteinase 3 (PR3) positive ANCA associated vasculitis (AAV) disease network integrating differentially expressed genes, dysregulated transcription factors (TFs), disease-specific genes derived from GWAS studies, drug–target and protein–protein interactions. The PR3+ AAV disease network captured genes previously reported to be dysregulated in AAV associated. A subnetwork focussing on interactions between SA virulence factors and enriched biological processes revealed potential mechanisms for SA's involvement in PR3+ AAV. Immunosuppressant treatment reduced differential expression and absolute TF activities in this subnetwork for patients with inactive nasal disease but not active nasal disease symptoms at the time of sampling. The disease network generated identified the key molecular signatures and highlighted the associated biological processes in PR3+ AAV and revealed potential mechanisms for SA to affect these processes. [ABSTRACT FROM AUTHOR]
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- 2023
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3. Molecular Pathology, Diagnostics, and Therapeutics of Nephropathy.
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Kronbichler, Andreas and Tesar, Vladimir
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MOLECULAR pathology , *KIDNEY diseases , *THERAPEUTICS , *POLYCYSTIC kidney disease - Abstract
Years of standing still have ended, and the field of nephrology has seen a plethora of clinical trials, changing the therapeutic landscape of chronic kidney disease (CKD) and immune-mediated kidney disease management. POP inhibition might be carried forward to develop therapies that aim to reduce the damage to kidneys caused by ischemia and reperfusion injury, such as after kidney transplantation. Overall, the provided results will further help to increase our understanding of kidney disease in more detail and will eventually lead to individualized treatment approaches for the plethora of kidney diseases. Kidney biopsies remain valuable to a final diagnosis and have achieved enormous value in predicting prognosis in several kidney diseases, such as anti-neutrophil cytoplasmic antibody (ANCA)-glomerulonephritis [[1]]. [Extracted from the article]
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- 2022
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4. Association of venous thromboembolic events with skin, pulmonary and kidney involvement in ANCA-associated vasculitis: a multinational study.
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Moiseev, Sergey, Kronbichler, Andreas, Makarov, Egor, Bulanov, Nikolay, Crnogorac, Matija, Direskeneli, Haner, Galesic, Kresimir, Gazel, Ummugulsum, Geetha, Duvuru, Guillevin, Loic, Hrušková, Zdenka, Little, Mark A, Ahmed, Adeel, McAdoo, Stephen P, Mohammad, Aladdin J, Moran, Sarah, Novikov, Pavel, Pusey, Charles D, Rahmattulla, Chinar, and Satrapová, Veronika
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THROMBOEMBOLISM risk factors , *SKIN diseases , *RESEARCH , *VEINS , *PULMONARY embolism , *CONFIDENCE intervals , *MULTIPLE regression analysis , *ANTINEUTROPHIL cytoplasmic antibodies , *MEDICAL cooperation , *TERTIARY care , *REGRESSION analysis , *RISK assessment , *KIDNEY diseases , *GRANULOMATOSIS with polyangiitis , *THROMBOEMBOLISM , *DESCRIPTIVE statistics , *STATISTICAL models , *ODDS ratio , *VASCULITIS , *MICROSCOPIC polyangiitis , *DISEASE complications - Abstract
Objective To investigate the occurrence of venous thromboembolic events (VTE) in a large cohort of patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) across the European Union, Turkey, Russia, UK and North America. Methods Patients with a definite diagnosis of AAV who were followed for at least 3 months and had sufficient documentation were included. Data on VTE, including either deep vein thrombosis or pulmonary embolism, were collected retrospectively from tertiary vasculitis centres. Univariate and multivariate regression models were used to estimate odds ratios (ORs) and 95% CIs. Results Over a median follow-up of 63 (interquartile range: 29, 101) months, VTE occurred in 278 (9.7%) of 2869 AAV patients with a similar frequency across different countries (from 6.3% to 13.7%), and AAV subtype [granulomatosis with polyangiitis: 9.8% (95% CI: 8.3, 11.6%); microscopic polyangiitis: 9.6% (95% CI: 7.9, 11.4%); and eosinophilic granulomatosis with polyangiitis: 9.8% (95% CI: 7.0, 13.3%)]. Most VTE (65.6%) were reported in the first-year post-diagnosis. Multiple factor logistic regression analysis adjusted for sex and age showed that skin (OR 1.71, 95% CI: 1.01, 2.92), pulmonary (OR 1.78, 95% CI: 1.04, 3.14) and kidney [eGFR 15–60 ml/min/1.73 m2, OR 2.86 (95% CI: 1.27, 6.47); eGFR <15 ml/min/1.73 m2, OR 6.71 (95% CI: 2.94, 15.33)] involvement were independent variables associated with a higher occurrence of VTE. Conclusion Two-thirds of VTE occurred during the initial phase of active disease. We confirmed previous findings from smaller studies that a decrease in kidney function, skin involvement and pulmonary disease are independently associated with VTE. [ABSTRACT FROM AUTHOR]
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- 2021
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5. Recommendations for the use of COVID-19 vaccines in patients with immune-mediated kidney diseases.
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Kronbichler, Andreas, Anders, Hans-Joachim, Fernandez-Juárez, Gema Maria, Floege, Jürgen, Goumenos, Dimitrios, Segelmark, Mårten, Tesar, Vladimir, Turkmen, Kultigin, Kooten, Cees van, Bruchfeld, Annette, and Association), the Immunonephrology Working Group of the ERA-EDTA (European Renal Association—European Dialysis and Transplant
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COVID-19 , *COVID-19 vaccines , *KIDNEY diseases , *TYPE I interferons - Abstract
Open in new tab Download slide Open in new tab Download slide Coronavirus disease 2019 (COVID-19) vaccine platforms are becoming available and are the most promising strategy to curb the spread of severe acute respiratory syndrome coronavirus 2 infections. However, numerous uncertainties exist regarding the pros and cons of vaccination, especially in patients with (immune-mediated) kidney diseases on immunosuppressive drugs. Here, members of the Immunonephrology Working Group of the European Renal Association–European Dialysis and Transplant Association discuss 13 frequently asked questions regarding the safety and efficacy of the most promising vaccine candidates. Post-marketing surveillance should be performed to estimate the rate of vaccine response (humoral and cellular) of different vaccine platforms and disease activity following the administration of COVID-19 vaccines. Some of the candidates induce signalling pathways, which also promote autoimmune kidney diseases, e.g. type I interferons in systemic lupus erythematosus. Efficacy estimates would thus far favour the use of selected COVID-19 vaccines, such as BNT162b2, mRNA-1273 or Gam-COVID-Vac. Humoral immune response after vaccination should be monitored using appropriate assays. Even in the absence of neutralizing antibodies, patients might be protected by a sufficient cellular immune response capable of reducing the severity of COVID-19. A reduced vaccine response after the use of CD20-depleting agents is anticipated and it is particularly important to discuss strategies to improve vaccine response with these patients. Distancing and shielding measures remain important, as not all vaccines fully protect from coronavirus infection. In-depth information about the most pressing vaccine questions is essential to reduce vaccine hesitancy of patients. [ABSTRACT FROM AUTHOR]
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- 2021
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6. Plasma exchange in ANCA-associated vasculitis: the pro position.
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Kronbichler, Andreas, Shin, Jae Il, Wang, Chia-Shi, Szpirt, Wladimir M, Segelmark, Mårten, and Tesar, Vladimir
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CHRONIC kidney failure , *VASCULITIS , *GLOMERULAR filtration rate , *GRANULOMATOSIS with polyangiitis , *KIDNEY physiology , *NEPHRITIS - Abstract
Plasma exchange (PLEX) is capable of removing significant amounts of circulating antibodies. In anti-neutrophil cytoplasmic antibody-associated vasculitis, PLEX was reserved for patients with severe presentation forms such as rapidly progressive glomerulonephritis and pulmonary haemorrhage. The Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis (PEXIVAS) trial included all comers with a glomerular filtration rate <50 mL/min/1.73 m2 and thus aimed to answer the question of whether PLEX is an option for patients with no relevant kidney function impairment or not. PEXIVAS revealed that after a follow-up of almost 3 years, routine administration of PLEX does not provide an additional benefit to reduce the rate of a composite comprising end-stage kidney disease or death. In the absence of histological parameters, it is tempting to speculate whether PLEX is effective or not in those with a potential for renal recovery. A subset of patients presented with alveolar haemorrhage, and there was a trend towards a better outcome of such cases receiving PLEX. This would be in line with observational studies reporting a recovery of alveolar haemorrhage following extracorporeal treatment. In this PRO part of the debate, we highlight the shortcomings of the PEXIVAS trial and stimulate further research paths, which in our eyes are necessary before abandoning PLEX from the therapeutic armamentarium. [ABSTRACT FROM AUTHOR]
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- 2021
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7. Asymptomatic patients as a source of COVID-19 infections: A systematic review and meta-analysis.
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Kronbichler, Andreas, Kresse, Daniela, Yoon, Sojung, Lee, Keum Hwa, Effenberger, Maria, and Shin, Jae Il
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COVID-19 , *META-analysis , *SYMPTOMS , *COMPUTED tomography - Abstract
• Asymptomatic patients with COVID-19 tend to be younger and may be more socially active. • Laboratory findings in most asymptomatic cases were unremarkable. • Around half of the cases had lung opacities, most frequently ground glass opacities. • Patients with normal CT were younger than patients with abnormal CT. Coronavirus Disease 2019 (COVID-19) is characterized by an unpredictable disease course, ranging from asymptomatic to severe, life-threatening infections. Asymptomatic COVID-19 infections have been described, and the aim of this systematic review was to summarise their presentation forms. We searched PubMed® and Google® (1 December 2019 to 29 March 2020) and extracted age, laboratory findings, and computed tomography (CT) scans. Pooled incidence rates of clinical characteristics were analyzed using random-effect models. In total, 506 patients from 34 studies (68 single cases and 438 from case-series) with an asymptomatic course were identified. Patients with normal radiology were younger (19.59 ± 17.17 years) than patients with abnormal radiology (39.14 ± 26.70 years) (p -value = 0.013). Despite being asymptomatic, CT investigations revealed abnormalities in 62.2% of the cases; ground-glass opacities were most frequently observed (43.09% by meta-analysis). Most studies reported normal laboratory findings (61.74% by meta-analysis). More than half of the patients without any symptoms present with CT abnormalities. Asymptomatic patients may be contagious and thus a potential source of transmission of COVID-19. [ABSTRACT FROM AUTHOR]
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- 2020
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8. Immunotherapy for ANCA-associated vasculitis during the COVID-19 pandemic.
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Gapud, Eric J., Kronbichler, Andreas, Gauckler, Philipp, and Geetha, Duvuru
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COVID-19 pandemic , *COVID-19 , *VASCULITIS , *DISEASE progression - Abstract
Since the first description of infections with severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2) in China in December 2019, it has evolved into a pandemic and emerged as an unprecedented worldwide crisis overwhelming healthcare systems globally. Analysis of the available literature to date suggests that, in addition to older age, patients with underlying co-morbidities including hypertension, diabetes, heart disease are at higher risk for severe disease with increased mortality. Practitioners around the world also have become increasingly concerned that immunosuppressed patients including those with autoimmune diseases may be at increased risk for developing Coronavirus Disease 2019 (COVID-19) with serious complications. Very little is known about how anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis modifies the susceptibility, clinical presentation and disease course of COVID-19. In this review, we discuss the mechanism of action and challenges of the current therapeutic armamentarium of ANCA-associated vasculitis and outline approaches to management of ANCA-associated vasculitis during the COVID-19 pandemic. [ABSTRACT FROM AUTHOR]
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- 2020
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9. Association of the COVID-19 pandemic with Internet Search Volumes: A Google TrendsTM Analysis.
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Effenberger, Maria, Kronbichler, Andreas, Shin, Jae Il, Mayer, Gert, Tilg, Herbert, and Perco, Paul
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COVID-19 pandemic , *INTERNET searching , *COVID-19 , *PUBLIC interest - Abstract
• Worldwide public interest in COVID-19 increased when numbers of newly infected patients started to increase exponentially in China. • The peak of worldwide interest was mid of March 2020 shortly after COVID-19 was declared a pandemic. • Public interest in COVID-19 correlates with the number of newly reported COVID-19 cases, with highest interest observed on average 11.5 days before the peak of newly reported COVID-19 cases. To assess the association of public interest in coronavirus infections with the actual number of infected cases for selected countries across the globe. We performed a Google TrendsTM search for "Coronavirus" and compared Relative Search Volumes (RSV) indices to the number of reported COVID-19 cases by the European Center for Disease Control (ECDC) using time-lag correlation analysis. Worldwide public interest in Coronavirus reached its first peak end of January when numbers of newly infected patients started to increase exponentially in China. The worldwide Google TrendsTM index reached its peak on the 12th of March 2020 at a time when numbers of infected patients started to increase in Europe and COVID-19 was declared a pandemic. At this time the general interest in China but also the Republic of Korea has already been significantly decreased as compared to end of January. Correlations between RSV indices and number of new COVID-19 cases were observed across all investigated countries with highest correlations observed with a time lag of −11.5 days, i.e. highest interest in coronavirus observed 11.5 days before the peak of newly infected cases. This pattern was very consistent across European countries but also holds true for the US. In Brazil and Australia, highest correlations were observed with a time lag of −7 days. In Egypt the highest correlation is given with a time lag of 0, potentially indicating that in this country, numbers of newly infected patients will increase exponentially within the course of April. Public interest indicated by RSV indices can help to monitor the progression of an outbreak such as the current COVID-19 pandemic. Public interest is on average highest 11.5 days before the peak of newly infected cases. [ABSTRACT FROM AUTHOR]
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- 2020
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10. Comorbidities in ANCA-associated vasculitis.
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Kronbichler, Andreas, Leierer, Johannes, Gauckler, Philipp, and Shin, Jae Il
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ATHEROSCLEROSIS risk factors , *CARDIOVASCULAR disease prevention , *DIABETES risk factors , *HYPERTENSION risk factors , *THROMBOEMBOLISM risk factors , *COMORBIDITY , *AUTOIMMUNE diseases , *BLOOD coagulation disorders , *CARDIOVASCULAR diseases risk factors , *DIABETES , *HYPERCHOLESTEREMIA , *HYPERTENSION , *RISK assessment , *VASCULITIS , *DISEASE remission , *ANTINEUTROPHIL cytoplasmic antibodies , *DISEASE complications , *DISEASE risk factors ,THROMBOEMBOLISM prevention ,MORTALITY risk factors - Abstract
The prognosis of patients with ANCA-associated vasculitis has improved over the past decades, but overall survival rates are still unsatisfactory. Recent research has focused on complications of immunosuppressive measures and comorbidities of ANCA-associated vasculitis. This review focuses on thromboembolic and cardiovascular events. A considerably increased risk of thromboembolic events has been reported, which is associated with active disease and impaired coagulation factors. There is mounting evidence that a hypercoagulable state is present even in patients in remission, and studies investigating the impact of tailored anticoagulation are needed to reduce the burden of thromboembolism. Cardiovascular mortality is one of the leading causes of death and accelerated atherosclerosis is frequently observed in patients with ANCA-associated vasculitis. A high frequency of patients develops hypertension, diabetes mellitus and hypercholesterolaemia, either as a consequence of immunosuppression or associated with the underlying disease. The current control of modifiable cardiovascular risk factors is insufficient and thorough reviews should be performed periodically. Treatment of these risk factors should be adopted according to current recommendations related to individual cardiovascular risk prediction. [ABSTRACT FROM AUTHOR]
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- 2020
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11. Association of Pulmonary Hemorrhage, Positive Proteinase 3, and Urinary Red Blood Cell Casts With Venous Thromboembolism in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis.
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Kronbichler, Andreas, Leierer, Johannes, Shin, Jae Il, Merkel, Peter A., Spiera, Robert, Seo, Philip, Langford, Carol A., Hoffman, Gary S., Kallenberg, Cees G. M., St.Clair, E. William, Brunetta, Paul, Fervenza, Fernando C., Geetha, Duvuru, Keogh, Karina A., Monach, Paul A., Ytterberg, Steven R., Mayer, Gert, Specks, Ulrich, and Stone, John H.
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AUTOIMMUNE disease diagnosis , *HEMORRHAGE complications , *THROMBOEMBOLISM risk factors , *RITUXIMAB , *ERYTHROCYTES , *AGE distribution , *AUTOIMMUNE diseases , *CONFIDENCE intervals , *HEART , *HEMATURIA , *LUNG diseases , *MULTIVARIATE analysis , *PROTEOLYTIC enzymes , *RISK assessment , *SEX distribution , *STATISTICS , *URINALYSIS , *VASCULITIS , *VEINS , *TREATMENT effectiveness , *DISEASE duration , *ODDS ratio , *ANTINEUTROPHIL cytoplasmic antibodies , *DISEASE complications - Abstract
Objective: To assess the frequency of venous thromboembolism (VTE) events in the Rituximab in Antineutrophil Cytoplasmic Antibody (ANCA)–Associated Vasculitis (RAVE) trial and identify novel potential risk factors. Methods: VTE events in 197 patients enrolled in the RAVE trial were analyzed. Baseline demographic and clinical characteristics were recorded, and univariate and multivariate analyses were performed to identify factors associated with VTE in ANCA‐associated vasculitis (AAV). Results: VTE occurred in 16 patients (8.1%) with an overall average time to event of 1.5 months (range 1.0–2.75). In univariate analyses with calculation of hazard ratios (HRs) and 95% confidence intervals (95% CIs), heart involvement (HR 17.408 [95% CI 2.247–134.842]; P = 0.006), positive proteinase 3 (PR3)–ANCA (HR 7.731 [95% CI 1.021–58.545]; P = 0.048), pulmonary hemorrhage (HR 3.889 [95% CI 1.448–10.448]; P = 0.008), and the presence of red blood cell casts (HR 15.617 [95% CI 3.491–69.854]; P < 0.001) were associated with the onset of VTE. In multivariate models adjusted for age and sex, the significant associations between VTE events and heart involvement (HR 21.836 [95% CI 2.566–185.805]; P = 0.005), PR3‐ANCA (HR 9.12 [95% CI 1.158–71.839]; P = 0.036), pulmonary hemorrhage (HR 3.91 [95% CI 1.453–10.522]; P = 0.007), and urinary red blood cell casts (HR 16.455 [95% CI 3.607–75.075]; P < 0.001) remained. Conclusion: Patients diagnosed as having AAV with pulmonary hemorrhage, positive PR3‐ANCA, heart involvement, and the presence of red blood cell casts are at an increased risk to develop VTE. Further studies are needed to confirm and expand these findings and to explore the mechanisms of hypercoagulability in these patients with the aim of informing potential targets for therapeutic intervention. [ABSTRACT FROM AUTHOR]
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- 2019
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12. Inhibition of clonal expansion of parietal epithelial cells and crescent–podocyte transition in severe glomerulonephritis: on the way to targeted therapy?
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Mentese, Ilay Berke and Kronbichler, Andreas
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BORTEZOMIB , *PARIETAL cells , *EPITHELIAL cells , *LUPUS nephritis , *MYELOFIBROSIS , *GLOMERULONEPHRITIS , *STEM cell niches - Abstract
The human kidney possesses progenitor cells in the glomerular and tubular compartments of the nephron, capable of self-renewal, proliferation and differentiation. Differentiation of crescent-forming kidney progenitor cells into podocytes attenuates severe glomerulonephritis in mice. The crescent-forming PEC subset in humans was found to be characterized by expression of CD133, a marker of renal progenitor cells, and stratifin, a cell cycle checkpoint protein involved in stem cell proliferation/differentiation. [Extracted from the article]
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- 2023
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13. COVID-19 and ANCA-associated vasculitis: recommendations for vaccine preparedness and the use of rituximab.
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Bruchfeld, Annette, Kronbichler, Andreas, Alberici, Federico, Fervenza, Fernando C, Jayne, David R W, Segelmark, Mårten, Tesar, Vladimir, and Szpirt, Wladimir M
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COVID-19 , *RITUXIMAB , *THERAPEUTICS , *VASCULITIS , *COVID-19 pandemic - Published
- 2021
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14. Rituximab in minimal change disease and focal segmental glomerulosclerosis.
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Kronbichler, Andreas, Gauckler, Philipp, and Bruchfeld, Annette
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FOCAL segmental glomerulosclerosis , *RITUXIMAB , *REGULATORY T cells - Published
- 2021
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15. Contrast-Associated Acute Kidney Injury (CA-AKI) in Children: Special Considerations.
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Windpessl, Martin and Kronbichler, Andreas
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ACUTE kidney failure , *CONTRAST media , *CHILD patients , *KIDNEY failure , *CONTRAST effect - Abstract
Contrast-associated acute kidney injury (CA-AKI) is a major concern when iodinated contrast material is administered, especially in patients at risk. Efforts have been undertaken to understand the detrimental effects of contrast media (CM). With the use of low-osmolar or iso-osmolar CM the incidence of CA-AKI has steadily decreased within the past decade; however, especially in the pediatric population information is scarce. Incidence rates have been reported to range between 0% to 18.75%, particularly depending on indication, selection of population (i.e. preexisting co-morbidities), and definition of AKI. Different biomarkers have been proposed, but confirmatory studies are either lacking or have contributed to their lack of diagnostic power. Proteomic approaches have been employed and may pave the way to such discovery. Prevention strategies have been tested and proposed, but the recently published AMACING and PRESERVE trials have shown that commonly used strategies (such as systematic hydration or administration of N-acetylcysteine) have no role in the prevention of CA-AKI. We propose that thoughtful assessment of one's fluid state is the most appropriate approach and depending on the hydration status diuretics or fluid administration should be provided to achieve an euvolemic state ahead of contrast exposure. [ABSTRACT FROM AUTHOR]
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- 2019
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16. Estimating the epidemiology of anti-neutrophil cytoplasm antibody-associated renal vasculitis and the role of histologic chronicity in predicting renal outcomes.
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Kronbichler, Andreas and Jayne, David R W
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VASCULITIS , *EPIDEMIOLOGY , *GRANULOMATOSIS with polyangiitis , *DISEASE risk factors , *CYTOPLASM - Published
- 2019
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17. Association between Serum Matrix Metalloproteinase- (MMP-) 3 Levels and Systemic Lupus Erythematosus: A Meta-analysis.
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Lee, Jiwon M., Kronbichler, Andreas, Park, Se Jin, Kim, Seong Heon, Han, Kyoung Hee, Kang, Hee Gyung, Ha, Il Soo, Cheong, Hae Il, Kim, Ki Hwan, Kim, Gaeun, Kim, Dong Soo, Chae, Hyun Wook, Lee, Chul Ho, Lee, Keum Hwa, and Shin, Jae Il
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SYSTEMIC lupus erythematosus , *LUPUS erythematosus , *RHEUMATISM , *DNA antibodies , *SERUM - Abstract
Introduction. Matrix metalloproteinase (MMP) is an emerging disease marker in rheumatic diseases. This is a meta-analysis aimed at systematically reviewing association between serum MMP-3 levels and systematic lupus erythematosus (SLE) activity, which sought to raise interest in MMP-3 as a putative biomarker. Methods. We conducted a meta-analysis of serum MMP-3 levels in patients with SLE and controls. We performed a PubMed search, EMBASE search, and forward search of the retrieved articles published until Oct. 1, 2018. In addition to this, we included data from a case-control study on a national pediatric SLE cohort, in which serum MMP-3 levels were measured in 11 SLE patients and 9 controls (unpublished). Subgroup analyses based on gender and disease activity were performed. Results. A total of 662 cases and 771 controls including 651 patients and 762 controls from 11 publications were studied. We observed significantly higher MMP-3 levels in SLE patients compared to healthy controls (P<0.001, Hedges' g: 2.104, 95% CI 1.426-2.782). In subgroup analyses, we found a significant elevation of MMP-3 in the patients with nephritis compared to those without (P=0.006, Hedges' g: 0.611, 95% CI 0.611-1.704). This finding was consistent between patients with persistent proteinuria and those without (P=0.023, Hedges' g: 1.535, 95% CI 0.207-2.862). Meta-analysis showed no association between MMP-3 levels and gender or anti-double strand DNA antibody titer. Conclusions. Our meta-analysis demonstrated significantly higher MMP-3 levels in SLE patients than in controls and in patients with renal involvement than in those without. [ABSTRACT FROM AUTHOR]
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- 2019
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18. Introduction to new CKJ section: In Context – in collaboration with YNP.
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Craenenbroeck, Amaryllis van and Kronbichler, Andreas
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RESEARCH questions , *PODCASTING - Published
- 2023
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19. Recent Progress in Deciphering the Etiopathogenesis of Primary Membranous Nephropathy.
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Kronbichler, Andreas, Oh, Jun, Meijers, Björn, Mayer, Gert, and Shin, Jae Il
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PROTEINURIA diagnosis , *NEPHROTIC syndrome diagnosis , *ANTIGENS , *ENZYMES , *KIDNEY diseases , *KIDNEY transplantation , *NEPHROTIC syndrome , *TREATMENT effectiveness , *DISEASE remission , *DISEASE complications - Abstract
Primary membranous nephropathy (MN) is the leading cause of nephrotic syndrome in adults. Discovery of several antibodies has contributed to an increased understanding of MN. Antibodies against the M-type phospholipase A2 receptor (PLA2R) are present in 50–100% with primary MN and are associated with a lower frequency of spontaneous remission. High levels are linked with a higher probability of treatment resistance, higher proteinuria, and impaired renal function, as well as a more rapid decline of kidney function during follow-up. Immunologic remission precedes reduction of proteinuria by months. Pretransplant evaluation of PLA2R antibodies is warranted to predict recurrence of disease following renal transplantation. Several risk alleles related to the PLA2R1 gene and within the HLA loci have been identified, whereas epitope spreading of PLA2R may predict treatment response. More recently, thrombospondin type 1 domain-containing 7A (THSD7A) antibodies have been discovered in primary MN. Several other rare antigens have been described, including antibodies against neutral endopeptidase as a cause of antenatal MN and circulating cationic bovine serum albumin as an antigen with implications in childhood MN. This review focuses on the progress with a special focus on diagnostic accuracy, predictive value, and treatment implications of the established and proposed antigens. [ABSTRACT FROM AUTHOR]
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- 2017
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20. Clinical associations with venous thromboembolism in anti-neutrophil cytoplasm antibody-associated vasculitides.
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Kronbichler, Andreas, Leierer, Johannes, Leierer, Gisela, Mayer, Gert, Casian, Alina, Höglund, Peter, Westman, Kerstin, and Jayne, David
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THROMBOEMBOLISM risk factors , *VEIN diseases , *AUTOIMMUNE diseases , *C-reactive protein , *CONFIDENCE intervals , *CREATININE , *EYE , *GASTROINTESTINAL system , *MUCOUS membranes , *MULTIVARIATE analysis , *SKIN , *STATISTICS , *THROMBOEMBOLISM , *TUMORS , *VASCULITIS , *VEINS , *DESCRIPTIVE statistics , *ODDS ratio , *ANTINEUTROPHIL cytoplasmic antibodies , *DISEASE risk factors - Abstract
Objective. To assess potential associations for the development of venous thromboembolic events in patients with ANCA-associated vasculitides (AAV). Methods. Four hundred and seventeen patients enrolled to participate in randomized controlled trials conducted by the European Vasculitis Society were identified. Univariate and multivariate analyses were performed to validate previously proposed and identify novel risks associated with venous thromboembol-ism (VTE) in AAV. Results. VTE occurred in 41 of 417 (9.8%) patients. Uncorrected univariate analysis identified BVAS (odds ratio, OR = 1.05, 95% CI: 1.01, 1.10; P = 0.013), subsequent development of malignancy (OR = 2.6, 95% CI: 1.19, 5.71; P = 0.017), mucous membrane or eye involvement (OR = 2.13, 95% CI: 1.10, 4.11; P = 0.024) and baseline creatinine (OR = 1.08, 95% CI: 0.99, 1.18; P = 0.037) as being associated with the development of VTE. Multivariate analysis highlighted CRP (per 10mg/l increase, OR = 1.05, 95% CI: 1.01, 1.09; P = 0.025), cutaneous involvement (OR = 4.83, 95% CI: 1.63, 14.38; P = 0.005) and gastrointestinal involvement (OR = 6.27, 95% CI: 1.34, 29.37; P = 0.02) among the BVAS items as well as baseline creatinine (per 100 mmol/l increase, OR = 1.17, 95% CI: 1.02, 1.35; P = 0.029) as being associated with VTEs. Conclusion. Our results highlight a role of CRP, baseline creatinine, and cutaneous and gastrointestinal involvement in the risk stratification as being associated with thromboembolic events. Moreover, there might be an association between VTEs and subsequent development of malignancy and disease activity in general. [ABSTRACT FROM AUTHOR]
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- 2017
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21. Nasal carriage of Staphylococcus pseudintermedius in patients with granulomatosis with polyangiitis.
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Kronbichler, Andreas, Blane, Beth, Holmes, Mark A, Wagner, Josef, Parkhill, Julian, Peacock, Sharon J, Jayne, David R W, and Harrison, Ewan M
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GRANULOMATOSIS with polyangiitis diagnosis , *BACTERIAL growth , *CULTURE media (Biology) , *GENETIC polymorphisms , *GENOMES , *IMMUNOSUPPRESSION , *MASS spectrometry , *MICROBIOLOGICAL techniques , *NASAL cavity , *STAPHYLOCOCCUS , *GRANULOMATOSIS with polyangiitis , *SEQUENCE analysis , *INFECTIOUS disease transmission , *GENETICS - Abstract
The article presents a study which examined the bacterial species that colonize the noses of patients with granulomatosis with polyangiitis (GPA), formerly Wegener's granulomatosis. Also cited are the bacterium Staphylococcus aureus as independent risk factor for GPA relapse, and the detection of Staphylococcus pseudintermedius in the study.
- Published
- 2019
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22. Moderator's view: The use of calcineurin inhibitors in the treatment of lupus nephritis.
- Author
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Kronbichler, Andreas, Neumann, Irmgard, and Mayer, Gert
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CALCINEURIN , *LUPUS nephritis , *SYSTEMIC lupus erythematosus , *DRUG toxicity , *DRUG efficacy , *THERAPEUTICS - Abstract
Lupus nephritis (LN) is one of the most severe manifestations of systemic lupus erythematosus (SLE), affecting ~50% of patients, and both renal disease and treatment-related toxicity contribute to significant morbidity and mortality. Although our understanding of the aetiopathogenesis of LN is improving, treatment still remains a challenge, with the achievement of complete remission at 1 year in <50% of patients treated with current standard of care immunosuppressive therapy; this is associated with considerable short- and long-term side effects, some of which further contribute to non-adherence. Calcineurin inhibitors (CNIs) have been successfully used in organ transplantation and there is increasing evidence that cyclosporin A (CSA), and especially tacrolimus (TAC), are also effective in the treatment of LN. Randomised controlled trials showed similar efficacy for TAC when compared with mycophenolate mofetil (MMF) and multitarget therapy, including TAC and low-dose MMF, and resulted in significantly more complete remissions and overall responses compared with intravenous cyclophosphamide (CYC). Flares are observed in up to 45% of patients with LN, and an increase in relapse rate following induction with CNIs may be an issue. Most studies on this matter have been restricted to patients from Asia, and studies in more balanced cohorts are desirable. Moreover, there is a need to understand and determine the long-term effects of CNIs on renal function, proteinuria and comorbidities, with a special focus on cardiovascular risk. In this 'Pros and Cons' debate, the potential benefits and disadvantages of CNIs in the treatment of LN will be critically highlighted. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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23. Soluble Urokinase Receptors in Focal Segmental Glomerulosclerosis: A Review on the Scientific Point of View.
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Kronbichler, Andreas, Saleem, Moin A., Meijers, Björn, and Shin, Jae Il
- Subjects
- *
GLOMERULOSCLEROSIS , *UROKINASE , *KIDNEY transplantation , *PLASMINOGEN activators , *MEMBRANE proteins , *GLOMERULAR filtration rate , *FIBRINOLYTIC agents , *ANIMALS , *BIOLOGICAL models , *CELL receptors , *CELLULAR signal transduction , *DISEASE susceptibility , *EPITHELIAL cells , *GLOMERULONEPHRITIS , *LIGANDS (Biochemistry) , *PROTEINURIA , *BLOOD , *DIAGNOSIS ,IMMUNE system physiology - Abstract
Focal segmental glomerulosclerosis (FSGS) is one of the primary glomerular disorders in both children and adults which can progress to end-stage renal failure. Although there are genetic and secondary causes, circulating factors have also been regarded as an important factor in the pathogenesis of FSGS, because about 40% of the patients with FSGS have recurrence after renal transplantation. Soluble urokinase-type plasminogen activator receptor (suPAR) is a soluble form of uPAR, which is a membrane-bound protein linked to GPI in various immunologically active cells, including podocytes. It has recently been suggested as a potential circulating factor in FSGS by in vitro podocyte experiments, in vivo mice models, and human studies. However, there have also been controversies on this issue, because subsequent studies showed conflicting results. suPAR levels were also increased in patients with other glomerular diseases and were inversely correlated with estimated glomerular filtration rate. Nevertheless, there has been no balanced review on this issue. In this review, we compare the conflicting data on the involvement of suPAR in the pathogenesis of FSGS and shed light on interpretation by taking into account many points and the potential variables and confounders influencing serum suPAR levels. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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24. Evaluation and validation of biomarkers in granulomatosis with polyangiitis and microscopic polyangiitis.
- Author
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Kronbichler, Andreas, Kerschbaum, Julia, Gründlinger, Georg, Leierer, Johannes, Mayer, Gert, and Rudnicki, Michael
- Subjects
- *
GRANULOMATOSIS with polyangiitis diagnosis , *BIOMARKERS , *VASCULITIS , *ANTINEUTROPHIL cytoplasmic antibodies , *ENZYME-linked immunosorbent assay , *DIAGNOSIS ,MEDICAL literature reviews - Abstract
Background. Studies in anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) have revealed promising biomarkers. The aim of our study was to validate the most encouraging markers of granulomatosis with polyangiitis and microscopic polyangiitis identified by literature search and to create biomarker panels. Methods. A systematic literature review was performed and we identified 161 marker molecules that were ranked by their quantitative differential expression between active and inactive disease. Enzyme-linked immunosorbent assays were used to validate the results in a cross-sectional cohort of patients with renal involvement. Active vasculitis as assessed by the Birmingham Vasculitis Score version 3 (BVAS v3) was defined as BVAS v3 ≥1 and inactive disease as BVAS v3 = 0. Statistical analysis was performed with SPSS version 21 and the Salford Predictive Modeler 7.0 was used to generate a predictive biomarker panel. Results. The review indicated abundant expression of sC5bC9, C3a, C5a and monocyte chemotactic protein (MCP)-1 in urine, whereas granulocyte macrophage colony-stimulating factor, Creactive protein (CRP), soluble fms-like tyrosine kinase-1, interleukin-17A (IL-17A), C5a, hyaluronan, C3a and interleukin- 18 binding protein (IL-18BP) were identified to be highly diverse in active and inactive disease in blood samples. Our cross-sectional analysis revealed significant up-regulation of CRP, C5a, C3a, IL-18BP in blood and C5a and MCP-1 in urine samples during active AAV (all P < 0.05). Creation of a biomarker panel comprising CRP and urinary MCP-1 yielded a sensitivity and specificity of 76% (area under the curve 0.89). Conclusions. We identified promising biomarkers in a literature- based review that were in part corroborated as has been shown for CRP, C3a, C5a, IL-18BP in blood and MCP-1 and C5a in urine samples. Moreover, we propose a biomarker panel comprising CRP and urinary MCP-1 in patients with AAV and renal involvement. Further investigations to confirm our preliminary results are clearly warranted, including the reliability to predict disease relapses. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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25. Immunologic Changes Implicated in the Pathogenesis of Focal Segmental Glomerulosclerosis.
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Kronbichler, Andreas, Leierer, Johannes, Oh, Jun, Meijers, Björn, and Shin, Jae Il
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FOCAL segmental glomerulosclerosis , *DISEASE progression - Abstract
Focal segmental glomerulosclerosis is a histological pattern on renal biopsy caused by diverse mechanisms. In its primary form, a circulatory factor is implicated in disease onset and recurrence. The natural history of primary FSGS is unpredictable, since some patients are unresponsive towards immunosuppressive measures. Immunologic changes, leading to a proinflammatory or profibrotic milieu, have been implicated in disease progression, namely, glomerular scarring, eventually leading to end-stage renal disease. Among these, interleukin-1ß, tumor-necrosis factor-α (TNF-α), and transforming growth factor-ß1 (TGF-ß1) have emerged as important factors. Translating these findings into clinical practice dampened the enthusiasm, since both TNF-α and TGF-ß1 blockade failed to achieve significant control of the disease. More recently, a role of the complement system has been demonstrated which in fact may be another attractive target in clinical practice. Rituximab, blocking CD20-bearing cells, demonstrated conflicting data regarding efficacy in FSGS. Finally, the T-cell costimulating molecule B7-1 (CD80) is implicated in development of proteinuria in general. Blockade of this target demonstrated significant benefits in a small cohort of resistant patients. Taken together, this review focuses on immunology of FSGS, attributable to either the disease or progression, and discusses novel therapeutic approaches aiming at targeting immunologic factors. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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26. Pro: Contrast-induced nephropathy—should we try to avoid contrast media in patients with chronic kidney disease?
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Windpessl, Martin and Kronbichler, Andreas
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ACUTE kidney failure , *KIDNEY diseases , *CELL-mediated cytotoxicity , *OXIDATIVE stress , *VASOCONSTRICTION , *PATIENTS , *DISEASE risk factors - Abstract
The administration of iodinated contrast medium (CM) has immediate negative impact on multiple levels of the nephron, including vasoconstriction, an increase in apoptotic pathways and oxidative stress. Therefore, contrast-induced acute kidney injury (CI-AKI) remains an important cause of sudden impairment of renal function. Far from being just a transient phenomenon, CI-AKI has consistently been shown to be associated with adverse outcomes. The phenomenon of chronic kidney disease (CKD) following AKI might explain why this entity portends a poor prognosis in the long run. While it is generally acknowledged that in individuals with normal renal function, the risk of CI-AKI is negligible, pre-existing renal disease is its greatest independent risk factor. Although several recent publications have challenged the dogma of CI-AKI as a stand-alone disease entity, these trials, despite careful propensity matching, are hampered by their retrospective nature. In this article, we concede that there is always a trade-off and that administration of CM may be justified if its diagnostic value is believed to outweigh its associated risks. However, we reason that despite considerable progress in the field, the risk of CI-AKI is still high in the modern era and that CM-based imaging should be employed with great restraint in patients with CKD. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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27. Con: Should all patients with anti-neutrophil cytoplasmic antibody-associated vasculitis be primarily treated with rituximab?
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Kronbichler, Andreas and Jayne, David R. W.
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VASCULITIS , *NEUTROPHILS , *CYTOPLASM , *IMMUNOGLOBULINS , *VASCULITIS treatment , *RITUXIMAB , *PATIENTS - Abstract
Rituximab has enriched our armamentarium in the treatment of anti-neutrophil cytoplasmic antibody (ANCA)- associated vasculitis. Two randomised controlled trials have shown that rituximab is non-inferior compared with cyclophosphamide followed by azathioprine for the induction of remission. The newly diagnosed patients in the Rituximab in ANCA-Associated Vasculitis (RAVE) and Rituximab Versus Cyclophosphamide in ANCA-Associated Vasculitis (RITUXVAS) trials had a numerically higher response rate in the cyclophosphamide/azathioprine arm, and the number of such patients treated with rituximab numbered <90.We are arguing that in newly diagnosed patients, the evidence for rituximab requires further confirmation and the length of experience with a cyclophosphamide-based induction therapy supports it continuing as the preferred first choice for induction. Also, there is an absence of information regarding rituximab as 'sole' remission induction along with steroids in patients with advanced renal presentations or lung haemorrhage. Reported side effects were similar in both trials; however, the number of participants with at least one serious adverse event following rituximab induction treatment was numerically higher in the RAVE trial. In addition, hypogammaglobulinaemia with the need of substitution in some cases and late-onset neutropaenia are complications not seen with cyclophosphamide. Over the longer term it is unclear what relapse prevention strategy should be employed after rituximab, and there was a trend to a higher relapse risk after rituximab in the RITUXVAS trial at 2 years. Further health economic studies are required to understand all the costs associated with rituximab. In the context of concomitant underlying infectious complications, in terms of fertility concerns, especially in young patients, and when malignancy is underlying we would recommend the use of rituximab as first-line therapy. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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28. The Influence and Role of Microbial Factors in Autoimmune Kidney Diseases: A Systematic Review.
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Kronbichler, Andreas, Kerschbaum, Julia, and Mayer, Gert
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- *
KIDNEY diseases , *PATHOLOGY , *ETIOLOGY of diseases , *EPIDEMIOLOGY , *DIAGNOSIS - Abstract
A better understanding of the pathophysiology of autoimmune disorders is desired to allow tailored interventions. Despite increased scientific interest a direct pathogenic factor in autoimmune renal disease has been described only in a minority like membranous nephropathy or ANCA-associated vasculitis. Nonetheless the initial step leading to the formation of these antibodies is still obscure. In this review we will focus on the possible role of microbial factors in this context. Staphylococcus aureus may be a direct pathogenetic factor in granulomatosis with polyangiitis (GPA). Chronic bacterial colonization or chronic infections of the upper respiratory tract have been proposed as trigger of IgA vasculitis and IgA nephropathy. Interventions to remove major lymphoid organs, such as tonsillectomy, have shown conflicting results but may be an option in IgA vasculitis. Interestingly no clear clinical benefit despite similar local colonization with bacterial strains has been detected in patients with IgA nephropathy. In systemic lupus erythematosus injection of bacterial lipopolysaccharide induced progressive lupus nephritis in mouse models. The aim of this review is to discuss and summarize the knowledge of microbial antigens in autoimmune renal disease. Novel methods may provide insight into the involvement of microbial antigens in the onset, progression, and prognosis of autoimmune kidney disorders. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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29. Renal involvement in autoimmune connective tissue diseases.
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Kronbichler, Andreas and Mayer, Gert
- Subjects
- *
CONNECTIVE tissue diseases , *AUTOIMMUNE diseases , *KIDNEY diseases , *RHEUMATOID arthritis , *ANTIPHOSPHOLIPID syndrome - Abstract
Connective tissue diseases (CTDs) are a heterogeneous group of disorders that share certain clinical presentations and a disturbed immunoregulation, leading to autoantibody production. Subclinical or overt renal manifestations are frequently observed and complicate the clinical course of CTDs. Alterations of kidney function in Sjögren syndrome, systemic scleroderma (SSc), auto-immune myopathies (dermatomyositis and polymyositis), systemic lupus erythematosus (SLE), antiphospholipid syndrome nephropathy (APSN) as well as rheumatoid arthritis (RA) are frequently present and physicians should be aware of that. In SLE, renal prognosis significantly improved based on specific classification and treatment strategies adjusted to kidney biopsy findings. Patients with scleroderma renal crisis (SRC), which is usually characterized by severe hypertension, progressive decline of renal function and thrombotic microangiopathy, show a significant benefit of early angiotensin-converting-enzyme (ACE) inhibitor use in particular and strict blood pressure control in general. Treatment of the underlying autoimmune disorder or discontinuation of specific therapeutic agents improves kidney function in most patients with Sjögren syndrome, auto-immune myopathies, APSN and RA. In this review we focus on impairment of renal function in relation to underlying disease or adverse drug effects and implications on treatment decisions. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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30. Extending the spectrum of a chameleon: IgG4-related disease appearing as interstitial nephritis and mimicking anti-neutrophil cytoplasmic antibodyassociated vasculitis.
- Author
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Kronbichler, Andreas, Gut, Nadezda, Zwerina, Jochen, Neuwirt, Hannes, Rudnicki, Michael, and Mayer, Gert
- Subjects
- *
AUTOIMMUNE disease diagnosis , *AUTOANTIBODIES , *BIOPSY , *BLOOD testing , *DIFFERENTIAL diagnosis , *IMMUNOGLOBULINS , *POSITRON emission tomography , *INTERSTITIAL nephritis , *GRANULOMATOSIS with polyangiitis , *DIAGNOSIS - Abstract
The article discusses the case of a 54 year old female patient of Caucasian descent presented with a past medical history including Hashimoto thyroiditis diagnosed in 2006. Further investigations were initiated including ENT, ophthamological and neurological assessments due to a suspected diagnosis of granulomatosis with polyangiitis. The case is the first description of an IgG4-related tubulointerstitiial nephritis with concomitant positivity of cytoplasmic ANCA and PR3.
- Published
- 2015
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31. Kynurenine Pathway after Kidney Transplantation: Friend or Foe?
- Author
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Zakrocka, Izabela, Urbańska, Ewa M., Załuska, Wojciech, and Kronbichler, Andreas
- Subjects
- *
CHRONIC kidney failure , *RENAL replacement therapy , *INDOLEAMINE 2,3-dioxygenase , *KIDNEY transplantation , *GRAFT rejection , *TRYPTOPHAN - Abstract
Kidney transplantation significantly improves the survival of patients with end-stage kidney disease (ESKD) compared to other forms of kidney replacement therapy. However, kidney transplant recipients' outcomes are not fully satisfactory due to increased risk of cardiovascular diseases, infections, and malignancies. Immune-related complications remain the biggest challenge in the management of kidney graft recipients. Despite the broad spectrum of immunosuppressive agents available and more detailed methods used to monitor their effectiveness, chronic allograft nephropathy remains the most common cause of kidney graft rejection. The kynurenine (KYN) pathway is the main route of tryptophan (Trp) degradation, resulting in the production of a plethora of substances with ambiguous properties. Conversion of Trp to KYN by the enzyme indoleamine 2,3-dioxygenase (IDO) is the rate-limiting step determining the formation of the next agents from the KYN pathway. IDO activity, as well as the production of subsequent metabolites of the pathway, is highly dependent on the balance between pro- and anti-inflammatory conditions. Moreover, KYN pathway products themselves possess immunomodulating properties, e.g., modify the activity of IDO and control other immune-related processes. KYN metabolites were widely studied in neurological disorders but recently gained the attention of researchers in the context of immune-mediated diseases. Evidence that this route of Trp degradation may represent a peripheral tolerogenic pathway with significant implications for transplantation further fueled this interest. Our review aimed to present recent knowledge about the role of the KYN pathway in the pathogenesis, diagnosis, monitoring, and treatment of kidney transplant recipients' complications. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
32. Paraneoplastic Syndrome After Kidney Transplantation: Frequency, Risk Factors, Differences to Paraneoplastic Occurrence of Glomerulonephritis in the Native Kidney, and Implications on Long-Term Kidney Graft Function.
- Author
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Zakrocka, Izabela, Nair, Gayatri, Soler, Maria Jose, Jhaveri, Kenar D., and Kronbichler, Andreas
- Subjects
- *
KIDNEY glomerulus diseases , *KIDNEY transplantation , *TRANSPLANTATION of organs, tissues, etc. , *DISEASE risk factors , *IMMUNOSUPPRESSIVE agents , *PARANEOPLASTIC syndromes - Abstract
Posttransplant malignancies are an important complication of solid organ transplantation. Kidney transplant recipients are at particularly high risk of cancer development. The most relevant risk factors of carcinogenesis are the use of immunosuppressive agents and oncogenic viral infections. Additionally, immune dysregulation caused by these factors may predispose to various types of organ damage. Paraneoplastic glomerular diseases are one of the most interesting and understudied cancer manifestations. The appropriate diagnosis of paraneoplastic glomerular damage can be challenging in kidney transplant recipients, due to factors inherent to concomitant medication and common comorbidities. Recent advances in the field of molecular and clinical nephrology led to a significant improvement in our understanding of glomerular diseases and their more targeted treatment. On the other hand, introduction of novel anticancer drugs tremendously increased patients' survival, at the cost of kidney-related side effects. Our review aims to provide insights into diagnosis and treatment of paraneoplastic glomerular diseases, with a special attention to kidney transplant recipients. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
33. Nephrotic syndrome; is rituximab the light at the end of the tunnel in the treatment of adult steroid-dependent minimal change disease and focal segmental glomerulosclerosis?
- Author
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Kronbichler, Andreas and Mayer, Gert
- Subjects
- *
NEPHROTIC syndrome , *MONOCLONAL antibodies , *ELECTROMAGNETIC waves , *SPECTRUM analysis , *CHANGE blindness - Abstract
Implication for health policy/practice/research/medical education: Reports on patients with steroid-dependent nephrotic syndrome and underlying minimal change disease or focal segmental glomerulosclerosis have shown promising results. There is a strong need for more trials conducted in a prospective, controlled manner to clearly recommend rituximab therapy in this indication on a regular basis. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
34. Immunopathogenesis of ANCA-Associated Vasculitis.
- Author
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Kronbichler, Andreas, Lee, Keum Hwa, Denicolò, Sara, Choi, Daeun, Lee, Hyojeong, Ahn, Donghyun, Kim, Kang Hyun, Lee, Ji Han, Kim, HyungTae, Hwang, Minha, Jung, Sun Wook, Lee, Changjun, Lee, Hojune, Sung, Haejune, Lee, Dongkyu, Hwang, Jaehyuk, Kim, Sohee, Hwang, Injae, Kim, Do Young, and Kim, Hyung Jun
- Subjects
- *
CHURG-Strauss syndrome , *VASCULITIS , *INDIVIDUALIZED medicine - Abstract
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is an autoimmune disorder which affects small- and, to a lesser degree, medium-sized vessels. ANCA-associated vasculitis encompasses three disease phenotypes: granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA). This classification is largely based on clinical presentations and has several limitations. Recent research provided evidence that genetic background, risk of relapse, prognosis, and co-morbidities are more closely related to the ANCA serotype, proteinase 3 (PR3)-ANCA and myeloperoxidase (MPO)-ANCA, compared to the disease phenotypes GPA or MPA. This finding has been extended to the investigation of biomarkers predicting disease activity, which again more closely relate to the ANCA serotype. Discoveries related to the immunopathogenesis translated into clinical practice as targeted therapies are on the rise. This review will summarize the current understanding of the immunopathogenesis of ANCA-associated vasculitis and the interplay between ANCA serotype and proposed disease biomarkers and illustrate how the extending knowledge of the immunopathogenesis will likely translate into development of a personalized medicine approach in the management of ANCA-associated vasculitis. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
35. Is There Decreasing Public Interest in Renal Transplantation? A Google TrendsTM Analysis.
- Author
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Kronbichler, Andreas, Effenberger, Maria, Shin, Jae Il, Koppelstätter, Christian, Denicolò, Sara, Rudnicki, Michael, Neuwirt, Hannes, Soler, Maria José, Stevens, Kate, Bruchfeld, Annette, Tilg, Herbert, Mayer, Gert, and Perco, Paul
- Subjects
- *
PUBLIC interest , *CHRONIC kidney failure , *KIDNEY transplantation , *TRANSPLANTATION of organs, tissues, etc. , *INTERNET searching - Abstract
Background and objectives: Renal transplantation is the preferred form of renal replacement therapy for the majority of patients with end stage renal disease (ESRD). The Internet is a key tool for people seeking healthcare-related information. This current work explored the interest in kidney transplantation based on Internet search queries using Google TrendsTM. Design, setting, participants, and measurements: We performed a Google TrendsTM search with the search term "kidney transplantation" between 2004 (year of inception) and 2018. We retrieved and analyzed data on the worldwide trend as well as data from the United Network for Organ Sharing (UNOS), the Organización Nacional de Trasplantes (ONT), the Eurotransplant area, and the National Health Service (NHS) Transplant Register. Google TrendsTM indices were investigated and compared to the numbers of performed kidney transplants, which were extracted from the respective official websites of UNOS, ONT, Eurotransplant, and the NHS. Results: During an investigational period of 15 years, there was a significant decrease of the worldwide Google TrendsTM index from 76.3 to 25.4, corresponding to an absolute reduction of −50.9% and a relative reduction by −66.7%. The trend was even more pronounced for the UNOS area (−75.2%), while in the same time period the number of transplanted kidneys in the UNOS area increased by 21.9%. Events of public interest had an impact on the search queries in the year of occurrence, as shown by an increase in the Google TrendsTM index by 39.2% in the year 2005 in Austria when a person of public interest received his second live donor kidney transplant. Conclusions: This study indicates a decreased public interest in kidney transplantation. There is a clear need to raise public awareness, since transplantation represents the best form of renal replacement therapy for patients with ESRD. Information should be provided on social media, with a special focus on readability and equitable access, as well as on web pages. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
36. Corrigendum to "Association between Serum Matrix Metalloproteinase- (MMP-) 3 Levels and Systemic Lupus Erythematosus: A Meta-Analysis".
- Author
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Lee, Jiwon M., Kronbichler, Andreas, Park, Se Jin, Kim, Seong Heon, Han, Kyoung Hee, Kang, Hee Gyung, Ha, Il Soo, Cheong, Hae Il, Kim, Ki Hwan, Kim, Gaeun, Kim, Dong Soo, Chae, Hyun Wook, Lee, Chul Ho, Lee, Keum Hwa, and Shin, Jae Il
- Subjects
- *
SYSTEMIC lupus erythematosus , *META-analysis , *SERUM , *MATRIX metalloproteinases - Published
- 2020
- Full Text
- View/download PDF
37. Tumor Mutational Burden and Efficacy of Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis.
- Author
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Kim, Jong Yeob, Kronbichler, Andreas, Eisenhut, Michael, Hong, Sung Hwi, van der Vliet, Hans J., Kang, Jeonghyun, Shin, Jae Il, and Gamerith, Gabriele
- Subjects
- *
ANTINEOPLASTIC agents , *THERAPEUTIC use of monoclonal antibodies , *CANCER patients , *CONFIDENCE intervals , *MEDICAL information storage & retrieval systems , *MEDLINE , *META-analysis , *GENETIC mutation , *ONLINE information services , *SURVIVAL , *TUMOR markers , *TUMORS , *SYSTEMATIC reviews , *TREATMENT effectiveness , *PREDICTIVE tests , *EVALUATION - Abstract
Tumor mutational burden (TMB) is a genomic biomarker that predicts favorable responses to immune checkpoint inhibitors (ICIs). Here, we set out to assess the predictive value of TMB on long-term survival outcomes in patients undergoing ICIs. We systematically searched PubMed, Embase, CENTRAL and clinicaltrials.gov from inception to 6 August 2019. We included retrospective studies or clinical trials of ICIs that reported hazard ratios (HRs) for overall survival (OS) and/or progression-free survival (PFS) according to TMB. Data on 5712 patients from 26 studies were included. Among patients who received ICIs, high TMB groups showed better OS (HR 0.53, 95% CI 0.42 to 0.67) and PFS (HR 0.52, 95% CI 0.40 to 0.67) compared to low TMB groups. In patients with high TMB, those who received ICIs had a better OS (HR 0.69, 95% CI 0.50 to 0.95) and PFS (HR = 0.66, 95% CI = 0.47 to 0.92) compared to those who received chemotherapy alone, while in patients with low TMB, such ICI benefits of OS or PFS were not statistically significant. In conclusion, TMB may be an effective biomarker to predict survival in patients undergoing ICI treatment. The role of TMB in identifying patient groups who may benefit from ICIs should be determined in future randomized controlled trials. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
38. Nephrotic Syndrome: Genetics, Mechanism, and Therapies.
- Author
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Shin, Jae Il, Kronbichler, Andreas, Oh, Jun, and Meijers, Björn
- Subjects
- *
RITUXIMAB , *GENETIC polymorphisms , *NEPHROTIC syndrome , *SERIAL publications , *FOCAL segmental glomerulosclerosis - Published
- 2018
- Full Text
- View/download PDF
39. Global burden of anticancer drug-induced acute kidney injury and tubulointerstitial nephritis from 1967 to 2023.
- Author
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Yoon, Soo-Young, Lee, Sooji, Lee, Kyeongmin, Kim, Jin Sug, Hwang, Hyeon Seok, Kronbichler, Andreas, Jacob, Louis, Shin, Ju-Young, Lee, Jin A., Park, Jaeyu, Lee, Hyeri, Lee, Hayeon, Jeong, Kyunghwan, and Yon, Dong Keon
- Subjects
- *
ACUTE kidney failure , *DRUG side effects , *NEPHRITIS , *GROUP psychotherapy - Abstract
This study aims to figure out the worldwide prevalence of anticancer therapy-associated acute kidney injury (AKI) and tubulointerstitial nephritis (TIN) and the relative risk of each cancer drug. We conducted an analysis of VigiBase, the World Health Organization pharmacovigilance database, 1967–2023 via disproportionate Bayesian reporting method. We further categorized the anticancer drugs into four groups: cytotoxic therapy, hormone therapy, immunotherapy, and targeted therapy. Reporting odds ratio (ROR) and information component (IC) compares observed and expected values to investigate the associations of each category of anticancer drugs with AKI and TIN. We identified 32,722 and 2056 reports (male, n = 17,829 and 1,293) of anticancer therapy-associated AKI and TIN, respectively, among 4,592,036 reports of all-drug caused AKI and TIN. There has been a significant increase in reports since 2010, primarily due to increased reports of targeted therapy and immunotherapy. Immunotherapy exhibited a significant association with both AKI (ROR: 8.92; IC0.25: 3.06) and TIN (21.74; 4.24), followed by cytotoxic therapy (7.14; 2.68), targeted therapy (5.83; 2.40), and hormone therapy (2.59; 1.24) for AKI, and by cytotoxic therapy (2.60; 1.21) and targeted therapy (1.54; 0.61) for TIN. AKI and TIN were more prevalent among individuals under 45 years of age, with a female preponderance for AKI and males for TIN. These events were reported in close temporal relationship after initiation of the respective drug (16.53 days for AKI and 27.97 days for TIN), and exhibited a high fatality rate, with 23.6% for AKI and 16.3% for TIN. These findings underscore that kidney-related adverse drug reactions are of prognostic significance and strategies to mitigate such side effects are required to optimize anticancer therapy. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
40. Genetic Variants in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Bayesian Approach and Systematic Review.
- Author
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Lee, Kwang Seob, Kronbichler, Andreas, Pereira Vasconcelos, Daniel Fernando, Pereira da Silva, Felipe Rodolfo, Ko, Younhee, Oh, Yeon Su, Eisenhut, Michael, Merkel, Peter A., Jayne, David, Amos, Christopher I., Siminovitch, Katherine A., Rahmattulla, Chinar, Lee, Keum Hwa, and Shin, Jae Il
- Subjects
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META-analysis , *ANTINEUTROPHIL cytoplasmic antibodies , *VASCULITIS , *SINGLE nucleotide polymorphisms , *MAJOR histocompatibility complex - Abstract
A number of genome-wide association studies (GWASs) and meta-analyses of genetic variants have been performed in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. We reinterpreted previous studies using false-positive report probability (FPRP) and Bayesian false discovery probability (BFDP). This study searched publications in PubMed and Excerpta Medica Database (EMBASE) up to February 2018. Identification of noteworthy associations were analyzed using FPRP and BFDP, and data (i.e., odds ratio (OR), 95% confidence interval (CI), p-value) related to significant associations were separately extracted. Using filtered gene variants, gene ontology (GO) enrichment analysis and protein–protein interaction (PPI) networks were performed. Overall, 241 articles were identified, and 7 were selected for analysis. Single nucleotide polymorphisms (SNPs) discovered by GWASs were shown to be noteworthy, whereas only 27% of significant results from meta-analyses of observational studies were noteworthy. Eighty-five percent of SNPs with borderline p-values (5.0 × 10−8 < p < 0.05) in GWASs were found to be noteworthy. No overlapping SNPs were found between PR3-ANCA and MPO-ANCA vasculitis. GO analysis revealed immune-related GO terms, including "antigen processing and presentation of peptide or polysaccharide antigen via major histocompatibility complex (MHC) class II", "interferon-gamma-mediated (IFN-γ) signaling pathway". By using FPRP and BFDP, network analysis of noteworthy genetic variants discovered genetic risk factors associated with the IFN-γ pathway as novel mechanisms potentially implicated in the complex pathogenesis of ANCA-associated vasculitis. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
41. Focal Segmental Glomerulosclerosis: Genetics, Mechanism, and Therapies.
- Author
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Kronbichler, Andreas, Oh, Jun, Meijers, Björn, and Shin, Jae Il
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- *
TREATMENT of glomerulonephritis , *GLOMERULONEPHRITIS , *SERIAL publications , *GENETICS - Published
- 2016
- Full Text
- View/download PDF
42. Opponent's comments.
- Author
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Kronbichler, Andreas and Jayne, David R. W.
- Subjects
- *
LUNG disease treatment , *CRITICAL care medicine , *CYCLOPHOSPHAMIDE , *COMBINATION drug therapy , *RITUXIMAB ,THERAPEUTIC use of glucocorticoids - Published
- 2015
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- View/download PDF
43. Increased Serum Soluble Urokinase-Type Plasminogen Activator Receptor (suPAR) Levels in FSGS: A Meta-Analysis.
- Author
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Lee, Jiwon M., Yang, Jae Won, Kronbichler, Andreas, Eisenhut, Michael, Kim, Gaeun, Lee, Keum Hwa, and Shin, Jae Il
- Subjects
- *
FOCAL segmental glomerulosclerosis , *PLASMINOGEN activators , *IGA glomerulonephritis , *META-analysis , *SERUM - Abstract
Introduction: The soluble urokinase-type plasminogen activator receptor (suPAR) has been found to be elevated in primary focal segmental glomerulosclerosis (pFSGS). However, its usefulness as a biomarker for FSGS remains controversial. We conducted a meta-analysis aiming at investigating the significance of suPAR in diagnosing pFSGS.Methods: Electronic databases (PubMed and EMBASE) were searched to identify studies comparing suPAR levels in FSGS patients and controls, from the earliest available date to May 1, 2018. A random-effects model with standardized mean difference (SMD) was used for meta-analyses. Risk of bias was assessed using the Newcastle-Ottawa quality assessment scale.Results: A total of 187 articles were screened, and the final analysis included 13 articles. In comparison to healthy controls, serum suPAR levels were significantly increased in pFSGS patients (SMD, 1.07, 95% confidence interval (CI) 0.65 to 1.48; participants = 814; studies = 9, I2 = 85%). Higher suPAR levels were also found in patients with pFSGS compared to those with minimal change disease (SMD 0.53, 95% CI 0.22 to 0.84). Of note, such a difference was not found in pediatric groups (SMD 0.42, 95% CI -0.13 to 0.96) while it was more evidently noted in adult patients (SMD 1.32, 95% CI 0.90 to 1.74). Serum suPAR levels did not differ between pFSGS patients in remission compared to those in active proteinuric state (SMD 0.29, 95% CI -0.30 to 0.88). Comparison with membranous nephropathy and IgA nephropathy showed no significant difference.Conclusions: Our meta-analysis demonstrated that, in comparison to both healthy controls and controls with minimal change disease, suPAR levels were significantly higher in adult patients with pFSGS. suPAR levels did not differ between pFSGS patients during the initial period of diagnosis and those in remission. [ABSTRACT FROM AUTHOR]- Published
- 2019
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44. Prophylactic and early outpatient treatment of COVID-19 in patients with kidney disease: considerations from the Immunonephrology Working Group of the European Renal Association (ERA-IWG).
- Author
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Hilhorst, Marc, Bemelman, Frederike J, Bruchfeld, Annette, Fernandez-Juarez, Gema M, Floege, Jürgen, Frangou, Eleni, Goumenos, Dimitrios, Kooten, Cees van, Kronbichler, Andreas, Stevens, Kate I, Turkmen, Kultigin, Wiersinga, W Joost, and Anders, Hans-Joachim
- Subjects
- *
SARS-CoV-2 , *COVID-19 , *COVID-19 treatment - Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic led to rapid vaccine development and large global vaccination schemes. However, patients with immune-mediated kidney disease, chronic kidney diseases and kidney transplant recipients show high non-response rates to vaccination despite more than three vaccinations and, consequently, reduced viral clearance capacity when infected while receiving certain immunosuppressants, carrying an elevated risk for coronavirus disease 2019 (COVID-19)-related morbidity and mortality. SARS-CoV-2 evolution has been characterized by the emergence of novel variants and spike mutations contributing to waning efficacy of neutralizing antibodies. To this end, the therapeutic field expands from vaccination towards a combined approach of immunization, pre-exposure prophylaxis and early post-exposure treatment using direct-acting antivirals and neutralizing monoclonal antibodies to treat early in the disease course and avoid hospitalization. This expert opinion paper from the Immunonephrology Working Group of the European Renal Association (ERA-IWG) summarizes available prophylactic and/or early treatment options (i.e. neutralizing monoclonal antibodies and direct-acting antivirals) of SARS-CoV-2-infected patients with immune-mediated kidney disease, chronic kidney disease and kidney transplant recipients. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
45. The Influence and Role of Microbial Factors in Autoimmune Kidney Diseases: A Systematic Review.
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Kronbichler, Andreas, Kerschbaum, Julia, and Mayer, Gert
- Abstract
A better understanding of the pathophysiology of autoimmune disorders is desired to allow tailored interventions. Despite increased scientific interest a direct pathogenic factor in autoimmune renal disease has been described only in a minority like membranous nephropathy or ANCA-associated vasculitis. Nonetheless the initial step leading to the formation of these antibodies is still obscure. In this review we will focus on the possible role of microbial factors in this context. Staphylococcus aureus may be a direct pathogenetic factor in granulomatosis with polyangiitis (GPA). Chronic bacterial colonization or chronic infections of the upper respiratory tract have been proposed as trigger of IgA vasculitis and IgA nephropathy. Interventions to remove major lymphoid organs, such as tonsillectomy, have shown conflicting results but may be an option in IgA vasculitis. Interestingly no clear clinical benefit despite similar local colonization with bacterial strains has been detected in patients with IgA nephropathy. In systemic lupus erythematosus injection of bacterial lipopolysaccharide induced progressive lupus nephritis in mouse models. The aim of this review is to discuss and summarize the knowledge of microbial antigens in autoimmune renal disease. Novel methods may provide insight into the involvement of microbial antigens in the onset, progression, and prognosis of autoimmune kidney disorders. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
46. Challenges of defining renal response in ANCA-associated vasculitis: call to action?
- Author
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Odler, Balazs, Bruchfeld, Annette, Scott, Jennifer, Geetha, Duvuru, Little, Mark A, Jayne, David R W, and Kronbichler, Andreas
- Subjects
- *
CHRONIC kidney failure , *VASCULITIS , *KIDNEY physiology , *BIOMARKERS , *GLOMERULAR filtration rate , *KIDNEY glomerulus diseases - Abstract
Avoiding end-stage kidney disease in patients with anti-neutrophil cytoplasmic antibody–associated vasculitis (AAV) has a high therapeutic priority. Although renal response is a crucial measure to capture clinically relevant changes, clinal trials have used various definitions and no well-studied key surrogate markers to predict renal outcome in AAV exist. Differences in clinical features and histopathologic and therapeutic approaches will influence the course of kidney function. Its assessment through traditional surrogates (i.e. serum creatinine, glomerular filtration rate, proteinuria, hematuria and disease activity scores) has limitations. Refinement of these markers and the incorporation of novel approaches such as the assessment of histopathological changes using cutting-edge molecular and machine learning mechanisms or new biomarkers could significantly improve prognostication. The timing is favourable since large datasets of trials conducted in AAV are available and provide a valuable resource to establish renal surrogate markers and, likely, aim to investigate optimized and tailored treatment approaches according to a renal response score. In this review we discuss important points missed in the assessment of kidney function in patients with AAV and point towards the importance of defining renal response and clinically important short- and long-term predictors of renal outcome. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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47. Avacopan for ANCA-associated vasculitis – information for prescribers.
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McGovern, Dominic, Jones, Rachel B, Willcocks, Lisa C, Smith, Rona M, Jayne, David R W, and Kronbichler, Andreas
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VASCULITIS , *MICROSCOPIC polyangiitis - Abstract
The approval of avacopan as a treatment for anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) by the US Food and Drug Administration (FDA) in 2021 and the European Medicines Agency (EMA) in 2022 represents an important therapeutic advance. Of the patients receiving avacopan, 13.3% suffered serious infections versus 15.2% in those in the prednisone group, and serious opportunistic infections were less common in patients receiving avacopan (3.6% in the avacopan group, 6.7% in the prednisone group) [[10]]. Insights from the ADVOCATE study: respiratory tract involvement in patients with ANCA-associated vasculitis in a randomized, double-blind, placebo-controlled, phase 3 trial of avacopan. Recovery of renal function among ANCA-associated vasculitis patients with baseline eGFR <=20 in the avacopan ADVOCATE trial. [Extracted from the article]
- Published
- 2023
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48. Renal involvement in autoimmune connective tissue diseases.
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Kronbichler, Andreas and Mayer, Gert
- Abstract
Connective tissue diseases (CTDs) are a heterogeneous group of disorders that share certain clinical presentations and a disturbed immunoregulation, leading to autoantibody production. Subclinical or overt renal manifestations are frequently observed and complicate the clinical course of CTDs. Alterations of kidney function in Sjögren syndrome, systemic scleroderma (SSc), auto-immune myopathies (dermatomyositis and polymyositis), systemic lupus erythematosus (SLE), antiphospholipid syndrome nephropathy (APSN) as well as rheumatoid arthritis (RA) are frequently present and physicians should be aware of that.In SLE, renal prognosis significantly improved based on specific classification and treatment strategies adjusted to kidney biopsy findings. Patients with scleroderma renal crisis (SRC), which is usually characterized by severe hypertension, progressive decline of renal function and thrombotic microangiopathy, show a significant benefit of early angiotensin-converting-enzyme (ACE) inhibitor use in particular and strict blood pressure control in general. Treatment of the underlying autoimmune disorder or discontinuation of specific therapeutic agents improves kidney function in most patients with Sjögren syndrome, auto-immune myopathies, APSN and RA.In this review we focus on impairment of renal function in relation to underlying disease or adverse drug effects and implications on treatment decisions. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
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49. National trends in the prevalence of chronic kidney disease among Korean adults, 2007–2020.
- Author
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Yoon, Soo-Young, Park, Hye Won, Kim, Hyeon Jin, Kronbichler, Andreas, Koyanagi, Ai, Smith, Lee, Shin, Jae Il, Rhee, Sang Youl, Lee, Seung Won, Kim, Jin Sug, Hwang, Hyeon Seok, Yon, Dong Keon, and Jeong, Kyunghwan
- Subjects
- *
COVID-19 , *KOREANS , *CHRONIC kidney failure , *GLOMERULAR filtration rate - Abstract
Little is known about the prevalence of chronic kidney disease (CKD) during the coronavirus disease 2019 (COVID-19) pandemic. We aimed to investigate the long-term trends in CKD prevalence from South Korea including the early pandemic. We used data from 108,152 Korean adults from 2007 to 2020 obtained from a representative longitudinal serial study. We defined CKD as a condition when the participant's estimated glomerular filtration rate was < 60 mL/min/1.73 m2, or one-time spot proteinuria was ≥ 1 +, and then examined the overall trends in the prevalence of CKD. Among the included adults (n = 80,010), the overall national prevalence of CKD was 6.2%. The trend slope gradually increased from 2007 to 2019, however, there was a sudden decrease in 2020 (2007–2010, 5.1% [95% confidence interval (CI) 4.7–5.5]; 2017–2019, 7.1% [95% CI 6.6–7.6]; pandemic period, 6.5% [95% CI 5.7–7.3]; and βdiff, − 0.19; 95% CI − 0.24 to − 0.13). The prevalence of CKD among younger adults and those with poor medical utilization significantly decreased during the early pandemic. This study was the first large-scale study to investigate the longitudinal prevalence of CKD from 2007 to 2020. Further research is needed to fully understand the exact causes for this decline and to identify healthcare policy strategies for preventing and managing CKD. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
50. The management of lupus nephritis as proposed by EULAR/ERA 2019 versus KDIGO 2021.
- Author
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Anders, Hans-Joachim, Loutan, Jerome, Bruchfeld, Annette, Fernández-Juárez, Gema M, Floege, Jürgen, Goumenos, Dimitrios, Turkmen, Kultigin, Kooten, Cees van, Frangou, Eleni, Stevens, Kate I, Kronbichler, Andreas, Segelmark, Mårten, and Tesar, Vladimir
- Subjects
- *
KIDNEY failure , *RENAL biopsy , *CHILD patients , *LUPUS nephritis , *CLINICAL indications , *KIDNEY diseases - Abstract
In 2019 and 2021, the European League for Rheumatism (EULAR) jointly with the European Renal Association (ERA) and the Kidney Disease: Improving Global Outcomes (KDIGO), respectively, released updated guidelines on the management of lupus nephritis (LN). The Immunology Working Group of the ERA reviewed and compared both updates. Recommendations were either consistent or differences were of negligible clinical relevance for: indication for kidney biopsy, kidney biopsy interpretation, treatment targets, hydroxychloroquine dosing, first-line initial immunosuppressive therapy for active class III, IV (±V) LN, pregnancy in LN, LN in paediatric patients and LN patients with kidney failure. Relevant differences in the recommended management relate to the recognition of lupus podocytopathies, uncertainties in steroid dosing, drug preferences in specific populations and maintenance therapy, treatment of pure class V LN, therapy of recurrent LN, evolving alternative drug options and diagnostic work-up of thrombotic microangiopathy. Altogether, both documents provide an excellent guidance to the growing complexity of LN management. This article endeavours to prevent confusion by identifying differences and clarifying discrepancies. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
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