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Objective To evaluate the short-term effects of anterior distal tibial semi-epiphyseal block surgery in treating sagittal plantar flexion deformity in children with equinovarus foot. Methods A retrospective analysis of the data of children with equinovarus foot treated with anterior distal tibial semi-epiphyseal block at Hunan Children's Hospital from February 2018 to March 2022. The preoperative and intraoperative angles of ankle dorsiflexion and anterior distal tibial angle (ADTA) on lateral X-rays were recorded, along with the occurrence of complications. Results A total of 5 cases (7 feet) were included, all male, with an average age of 10 years and 4 months (range:7 years and 11 months to 12 years and 4 months). The average duration of internal fixation was 26.2 months (range: 15 to 36 months). All 5 cases achieved a plantigrade foot. The preoperative AD-TA was (87.43 ±3.15), and the ADTA at the time of internal fixation removal was (72.43 ± 5.56)°, with a statistically significant difference (P<0.05); the preoperative ankle dorsiflexion was (15.00±14.72), and at the time of internal fixation removal, it was (14.29 ±8.86), also with a statistically significant difference (P<0.05). One case experienced screw loosening, but no cases had complications such as internal fixation fracture, infection, ankle subluxation, or bridge formation. Conclusions Anterior distal tibial semi-epiphyseal block surgery demonstrates good short-term efficacy in treating sagittal plantar flexion deformity in children with equinovarus foot. [ABSTRACT FROM AUTHOR]

Computer wargame is a simulation tool that describes war operations. Force maneuver is the foundation of operations, and path planning is the core content. Path planning is simplified as the solution of the shortest path in graph theory. However, the tactical path is not equivalent to the shortest path. Considering the complexity of battlefield maneuvering, information diversity, dynamics and other characteristics, the use of a decisionmaking method that separates battlefield situation and path planning can lead to operational failure. This article provides a tactical path planning method that effectively integrates battlefield situation and map information. This method, based on traditional A* algorithm, combines influence map to digitize battlefield situation factors, and uses digitized situation factors combined with terrain factors as the objective function of the improved A* algorithm. Thus, under the same algorithm complexity conditions, the A* algorithm converges to the tactically optimal path. Simulation experiments effectively verify that this method can support more complex and diverse tactical path planning compared to traditional A* algorithm. Battlefield situation information can guide path planning to effectively reduce the damage suffered by one party during maneuvering and improve our offensive capabilities, shaping a generally advantageous situation. [ABSTRACT FROM AUTHOR]

With the rapid development of society and economy, great changes have taken place in people′s living habits and working styles.The number of patients with lumbar disc herniation（LDH） is increasing year by year, and tends to be younger and younger.At present, LDH is mainly treated by surgery, anti-inflammatory painkillers, physical therapy and other means.Compared with traditional Chinese medicine（TCM） compound, they are less targeted, and some patients with advanced age and multiple underlying diseases have higher surgical risk.In recent years, TCM compound under the guidance of basic holistic view and syndrome differentiation and treatment theory is highly targeted, which not only has a good effect on the treatment of LDH,but also has achieved certain satisfactory results in its perioperative application.Therefore, this paper collected the literature of recent 10 years from the aspects of molecular biology, histomorphology, autoimmunology and hemorheology, and described the mechanism of TCM compound treatment of LDH.It is expected to provide diagnosis and treatment basis for clinical treatment of LDH and provide direction for further study of LDH by using TCM compound. [ABSTRACT FROM AUTHOR]

BACKGROUND: Most studies mainly focus on using small molecules or viruses to obtain cardiomyocytes, but reports about the use of recombinant proteins to reprogram cells to obtain cardiomyocytes are rare. OBJECTIVE: To explore the effect of recombinant Nkx2.5 protein on the transdifferentiation of human bone marrow mesenchymal stem cells into cardiomyocytes. METHODS: The prokaryotic expression vector of Nkx2.5 was constructed. Nkx2.5 protein was induced to express at different time points, and then was isolated and purified. Nkx2.5 was encapsulated with nano-transducers to form nano-protein complexes, which were transfected into human bone marrow mesenchymal stem cells. The protein transfection efficiency was then detected. After successful protein transduction, the expression of myosin heavy chain, a specific marker of cardiomyocytes, was detected and the transformation of human bone marrow mesenchymal stem cells into cardiomyocytes was observed. RESULTS AND CONCLUSION: The protein expression was higher when the cells were induced with isopropyl-β-d-thiogalactoside at 28 oC for 4 hours. To conclude, the nano-Nkx2.5 complexes can be efficiently transfected into human bone marrow mesenchymal stem cells and promote the reprogramming of bone marrow mesenchymal stem cells into cardiomyocytes, but future studies are needed to improve the efficiency of the transdifferentiation. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the effects of docetaxel (DTX) combined with loplatin (LBP) synchronous intensity modulated radiotherapy (IMRT) on the short-term and long-term efficacy, tumor markers, and quality of life in advanced esophageal cancer (EC). Methods: 276 patients with advanced EC admitted to our hospital from January 2018 to June 2022 were selected and divided into a control group (IMRT treatment) and an observation group (DTX combined with LBP synchronous IMRT treatment) based on different treatment methods, with 138 cases in each group. Compare the recent efficacy, tumor markers, quality of life, and toxic side effects between two groups. Follow up until November 2023, record the survival status of two groups of patients and draw Kaplan-Meier survival curves. Results: The ORR, PFS, OS, and post treatment EORTC QLQ-C30 scores of the observation group were 89.86%, 10.100 (95%CI: 9.552~10.648) months, 14.300 (95%CI: 13.940~14.660) months, and (75.52±9.35) points, respectively, while those of the control group were 68.84%, 7.800 (95% CI: 7.307~8.293) months, 12.500 (95%CI: 11.643~13.357) months, and (64.71±9.81) points, respectively, the observation group was higher than the control group (P<0.05). After treatment, the serum levels of CEA, CA199, and CYFRA21-1 in the observation group were (14.94±3.25) ng/mL, (14.36±3.74) U/mL, and (9.29±1.34) ng/mL, respectively, while those in the control group were (22.37±3.86) ng/mL, (14.36±3.74) U/mL, (9.29±1.34) ng/mL, respectively, the observation group was lower than the control group (P<0.05). The severity of gastrointestinal reactions in the observation group was higher than that in the control group (P<0.05). Conclusion: Compared with IMRT alone, DTX combined with LBP synchronous IMRT has a short-term therapeutic effect in the treatment of advanced EC, which can effectively reduce serum tumor marker levels, prolong survival, improve quality of life, and tolerate toxic side effects. [ABSTRACT FROM AUTHOR]

Under different planting technologies, we researched the effects of different planting densities and planting technologies on major agronomic characters and yield of Jihua 2 in Jilin Province. We screened the proper planting technology and planting density for ecological environment of Jilin Province and improved the supporting efficient cultivation technology of Jihua 2. Two planting technologies and five planting densities（1.79×105,2.02×105,2.30×105,2.69×105,3.23×105 plants/hm²）,we researched the changes of photosynthetic index and yield of peanut. Results showed that treatment of small ridges and double rows and 2.02×105 plants/hm² planting density had the shortest growth period, which was 1-2 d earlier than that of double-grain cave sowing. Besides, the plant was shortest, which was suitable for underground dry matter accumulation, the leaf area index and total photosynthetic potential were the maximum. The yield of treatment was the highest, which was 3 651.15 kg/hm²,and enhanced by 10.17% compared with that of double-grain cave sowing. Thus, the production technology of small ridges and double rows should be vigorously promoted. [ABSTRACT FROM AUTHOR]

QUIC, as an emerging transmission protocol parallel to TCP, follows the TCP research approach. The mainstream research way is hardware offloading, which offloads computation-intensive functional modules to network devices and replaces host CPU computation by hardware processing. However, due to the poor generality of hardware offloading, although its performance is high, it cannot guarantee user programmability. To overcome this limitation, this paper proposes a software offloading model--NanoBPF, which is a protocol offloading model based on the RISC-style many-core DPU (Data Processing Unit). By modifying the Bootloader's startup code, it guides the eBPF (extended Berkeley Packet Filter) code as a runtime environment and offloads encryption and decryption functional modules with high CPU utilization rates in the protocol stack using software. The encryption and decryption functional modules are written in high-level languages (C) and compiled into custom BPF (Berkeley Packet Filter) bytecode dynamically loaded into the DPU. The throughput and fairness of the prototype system are validated using local and Docker-based network topologies. The results show that software offloading of message encryption and decryption can increase the message throughput of the protocol stack by nearly 13%, and under certain conditions, it can ensure link fairness with TCP. [ABSTRACT FROM AUTHOR]

【Objective】 In order to establish the reasonable planting density under the double-row planting model of large ridges and build a high-yielding peanut group model, the impact of the double-row planting density of large ridges (90 cm) on the characteristics, group structure changes and yield of peanut plants was studied.【Method】 The semi-trailing type peanut variety ‘Silihong’ and the erect type ‘Jihua26’were used as experimental materials. Set 6 planting densities: M1 (31.71×104 plants/hm² ), M2 (27.75×104 plants/hm² ), M3 (24.67×104 plants/hm² ), M4 (22.20×104 plants/hm² ), M5 (18.50×104 plants/hm² ), M6 (15.85×104 plants/hm² ), based on single ridge (60 cm) double-seed sowing (11.93×104 holes/hm² ) as a comparison (CK). Determine the seedling rate, plant growth, SPAD value, dry matter accumulation and yield of each peanut variety under different density, and establish a reasonable group structure of peanuts and the optimal planting density of different varieties.【Result】 The emergence time of different varieties was different under different planting densities, the emergence time of ‘Silihong’ was earlier than ‘Jihua 26’. 25 days after sowing, the seedling rate of ‘Silihong’ was up to 100% at M3 density, 30 days after sowing, the seedling rate of ‘Jihua26’ was up to 100% at M3 density, which were significantly higher than other densities. With the decrease of planting density, the height of the main stem and the length of the side branch gradually increase with the decrease of the number of plants per unit area; the SPAD value tends to increase first and then decrease with the decrease of planting density; ‘Jihua 26’ with the decrease of density, the quality of dry matter showed a tendency to rise first and then decrease, and ‘Silihong’ the accumulated amount showed a trend of gradually increasing. With the reduction of planting density, the number of pods per plant, pod yield per plant and weight of 100-pod increased first and then decreased of the two experimental varieties, the highest value was under M4 density of ‘Jihua26’ and M5 density of ‘Silihong’, which were significantly higher than other densities. The yield of the two experimental varieties continues to increase, Jihua 26 at M4 density had highest yield was 7 956.67 kg/hm² and ‘Silihong’ at M5 density had highest yield was 4 790.73 kg/hm², compare to control increase 96.14% and 65.42% respectively. 【Conclusion】 Compared with the singlerow double-seed planting mode, the large ridge double-row + single-seed planting mode can increase the peanut height, SPAD and dry matter accumulation. At the same time, the yield is improved. Under the condition that the density remains unchanged, peanuts can be changed from double-seed to single-seed precision sowing, which increases the yield. When planting in two rows of large ridges, the appropriate sowing density should be selected according to the type of peanut varieties. The M5 density of the semi-trailing type peanut varieties is the best, and the M4 density of the erect type peanut is the best [ABSTRACT FROM AUTHOR]

With the increase of network transmission bandwidth, complex infrastructure operations in data centers oc-cupy more and more computing resources, affecting service processing performance. Data Processor Unit (DPU) is a newly developed special purpose processor. The background is to deal with the performance bottleneck caused by the exponential growth of data volume and complexity in data center. The emergence of DPU is a phased symbol of heterogeneous computing. The core problem to be solved is to reduce the total cost of ownership of the entire system and improve the efficiency of the entire computing system based on the infrastructure. That is, the load that is "inefficient in CPU processing and unable to be handled by GPU" is offloaded to DPU. Firstly, the development background of DPU is introduced, and the hardware architecture of DPU is analyzed based on network processing model. Besides, DPU is compared with smart network interface card and network processor. After that, DPU programming model, DPU products and applications in the industry are introduced. Finally, the future research directions of DPU are summarized and prospected. [ABSTRACT FROM AUTHOR]

In order to provide theoretical basis for application of the ectopic microbial fermentation bed, the efficiency and quality of the ectopic microbial fermentation bed in processing piggery waste were evaluated by measuring the changes of physicochemical and environmental factors and the absorption of piggery wastewater. The results showed that the fermentation temperature of the filler maintained above 40℃ for up to 48 days and the highest fermentation temperature was 66℃. The alkaline environment and the moisture of filler remaining 50%~65% during the fermentation was suitable for aerobic fermentation of microorganisms. The absorption coeffient of piggery wastewater of the filler was 2.53, which was better than that of dairy wastewater. Microbial activity was mainly based on bacteria in the fermentation system and the organic matter was degraded and utilized by microorganisms at the same time. After the fermentation, the total nutrient content and the organic matter mass fraction of the filler was 6.19% and 56.11%, respectively, which met with the national standard for organic fertilizer. [ABSTRACT FROM AUTHOR]