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Implementing industrial symbiosis has emerged as a pivotal strategy for establishing eco-industrial parks worldwide to promote sustainable development and optimize resource utilization within industrial parks. However, the present evaluation framework for industrial symbiosis is nascent, which may hinder the ecological development of industrial parks. Therefore, to gauge industrial symbiosis efficacy and infrastructure soundness, we propose a revolutionary evaluation system that amalgamates social network analysis and ecological network analysis methodologies. Our evaluation system is meticulously customized to cater to the distinctive features and analytical requirements of eco-industrial parks and encompasses three primary facets: impact dissemination, sustainability, and resource optimization. To demonstrate the effectiveness of the proposed evaluation system, we conducted a case study of Qinghai Salt Lake industrial park. The findings reveal that the industrial symbiosis level in Qinghai Salt Lake industrial park (QSLIP) improved during 2014–2018. Nevertheless, conventional indicators are unable to pinpoint certain issues, such as deterioration in waste reutilization quality, underscoring the significance and necessity of the indicator system proposed in this study. • This study presents a innovative assessment methodology for eco-industrial parks. • A detailed examination of the Qinghai Salt Lake Industrial Park was undertaken. • A fusion of social network analysis and ecological network analysis was introduced. [ABSTRACT FROM AUTHOR]