4 results on '"Mendelson, Marc"'
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2. WHO's essential medicines and AWaRe: recommendations on first- and second-choice antibiotics for empiric treatment of clinical infections.
- Author
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Moja, Lorenzo, Zanichelli, Veronica, Mertz, Dominik, Gandra, Sumanth, Cappello, Bernadette, Cooke, Graham S., Chuki, Pem, Harbarth, Stephan, Pulcini, Celine, Mendelson, Marc, Tacconelli, Evelina, Ombajo, Loice Achieng, Chitatanga, Ronald, Zeng, Mei, Imi, Monica, Elias, Christelle, Ashorn, Per, Marata, Annamaria, Paulin, Sarah, and Muller, Arno
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HEALTH facilities , *MEDICAL personnel , *ANTIBIOTICS , *MOBILE apps , *DRUG resistance in microorganisms , *ANTIBACTERIAL agents , *BLACKBERRIES - Abstract
The WHO Model List of Essential Medicines (EML) prioritizes medicines that have significant global public health value. The EML can also deliver important messages on appropriate medicine use. Since 2017, in response to the growing challenge of antimicrobial resistance, antibiotics on the EML have been reviewed and categorized into three groups: Access, Watch, and Reserve, leading to a new categorization called AWaRe. These categories were developed taking into account the impact of different antibiotics and classes on antimicrobial resistance and the implications for their appropriate use. The 2023 AWaRe classification provides empirical guidance on 41 essential antibiotics for over 30 clinical infections targeting both the primary health care and hospital facility setting. A further 257 antibiotics not included on the EML have been allocated an AWaRe group for stewardship and monitoring purposes. This article describes the development of AWaRe, focussing on the clinical evidence base that guided the selection of Access, Watch, or Reserve antibiotics as first and second choices for each infection. The overarching objective was to offer a tool for optimizing the quality of global antibiotic prescribing and reduce inappropriate use by encouraging the use of Access antibiotics (or no antibiotics) where appropriate. This clinical evidence evaluation and subsequent EML recommendations are the basis for the AWaRe antibiotic book and related smartphone applications. By providing guidance on antibiotic prioritization, AWaRe aims to facilitate the revision of national lists of essential medicines, update national prescribing guidelines, and supervise antibiotic use. Adherence to AWaRe would extend the effectiveness of current antibiotics while helping countries expand access to these life-saving medicines for the benefit of current and future patients, health professionals, and the environment. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
3. A situational analysis of current antimicrobial governance, regulation, and utilization in South Africa.
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Schellack, Natalie, Benjamin, Deon, Brink, Adrian, Duse, Adriano, Faure, Kim, Goff, Debra, Mendelson, Marc, Meyer, Johanna, Miot, Jacqui, Perovic, Olga, Pople, Troy, Suleman, Fatima, van Vuuren, Moritz, and Essack, Sabiha
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ANTI-infective agents , *PUBLIC health , *DRUG resistance , *ANTIRETROVIRAL agents - Abstract
The Global Action Plan on antimicrobial resistance calls for the use of antimicrobial medicines in human and animal health to be optimized, in tandem with a strengthening of the knowledge and evidence base through surveillance and research. However, there is a paucity of consumption data for African countries such as South Africa. Determining antimicrobial consumption data in low-resource settings remains a challenge. This article describes alternative mechanisms of assessing antimicrobial consumption data, such as the use of Intercontinental Marketing Services (IMS) data and contract data arising from tenders (an open Request for Proposal, RFP), as opposed to the international norms of daily defined doses per 100 patient-days or per 1000 population. Despite their limitations, these serve as indicators of antimicrobial exposure at the population level and represent an alternative method for ascertaining antimicrobial consumption in human health. Furthermore, South Africa has the largest antiretroviral treatment programme globally and carries a high burden of tuberculosis. This prompted the inclusion of antiretroviral and anti-tuberculosis antibiotic consumption data. Knowledge of antimicrobial utilization is imperative for meaningful future interventions. Baseline antimicrobial utilization data could guide future research initiatives that could provide a better understanding of the different measures of antibiotic use and the level of antibiotic resistance. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
4. A global call from five countries to collaborate in antibiotic stewardship: united we succeed, divided we might fail.
- Author
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Goff, Debra A, Kullar, Ravina, Goldstein, Ellie J C, Gilchrist, Mark, Nathwani, Dilip, Cheng, Allen C, Cairns, Kelly A, Escandón-Vargas, Kevin, Villegas, Maria Virginia, Brink, Adrian, van den Bergh, Dena, and Mendelson, Marc
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ANTIBIOTICS , *DRUG resistance , *INFECTION prevention , *MEDICAL care , *POPULATION , *MEDICAL education , *ANTI-infective agents , *DRUG therapy , *CONTINUING education , *COOPERATIVENESS , *DRUG resistance in microorganisms , *DRUG utilization , *HOSPITALS , *INTERNATIONAL relations , *WORLD health - Abstract
In February, 2016, WHO released a report for the development of national action plans to address the threat of antibiotic resistance, the catastrophic consequences of inaction, and the need for antibiotic stewardship. Antibiotic stewardship combined with infection prevention comprises a collaborative, multidisciplinary approach to optimise use of antibiotics. Efforts to mitigate overuse will be unsustainable without learning and coordinating activities globally. In this Personal View, we provide examples of international collaborations to address optimal prescribing, focusing on five countries that have developed different approaches to antibiotic stewardship-the USA, South Africa, Colombia, Australia, and the UK. Although each country's approach differed, when nurtured, individual efforts can positively affect local and national antimicrobial stewardship programmes. Government advocacy, national guidelines, collaborative research, online training programmes, mentoring programmes, and social media in stewardship all played a role. Personal relationships and willingness to learn from each other's successes and failures continues to foster collaboration. We recommend that antibiotic stewardship models need to evolve from infection specialist-based teams to develop and use cadres of health-care professionals, including pharmacists, nurses, and community health workers, to meet the needs of the global population. We also recommend that all health-care providers who prescribe antibiotics take ownership and understand the societal burden of suboptimal antibiotic use, providing examples of how countries can learn, act globally, and share best antibiotic stewardship practices. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
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