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Functionalized cyclic amines are essential structural motifs in synthetic chemistry and pharmaceutical chemistry, and Shono-type oxidation is a well-developed electrochemical approach for the synthesis of α- amines. In sharp contrast, electrochemically driven direct β-C(sp3)–H functionalization of amines has been far proven elusive. Herein, we outline the recent advances in this field and highlight our group's effort to achieve electrochemical β-C(sp3)–H functionalization assisted by ferrocene as molecular electrocatalyst under mild conditions. 1 Introduction 2 Case studies of α-Functionalization (Shono-Type Oxidation) 3 Electrochemical β-C(sp3)–H Acylation 4 Conclusion [ABSTRACT FROM AUTHOR]

Carbon dioxide (CO2) is an abundant, inexpensive, renewable C1 resource and the main component of greenhouse gas, thereby the research for its sustainable and efficient conversion has received notable attention in recent years. Electrochemical organic synthesis, as a green and efficient synthetic method, is convinced to be an ideal approach for CO2 utilization. In this review, recent advances in electrocarboxylation with CO2 were summarized through different reaction types, which would disclose the great potential of electrocarboxylation in green organic synthesis. [ABSTRACT FROM AUTHOR]

Herein, we disclose a straightforward, robust, and simple route to access β‐substituted desaturated cyclic amines via an electrochemically driven desaturative β‐functionalization of cyclic amines. This transformation is based on multiple single‐electron oxidation processes using catalytic amounts of ferrocene. The reaction proceeds in the absence of stoichiometric amounts of electrolyte under mild conditions, affording the desired products with high chemo‐ and regioselectivity. The reaction was tolerant of a broad range of substrates and also enables late‐stage β‐C(sp3)−H acylation of potentially valuable products. Preliminary mechanistic studies using cyclic voltammetry reveal the key role of ferrocene as a redox mediator in the reaction. [ABSTRACT FROM AUTHOR]

Herein, we disclose a straightforward, robust, and simple route to access β‐substituted desaturated cyclic amines via an electrochemically driven desaturative β‐functionalization of cyclic amines. This transformation is based on multiple single‐electron oxidation processes using catalytic amounts of ferrocene. The reaction proceeds in the absence of stoichiometric amounts of electrolyte under mild conditions, affording the desired products with high chemo‐ and regioselectivity. The reaction was tolerant of a broad range of substrates and also enables late‐stage β‐C(sp3)−H acylation of potentially valuable products. Preliminary mechanistic studies using cyclic voltammetry reveal the key role of ferrocene as a redox mediator in the reaction. [ABSTRACT FROM AUTHOR]

Electrochemistry. An electrochemical desaturative α‐acylation of cyclic N‐aryl amines to access α‐substituted enamines is reported in the Communication by Youai Qiu et al. (e202115178). [ABSTRACT FROM AUTHOR]

Frontispiece: Electrochemical Desaturative -Acylation of Cyclic N-Aryl Amines Keywords: -Acylation; Desaturation; Electrochemistry; Ferrocene mediator; Selectivity EN -Acylation Desaturation Electrochemistry Ferrocene mediator Selectivity 1 1 1 01/28/22 20220201 NES 220201 B Electrochemistry b . An electrochemical desaturative -acylation of cyclic N-aryl amines to access -substituted enamines is reported in the Communication by Youai Qiu et al. (e202115178). [Extracted from the article]

Elektrochemie. Die elektrochemische desaturierende α‐Acylierung von cyclischen N‐Arylaminen zu α‐substituierten Enaminen wird in der Zuschrift von Youai Qiu et al. vorgestellt (e202115178). [ABSTRACT FROM AUTHOR]

-Acylation, Desaturation, Electrochemistry, Ferrocene mediator, Selectivity Keywords: -Acylation; Desaturation; Electrochemistry; Ferrocene mediator; Selectivity EN -Acylation Desaturation Electrochemistry Ferrocene mediator Selectivity 1 1 1 01/28/22 20220201 NES 220201 B Elektrochemie b . Frontispiz: Electrochemical Desaturative -Acylation of Cyclic N-Aryl Amines. [Extracted from the article]

Abstract: A biosensor was fabricated using graphene nano-sheets (GNSs) as the component for signal amplification and cetyltrimethylammonium bromide (CTAB) as the discriminating agent with the aim of achieving the selective and sensitive determination of dopamine (DA) in the presence of ascorbic acid (AA). The electrochemical behavior of DA was studied by cyclic voltammetry and differential pulse voltammetry (DPV). The results showed that DA and AA in coexisting solutions can be simultaneously oxidized in an electrochemical manner at significantly different potentials in the presence of CTAB. Therefore, DA can be selectively determined from a mixed solution even in the presence of interferents. The DPV current showed a linear dependence on DA concentrations ranging from 4×10−6 M to 5.2×10−5 M with a detection limit of 6.0×10−7 M. The proposed method was used to detect DA in real human blood serum using the standard addition method with satisfactory results. The reliability of the method was also examined with the fluorescence spectroscopy. The reaction mechanism was explored and a defect in micelles was highlighted to explain the high sensitivity and selectivity of the method. [Copyright &y& Elsevier]