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Photodynamic therapy (PDT) has become a promising approach and non-invasive modality for cancer treatment, however the therapeutic effect of PDT is limited in tumor metastasis and local recurrence. Herein, a tumor targeted nanomedicine (designated as PCN@HA) is constructed for enhanced PDT against tumors. By modified with hyaluronic acid (HA), which could target the CD44 receptor that expressed on the cancer cells, the targeting ability of PCN@HA has been enhanced. Under light irradiation, PCN@HA can produce cytotoxic singlet oxygen (1O 2) and kill cancer cells, then eliminate tumors. Furthermore, PCN@HA exhibits fluorescence (FL)/ photoacoustic (PA) effects for multimodal imaging-guided cancer treatment. And PCN@HA-mediated PDT also can induce immunogenic cell death (ICD) and stimulate adaptive immune responses by releasing of tumor antigens. By combining with anti-PD-L1 checkpoint blockade therapy, it can not only effectively suppress the growth of primary tumor, but also inhibit the metastatic tumor growth. • PCN@HA achieved fluorescence/photoacoustic dual-mode imaging guided cancer treatment. • PCN@HA-mediated PDT induced immunogenic cell death. • By combining with anti-PD-L1 checkpoint blockade therapy, both primary tumor and metastatic tumor were suppressed. [ABSTRACT FROM AUTHOR]

Although conventional nanofiltration (NF) membrane is widely applied in water treatment, it faces the challenges of insufficient selectivity toward emerging contaminants, low permeability and non-sustainable fouling control. Herein, a novel electroactive metal-organic frameworks/carbon nanotubes membrane was constructed by facile and green nanobubbles-mediated non-solvent-induced phase separation (NIPS) strategy for ultrafast antibiotics removal. It presented 3-fold to 100-fold higher permeability (101.3–105.7 L·h−1·m−2·bar−1) without compromising rejection (71.8 %−99.3 %) of common antibiotics (tetracycline, norfloxacin, sulfamethoxazole, sulfamethazine) than most commercial and state-of-the-art NF membranes. The separation mechanism was due to the synergy of loose selective layer with three-dimensional interconnected networks and UiO-66/CNTs with unique pore sieving and charge property. It also presented excellent antibiotics selectivity with high NaCl/tetracycline separation factor of 194 and CuCl 2 /tetracycline separation factor of 316 for remediation of antibiotics and heavy metal combined pollution. Meanwhile, it possessed efficient anti-fouling, antibacterial and electro-driven self-cleaning ability, which enabled sustainable fouling control and disinfection with short process, low energy and chemical consumption. Furthermore, potential application of UiO-66/CNTs membrane in wastewater reclamation was demonstrated by stable antibiotics rejection, efficient flux recovery and long-term stability over 260 h. This study would provide useful insights into removal of emerging contaminants from water by advanced NF membrane. [Display omitted] • Novel membrane was designed for ultrafast and selective separation of antibiotics. • The role of loose active layer and UiO-66/CNTs in membrane separation was revealed. • Membrane has high flux (101.3 L·h−1·m−2·bar−1) and tetracycline rejection (99.3 %). • Sustainable membrane fouling control and disinfection were achieved by electricity. • It has stable antibiotic rejection, high permeate quality and stability over 260 h. [ABSTRACT FROM AUTHOR]

[Display omitted] • Novel electrocatalytic membrane (ECM) system was developed for antibiotics removal. • Defect and hierarchical pore of MOF imparted ECM with superior antibiotics removal. • Antibiotics degradation and self-cleaning mechanisms of membrane were proposed. • Application of ECM in reclamation of simulated municipal wastewater was explored. The spread of antibiotics became a serious risk to human health during wastewater reclamation. Herein, a novel electrocatalytic membrane (ECM) was constructed by facile incorporation of titanium metal organic frameworks (Ti-MOFs) with tunable defect and pore structure into polyvinylidene fluoride (PVDF) membrane for antibiotics removal under electro-assistance. The results showed Ti-MOFs with moderate missing-linker defects and hierarchical pores (Ti-MOFs-1) imparted the membrane with much higher water flux (618.6 L·m−2·h−1·bar−1), oxygen evolution potential (2.16 V), electrochemically active surface area (0.0306 cm2), and lower charge-transfer resistance compared to defect-free Ti-MOFs, thereby rendering higher electrocatalytic activity, increasing tetracycline (TC) removal by more than 40% and reducing the toxicities of intermediates. Interestingly, ECM presented a volcano-type trend in TC removal with the gradual increase of defects and pore size in Ti-MOFs due to the synergistic effect of moderately exposed active sites for generation of •OH and •O 2 – and hierarchical pore feature for accelerated mass transfer of antibiotics toward the catalytic sites. In addition, the application of ECM in reclamation of simulated municipal wastewater was evaluated. The efficient antibiotics removal efficiency (100%), electrically-driven self-cleaning ability (flux recovery = 100%) and electrochemical stability with low residence time (50.2 s) and energy consumption (0.533 W•h/m3) verify its potential in antibiotics removal. [ABSTRACT FROM AUTHOR]

One-step adsorptive purification of methane (CH 4) from the multi-component mixtures containing CO 2 , acetylene (C 2 H 2) and ethane (C 2 H 6) is of great significance but challenging as distinct mechanisms are involved in the uptake of various gas molecules. Herein, a bismuth-based metal-organic framework (SU-100) bearing multi-affinity sites is applied for simultaneously sequestrating these impurities from CH 4. The intrinsic unsaturated Bi (III) sites endow SU-100 with specific recognition of CO 2 and C 2 H 2 via complexation with the open metal sites, while the dense distribution of carboxylate and biphenyl moieties in the nano-channels provides strong affinity for C 2 H 6 as well as additional affinity sites for C 2 H 2. Profiting from the exposed functional sites and suitable pore size, SU-100 exhibits decent ideal adsorbed solution theory (IAST) selectivity (CO 2 /CH 4 , C 2 H 2 /CH 4 and C 2 H 6 /CH 4) under ambient conditions. Moreover, the adsorption capacity remains unchanged for 10 consecutive cycles. The practical CH 4 purification performance is fully demonstrated by dynamic breakthroughs of various binary, ternary (CO 2 /C 2 H 2 /CH 4), and quaternary (CO 2 /C 2 H 2 /C 2 H 6 /CH 4) mixtures, in which more than 2.44 mol kg−1 of pure CH 4 can be produced from typical quaternary mixtures. Based on theoretical calculation and in-situ infrared analysis, synergistic effect of multiple interactions (π complexation, hydrogen bonding and CH−π interactions) accounts for simultaneous adsorption of multiple gases from CH 4. These results underpin highly selective capture of a range of gas mixtures that are relevant to one-step purification of natural gas. [Display omitted] • SU-100 bears multi-affinity sites in confined channel for gas accommodation. • Well-balanced sequestration of CO 2 , C 2 H 2 and C 2 H 6 from CH 4 was observed. • Pure CH 4 was produced in the breakthroughs of multi-component mixtures. • Co-adsorption of impurities over CH 4 is driven by synergic interactions. [ABSTRACT FROM AUTHOR]

[Display omitted] • Effect of ligand substitution on performance of UiO-66 based membrane was revealed. • Electronic effect of substitution governed electrocatalytic activity of membrane. • UiO-66-NO 2 based membrane has high tetracycline removal and self-cleaning ability. Herein, UiO-66-X (X = H, NH 2 , Br, NO 2) were employed to construct the electrocatalytic membranes by blending with conductive graphite and Polyvinylidene fluoride (PVDF) for removal of tetracycline under low current density of 0.01 mA/cm2. The physicochemical and electrochemical properties of the fabricated membrane were investigated systematically. Results showed that ligand substitution reduced the molecular weight cutoff (MWCO) and pure water flux of UiO-66-X based membranes in the order of –Br > –NO 2 > –NH 2 due to the size exclusion effect. In addition, compared with UiO-66, UiO-66 functionalized with electron-donating group (–NH 2) endowed the electrocatalytic membrane with superior anti-fouling ability using bovine serum albumin (BSA) as model foulant, and inferior tetracycline removal and self-cleaning property, while the opposite phenomenon occurred for the functionalization of electronic-accepting groups (–Br and –NO 2) owing to the promoted electrocatalytic activity and inhibited oxygen evolution side reaction. Notably, UiO-66-NO 2 /Graphite/PVDF membrane removed 99.5 % of tetracycline and flux of fouled membrane was almost fully recovered by electric field for six cycles under low current density of 0.01 mA/cm2. •OH and •O 2 – radicals played dominant roles in tetracycline removal by electrocatalytic membranes and three degradation pathways of tetracycline were proposed according to the liquid chromatography-mass spectrometry. Electrically-driven self-cleaning mechanism was related to the reduced fouling potential of BSA after oxidation degradation. This work gets new insights into the effect of ligand substitution on the performance of Zr-MOFs based electrocatalytic membrane for antibiotics removal. [ABSTRACT FROM AUTHOR]

Adsorptive separation is an energy‐efficient technology for the separation of C2 hydrocarbons. However, it remains a critical problem to directly produce high‐purity C2H4 from ternary C2H2/C2H4/C2H6 mixtures by simultaneously trapping C2H2 and C2H6. Herein, we report the one‐step C2H4 purification from the ternary mixture by a metal–organic framework Zn(ad)(int) (ad=adeninate; int=isonicotinate). The material combines dense heterocyclic rings and accessible uncoordinated O atoms as strong binding sites for C2H6 and C2H2. Its spindle‐like cage exhibits an interesting shape matching with the targeted molecules, affording Zn(ad)(int) not only high separation selectivity for C2H6/C2H4 and C2H2/C2H4, but also excellent gas capacity. Breakthrough experiments show that polymer‐grade C2H4 can be separated from the ternary mixtures with a record productivity of 1.43 mmol g−1. In situ powder X‐ray diffraction and Fourier transform infrared spectrum analyses further provide deep insights into the separation mechanism. [ABSTRACT FROM AUTHOR]

Adsorptive separation is an energy‐efficient technology for the separation of C2 hydrocarbons. However, it remains a critical problem to directly produce high‐purity C2H4 from ternary C2H2/C2H4/C2H6 mixtures by simultaneously trapping C2H2 and C2H6. Herein, we report the one‐step C2H4 purification from the ternary mixture by a metal–organic framework Zn(ad)(int) (ad=adeninate; int=isonicotinate). The material combines dense heterocyclic rings and accessible uncoordinated O atoms as strong binding sites for C2H6 and C2H2. Its spindle‐like cage exhibits an interesting shape matching with the targeted molecules, affording Zn(ad)(int) not only high separation selectivity for C2H6/C2H4 and C2H2/C2H4, but also excellent gas capacity. Breakthrough experiments show that polymer‐grade C2H4 can be separated from the ternary mixtures with a record productivity of 1.43 mmol g−1. In situ powder X‐ray diffraction and Fourier transform infrared spectrum analyses further provide deep insights into the separation mechanism. [ABSTRACT FROM AUTHOR]

Practical applications of room temperature sodium–sulfur batteries are still inhibited by the poor conductivity and slow reaction kinetics of sulfur, and dissolution of intermediate polysulfides in the commonly used electrolytes. To address these issues, starting from a novel 3D Zn‐based metal–organic framework with 2,5‐thiophenedicarboxylic acid and 1,4‐bis(pyrid‐4‐yl) benzene as ligands, a S, N‐doped porous carbon host with 3D tubular holes for sulfur storage is fabricated. In contrast to the commonly used melt‐diffusion method to confine sulfur physically, a vapor‐infiltration method is utilized to achieve sulfur/carbon composite with covalent bonds, which can join electrochemical reaction without low voltage activation. A polydopamine derived N‐doped carbon layer is further coated on the composite to confine the high‐temperature‐induced gas‐phase sulfur inside the host. S and N dopants increase the polarity of the carbon host to restrict diffusion of sulfur, and its 3D porous structure provides a large storage area for sulfur. As a result, the obtained composite shows outstanding electrochemical performance with 467 mAh g−1 (1262 mAh g−1(sulfur)) at 0.1 A g−1, 270 mAh g−1 (730 mAh g−1(sulfur)) after 1000 cycles at 1 A g−1 and 201 mAh g−1 (543 mAh g−1(sulfur)) at 5.0 A g−1. [ABSTRACT FROM AUTHOR]