Search

Your search keyword '"Li, Chufang"' showing total 1 results

Refine your results

1 results on '"Li, Chufang"'

1. Identification of Hits as Matrix-2 Protein Inhibitors through the Focused Screening of a Small Primary Amine Library.

Author

Hu, Wenhui, Zeng, Shaogao, Li, Chufang, Jie, Yanling, Li, Zhiyuan, and Chen, Ling

Subjects
*CHEMICAL inhibitors, *PROTEINS, *AMINES, *AMANTADINE, *INFLUENZA A virus, *DRUG resistance
Abstract

Although amantadine derivatives are the only M2 drugs for influenza virus A, their use is limited in the U.S. because of drug resistance. Here we report the identification of multiple M2 inhibitors that were rapidly generated through focused screening of a small primary amine library that was designed using a scaffold-hopping strategy based on amantadine. These compounds are as active as amantadine and might be hits for further lead generation processes. [ABSTRACT FROM AUTHOR]

Published
2010
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results