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Objective: To discuss the risk factors, clinical characteristics, diagnosis methods and outcome of uterine rupture during pregnancy in primipara. Methods: Restrospective analysis was done on 11 primiparas with uterine rupture during pregnancy admitted to Tongji Hospital Affiliated to Huazhong University of Science and Technology from March 2010 to June 2018. Results: The age of the 11 patients was 21-36 years old and the gestational age was 12-39 weeks. There were 10 cases of previous uterine surgery, 4 cases of incomplete rupture and 7 cases of complete rupture. Rupture of uterus was located in the lower segment in 1 case, uterine body and fundus in 5 cases, uterine horn in 5 cases. 8 cases were diagnosed by B-scan ultrasonoprapny and 3 were diagnosed by surgery. All the patients underwent cesarean section, and one of them had a hysterectomy. There was no death in the patients and 4 fetus survived. Conclusions: The risk factors of uterine rupture during pregnancy are mainly related to uterine surgery, and the rupture site is different from patients with previous cesarean section history, so the clinical manifestations and diagnosis and treatment of patients need to be differentiated from patients with previous cesarean section. Patients and medical staff should strengthen the awareness of early risk screening to reduce fetal death and avoid the occurrence of more serious complications. [ABSTRACT FROM AUTHOR]