1. Muscle stem cells at a glance.
- Author
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Wang, Yu Xin, Dumont, Nicolas A., and Rudnicki, Michael A.
- Subjects
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STEM cell research , *SKELETAL muscle , *REGENERATIVE medicine , *SATELLITE cells , *STEM cell treatment , *CELLULAR therapy , *CELL determination - Abstract
Muscle stem cells facilitate the long-term regenerative capacity of skeletal muscle. This self-renewing population of satellite cells has only recently been defined through genetic and transplantation experiments. Although muscle stem cells remain in a dormant quiescent state in uninjured muscle, they are poised to activate and produce committed progeny. Unlike committed myogenic progenitor cells, the self-renewal capacity gives muscle stem cells the ability to engraft as satellite cells and capitulate long-term regeneration. Similar to other adult stem cells, understanding the molecular regulation of muscle stem cells has significant implications towards the development of pharmacological or cell-based therapies for muscle disorders. This Cell Science at a Glance article and accompanying poster will review satellite cell characteristics and therapeutic potential, and provide an overview of the muscle stem cell hallmarks: quiescence, self-renewal and commitment. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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