1. The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin.
- Author
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Mackay, Laura K, Rahimpour, Azad, Ma, Joel Z, Collins, Nicholas, Stock, Angus T, Hafon, Ming-Li, Vega-Ramos, Javier, Lauzurica, Pilar, Mueller, Scott N, Stefanovic, Tijana, Tscharke, David C, Heath, William R, Inouye, Michael, Carbone, Francis R, and Gebhardt, Thomas
- Subjects
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CD8 antigen , *T cells , *SKIN , *LYMPHOID tissue , *INTERLEUKIN-15 , *TRANSFORMING growth factors , *CELL differentiation , *ANATOMY - Abstract
Tissue-resident memory T cells (TRM cells) provide superior protection against infection in extralymphoid tissues. Here we found that CD103+CD8+ TRM cells developed in the skin from epithelium-infiltrating precursor cells that lacked expression of the effector-cell marker KLRG1. A combination of entry into the epithelium plus local signaling by interleukin 15 (IL-15) and transforming growth factor-β (TGF-β) was required for the formation of these long-lived memory cells. Notably, differentiation into TRM cells resulted in the progressive acquisition of a unique transcriptional profile that differed from that of circulating memory cells and other types of T cells that permanently reside in skin epithelium. We provide a comprehensive molecular framework for the local differentiation of a distinct peripheral population of memory cells that forms a first-line immunological defense system in barrier tissues. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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