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Food contact materials (FCM) are any type of item intended to come into contact with foods and thus represent a potential source for human exposure to chemicals. Regarding FCMs made of paper and board, information pertaining to their chemical constituents and the potential impacts on human health remains scarce, which hampers safety evaluation. We describe an effect-directed strategy to identify and characterize emerging chemicals in paper and board FCMs. Twenty FCMs were tested in eight reporter gene assays, including assays for the AR, ER, AhR, PPARγ, Nrf2 and p53, as well as mutagenicity. All FCMs exhibited activities in at least one assay. As proof-of-principle, FCM samples obtained from a sandwich wrapper and a pizza box were carried through a complete step-by-step multi-tiered approach. The pizza box exhibited ER activity, likely caused by the presence of bisphenol A, dibutyl phthalate, and benzylbutyl phthalate. The sandwich wrapper exhibited AR antagonism, likely caused by abietic acid and dehydroabietic acid. Migration studies confirmed that the active chemicals can transfer from FCMs to food simulants. In conclusion, we report an effect-directed strategy that can identify hazards posed by FCMs made from paper and board, including the identification of the chemical(s) responsible for the observed activity. [ABSTRACT FROM AUTHOR]

For mining engineering and geological engineering, the deformation and fracture of coal and rock are the essential causes of dynamic disasters. In this paper, the loading experimental system was established on gas-bearing coal, to study the internal relationship between the spatial distribution of EP and the development process of damaging localization on coal mass. The results indicated the temporal response of EP signal could reflect the stress state and damage degree of gas-bearing coal, showing the precursor feather when coal mass failed. Particularly, when the stress dropped suddenly, the EP signal has a sudden mutation, and the acoustic emission (AE) signal suffered the pulsed increase, while the crack grew and expanded rapidly. Furthermore, when local severe damage occurs inside the coal mass, there was abnormal EP spatial distribution with high-value or dense contours in these zones, where simultaneously AE rupture events frequently occurred, and cracks expanded and gathered. The characteristics of EP spatial distribution can reveal the development process of coal mass damaging localization. Meanwhile, the mentioned zones with abnormal EP distribution above are hazard sources inducing coal mass’s instability and failure. The study results provide the foundational research work of fine forecasting on coal and gas outburst disaster hazard. [ABSTRACT FROM AUTHOR]

Endocrine disrupting chemicals or carcinogens have been known for decades for their endocrine signal disruption. Endocrine disrupting chemicals are a serious concern and they have been included in the top priority toxicants and persistent organic pollutants. Therefore, researchers have been working for a long time to understand their mechanisms of interaction in different human organs. Several reports are available about the carcinogen potential of these chemicals. The presented review is an endeavor to understand the hazard identification associated with endocrine disrupting carcinogens in relation to the human body. The paper discusses the major endocrine disrupting carcinogens and their potency for carcinogenesis. It discusses human exposure, route of entry, carcinogenicity and mechanisms. In addition, the paper discusses the research gaps and bottlenecks associated with the research. Moreover, it discusses the limitations associated with the analytical techniques for detection of endocrine disrupting carcinogens. [Display omitted] • Types of endocrine disrupting chemicals (EDCs) related to cancer were analyzed. • EDCs associated cancers and their mechanisms were discussed. • Human exposure to EDCs was explored. • Assessment of EDCs carcinogenicity was performed. • Research gaps and future studies were suggested. [ABSTRACT FROM AUTHOR]

Sucralose, a sugar substitute first approved for use in 1991, is a non-caloric sweetener regulated globally as a food additive. Based on numerous experimental animal studies (dating to the 1980s) and human epidemiology studies, international health agencies have determined that sucralose is safe when consumed as intended. A single lifetime rodent carcinogenicity bioassay conducted by the Ramazzini Institute (RI) reported that mice fed diets containing sucralose develop hematopoietic neoplasia, but controversy continues regarding the validity and relevance of these data for predicting health effects in humans. The present paper addresses the controversy by providing the perspective of experienced pathologists on sucralose-related animal toxicity and carcinogenicity data generally, and the RI carcinogenicity bioassay findings specifically, using results from publicly available papers and international regulatory authority decisions. In the authors' view, flaws in the design, methodology, data evaluation, and reporting of the RI carcinogenicity bioassay for sucralose diminish the value of the data as evidence that this agent represents a carcinogenic hazard to humans. This limitation will remain until the RI bioassay is repeated under Good Laboratory Practices and the design, data, and accuracy of the pathology diagnoses and interpretations are reviewed by qualified pathologists with experience in evaluating potential chemically-induced carcinogenic hazards. [ABSTRACT FROM AUTHOR]

The manufacture and production of industrial chemicals continues to increase, with hundreds of thousands of chemicals and chemical mixtures used worldwide, leading to widespread population exposures and resultant health impacts. Low-wealth communities and communities of color often bear disproportionate burdens of exposure and impact; all compounded by regulatory delays to the detriment of public health. Multiple authoritative bodies and scientific consensus groups have called for actions to prevent harmful exposures via improved policy approaches. We worked across multiple disciplines to develop consensus recommendations for health-protective, scientific approaches to reduce harmful chemical exposures, which can be applied to current US policies governing industrial chemicals and environmental pollutants. This consensus identifies five principles and scientific recommendations for improving how agencies like the US Environmental Protection Agency (EPA) approach and conduct hazard and risk assessment and risk management analyses: (1) the financial burden of data generation for any given chemical on (or to be introduced to) the market should be on the chemical producers that benefit from their production and use; (2) lack of data does not equate to lack of hazard, exposure, or risk; (3) populations at greater risk, including those that are more susceptible or more highly exposed, must be better identified and protected to account for their real-world risks; (4) hazard and risk assessments should not assume existence of a "safe" or "no-risk" level of chemical exposure in the diverse general population; and (5) hazard and risk assessments must evaluate and account for financial conflicts of interest in the body of evidence. While many of these recommendations focus specifically on the EPA, they are general principles for environmental health that could be adopted by any agency or entity engaged in exposure, hazard, and risk assessment. We also detail recommendations for four priority areas in companion papers (exposure assessment methods, human variability assessment, methods for quantifying non-cancer health outcomes, and a framework for defining chemical classes). These recommendations constitute key steps for improved evidence-based environmental health decision-making and public health protection. [ABSTRACT FROM AUTHOR]

The use of robotics and automation (RA) within construction operations to combat stagnant productivity, high rates of injuries and fatalities, and a declining workforce is increasing. However, utilizing RA for construction operations creates human-robot interactions (HRIs) that can lead to the emergence of novel hazards or exacerbate existing safety risk levels. These hazards, if ignored, could worsen worker safety performance. This paper presents a study intended to identify critical HRI safety risks and develop a pre-task planning protocol for the assessment of safety risks associated with the use of RA. To achieve this goal, the authors utilized a sequential multi-phase approach relying on information obtained from a literature review, a 3-round Delphi process consisting of a panel of experts from industry and academia, and interviews with safety experts. Forty hazards associated with RA and 20 potential strategies for the mitigation of HRI safety risks were identified and evaluated. This information was used to develop a safety risk assessment tool that yields an overall risk rating of using RA. This study contributes to knowledge and practice by identifying and quantifying critical safety risks associated with HRI and developing a tool to assess and mitigate unique HRI safety risks. Utilizing insights developed in this study could improve construction worker safety and health and aid the industry's increasing push towards a smart and safe workforce. [ABSTRACT FROM AUTHOR]

Evaluation of water inrush risk is becoming increasingly important as coal mining activities reach greater depths. Hazard identification, as well as hazard analysis, is the first step in accident prevention. However, there have not been any studies that focus on the hazard analysis system for mine water inrush. In this paper, hazard identification and its definitions are briefly summarized and a comprehensive review of methods for hazard identification and classification are conducted. To illustrate the hazard of coal mine water inrush, data on coal mine accidents (since 2001) are collected and hundreds water inrush accidents were analyzed in depth. Empirical, statistical analysis and case study method were used to conduct the research. By collecting a large number of mine water inrush cases, hazard identification and risk control measures for coal mine water inrush accidents were conducted. Hazard identification method based on fault tree analysis, as well as a method based on management oversight and risk tree (MORT) and energy release theory were put forward. The analysis results show that the historical information and experiences are critically important in hazard identification of mine water inrush. Hazard of mine water inrush is divided into dynamic root hazard and static root hazard which can be further categorized into static innate hazard and dynamic-triggered hazard. Strategies for risk control of mine water inrush are combined into three aspects: engineering controls, operation system controls, and human behavior controls. Finally, a case study of the Taoyuan coal mine was conducted to illustrate the proposed system, with limitations and future studies are discussed. The hazard identification and classification system can be broadly applied to coal mines and will improve risk control and prevention of mine water inrush accidents. [ABSTRACT FROM AUTHOR]

Crane-related accidents often occur due to failure in timely and accurate hazard identification. Virtual Reality (VR) technology facilitates immersive environments for improving hazard identification without real-world consequences. However, the impact of simulation fidelity on hazard identification performance, particularly for novice crane operators, remains underexplored. This paper examines how simulation fidelity and task complexity affect hazard identification performance among novice operators through a VR experiment with two fidelity and two complexity levels. Findings demonstrate high-fidelity (HF) scenarios significantly improve hazard identification success rate and speed for swing-over hazards but extend task completion times. Task complexity modulates simulation fidelity's impact on task completion, with significant differences between fidelity levels observed only under low complexity. These insights inform the design and calibration of simulation fidelity in VR platforms, potentially improving training efficacy and crane lifting safety for novice operators. • Explores the impact of simulation fidelity on novice crane operators' hazard identification. • Finds that high-fidelity boosts success rate but reduces speed in hazard identification. • Highlights accuracy-speed trade-off due to simulation fidelity changes. • Emphasises interaction fidelity for immersive, real-world-like experiences. • Guides on balancing simulation fidelity and cost-effectiveness in VR safety training. [ABSTRACT FROM AUTHOR]

Nanoplastics are associated with several risks to the ecology and toxicity to humans. Nanoplastics are synthetic polymers with dimensions ranging from 1 nm to 1 μm. They are directly released to the environment or secondarily derived from plastic disintegration in the environment. Nanoplastics are widely detected in environmental samples and the food chain; therefore, their potentially toxic effects have been widely explored. In the present review, an overview of another two potential sources of nanoplastics, exposure routes to illustrate hazard identification of nanoplastics, cell internalization, and effects on intracellular target organelles are presented. In addition, challenges on the study of nanoplastics and future research areas are summarized. This paper also summarizes some approaches to eliminate or minimize the levels of nanoplastics to ensure environmental safety and improve human health. [ABSTRACT FROM AUTHOR]

Hazard identification in the construction industry is subject to a larger number of variables and unknowns than in other manufacturing industries making the hazard identification process more difficult and resulting in many injuries and fatalities. Moreover, previous research identified a research gap with regards to a universal hazard identification method. The results presented in this paper are a prerequisite for the development of such a method. Specifically, this paper proposes a novel classification of hazards in order to enable a more accurate hazard identification process which can take all possible hazards into consideration. Based on the theoretical framework, three hazard types are proposed in the research: self-induced hazards, peer-induced hazards, and global hazards. This classification is based on who is the source (who causes) the hazards in relation to who is affected by the hazards. Such classification was not identified in previous literature. This research also has practical implications. Such classification of hazards may influence safety experts to more actively focus on peer-induced hazards which are the hardest to identify. Finally, the outputs of the entire research should enable a more accurate and comprehensive hazard identification resulting in reduced injury and fatality rates in the construction industry. [ABSTRACT FROM AUTHOR]

Power systems and their primary components, mostly the transmission and distribution of overhead lines, substations, and other power facilities, are distributed in space and are exposed to various atmospheric and meteorological conditions. These conditions carry a certain level of risk for reliable electrical power delivery. Various atmospheric hazards endanger the operation of power systems, where the most significant are thunderstorms, wildfire events, and floods which can cause various ranges of disturbances, faults, and damages to the power grid, or even negatively affect the quality of life. By utilizing a weather monitoring and early warning system, it is possible to ensure a faster reaction against different weather-caused fault detections and elimination, to ensure a faster and more adequate preparation for fighting extreme weather events, while maintaining overhead line protection and fault elimination. Moreso, it is possible to bypass overhead lines that have the highest risk of unfavorable meteorological events and hazards, and reroute the energy, thus providing electricity to endangered areas in times of need while minimizing blackouts, and consequently, improving the quality of human life. This paper will present an analysis of the various risks of atmospheric phenomena, in the meteorological and climate context, and discuss various power system components, the power system control, operations, planning, and power quality. A concept with the main functionalities and data sources needed for the establishment of an early warning weather hazard system will be proposed. The proposed solution can be used as a utility function in power system control to mitigate risks to the power system due to atmospheric influences and ongoing climate change. [ABSTRACT FROM AUTHOR]

A requirement arose during decommissioning work at a UK Magnox Nuclear Power Station to identify the hazards involved in removing High Dose Rate Items from a Cartridge Cooling Pond. Removing objects from the cooling pond under normal situations is a routine event with well understood risks but the situation described in this paper is not a routine event. The power station has shifted from an operational phase in its life-cycle to a decommissioning phase, and as such the risks, and procedures to deal with them, have become more novel and uncertain. This raises an important question. Are the hazard identification methods that have proven useful in one phase of the system lifecycle just as useful in another, and if not, what methods should be used? An opportunity arose at this site to put the issue to a direct test. Two methods were used, one practitioner focussed and in widespread use during the plant's operational phase (the Structured What-If method), the other was an analyst method (Cognitive Work Analysis). The former is proven on this site but might not be best suited to the novelty and uncertainty brought about by a shift in context from operations to decommissioning. The latter is not proven on this site but it is designed for novelty and uncertainty. The paper presents the outcomes of applying both methods to a real-world hazard identification task. [ABSTRACT FROM AUTHOR]

The analysis of remote sensing data to assess geohazards is being improved by web-based platforms and collaborative projects, such as the Geohazard Exploitation Platform (GEP) of the European Space Agency (ESA). This paper presents the evaluation of a surface velocity map that is generated by this platform. The map was produced through an unsupervised Multi-temporal InSAR (MTI) analysis applying the Parallel-SBAS (P-SBAS) algorithm to 25 ENVISAT satellite images from the South of Spain that were acquired between 2003 and 2008. This analysis was carried out using a service implemented in the GEP called "SBAS InSAR". Thanks to the map that was generated by the SBAS InSAR service, we identified processes not documented so far; provided new monitoring data in places affected by known ground instabilities; defined the area affected by these instabilities; and, studied a case where GEP could have been able to help in the forecast of a slope movement reactivation. This amply demonstrates the reliability and usefulness of the GEP, and shows how web-based platforms may enhance the capacity to identify, monitor, and assess hazards that are associated to geological processes. [ABSTRACT FROM AUTHOR]

Current onsite safety management always relies on time-consuming predefinitions of hazardous zones based on the managers' personal capabilities. However, in a typical labor-intensive industry such as construction, the workers themselves can provide a wealth of information for hazard identification. Historical accident-free working locations on site provide a valuable means of recognizing safe workplaces. This paper presents an approach to the automated classification of construction site zones derived from the location tracks of workers collected from a real-time location system (RTLS). Through data mining, filtering and analysis, the location tracks are transformed into grid density maps and continuous density maps. These illustrate the characteristics of spatial-temporal activities onsite as well as providing a visual representation of the distribution of safe and hazardous individual workplaces. A personnel hazard map is generated automatically based on historical accident-free location tracks from a field project using the proposed approach. Compared with the actual workplaces in terms of accuracy, precision, sensitivity and specificity, the evaluation result reveals that the hazardous areas on a construction site can be automatically classified to improve the workplace management of individual workers. The contributions of this research include an automated zone classification algorithm and an evaluation framework consisting of four indicators for hazard awareness onsite. [ABSTRACT FROM AUTHOR]

[Display omitted] • Approaches and models in Human Health Risk Assessment are comprehensively reviewed. • Method on the mechanisms of contaminant actions on human health hazards is needed. • Integration and update of existing toxicity databases are necessary. • Lack of health-based screening values is a barrier to biomonitoring. • The integration of fate and transport models and risk assessment systems is essential. Soil contamination is a serious global hazard as contaminants can migrate to the human body through the soil, water, air, and food, threatening human health. Human Health Risk Assessment (HHRA) is a commonly used method for estimating the magnitude and probability of adverse health effects in humans that may be exposed to contaminants in contaminated environmental media in the present or future. Such estimations have improved for decades with various risk assessment frameworks and well-established models. However, the existing literature does not provide a comprehensive overview of the methods and models of HHRA that are needed to grasp the current status of HHRA and future research directions. Thus, this paper aims to systematically review the HHRA approaches and models, particularly those related to contaminated sites from peer-reviewed literature and guidelines. The approaches and models focus on methods used in hazard identification, toxicity databases in dose–response assessment, approaches and fate and transport models in exposure assessment, risk characterization, and uncertainty characterization. The features and applicability of the most commonly used HHRA tools are also described. The future research trend for HHRA for contaminated sites is also forecasted. The transition from animal experiments to new methods in risk identification, the integration and update and sharing of existing toxicity databases, the integration of human biomonitoring into the risk assessment process, and the integration of migration and transformation models and risk assessment are the way forward for risk assessment in the future. This review provides readers with an overall understanding of HHRA and a grasp of its developmental direction. [ABSTRACT FROM AUTHOR]

The paper presents problems of hazard identification in transportation systems, where not only field of action is large but also cause-consequences relations between failure causes and losses are distant in time and space. It is observed in transportation systems of goods and passengers, systems of water, gas, oil distribution and electro-energetic nets. Proposed systemic approach based on system elements classification on active (casual) and passive ones (affected). There are described concepts of vulnerability (damageability), resilience (ability of recovering and risk controlling by introducing safety measures to undesired event chain. [ABSTRACT FROM AUTHOR]

The pre-marketing testing of drugs and chemicals is now a paradigm of contribution to the safeguard of public health. As pointed out by the ICH concept paper E14/S7B, there is a need for science-based frameworks that allow a better design, conduction, and interpretation of nonclinical and toxicity tests, particularly, in order for those assays to influence nonclinical and clinical evaluations and decisions better. Critical issues related to the performance and predictive values of nonclinical testing were highlighted and discussed in this article, specifically, to help pharmacologists, toxicologists, and regulators in the evaluation of the reliability of such tests, and basing the prospective decisions on the true predictivity of selected screening tests. This review addressed two common mistakes in drug and chemical testing, namely, (a) the assumption of either sensitivity or specificity as automatically "predictive," and (b) the reporting of the predictive values disregarding a truly representative prevalence. This review also discussed a statistical basis to apply for (industry standpoint) or grant (regulatory standpoint) authorization for the waiving of selected nonclinical tests. Furthermore, this review can be guiding for those who are entering into the field of drug and chemical testing. Through application, investigation, and enhancement of the conceptual framework discussed in this review, nonclinical testing is expected to provide a higher contribution to drug and chemical development, regulatory science, and public health. [ABSTRACT FROM AUTHOR]

Many civilian applications of commercial unmanned aircraft are being planned to operate in the years ahead. Several countries have developed their own framework to design the operation of unmanned aircraft and the different services that demand safe operation. This paper focuses on the European framework denoted as U-space which concludes with the joint integration of manned and unmanned aircraft in the airspace. U-space is a set of novel services and specific procedures designed to provide safe and efficient access into the airspace to the airspace users. U-space constitutes a management system to organise unmanned operations and provides relevant information to drone operators as well as manned aircraft, air navigation service providers and authorities. The understanding of associated hazards and risks to unmanned aircraft is a critical issue for their operation in complex and non-segregated airspaces. The safety assessment developed herein is crucial to identify safety indicators for U-space. In addition, the identification of safety indicators was used to identify gaps in U-spaces services that are not correctly covered by the U-space framework. Particularly, several safety indicators are identified that currently U-space services do not consider and can imply an increase in the operational risk of unmanned operations. [ABSTRACT FROM AUTHOR]

Most construction safety management processes rely on the hazard recognition capability of workers. Hazards that remain unidentified can potentially result in catastrophic injuries and illnesses. As such, thorough hazard recognition is fundamentally essential to protect the health and well-being of the construction workforce. Despite its importance, recent research indicates that a large proportion of hazards remain unrecognized, exposing workers to unmitigated risks. Surprisingly, safety research has not adequately focused on developing specialized strategies to develop construction worker competency in hazard recognition. This paper reports a two-year research effort with the following objectives: (1) develop a high-fidelity augmented virtual environment [System for Augmented Virtuality Environment Safety (SAVES)] that helps develop workers' hazard recognition skill through risk-free learning and immediate feedback; (2) embed cognitive retrieval mnemonics to improve long-term retention of cues for construction hazards; (3) evaluate the effectiveness of the strategy as an intervention on active construction crew by using the multiple baseline testing approach. The first two objectives were accomplished through a combined effort from a panel of 14 subject matter experts and five academic researchers. This was followed by field experiments to test the hypothesis that the experience with SAVES improves the proportion of hazards identified by participants during subsequent field operations. The findings revealed that crews, on average, were able to only identify 46% of hazards prior to the introduction of the intervention, but were able to recognize 77% of hazards in the postintervention phase. This study represents the first endeavor to measure the effectiveness of augmented virtuality and serious gaming in developing hazard signal detection skills in construction field settings. [ABSTRACT FROM AUTHOR]