Search

60% (6/10) with I BCR-ABL i SP like sp CGFs showed MRD positivity compared to 41.1% (23/56) of I BCR-ABL1 i SP pos sp B-ALLs. Summary of the diagnostic approach used to detect BCR-ABL1-like B-acute lymphoblastic leukemia associated chimeric gene fusions (BCR-ABL-like CGFs). I BCR-ABL1 i -like or Philadelphia chromosome-like B-acute lymphoblastic leukemia/lymphoma ( I BCR-ABL1 i SP like sp B-ALL) initially described based on gene expression profiles (GEP) is characterized by the presence of tyrosine-kinase inhibitor (TKI) targetable chimeric gene fusions (CGF), the spectrum of which is yet to be fully elucidated. The higher frequency of MRD positivity compared to I BCR-ABL1 i SP pos sp group (60% vs. 41%) can be explained by the inclusion of TKIs in treatment of I BCR-ABL1 i SP pos sp cases. [Extracted from the article]

Background: Hyperferritinemia is increasingly associated with mortality in sepsis. Studies estimating the prevalence of hyperferritinemia in pediatric scrub typhus are limited. Methods: This was a secondary analysis of a prospective observational study (FERRIS) from a tertiary care teaching hospital in North India where 72 children with confirmed scrub typhus, 4 (5.5%) PCR positive, 55 (76.4%)-IgM ELISA positive, and 13 (18.1%)-both PCR and ELISA positive, were analyzed. Serum ferritin was measured in 62 children to identify the prevalence of hyperferritinemia and determine its association with mortality. Results: Hyperferritinemia (> 500 μg/L) was seen in 72.6% [n = 45] children; 26 (41.9%) were mild (500–2000 μg/L), 13 (21%) were moderate (2000–10,000 μg/L), and 6 (9.7%) were severe (> 10,000 μg/L). Early presentation to hospital (≤ 7 days of febrile illness) had more survivors than late presentation (> 7 days). Non-survivors had significantly higher PRISM III, PELOD-2, hyperlactatemia, hypoalbuminemia, organ dysfunction, need for mechanical ventilation, and need of RRT. Ferritin had poor sensitivity and specificity in predicting survival with AUC of 0.56. Organ dysfunction and risk scores as PRISM III, PELOD 2, and VIS at admission were better predictors with AUC (95% CI) of 0.72 (0.56, 0.89), 0.77 (0.63, 0.92), and 0.90 (0.78, 1.0) respectively. Conclusions: Hyperferritinemia is common in scrub typhus but it did not predict survival. Organ dysfunction and risk scores were better predictors of mortality than ferritin. [ABSTRACT FROM AUTHOR]