1. Hematological findings in coronavirus disease 2019: indications of progression of disease.
- Author
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Liu, Xiaoqing, Zhang, Run, and He, Guangsheng
- Subjects
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COVID-19 , *EMERGING infectious diseases , *SARS-CoV-2 , *DISEASE progression , *T cells , *VIRAL pneumonia , *HEMOGLOBINS , *LUNGS , *NEUTROPHILS , *LYMPHOPENIA , *EPIDEMICS , *LEUKOCYTE count , *CD4 lymphocyte count , *THROMBOCYTOPENIA - Abstract
Coronavirus disease 2019 (COVID-19) is a new human infectious disease. The etiology for this outbreak is a novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Thus far, related research on COVID-19 is still in preliminary stage. This paper summarized the latest outcomes of corresponding study from Chinese centers and clarified the hematopoietic abnormality caused by SARS-CoV-2 and potential mechanism. Lymphopenia was common in the early stage after the onset of COVID-19. A significant decrease was observed in peripheral CD4+ and CD8+ T lymphocytes. As the illness progressed, neutrophilia emerged in several cases, and patients with severe critical pulmonary conditions showed higher neutrophils than common type. Thrombocytopenia was resulting from the consumption and/or the reduced production of platelets in damaged lungs. Anemia was not observed notably, but the decrease in hemoglobin was frequent. The activation of monocyte-macrophage system aggravates the immune damage of lung and other tissues, which leads to the increase of D-dimer, prothrombin time, and platelet consumption. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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