1. ImmunoGrid, an integrative environment for large-scale simulation of the immune system for vaccine discovery, design and optimization.
- Author
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Pappalardo, Francesco, Hailing-Brown, Mark D., Rapin, Nicolas, Zhang, Ping, Aleman, Davide, Emerson, Andrew, Paci, Paola, Duroux, Patrice, Pennisi, Marzio, Palladini, Arianna, Miotto, Olivo, Churchill, Daniel, Rossi, Elda, Shepherd, Adrian J., Moss, David S., Castigiione, Filippo, Bernaschi, Massimo, Lefranc, Marie-Pauie, Brunak, Søren, and Motta, Santo
- Subjects
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GRID computing , *IMMUNOINFORMATICS , *VACCINE research , *SIMULATION methods & models , *MATHEMATICAL models - Abstract
Vaccine research is a combinatorial science requiring computational analysis of vaccine components, formulations and optimization. We have developed a framework that combines computational tools for the study of immune function and vaccine development. This framework, named ImmunoGrid combines conceptual models of the immune system, models of antigen processing and presentation, system-level models of the immune system, Grid computing, and database technology to facilitate discovery, formulation and optimization of vaccines. ImmunoGrid modules share common con- ceptual models and ontologies. The lmmunoGrid portal offers access to educational simulators where previously defined cases can be displayed, and to research simulators that allow the development of new, or tuning of existing, computational models. The portal is accessible at
. [ABSTRACT FROM AUTHOR] - Published
- 2009
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