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Objective To explore the relationship between the serum level of placental growth factor (PLGF) and ultrasonic blood flow parameters and pregnancy outcome in patients with late-onset preeclampsia (LOPE). Methods A total of 152 patients with LOPE were selected and divided into the P1 (＜ 12.00 ng/L) group, the P2 (12.00-56.73 ng/L) group, the P3 (＞56.73-89.41 ng/L) group and the P4 (＞ 89.41 ng/L) group according to serum level of PLGF. There were 38 cases in each group. The clinical data, uterine artery pulsatility index (PI), resistance index (RI), peak systolic velocity (S)/ end-diastolic velocity (D) and adverse pregnancy outcome were compared between the four groups. The relationship between PLGF level and clinical characteristics was analyzed by linear regression analysis. The influence of LOPE severity on the relationship between PLGF and ultrasonic blood flow parameters was analyzed by stratified interactive analysis. Multivariate generalized linear mixed effect model was used to analyze the relationship between PLGF level and adverse pregnancy outcome in patients with LOPE. Results The diastolic blood pressure, 24 h urinary protein, PI, RI and S/D decreased significantly with the increase of PLGF level (P＜0.05). The proportion of severe LOPE and systolic blood pressure were significantly higher in the P1 group than those of the other groups (P＜0.05), and the above indexes were influencing factors of the level of PLGF (P＜0.05). The results of stratified interactive test showed that the LOPE severity did not affect the relationship between PLGF and ultrasonic blood flow parameters. There were significant differences in the incidence of HELLP syndrome, fetal growth restriction, fetal distress, premature delivery and neonatal asphyxia between patients with different PLGF levels (P＜0.05). The incidence of preterm delivery was higher in the P1 group than that in the other groups, and the other adverse pregnancy outcomes were higher in the P3 group and P4 group. Conclusion Serum PLGF levels affect uterine artery blood flow parameters and adverse pregnancy outcome in patients with LOPE. [ABSTRACT FROM AUTHOR]

Objective To explore the therapeutic and prognosis effects of delayed thoracic drainage in the treatment of medium volume hemothorax caused by blunt trauma. Methods Forty-two patients with medium volumn of blunt trauma hemothorax were selected as the delayed group. Clinical observation was carried out first, and catheterization was performed 72 hours after diagnosis. Another 43 patients with blunt trauma medium hemothorax were treated with traditional early catheterization within 24 hours after diagnosis, and they were used as the control group. Data of gender, age, body mass index, chest volume on admission, number of rib fractures, hemoglobin (Hb), systolic blood pressure, mean arterial pressure, heart rate and the interval from injury to admission were compared between the two groups. Data of final thoracic drainage volume, oxygen saturation (SpO2) at discharge, decline level of Hb, number of days with tube, length of hospital stay, total hospitalization cost, presence of thoracic infection and atelectasis, and converted to surgery were also compared between the two groups. Results There were no significant differences in basic conditions between the two groups. Compared with the control group, the final thoracic drainage volume and Hb decreased, the days with tube, the days of hospitalization and the total hospitalization cost decreased, and SpO2 increased after hospital discharge in the delayed group (P＜0.01). No chest infection or atelectasis occurred in the delayed group. There were no cases requiring transfer to surgery in the two groups. Conclusion Delayed thoracic drainage can effectively improve the treatment and prognosis of patients with blunt traumatic medium volumn hemothorax, and reduce the medical economic burden. [ABSTRACT FROM AUTHOR]

Breast cancer is a serious threat to human life and health. Tamoxifen is a common treatment for breast cancer patients after surgery. However, patients still face the risk of recurrence or metastasis after treatment, so effective prognostic methods are needed to predict efficacy. In order to explore a method for prognostic analysis of postoperative tamoxifen treatment for breast cancer based on molybdenum target X-ray image. In this paper, the model for mammographic density extraction from molybdenum target X-ray image is studied by using the Squeeze-and- Excitation Convolutional Neural Network (SE-CNN) method. A prognostic imaging marker, mammographic density change rate (MDCR), was proposed and survival analysis was performed to study its prognostic ability for postoperative tamoxifen treatment of breast cancer. The results show that the threshold absolute error of SE-CNN is 9.92±4.78, and the determination coefficient is 0.77. The results show that this method can accurately extract the threshold. The progression-free survival was HR 2.654(95%CI,1.102-6.395), P =0.030.Patients with high MDCR had a better prognosis, while those with low MDCR had a worse prognosis. It is concluded that the rate of mammographic density change can be used as a prognostic imaging marker of postoperative tamoxifen treatment for breast cancer. [ABSTRACT FROM AUTHOR]

目的：观察鼻咽癌患者中耳积液情况，评价咽鼓管开放功能，分析中耳积液及咽鼓管功能开放障碍的发生原因。方法鼻咽癌患者53例，常规MR检查后，分别于Valsalva实验前后对咽鼓管进行MR扫描，观察咽鼓管开放功能、中耳积液情况及肿瘤侵犯咽鼓管周围解剖结构情况。分析中耳积液、咽鼓管开放功能障碍发生情况与咽鼓管周围结构受侵范围及鼻咽癌T分期的关系。结果53例患者中，22例（单侧18例、双侧4例）MR图像显示有中耳积液，伴同侧咽鼓管开放功能障碍及肿瘤侵犯同侧咽鼓管周围结构。本组共观察到37个（单侧25例、双侧12例）咽鼓管咽口开放功能受损，伴肿瘤侵犯同侧咽鼓管周围结构。咽鼓管开放功能障碍（r2＝0．731，P＜0．001）、中耳积液发生情况（ r2＝0．661，P＜0．001）与鼻咽癌T分期均呈正相关关系。结论鼻咽癌患者存在中耳积液，同时伴有同侧咽鼓管开放功能障碍。咽鼓管开放功能障碍多因肿瘤侵犯咽鼓管周围结构引起，是鼻咽癌患者发生中耳积液的主要原因。 [ABSTRACT FROM AUTHOR]