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Objective To analyze the postoperative therapeutic effect of prokinetic agents in patients after tricuspid valve replacement (TVR) under cardiopulmonary bypass. Methods Patients received TVR under cardiopulmonary bypass (during June 2010 to December 2021) in the department of Cardiovascular Surgery of the First Affiliated Hospital of Naval Medical University were selected as the subjects of our study. The data of basic characteristics, first postoperative defecation time and postoperative recovery condition were collected and retrospectively analyzed in the patients taking prokinetic agents within three days after surgery (prevention group) and patients not taking prokinetic agents within three days after surgery (control group）. Results A total of 184 patients were selected, including 101 in the prevention group and 83 in the control group. The first defecation time of patients in the prevention group was significantly earlier than that in the control group (P<0.05) . The incidences of abdominal distension and pulmonary infection in the prevention group were significantly lower than that in the control group. The length of time in ICU, postoperative mechanical ventilation and nasogastric tube decompression in the prevention group were significantly shorter than that in the control group ( P<0.05) . Conclusion Taking prokinetic agents within three days after TVR under cardiopulmonary bypass could effectively improve the prognosis of patients. [ABSTRACT FROM AUTHOR]

Under the goals of carbon emissions peaking and neutrality, China and its provinces are actively promoting emission reductions. As China's largest emission sector, the electric power industry has become the focus of emission reduction. However, the implicit carbon emissions in the power industry have caused actual emissions to be underestimated, and inter-provincial carbon transfer has led to a prominent problem of unfair provincial emission reduction responsibilities. Therefore, identifying the life-cycle carbon footprint of the power industry, especially the characteristics of the implicit carbon footprints of different provinces and the transfer of carbon footprints between provinces, will help to correctly assess the emissions of the power industry, scientifically determine the emission reduction responsibilities of different provinces, and rationally allocate emission reduction responsibilities. This paper constructed a life-cycle node-flow model of the power industry to reveal the energy activities existing in the power industry chain, and then defined the lifecycle carbon footprint based on the consideration of the power consumption side in 2018. Carbon implicit ratio and transfer ratio were established to analyze the implicit emissions and inter-provincial transfer emissions of the power industry. The results showed that: ① The life-cycle emission coefficient of China's power industry was 689 g/(kW·h), and the carbon emissions were 4 .747×109 t, among which the emission coefficient was high in most parts of northern China, with the highest in Shandong (891 g/(kW·h)); the coefficient was low in most parts of southern China, with the lowest in Yunnan (101 g/(kW·h)). ② The carbon implicit ratio of nationwide power industry was 8.95%, and the carbon implicit emissions were 4.25×108 t. The carbon implicit ratio of the coal-poor provinces located in the southeastern coastal areas and the provinces with high carbon emissions in the coal production process was high, with the highest carbon implicit ratio in Guizhou (14.63%). The carbon implicit ratio of the coal-rich provinces in northwestern China and northern China was low, with the lowest carbon implicit ratio in Xinjiang (only 4.94%). The highest carbon implicit emissions in Guangdong were 5.0×107 t, while the lowest emissions in Qinghai were only 1.17×106 t. ③ The carbon transfer emissions of nationwide power industry were 9.26×108 t, accounting for 19.5% of the total carbon emissions. The provinces with lower self-sufficiency ratio of power and coal had higher dependence on external carbon transfer, among which Beijing had the highest ratio of 71.24%. Inner Mongolia, Shanxi, Shaanxi, Ningxia, Anhui, Xinjiang, and Guizhou were the main carbon transfer-in provinces, with a total carbon transfer-in of 7.11×108 t, among which Inner Mongolia was as high as 2.64×108 t; Jiangsu, Zhejiang, Guangdong, Shandong, Hebei, Beijing, Liaoning, Henan, and Shanghai were the main carbon transfer-out provinces, with a total transfer-out of 6.92×108 t, among which Jiangsu was as high as 1.12×108 t. 240 pairs of provinces existed carbon transfer, and 102 pairs exceeded 1.0×106 t. Based on the research, corresponding suggestions are put forward to promote the fair and reasonable low-carbon development of the provincial power industry. [ABSTRACT FROM AUTHOR]

SOC for lithiumion power battery management system is one of the important parameters,the real-time accurate measurement of SOC for maintaining the safe and stable operation of electric vehicles has important practical significance, because lithiumion power battery management system is a highly complex non linear characteristics of the lithium ion power battery, so it is difficult to through the direct method to accurately obtain the SOC. For lithium ion power battery for this non linear characteristics,this paper puts forward the vehicle lithium ion power battery SOC double BP neural network prediction model of chaotic time series.Using phase space reconstruction technique to restore the non linear characteristics of lithium ion power battery original,get a multidimensional state space o f the lithium ion power battery chaotic time series,and then take advantage of the chaos time series of double BP neural network predict ion model for t raining and predict ion of SOC prediction results a re obtained.The simulation results show that the double BP neural network predict ion model has higher predict ion accuracy,good real-time performance and practical application. [ABSTRACT FROM AUTHOR]

The National Demonstration Center for Experimental Chemistry Education (Lanzhou University) is an important support platform for the "Double First-Class" initiative in the university’s chemistry discipline. It remains committed to the mission of the Party’s education, implementing the fundamental task of cultivating virtues and talents, and aims to nurture innovative talents through a high-quality experimental teaching resource sharing platform. The center has developed a three-level experimental teaching system of “Foundation → Comprehensive → Scientific research training”. In the reform of experimental teaching, the center emphasizes the integration of science and education, promotes development through competition, and fosters studentsʼ innovation abilities. High-level experimental teaching supports the cultivation of high-quality innovative chemistry talents, enhancing students’ practical and innovative capabilities and overall excellence. Significant progress has been made in curriculum and textbook construction, experimental teaching reform and research, as well as laboratory construction, with notable demonstration and outreach effects. [ABSTRACT FROM AUTHOR]

There are numerous hazards present in university chemistry teaching laboratories. Improper implementation of management methods and technical measures can result in injuries to both teachers and students, consequently disrupting the normal flow of experimental teaching. The negative list management system allows for a concise and comprehensive summary of issues encountered during various experimental teaching and laboratory management processes. Proper organization and continuous improvement of the negative list is one effective approach to strengthening the safety management of chemistry teaching laboratories in universities. This article, based on an analysis of the various factors impacting current university chemistry teaching laboratories, establishes a targeted negative list. It also promotes targeted laboratory safety education and training, the implementation of effective laboratory engineering and technical safety measures, and the reinforcement of mandatory laboratory safety measures. This approach, combined with the 3E method, forms a chemistry teaching laboratory safety model. The sustained development of this model, in conjunction with the negative list management system, has yielded positive results in the management of chemistry teaching laboratories and serves as a valuable reference for the safety management of such laboratories in universities. [ABSTRACT FROM AUTHOR]

BACKGROUND: Huangqi Guizhi Wuwu Decoction has a certain protective effect on intervertebral disc degenerative diseases. Mitophagy plays an important role in regulating mitochondrial damage and oxidative stress. However, the effect of Huangqi Guizhi Wuwu Decoction on mitophagy in chondrocytes of intervertebral disc endplate is still unclear. OBJECTIVE: To investigate the effect of Huangqi Guizhi Wuwu Decoction on hydrogen peroxide-induced injury of intervertebral disc endplate chondrocytes and its possible molecular mechanism. METHODS: Chondrocytes were obtained from the intervertebral disc endplate of rats and divided into five groups. Cells in low-, medium-, and high-dose groups were treated with 6.25, 12.5, and 25 mg/mL Huangqi Guizhi Wuwu Decoction for 24 hours, respectively. Cells in normal and models groups were cultured with no treatment. Except for the normal group, the cells in the model group and Huangqi Guizhi Wuwu Decoction groups were treated with 400 μmol/L H2O2 for 2 hours. Cell proliferation was then detected by cell counting kit-8 assay. Lactate dehydrogenase, adenosine triphosphate, superoxide dismutase, catalase and malondialdehyde levels were detected by colorimetric assay. The changes in mitochondrial membrane potential were detected by immunofluorescence. Reactive oxygen species and apoptosis were detected by flow cytometry. Mitophagy was detected by immunofluorescence double staining. Cells were transfected with siRNA, and the protein expressions of Parkinson-related gene (Parkin), LC3 and p62 were detected by western blot. Cells were transfected with Parkin adenovirus overexpression vector, and the survival rate of cells was detected. RESULTS AND CONCLUSION: Compared with the model group, Huangqi Guizhi Wuwu Decoction treatment significantly improved the survival rate of chondrocytes, increased the levels of adenosine triphosphate, superoxide dismutase, catalase and mitochondrial membrane potential in chondrocytes, and effectively attenuated the apoptotic rate of chondrocytes (P < 0.05, P < 0.01). After treatment with Huangqi Guizhi Wuwu Decoction, the activity of lactate dehydrogenase and the levels of reactive oxygen species and malondialdehyde in chondrocytes were significantly decreased compared with those in the model group (P < 0.01). Parkin siRNA significantly decreased mitophagy induced by hydrogen peroxide (P < 0.01), increased cell survival rate and adenosine triphosphate level (P < 0.01), and decreased reactive oxygen species level, malondialdehyde level and apoptosis rate (P < 0.01). Compared with the model group, the treatment with Huangqi Guizhi Wuwu Decoction could attenuate the increase of Parkin and LC3 II protein levels caused by hydrogen peroxide (P < 0.05, P < 0.01), while the protein level of p62 in the Huangqi Guizhi Wuwu Decoction treatment groups was significantly increased compared with the model group (P < 0.01). On the contrary, overexpression of Parkin attenuated the protective effect of Huangqi Guizhi Wuwu Decoction on the survival rate of cells treated with hydrogen peroxide. To conclude, Huangqi Guizhi Wuwu Decoction can effectively inhibit hydrogen peroxide-induced mitochondrial damage and oxidative stress in intervertebral disc endplate chondrocytes, and its protective mechanism may be related to attenuating Parkin-regulated mitophagy. [ABSTRACT FROM AUTHOR]

As the economic development of China enters into a new normal, coal industry is changing greatly. To reduce the total cost of the coal supply industry in China and calculate the carbon emission of it, we developed the R-CSSM model based on linear program method to optimize the future pattern of China's coal production and transportation on the basis of the collection and analysis of the present situation of the coal supply industry and relevant policy. The carbon emission coefficients were calculated after we examined each link of the coal supply industry in different regions. Then we used these coefficients to calculate the carbon emissions from coal related activities under the optimized pattern. The results show that, under the existing arrangements and the constraints of resources and policy, China's coal production will continue to be centralized, the coal production of Shanxi, Shaanxi, Inner Mongolia, Ningxia, Gansu and Xinjiang will continue to rise, accounting for nearly 88% of all coal production in China by 2030, and this ratio rises by 17% compared with 2015. The pressure of coal transportation would increase first and then decrease, the railway transportation ability of Xinjiang, and southwestern and northeastern China for coal will be low, and railway expansion and reconstruction project need to be taken in these places. By 2020, the coal supply industry would have a total emission of about 641 million tons of carbon dioxide-equivalent, compared with 2015, and emission per unit of supply will fall by 8.75%. And the coal supply industry would have a total emission of about 526 million tons of carbon dioxide- equivalent in 2030, compared with 2015, emission per unit of supply will fall by 15.34%. Based on that, the coal production capacity, the coal transportation capacity, and the carbon emissions of coal supply industry in each province were analyzed. And the relevant suggestions for the development of China's coal industry have been put forward, which can provide a good support for the related decision making and the carbon emission reduction of coal industry. [ABSTRACT FROM AUTHOR]

BACKGROUND: Based on the previous studies, the New Zealand rabbit talar chondrocyts were isolated, cultured and identified in vitro. OBJECTIVE: To explore the isolation, culture and identification of New Zealand rabbit talar chondrocyts in vitro. METHODS: The chondrocyts were isolated from the talar cartilage of New Zealand white rabbits by type II collagen enzyme digestion, and then cultured in vitro. The cells were identified by inverted phase contrast microscope, toluidine blue staining and collagen type II immunohistochemical staining. RESULTS AND CONCLUSION: Under the inverted phase contrast microscope, most of passaged chondrocytes presented with polygonal or triangle shape and had round or oval nuclei. Toluidine blue staining showed the hyacinthine chondrocytes and blue cellular matrix. Collagen type II immunohistochemical staining showed that the chondrocytes appeared with brown granules in the cytoplasm and membrane. To conclude, a system that can isolate, culture and identify talar chondrocytes from New Zealand rabbits is successfully established. Talar chondrocytes at passages 1-3 grow well and have stable biological properties. [ABSTRACT FROM AUTHOR]

Objective To investigate the effect and mechanism of achyranthes bidentata polysaccharides（ABPS）on the differentiation of bone mesenchymal stem cells（BMSCs）into nucleus pulposus-like cells. Methods Five 4-week-old SD rats were sacrificed and their BMSCs were isolated and purified by repeated adherent method. The third-generation BMSCs were treated with different concentrations of ABPS for 48 h. The cell viability was detected by MTT method. The highest concentration of ABPS was selected for subsequent experiments. According to different treatment methods， cells were divided into control group（conventional culture）， ABPS group（200 mg/L of ABPS）， Notch1 group（transfected with Notch1）， Notch1 negative control group（transfected with Notch1 negative control）， and ABPS+Notch1 group （200 mg/L of ABPS was added after transfection with Notch1）. After 14 days of induction， the cell survival rate was measured by MTT method. Collagen Ⅱ was detected by immunohistochemical staining. The mRNA and protein expression levels of collagenⅡ， aggrecan， Notch1 and Hes1 were detected by qPCR and Western Blotting respectively. The glucosaminoglycan（GAG）was detected by alcian blue method on the 1st，4th，7th，10th and 14th day of cell culture. Results After BMSCs were treated with 400 mg/L of ABPS for 48 h，the cell survival rate was significantly lower than that in the control group（P<0. 05）. When the concentration was ≤200 mg/L，ABPS had no significant toxic effect on the growth of BMSCs. After 14 days of induction，compared with the control group，A value，GAG content in the medium， the expressions of collagen II and aggrecan mRNA and protein in the ABPS group were increased，and the expressions of Notch1 and Hes1 mRNA and protein were decreased（P<0. 05）. The relative cell viability，GAG content in the medium， the expressions of collagen II and aggrecan mRNA and protein in the Notch1 group were decreased，and the expressions of Notch1 and Hes1 mRNA and protein were increased（P<0. 05）. ABPS+Notch1 could partially reverse the inhibitory effect of Notch1 overexpression on the differentiation of BMSCs into nucleus pulposus-like cells. Conclusion ABPS can promote the differentiation of BMSCs into nucleus pulposus-like cells，and the mechanism may be related to the inhibition of Notch1 pathway. [ABSTRACT FROM AUTHOR]

To meet the requirements of current stormwater management practices, a model focusing on effective impervious surface and its influence on urban hydrological processes should be developed. Therefore, a model structure was developed based on model complexity, data availability, and prediction capability. The highly heterogeneous urban surface was discretized into subcatchments with uniform or “quasi-uniform” characteristics. Different hydrological calculation methods were used to develop a model that can explicitly distinguish the water generation and concentration processes of effective and non-effective impervious surfaces by considering the flow paths within and between subcatchments of different surfaces. This refined stormwater model can provide technical support for urban flood control and sponge city construction. [ABSTRACT FROM AUTHOR]

An urban stormwater model was developed to analyze the hydrological response mechanism of effective impervious surfaces under urban stormwater simulation. The model focused on effective impervious area, and the Shuangqiaobang runoff- plot in Changzhou City was used as the study area. The model was calibrated using measured data, where the effective impervious area of roofs was first determined, followed by the remaining parameters. Different methods were adopted to characterize the imperviousness, and distinct simulation scenarios were set up to analyze the hydrological response of both the effective and total impervious areas. The results show that, the peak discharge and flood volume are overestimated when the total impervious area is used rather than the effective impervious area to characterize the imperviousness and when the parameters of the effective impervious area model are directly used; however, the peak discharge is higher in the low return period and lower in the high return period, and the flood volume is underestimated when a calibrated total impervious area model is used. [ABSTRACT FROM AUTHOR]

The engine idling start-stop technology can realize energy conservation and emission reduction, thus it has a very promising application. However, the start-stop technology does not match well with conventional automatic transmissions because of the vehicle starting delay, starting shock and safety problems. In order to overcome these problems, in this paper, we conducted a research on system level, based on a start-stop vehicle platform and the interfaces between engine, automatic transmission and other parts were analyzed. Based on comprehensive analyzing of the start-stop principle, the technical scheme of TCU (transmission control unit) control system was designed and a coordinated control strategy between TCU, EMS (engine management system) and the electrical oil pump was built. The coordinated control module contained three parts corresponding the engine auto-stop process, engine auto-start process, and the electrical oil pump control strategy. The control strategy for engine auto-stop and auto-stop process was to guarantee the starter operating only when the driveline was open to avoid starting failure and damage to the engine starter device, and the boundary conditions and CAN communication signals were expressed in these parts. An intelligent control strategy of the electrical oil pump was developed to satisfy the automatic transmission pressure requirement during engine restart and auto-stop, as well as decreasing the energy consumption. The rotating speed of the electrical oil pump was controlled based on the engine starting process and engine speed. This coordinated control strategy can avoid engine starting failure and guarantee the system normal operation and driving safety. In order to satisfy the special starting requirements of start-stop function, a mathematical model of starting process and clutch control system was built. The model contained the engine, torque converter, AT starting clutch, and vehicle body, the current to pressure characteristic, and friction characteristic of clutch. Based on model simulation, abnormal shifting operations caused by driver such as shift selector changing during start-stop process were considered in the starting control strategy. In different conditions, the control pressure for five clutches was different. By this control logic design, vehicle launching delay can be eliminated, and the shifting shock caused by abnomal operations can be avoided. The starting control strategy improved vehicle launching responsiveness and comfort significantly. The TCU application software was developed based on 'V process' firom control module to target code，then the code was integrated with ie target controller. A test environment on a prototype vehicle was established to verify the feasibility of the proposed control strategies. The test results indicated that the transmission flmctioned favorably，the speed of output shaft changed smoothly instead of changing sharply，and a quick smooth starting performance of intuitive feeling was achieved when the engine was restarted. The findings in this study are valuable for forward designs of an AT for matching with start-stop system and also have great engineering application value. [ABSTRACT FROM AUTHOR]