1. The causal effects of leisure screen time on irritable bowel syndrome risk from a Mendelian randomization study.
- Author
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Lu, Liesheng, Liu, Changqin, Liu, Kunpeng, Shi, Chenzhang, Liu, Zhongchen, Jiang, Xun, and Wang, Feng
- Subjects
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SCREEN time , *IRRITABLE colon , *LEISURE , *GENOME-wide association studies , *SINGLE nucleotide polymorphisms - Abstract
Associations between leisure sedentary behavior (especially leisure screen time, LST) and irritable bowel syndrome (IBS) have been reported, but causality is unclear. Here, the two-sample Mendelian randomization was performed to investigate the causal association between LST and IBS. Two recently published genome-wide association studies (GWASs) including a total of 1,190,502 people from Europe were used as our data source. Inverse variance weighting (OR = 1.120, 95% CI 1.029–1.219) and weighted median (OR = 1.112, 95% CI 1.000–1.236) analyses revealed a causal effect between LST and IBS. There was no evidence of pleiotropy in the sensitive analysis (MR-Egger, p = 0.139). After removing potentially confounding single nucleotide polymorphisms (SNPs), similar results were found using inverse variance weighting (OR = 1.131, 95% CI 1.025–1.248) and weighted median (OR = 1.151, 95% CI 1.020–1.299), as well as in the validation analyses using inverse variance weighting (OR = 1.287, 95% CI 0.996–1.662). This study provided support for a possible causal relationship between leisure screen time and IBS. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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