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Thermal conductivities of iron at high pressure and temperature are key parameters to constrain the dynamics and thermal evolution of the Earth’s core. In previous investigations,the thermal conductivity is mainly attributed to the electronic conductivity,we found that the contribution of lattice vibration to thermal conductivity under high pressure cannot be ignored. The phonon dispersion,Hugoniot equation of state and thermal transport properties of iron are calculated with the lattice dynamics and Boltzmann transport theory in this work. The simulation temperature for iron is 3500 K near the core-mantle boundary and 6500 K at Earth’s inner core conditions. The thermal conductivities considering lattice vibration are respectively 112 W/m K near the core-mantle boundary and 200 W/m K at Earth’s inner core conditions. [ABSTRACT FROM AUTHOR]

Intrahepatic cholangiocarcinoma （ICC） is a special type of liver cancer with atypical clinical symptoms in the early stage， and most patients are already in the advanced stage at the time of initial diagnosis. Due to a lack of effective molecular markers and treatment options， ICC patients tend to have an extremely low five-year survival rate. Exosomes are vesicles secreted by cells that contain proteins， RNA， and lipids， and they are important carriers of intercellular communication. Recent studies have shown that exosomes play a crucial role in the development and progression of ICC， and this article reviews the role and mechanism of exosomes in the diagnosis and treatment of ICC and looks into the future treatment prospect and potential clinical application of exosomes. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of Vitamin D combined with anti tuberculosis drugs on the serum levels of IL-1 and interferon gamma of elderly patients with spinal tuberculosis. Methods: 96 elderly patients with spinal tuberculosis in our hospital from July 2014 to July 2016 were selected and randomly divided into the control group and the experiment group, with 48 cases in each group. The control group was treated by regular anti tuberculosis treatment and the experiment group was treated on the base of the control group with VitaminD Drops. 8 weeks for a course of treatment, a total of a course of treatment. The VAS score, degree of spinal cord injury, serum levels of IL-1 and interferon gamma were compared between two groups after treatment. Compared with before treatment, the VAS scores of two groups were lower after treatment (P<0.05), the degrees of spinal cord injury were less (P<0.05), the serum IL-1βand IFN-γlevels were lower (P<0.05). Results: Compared with the control group, the VAS score was lower the in the experiment group (P<0.05), the degree of spinal cord injury was less (P<0.05), the serum IL-1βand IFN-γlevels were lower (P<0.05). Conclusion: Vitamin D combined with anti tuberculosis drugs could significantly reduce the pain and the degree of spinal cord injury in elderly patients with spinal tuberculosis, which might be related to the decrease of serumIL-1 beta and interferon gamma levels. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of Vitamin D combined with anti tuberculosis drugs on the serum levels of IL-1 and interferon gamma of elderly patients with spinal tuberculosis. Methods: 96 elderly patients with spinal tuberculosis in our hospital from July 2014 to July 2016 were selected and randomly divided into the control group and the experiment group, with 48 cases in each group. The control group was treated by regular anti tuberculosis treatment and the experiment group was treated on the base of the control group with Vitamin D Drops. 8 weeks for a course of treatment, a total of a course of treatment. The VAS score, degree of spinal cord injury, serum levels of IL-1 and interferon gamma were compared between two groups after treatment. Results: Compared with before treatment, the VAS scores of two groups were lower after treatment (P<0.05), the degrees of spinal cord injury were less (P<0.05), the serum IL-1β and IFN-γ levels were lower (P<0.05). Compared with the control group, the VAS score was lower the in the experiment group (P<0.05), the degree of spinal cord injury was less (P<0.05), the serum IL-1β and IFN-γ levels were lower (P<0.05). Conclusion: Vitamin D combined with anti tuberculosis drugs could significantly reduce the pain and the degree of spinal cord injury in elderly patients with spinal tuberculosis, which might be related to the decrease of serumIL-1 beta and interferon gamma levels. [ABSTRACT FROM AUTHOR]

Objective: To investigate the clinical effect of retroperitoneal laparoscopic adrenal gland resection and partial resection in the treatment of aldosterone. Methods: 60 cases of patients with aldosterone in our hospital were selected and randomly divided into the partial resection group and the total resection group. The partial resection group were treated by partial excision of adrenal gland and the total resection group were treated by total removal of adrenal gland. The hospital stay, blood loss during operation, operation time, serum potassium, serum aldosterone level and treatment effect were tested and compared before and after treatment. Result: Compared with before treatment, the serum potassium level were higher and the aldosterone level were lower in two groups after treatment(P<0. 05). Compared with the total resection group, the amount of bleeding during operation and length of stay were shorter in partial resection group(P<0.05), and the serumpotassiumlevel were higher(P<0.05), the aldosterone level were lower in the partial resection group(P<0. 05). There was no significant difference in operation time and clinical effect between two groups(P>0.05). Conclusions: After laparoscopic partial resection of adrenal gland, it can significantly shorten hospitalization time, reduce the bleeding volume, increase serum potassiumlevel, and lower the level of aldosterone. But there is no significant difference between the total and partial resection of adrenal gland in operation time and clinical efficacy. [ABSTRACT FROM AUTHOR]

Aiming at the problem of production imbalance caused by experience-based equipment purchase strategy in hybrid flow shop, this paper proposed a barrel-greedy algorithm. Under the constraint of fixed equipment cost, this algorithm took the fastest production cycle of the production line as the goal, and used the short board idea of barrel effect to identify the bottleneck process, and on this basis, it introduced the greedy idea for the inconsistent characteristics of the bottleneck processes of multiple products in the production line. Then, comparing the solution results of different algorithms based on the actual production line case, the barrel-greedy algorithm has certain advantages in solving quality and efficiency compared with exhaustive search algorithm and improved genetic algorithm. Finally, taking the actual production line as the background, this paper used Plant Simulation to compare the production line before and after transformation, and verifies the feasibility and effectiveness of the algorithm in practical production. [ABSTRACT FROM AUTHOR]

Findings confirm that poor people may be more vulnerable to climate change. The huge socioeconomic costs of droughts make themselves a crucial target for impact assessments of climate change scenarios. Based on outputs from fifteen CMIP6 climate models under the four latest SSP-RCP scenarios（SSP1-2.6,SSP2-4.5,SSP3-7.0,and SSP5-8.5）,drought characteristics (frequency, intensity and duration) at 1.5 and 2 ℃ warming levels were analyzed over the poverty-stricken areas of China. Results show that: (1) Relative to the baseline period（1995-2014）,the annual mean temperature in poverty-stricken areas will increase by 1.1 and 1.8 ℃ at 1.5 and 2 ℃ global warming, respectively, which is faster than the global warming rate. The annual precipitation will also increase significantly, especially in north-west of poverty-stricken areas; (2) Relative to the baseline period, drought intensity will increase from slightly dryness to moderate dryness at the global warming of 1.5 ℃.However, most regions will see a decrease trend in both drought frequency（74% of whole region） and duration（61% of whole region). (3) At the global warming level of 2 ℃,drought intensity will still remain a moderate level, while drought frequency may keep decreasing. In some areas, the frequency is possible to decrease by 0.6 times annually. The drought duration tends to increase in the south and decrease in the north, which is expected to decrease by 1.3 months in some places（55% of whole region). (4) When facing the additional global warming of 0.5 ℃,there are spatial similarities in the change of drought characteristics. The frequency and duration will both increase in southern region and decrease in northern region, while the intensity will increase in most regions. Our study suggests that limiting anthropogenic warming to 1.5 ℃,as aspired by the Paris Climate Agreement, may have benefits for future drought risk alleviation over the poverty-stricken areas of China. [ABSTRACT FROM AUTHOR]

Objective To investigate the clinical characteristics and individualized treatment strategy of patients with aspirin related intracerebral hemorrhage. Methods The clinical data of 83 patients with aspirin associated intracerebral hemorrhage and 55 without aspirin were analyzed retrospectively. Whether or not the patients with aspirin related intracerebral hemorrhage were examined with a rebound,41 patients in the individualized treatment group were optimized,and 42 patients in the general treatment group. Compared each group in the elasticity,operation mode,rebleeding and GOS score 3 months after the bleeding. Results At the time of admission thrombelastogram detection of platelet function,individual treatment group MA was( 30. 85 ± 10. 49) mm,AA inhibition rate was( 67. 50 ± 5. 16) %,normal cerebral hemorrhage group MA was( 54. 83 ± 8. 34)mm,AA inhibition rate was( 34. 64 ± 6. 73) %,there was significant difference between two groups( all P 0. 05); In the individualized treatment group,there were 36 cases with platelet dysfunction and platelet transfusion. The MA value and AA inhibitory rate index changed significantly before and after the input,and the difference was statistically significant( all P 0. 05). In the three groups,the GOS score was better in March than in the group with normal cerebral hemorrhage( P 0. 05),but they were better than those in the conventional group( all P 0. 05). Conclusion Patients with long-term oral aspirin cerebral hemorrhage and rebleeding rate is higher than that of aspirin in patients with non cerebral hemorrhage,but by thrombela-stogram detection can be carried out targeted treatment,select the appropriate surgical approach and timing based on coagulation and platelet function,can reduce bleeding,improve clinical prognosis. [ABSTRACT FROM AUTHOR]

An index, generalized water efficiency (Eg), for the effective utilization rate of blue-green water evaluation was established in this paper. Eg in grain production for 31 provinces of China during 1998-2010 were calculated. Then temporal-spatial patterns and attribution analysis of Eg in China were explored and conducted by using spatial autocorrelation and path analysis methods, respectively. The results show that, national value of Eg was estimated to be 0.588 in 1998-2010 and the index increased slightly in most of the provinces. Spatial autocorrelation analysis results shows, provinces with resemble Eg value shown significant aggregation. Regions with high Eg values are gathered in Western China while ones with lower Eg distributed in Southeast China; and the global and local spatial aggregation showed decreasing trends over time. Eg was affected strongly by regional agricultural production management level, while the climate and economic conditions had less influence on the effective rate of blue-green water resources. Making a general survey of provincial Eg, water productivity (Pw), water stress index (WSI) and grain production ability, southwest provinces may expand grain production scale in order to play the advantage of high Eg, and major grain producing areas of Northeast China should take measures to raise Eg to ensure food security and sustainable utilization of water resources. The results of this report can provide reference for the development of national water efficiency in agriculture and food production and water resources management strategy. [ABSTRACT FROM AUTHOR]

目的 观察中国胶东半岛地区大动脉粥样硬化（LAA)型脑梗死汉族患者TLR4基因的rs1927911、 rS1927914、rS2149356位点单核苷酸多态性情况。方法将LAA型脑梗死患者105例纳人病例组,选择同期健康 体检者125例纳人对照组。采用PCR-RFLP法或直接测序法观察两组白细胞TLR4基因rS1927911、rS1927914、 rS2149356位点的单核苷酸多态性情况。结果两组各多态性位点的基因型和等位基因频率均符合Hardy-Wem- berg遗传平衡定律(P>0.05)。病例组TLR4基因rS1927911位点CC、TT基因型频率低于对照组，CT基因型频率 高于对照组（P均<0.05)。病例组rS2149356位点CC、AC基因型频率低于对照组,AA基因型频率高于对照组,A 等位基因频率高于对照组（P均<0.05)。结论中国胶东半岛地区LAA型脑梗死汉族患者白细胞TLR4基因 rS1927911、rS2149356位点多态性可能与LAA型脑梗死的发病有关。 [ABSTRACT FROM AUTHOR]