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BACKGROUND: It was found that moxibustion can inhibit the inflammatory factors in the serum of rats with cerebral ischemia/reperfusion injury, resist oxidative stress, inhibit cell apoptosis, and effectively reduce cerebral ischemia/reperfusion injury. OBJECTIVE: To observe the effects of different moxibustion intervention time on the expression levels of nucleotide binding oligomerization domain-like protein 3 inflammasome (NLRP3), cysteine aspartase (caspase-1), apoptosis-related speck-like protein, exfoliatin-D protein, interleukin-1β and interleukin-18 in rats with cerebral ischemia/reperfusion injury, and to explore its action mechanism. METHODS: SD rats were randomly divided into sham operation group (n=9) and operation group (n=36). The model of focal cerebral ischemia/reperfusion injury was established by middle cerebral artery occlusion in the operation group. After successful modeling, the rats in the operation group were further divided into model group, moxibustion 10-minute group, moxibustion 15-minute group and moxibustion 30-minute group, with 9 rats in each group. Rats in the moxibustion 10-minute, 15-minute and 30-minute groups were given moxibustion at “Baihui, Dazhui and Zusanli”, respectively, once a day for a total of 7 days. The neurological deficits of rats were evaluated by LONGA method. The cerebral infarction was observed by 2,3,5-triphenyltetrazolium chloride staining. The pathological changes of brain tissue were observed by hematoxylin-eosin staining. The contents of interleukin-1β and interleukin-18 in serum of rats in each group were detected by ELISA. Immunohistochemistry and western blot assay were used to detect the expression levels of NLRP3, caspase-1, apoptosis-related spot-like protein and gasdermin D in the ischemic cortex of rats in each group. RESULTS AND CONCLUSION: Compared with the sham operation group, the neurological deficit score of the model group was significantly increased (P < 0.01). Compared with the model group, the neurological deficit score of the moxibustion groups was significantly reduced (P < 0.01). Compared with the sham operation group, the infarct volume of the model group was significantly increased (P < 0.01). Compared with the model group, the infarct volume of the moxibustion groups was significantly reduced (P < 0.01); the infarct volume of the rats was smallest in the moxibustion 30-minute group (P < 0.05). Compared with the model group, the contents of inflammatory factors interleukin-1β and interleukin-18 in the serum of rats in the moxibustion groups were decreased (P < 0.01). Compared with the moxibustion 10-minute group, the contents of inflammatory factors in the serum of rats in the moxibustion 30-minute group were significantly decreased (P < 0.05). Compared with the model group, the expression of NLRP3, apoptosis-related spot-like protein, Caspase-1 and gasdermin D protein in the ischemic cortex of the moxibustion groups was significantly decreased (P < 0.01). Compared with the moxibustion 10-minute and 15-minute groups, the expression of protein in the moxibustion 30-minute group was significantly decreased (P < 0.05). It is concluded that moxibustion at Baihui, Dazhui and Zusanli can reduce cerebral ischemia/reperfusion injury, among which moxibustion for 30 minutes has the best effect, and its mechanism may be related to the inhibition of pyroptosis mediated by NLRP3/Caspase-1 pathway. [ABSTRACT FROM AUTHOR]

Objective To observe the effect of moxibustion on the Young's modulus of lumbar muscle groups, hind limb gait parameters, and bone mineral density in ovariectomized rats, and to explore the role of moxibustion in improving muscle function in ovariectomized rats based on the theory of musculoskeletal interaction. Methods Thirty-two SD rats were randomly divided into 4 groups: sham operation group, model group, moxibustion group, and estrogen group, with 8 rats in each group. Rats in the model group, moxibustion group, and estrogen group were ovariectomized. The acupoints of the moxibustion group were taken from both sides of the Liver-Yu and Kidney- Yu for 15 minutes each time, once every other day, 3 times a week for a total of 12 weeks. After the intervention, real-time shear wave ultrasound elastography (SWE) was used to determine the Young's modulus of lumbar muscle groups in rats. The gait analysis system WalkAnalysator VTX recorded the support duration (s), swing duration (s), swing speed (cm/s), and stride width (cm) of the hind limb. Micro-CT was used to detect bone mineral density (BMD), bone volume fraction (BV/TV), trabecular bone thickness (Tb.Th), and trabecular bone separation (Tb.Sp) in the right femur. Results Compared to those in the sham operation group, the Young's modulus in lumbar muscle group decreased (P<0.01), the support duration, swing duration, and step width of hind limbs increased (P<0.05, P<0.01), the swing speed decreased (P<0.01), BMD, Tb.Th, and BV/TV of the right femur decreased (P<0.01), and the Tb.Sp increased (P<0.01). Compared to those in the model group, the Young's modulus of lumbar muscle group in the moxibustion group and estrogen group increased (P<0.05), the hindlimb support duration, swing duration, and step width shortened (P<0.05, P<0.01), the swing speed increased (P<0.01), BMD, Tb.Th, and BV/TV of the right femur increased (P<0.01), and the Tb.Sp decreased (P<0.01). Conclusion Moxibustion Liver-Yu and Kidney-Yu increases the Young's modulus value of lumbar muscle groups in ovariectomized rats, affects the gait parameters of hind limbs, thereby improving muscle function and improving BMD. This provides a traditional Chinese medicine solution for the prevention and treatment of osteoporosis from the perspective of musculoskeletal interaction. [ABSTRACT FROM AUTHOR]

Objective To observe the clinical effect of traditional Chinese medicine nursing combined with comprehensive rehabilitation training and routine rehabilitation nursing on children with mental retarda- tion by moxibustion with aconite. Methods A total of 120 children with mental retardation diagnosed in the outpatient department or in the hospital from February to December, 2022 were selected and divided into the observation group and the control group, with 60 cases in each group. The control group was given comprehensive rehabilitation training and routine rehabilitation nursing, while the observation group was given tradition- al Chinese medicine nursing on Baihui point with aconite moxibustion on the basis of the control group. To observe the changes of development quotient(DQ) of each energy area of Gesell Intelligence Development Diagnostic Scale(GDS) and the scores of children's comprehensive function evaluation scale before and after treatment, as well as the clinical efficacy. Results After treatment, the DQ of each energy area of GDS was improved in both groups. The scores of adaptive behavior, large exercise, fine movements, language and personal- social behavior in the observation group were(67.92±11.69),(61.88±13.20),(63.50±13.20),(57.35± 11.91),(57.87±11.89) points respectively. All the scores were higher than those of the control group (46.70±18.15),(49.85±17.78),(48.25±16.69),(37.78±13.46),(42.35±14.20) points, and the differences were statistically significant (P<0.05). The scores of all items in the children's comprehensive function evaluation table had been improved. The scores of cognitive function, speech function, sports ability, self-care action and social adaptation in the observation group were (10.98±3.61), (12.12±4.08),(18.81±5.42), (11.83±6.03),(8,87±3.14) points respectively. All the scores were higher than those of the control group (5.29±1.65),(6,58±3.20),(15.30±5.42), (5.11±4.09), (6.11±1.79) points, and the differences were statistically significant (P<0.05). The total effective rate of GDS in the observation group [91.7%(55/60)] was higher than that in the control group [76.7%(46/60)],and the total effective rate of children's comprehensive function evaluation [93.3%(56/60)] was also better than that in the control group [80.0%(48/60)], with statistical significance (P<0.05). Conclusion Moxibustion of Baihui point with aconite root combined with comprehensive rehabilitation training and routine rehabilitation nursing is effective in treating mental retardation. [ABSTRACT FROM AUTHOR]

Objective: To analyze the effect of Nuangqi Sanshenque patch combined with moxibustion on children with splenic deficiency diarrhea and its influence on intestinal microecology. Methods: 120 children with spleen deficiency diarrhea admitted to The First Affiliated Hospital of Henan University of Chinese Medicine from January 2022 to July 2023 were randomly divided into control group and observation group, 60 cases in each group. The control group was treated with bifidum triple viable bacteria capsule and montmorillonite powder; On the basis of the control group, the observation group was treated with warm umbilical Sanshenque patch combined with moxibustion. The moxibustion points were Shenque, Zhongwan, Zusanli, Tianshu, Pishu and Shenshu for 14 days. Symptom relief (normal time of stool traits and stop time of diarrhea) of the children in the two groups were recorded, and intestinal barrier function indexes (diamine oxidase, D-lactic acid), intestinal flora number (bifidobacterium, lactobacillus, fecal coccus, Escoli), serum inflammatory factors (interleukin-6, interleukin-8, tumor necrosis factor a) before and after treatment were detected. Results: Compared the control group, the observation group shit character normal time and diarrhea stop time are shorter (P<0.05). After treatment, the observation group of serum diamine oxidase, D-lactic acid levels are lower than the control group (P<0.05). After treatment, compared to control group and observation group serum interleukin 6 and interleukin 8, tumor necrosis factor alpha levels are lower (P<0.05). After treatment, compared to control group and observation group more the number of bifidobacterium, lactobacillus, less number of dung aureus, escherichia coli (P<0.05). Observation group total effective rate is 93.33%, compared to 83.33% of the control group (P<0.05). Conclusion: Nuanqi Sanshenque patch combined with moxibustion is effective in the treatment of children with splenic deficiency diarrhea, which is helpful to shorten the course of disease, improve intestinal barrier function and intestinal microecology. [ABSTRACT FROM AUTHOR]

BACKGROUND: The repair process of skin trauma is complex and susceptible to infection, easy to lead to poor healing, is the current difficulty and hot spot in wound repair research, and has received extensive attention in the fields of traditional Chinese medicine and tissue engineering. OBJECTIVE: To investigate the effect of moxibustion and reduced graphene oxide/cerium oxide nanocomposite on promoting the healing of infectious wounds. METHODS: (1) Reduced graphene oxide/cerium dioxide nanocomposites with mass ratios of 2:1, 1:1 and 1:2 were synthesized by hydrothermal method. The resulting composites were recorded as G2C1, G1C1and G1C2, respectively. The photothermal properties, cytotoxicity and antibacterial properties of the three kinds of materials were tested. After taking moxa sticks, three kinds of moxibustion distances were set (3.0-3.5 cm, recorded as moxibustion 1; 2.5-3.0 cm, recorded as moxibustion 2; 2.0-2.5 cm, recorded as moxibustion 3). Moxibustion was applied to the surface of human skin for 10 minutes to detect the photothermal properties. The antibacterial properties of moxibustion were tested at three different distance intervals. Simultaneously, the back body surface infrared imaging of rats with different mass concentrations of G1C1material, moxibustion (three kinds of moxibustion distances) and moxibustion 2+G1C1material was detected. (2) Sixty male Sprague-Dawley rats were selected to model the wound of Staphylococcus aureus infection. 48 hours later, they were randomly divided into 10 groups with 6 rats in each group: control group (did not receive any treatment), mupirocin group, moxibustion 2+G1C1group, moxibustion 1 group, moxibustion 2 group, moxibustion 3 group and 60, 80, 100, and 120 μg/mL G1C1groups (The G1C1group was given 808 nm near-infrared laser irradiation for 10 min/time, and the G1C1suspension was loaded on the wound surface before each treatment. Each group of moxibustion underwent insitu suspension moxibustion, and the intervention time was 10 min/time. Moxibustion 2+G1C1group was loaded with G1C1suspension on the wound surface before each treatment, and moxibustion was suspended in situ with moxa strips, and the intervention time was 10 min/time). The frequency of treatment was 2 days once. Wound healing, wound colony count and repair were detected after 7 days of intervention. RESULTS AND CONCLUSION: (1) The three kinds of reduced graphene oxide/cerium dioxide nanocomposites had good photothermal properties, and the higher the mass concentration of the composites, the better the photothermal properties. The temperature of the moxibustion 2 group reached 47.6 °C for 10 minutes without causing thermal damage, which was more suitable for animal experiments. The results of co-culture with NIH-3T3 cells exhibited that 60, 80, and 100 μg/mL G1C1had good biocompatibility. The results of a co-culture experiment with Staphylococcus aureus suspension displayed that G2C1, G1C1and G1C2 had good antibacterial activity, among which G1C1group demonstrated excellent antibacterial performance, and the antibacterial rate reached 100% when its mass concentration was 80 μg/mL. 60-120 μg/mL G1C1could effectively remove Staphylococcus aureus biofilm, and the higher the material mass concentration, the better the removal effect. Moxibustion could also effectively remove Staphylococcus aureus biofilm, and the closer the moxibustion was, the better the removal effect. (2) Compared with the control group, the wound area of the mupirocin group, moxibustion 2 group, moxibustion 2+G1C1group and 80, 100 μg/mL G1C1groups was significantly reduced on day 7 of treatment, and the quality of wound repair was better. Mupirocin, G1C1, moxibustion and moxibustion 2+G1C1could effectively remove the residual bacteria on the wound surface, and the higher the mass concentration of G1C1, the lower the residual bacteria. Among them, the wound repair efficiency and bacterial residue of 80 μg/mL G1C1group and moxibustion 2 group were very similar, and the wound repair efficiency of both was better than that of mupirocin group. In addition, it was also observed that the combination of materials and moxibustion had a better ability to clear wound bacteria than that used alone. (3) The results confirm that moxibustion, reduced graphene oxide/cerium dioxide nanocomposites and their combination have good anti-infection and wound healing effects. [ABSTRACT FROM AUTHOR]

Objective: Based on Toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)/nuclear factor-κB (NF-κB) signaling pathway to explore efficacy and mechanism of anchang decoction combined with moxibustion in the treatment of diarrhea-predominant irritable bowel syndrome (IBS) with liver stagnation and spleen deficiency syndrome. Methods: According to random number table method, 108 patients with diarrhea type IBS who were admitted to the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine from April 2019 to December 2022 were divided into control group (treated with conventional drugs combined with moxibustion, n=54) and study group (treated with Anchang Tang on the basis of the control group, n=54). The efficacy, chinese medicine syndrome total scores, IBS symptom severity questionnaire(IBS-SSS) score, intestinal barrier function index, TLR4/MyD88/NF-κB signaling pathway related messenger ribonucleic acid (mRNA) expression level were compared between two groups. Results: The total clinical effective rate in study group was higher than that in control group (P<0.05). Chinese medicine syndrome total scores and IBS-SSS scores in two groups decreased after treatment, and study group was lower than that of control group (P<0.05). The intestinal fatty acid binding protein (IFABP), D-lactate and diamine oxidase (DAO) decreased in two groups after treatment, and study group was lower than that of control group (P<0.05). TLR4, MyD88 and NF-κB mRNA decreased expression in two groups after treatment, and study group was lower than that of control group (P<0.05). Conclusion: Anchang decoction combine with moxibustion can effectively improve the clinical symptoms and intestinal barrier function of diarrhea-predominant IBS patients with liver depression and spleen deficiency syndrome, and the curative effect is good, which may be relate to the regulation of TLR4/MyD88/NF-κB signaling pathway. [ABSTRACT FROM AUTHOR]

目的 观察品管圈活动在降低中医适宜技术艾灸烫伤率中的应用效果。方法 选取针灸科 2021年1-6月进行艾灸治疗的205例住院患者,回顾性分析艾灸烫伤的不良事件资料,统计烫伤率。选取 2021年7-12月进行艾灸治疗的227例住院患者进行品管圈实践,实践过程中分析造成艾灸烫伤的各种原因, 比较实施前后艾灸烫伤率的管理效果及圈员的自我成长能力评分,总结品管圈活动的有形成果及无形成果。 结果 在有形成果方面:实施品管圈后艾灸烫伤率由改善前的11.7%降至改善后的3.5%,与活动前比较,差 异有统计学意义(P<0.05)。目标达成率为100.8%,进步率为96.5%,改良并发明了一种新型的艾灸盒辅助 装置,申请专利2项;在无形成果方面:活动后圈员的自我成长能力评分优于活动前,活动前后比较,差异有统 计学意义(P<0.05)。结论 品管圈活动的开展,切实降低了中医适宜技术艾灸的烫伤率,同时提升了护理人 员发现问题、分析问题、解决问题等方面的能力,团队凝聚力大大增强,为今后解决其他临床问题提供了良好的 途径。 [ABSTRACT FROM AUTHOR]

目的：分析统计腰突症治疗护理中, 中医定向透药联合艾灸的作用及价值。方法：本研究以2023年4月 1日-11月15日时段为基础开展数据统计分析工作, 期间入院的60例腰突症病人为研究对象, 随机进行对照组, 观察组 划分, 分别设定30个病例, 对照组-艾灸治疗与护理, 观察组-中医定向透药联合艾灸治疗与护理, 对比组间效果差异 性。结果：有效性统计证实, 观察组指标表现更加理想, 相比对照组, 差异显著（P < 0.05）；观察组研究对象服务意 识, 护患沟通, 安全性及专业性等维度临床护理满意度都相对更高, 相较于对照组, 差异显著（P < 0.05）；生活质量 与疼痛评分统计证实, 观察组指标表现更加理想, 相比对照组, 差异显著（P < 0.05）。结论：腰突症病人, 给予中医 定向透药联合艾灸方案治疗与护理, 作用突出, 临床价值较高。 [ABSTRACT FROM AUTHOR]

BACKGROUND: Heat-sensitive moxibustion is confirmed to be effective in the treatment of psoriasis, but the specific mechanism is still unclear. OBJECTIVE: To explore the effect of heat-sensitive moxibustion on psoriasis rats and its mechanism. METHODS: Sixty healthy Sprague-Dawley rats aged 8-10 weeks were randomly divided into blank control group (n=15), model group (n=15), and treatment group (n=30). Except for the blank group, animal models of psoriatic lesions were made on the back and the skin along the Sanjiao meridian of hand-Shaoyang. After successful modeling, the treatment group was treated with heat-sensitive moxibustion at Waiguan point of the Sanjiao meridian of hand-Shaoyang at the same time every day, 40 minutes once, for 7 continuous days. The treatment group was subdivided into heat-sensitive moxibustion group (n=15) and moxibustion group (n=15) according to the changes of tail temperature in the daily moxibustion process. After treatment, the rats in each group were scored by the psoriasis area and severity index (PASI), and after treatment, the protein expressions of JAK3, STAT3, p-JAK3, and p-STAT3 in the skin and fascia of Waiguan point were detected by western blot assay. RESULTS AND CONCLUSION: The PASI scores in the moxibustion group and heat-sensitive moxibustion group were lower than that in the model group, while the PASI score in the heat-sensitive moxibustion group was lower than that in the moxibustion group and there was no significant difference between groups. Compared with the model group, the protein expressions of p-JAK3 and p-STAT3 in the fascia of Waiguan point were significantly decreased (P < 0.05), and the protein expression of p-JAK3 in the skin of Waiguan point was also significantly reduced in the moxibustion group (P < 0.05). Compared with the model group, the protein expressions of JAK3, STAT3, p-JAK3, and p-STAT in the fascia and skin of Waiguan point were significantly decreased in the heat-sensitive moxibustion group (P < 0.05). Compared with the moxibustion group, the protein expression of STAT3 in the fascia of Waiguan point was significantly reduced in the heat-sensitive moxibustion group (P < 0.05). To conclude, both moxibustion and heat-sensitive moxibustion can improve the skin lesions of psoriatic rats and inhibit the inflammation of psoriasis. Furthermore, heat-sensitive moxibustion has a better efficacy than moxibustion, and its mechanism may be related to the inhibition of STAT3 signal pathway. [ABSTRACT FROM AUTHOR]

BACKGROUND: Rheumatoid arthritis is an inflammatory disease with a circadian variation of symptoms. Moxibustion has achieved remarkable efficacy in the treatment of rheumatoid arthritis, but it is unclear whether the specific mechanism is related to the regulation of the clock gene and the inhibition of pyroptosis. OBJECTIVE: To explore the effects of moxibustion at different time points on core clock genes Clock, Bmal1 and pyroptosis in rats with rheumatoid arthritis. METHODS: Forty adult Sprague-Dawley rats of both sexes were randomized into a control group, a model group, a moxibustion at 7:00-9:00 A.M. group and a moxibustion at 5:00-7:00 P.M. group, with 10 rats in each group. To establish the rheumatoid arthritis model, the rats were injected with Freund’s Complete Adjuvant at the right foot. Rats in the control group were given the normal saline at the right foot. At the 7th after modeling, the two moxibustion groups began to be treated with moxibustion at Zusanli and Shenshu acupoints at 7:00-9:00 A.M. or 5:00-7:00 P.M., once a day, for total 18 treatments with a 1-day break every 6 days. We measured the right foot volume of rats using drainage method before model establishment, after model establishment and after treatment. The hypothalamus and the synovium of the right knee joint were collected from the rats after treatment. The expressions of Clock, Bmal1, Nodlike receptor family pyrin domain-containing 3 (NLRP3), Caspase-1, and Gasdermin D (GSDMD) in the hypothalamus or knee synovium were tested by real-time fluorescence quantitative PCR and western blot. RESULTS AND CONCLUSION: The mRNA expreession of Clock and BMAL1 in the hypothalamus had no obvious change among the four groups (P > 0.05). The relative mRNA expression of Clock and Bmal in the hypothalamus was higher than that in the synovium (P < 0.01). The expression of Clock and Bmal1 in the synovium was significantly down-regulated in the model group compared with the control group (P < 0.01). Moxibustion significantly increased the mRNA and protein expression of Clock and Bmal1 in the synoviums compared with the model group (P < 0.05). Compared with the moxibustion at 7:00-9:00 A.M. group, the mRNA and protein expressions of Clock and Bmal1 in the moxibustion at 5:00-7:00 P.M. group were slightly but insignificantly up-regulated (P > 0.05). The mRNA expressions of NLRP3, Caspase-1 and GSDMD in the synovium were significantly increased in the model group compared with the control group (P < 0.01). Compared with the model group, moxibustion at 5:00-7:00 P.M. could significantly reduce the relative mRNA expression of NLRP3, Caspase-1 and GSDMD in the synovium (P < 0.01). Compared with the moxibustion at 7:00-9:00 A.M. group, the relative mRNA expressions of NLRP3 and Caspase-1 were significantly lowered in the moxibustion at 5:00-7:00 P.M. group (P < 0.05, P < 0.01). All these findings indicate that moxibustion can treat rheumatoid arthritis rats by upregulating the expression of Clock and Bmal1 mRNA and protein in different tissues, down-regulating the mRNA expression of NLRP3, Caspase-1 and GSDMD in the classical signal pathway of pyroptosis, and reducing synovitis and pyroptosis. The anti-inflammatory mechanism of core clock genes Clock and BMAL1 in rheumatoid arthritis may be related to the inhibition of pyrolytic effectors. [ABSTRACT FROM AUTHOR]

BACKGROUND: Insufficient gastrointestinal motility in patients with rheumatoid arthritis has been gradually concerned. As a treatment of rheumatoid arthritis, whether acupuncture can improve insufficient gastrointestinal motility is worthy of further exploration. OBJECTIVE: To explore the effect of acupuncture and moxibustion treatment at Zusanli (ST 36) on gastrointestinal motility in a rat model of adjuvant arthritis. METHODS: A total of 60 clean and healthy 3-month-old Sprague-Dawley rats were randomly divided into 5 groups: normal group, model group, acupuncture group, moxibustion group, and acupuncture plus moxibustion group, with 12 rats in each group. Adjuvant arthritis models were established in the latter four groups using Freund’s complete adjuvant. The acupuncture group, moxibustion group, and acupuncture plus moxibustion group were treated with acupuncture, moxibustion or both at Zusanli on the 1st day of modeling, for 15 minutes per day, for 14 continuous days. At the end of the corresponding treatment, all rats were measured for plantar circumference. Hematoxylin-eosin staining was used to observe the pathological changes of the knee joint. The number of peristaltic waves in the rat intestine was measured by the method of colonic peristaltic wave. The first black stool discharge time was observed after gavage with activated carbon suspension, to calculate the gastric emptying rate and intestinal propulsion rate. The contraction degree of jejunum smooth muscle strips of rats was detected by an in vitro perfusion device, and the distribution of jejunal nerve fibers were observed by immunofluorescence staining. RESULTS AND CONCLUSION: After acupuncture and moxibustion at Zusanli, sacroiliac joint swelling in rats was significantly reduced, cartilage destruction and inflammatory cells decreased, the number of intestinal peristaltic waves was increased, the total gastrointestinal activated carbon discharge time was shortened, gastric emptying rate and intestinal propulsion rate were improved, the contraction of the jejunal smooth muscle strip increased, and the amount of jejunal nerve fibers decreased. The combination of acupuncture and moxibustion achieved the best results. To conclude, acupuncture and moxibustion at Zusanli can prevent and treat bowel dysfunction in adjuvant arthritis rats, and acupuncture combined with moxibustion method is better than acupuncture or moxibustion used alone. [ABSTRACT FROM AUTHOR]

Objective: To observe the clinical effect of moxibustion therapy in patients with rheumatoid arthritis (RA). Methods: 44 patients with rheumatoid arthritis from January 2019 to January 2022 were randomly divided into 2 groups of 22 patients each. The control group was treated with leflunomide tablets and celecoxib capsules, and the observation group used pain sensitive point acupuncture and moxibustion therapy based on the control group. Pretherapy and Post-treatment, visual analog score (VAS) and disease activity score (DAS-28) were evaluated, and the levels of rheumatoid factor (RF), hypersensitive C reactive protein (hs-CRP), blood sink (ESR), rheumatoid factor (RF), fibrinogen (FIB), and D dimer were detected. Results: The VAS score was significantly lower after both groups (P<0.05), while the study group was significantly lower than the control group (P<0.05). The DAS-28 score was significantly lower after both treatment(P<0.05), while the study group was significantly lower than the control group(P<0.05). The levels of RF, hs-CRP, FIB and D dimer decreased significantly after both groups (P<0.05), while the study group was significantly lower than the control group (P<0.05). The total response rate of the observation group (100.00 %) was significantly higher than that of the control group (72.73 %) (P<0.05). Conclusion: Acupuncture and moxibustion can improve the clinical effect of RA patients and improve the anti-inflammatory effect of the body. [ABSTRACT FROM AUTHOR]

Objective: To explore the effect of moxibustion on the aerobic exercise capacity of rats living low and training high under simulated altitude training and its mechanism. Methods: Forty male Wistar rats were randomly divided into four groups: A, B, C, and D. Group A: Rats swim freely until they drown in (13.5± 0.5%) O2 environment, and then take bilateral "Zusanli" and "Guanyuan" for intervention, moxibustion for each point for 15 minutes per day; Group B: same training method as group A, No moxibustion intervention; C group: the same moxibustion method as group A, no training; D group: no intervention. Measure rat body mass, limb grip, first drowning time, one-time exhaustion ECG and hemoglobin, erythropoietin, vascular endothelial growth factor content, observe skeletal muscle tissue morphology, detect Hipper-lindau protein (PVHL), Transcription elongation protein β (Elongin-β ), induced hypoxia factor 1 (HIF-Ⅰα) protein expression levels. Results: There were no deaths and other abnormalities in each group, and the body weight increased steadily, and the difference between the groups was not statistically significant (P>0.05); comparison of limb grip FA>FC>FB>FD (P<0.05); first drowning The swimming time of group A was longer than that of group B (P＜0.05); ECG showed HRA＜HRC＜HRB＜ HRD, one-time exhaustion time SA＜SC＜SB＜SD, cardiac coefficient MB>MA>MD>MC, T wave TB>TA, ST segment STB>STA (P＜0.05); HB content detection showed: compared with group D, group A was the highest, group C was the second, group B was the smallest (P＜ 0.05); compared with group D, group B EPO, VEGF decreased (P＜0.05), EPO and VEGF increased in group C (P＜0.05). Compared with group A, EPO and VEGF in group B and C decreased (P＜0.05); skeletal muscle of group A was higher than that of B, C, D The three groups are arranged neatly, the diameter of the muscle fibers is uniform and the arrangement is neat and tight. Compared with group D, group A had the highest HIF-Ⅰα content, followed by group B, and group C was the smallest (P＜0.05); compared with group D, group A had the lowest expression of PVHL and Elongin-β, group B was the second, and group C was the smallest (P<0.05). Conclusion: Moxibustion of Zusanli and Guanyuan can improve the aerobic exercise capacity of rats; the mechanism may be related to improving the muscle fiber structure disorder and relieving cardiac compensation in simulated low-living and high-training rats. [ABSTRACT FROM AUTHOR]

Objective: Based on the JAK2/STAT3 signaling pathway, to explore the effect of scalp acupuncture combined withmoxibustion on a rat model of ischemic-hypoxic cerebral palsy and its mechanism. Methods: Selected 40 7-day-old clean-grade SDyoung rats and divide them into group A, group B, group C, group D, group E according to the random number table method, with 8 ineach group. No treatment was given to the group E, and the young rats of the other groups were all constructed models of ischemic-hy-poxic cerebral palsy using the modified hypoxic-ischemic encephalopathy modeling method. After successful model building, groups A,B, and C were given scalp acupuncture combined with moxibustion, scalp acupuncture, and moxibustion respectively. Groups D and Ewere given 50 μL of normal saline. To compare the expression of Janus protein tyrosine kinase 2 (JAK2) and activator of transcription 3(STAT3) protein, serum inflammatory factors [interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1)] level, neurotransmitter [norepinephrine (NE), serotonin (5-HT)] level, memory function among young rats of each group. Results: The expression ofJAK2 and STAT3 protein in the brain tissue of group A was lower than that of groups B, C, D, but higher than that of group E (P<0.05).Serum IL-6, IL-1 and TNF-α levels of group A were lower than groups B, C, D, but higher than group E (P<0.05). Serum NE and 5-HTlevels in group A were lower than those in groups B, C and D, but higher than those in group E (P<0.05). Group A has more correct Ymaze experiments than groups B, C, and D (P<0.05), but less than group E(P<0.05). Conclusion: Scalp acupuncture combined with moxibustion can down-regulate the inflammatory response level by targeting the expression of related proteins in the JAK2/STAT3 signalingpathway, thereby reducing brain tissue damage in young rats with ischemic-hypoxic cerebral palsy and promoting the recovery of theirmemory function. [ABSTRACT FROM AUTHOR]

消化内科疾病是临床常见的疾病之一，中医内科治疗消化内科疾病是一种古老但有效的治疗方法，越来 越受到欢迎。本论文对中药、针灸和艾灸在消化内科疾病治疗中的应用进行了系统归纳和总结，并就疾病的预防和治 疗提出了一些建议。 [ABSTRACT FROM AUTHOR]

BACKGROUND: From clinical experience and basic experiments, it is concluded that thermosensitive moxibustion has a positive effect on the treatment of pelvic inflammatory disease, but its mechanism of action has not been fully explained. OBJECTIVE: To investigate the effect of thermosensitive moxibustion on fascial connective tissue and its therapeutic mechanism in rats with pelvic inflammatory disease. METHODS: Sixty SPF female rats were randomly divided into normal group (n=15) and model group (n=45). The pelvic inflammatory disease model was prepared by mixed bacteria injection. After modeling, 45 model rats were randomly divided into model group, moxibustion group and thermosensitive moxibustion group according to the change of tail temperature. The normal and model groups did not receive any intervention measures, and the remaining two groups were given moxa-moxibustion (15 minutes per day) and thermosensitive moxibustion (40 minutes per day) at Sanyin Jiao, Zusanli and Guanyuan acupoints, respectively. All treatments were observed over a 7-day period. At the end of the treatment, MASSON staining was used to observe the morphological changes of the uterus, peritoneum and fascia around the acupoints. The contents of interleukin-6 and tumor necrosis factor-α in the rat serum were determined by ELISA. RESULTS AND CONCLUSION: MASSON staining of the uterus, peritoneum and fascia around the acupoints showed that, compared with the model group, the collagen fibers in the fascia of the thermosensitive moxibustion group showed wavy distribution and the diameter of cytoplasm became longer. The serum levels of tumor necrosis factor-α and interleukin-6 in the model group were significantly higher than those in the normal group (P < 0.05). After treatment, the levels of tumor necrosis factor-α and interleukin-6 in the thermosensitive moxibustion group and the moxibustion group were significantly lower than those in the model group (P < 0.01), while the levels of tumor necrosis factor-α and interleukin-6 in the thermosensitive moxibustion group were significantly lower than those in the moxibustion group (P < 0.05). The results suggest that the role of thermosensitive acupuncture points may be closely related to the trifocal film of the whole body, and thermosensitive moxibustion may realize the heat signal conduction by changing the morphology and structure of fibroblasts in the relevant connective tissue of the whole body. The relief of pelvic inflammatory symptoms by thermosensitive moxibustion may be related to the changes in serum levels of tumor necrosis factor-α and interleukin-6. [ABSTRACT FROM AUTHOR]

Objective To explore whether the protective effect of moxibustion on ovary of rats with diminished ovarian reserve （ DOR） is related to the inflammatory regulation mediated by nuclear factor erythroid2-related factor 2 （Nrf2）/hemeoxygenasel （HO-1） signaling pathway. Methods Fifty female rats were randomly divided into blank group, multi-glycosides of Tripterygium wilfordii (GTW) group, moxibustion group, all-trans retinoic acid (ATR A) group and dimethyl sulfoxide (DMSO) group, 10 in each group. The GTW group, moxibustion group, ATR A group and DMSO group were treated with Tripterygium wilfordii polyglycoside tablet suspension by gavage to establish DOR rat model. The blank group were given the same amount of normal saline by gavage daily. The moxibustion group was treated by moxibustion at bilateral BL23 on alternate days and CV4 and CV12 on the other days for 10 minutes each time one hour after intragas trie administration. The ATR A group received intraperitoneal injection of ATR A suspension 30 minutes after intragas trie administration and moxibustion intervention together with the moxibustion group 30 minutes later. The DMSO group received intraperitoneal injection of the same volume of DMSO solution 30 minutes after intragas trie administration and the same moxibustion treatment as the ATR A group. The weight and the estrous cycle of rats were observed every morning. After the intervention, the coefficients of ovarian organs of the rats were calculated, the histological structure of ovaries wa5 observed with HE staining, the changes in serum sex hormones and inflammatory factors were detected by ELISA, the expression levels of Nr£2, HO-1 protein and mRNA were detected by immunohistochemistry and PCR respectively. Results Compared with the blank group, the ovarian coefficients of rats in the GTW group decreased significantly (P <0. 05), the detection rate of estrous cycle disorder increased significantly (P <0. 01), the serum levels of FSH, T, INF-7 increased (all P <0. 01), the levels of AMH(P <0. 01, P <0. 05) and IL-4(all P <0. 01) decreased, and the expression levels of Nr£2 and HO-1 protein (all P < 0. 01) and mRNA (all P <0. 05) in ovarian tissues decreased significantly. Compared with the GTW group, the ovarian coefficients of rats in the moxibustion group and the DMSO group increased (all jP < 0. 05), the detection rates of estrous cycle disorder decreased (all P <0. 01), the serum levels of FSH, T, INF-7 decreased (all P < 0. 01), the levels of AMH (P <0. 01, /> < 0. 05) and IL-4 increased (all P < 0. 01), the expression levels of Nrf2 and HO-1 protein and mRNA in ovarian tissues increased significantly (all P <0. 01). Compared with the moxibustion group, the ovarian coefficients of rats in the ATR A group decreased (P <0< 01), the detection rate of estrus cycle disorder increased (P <0. 01), the serum levels of FSH, T, INF-7 increased (all P <0. 01), the levels of AMH and IL-4 decreased (P <0. 05, P <0. 01), the expression levels of Nrf2 and HO-1 protein (all P < 0. 01) and mRNA (all P < 0. 05) in ovarian tissues decreased. Conclusion Moxibustion can attenuate the inflammatory injury induced by GTW in DOR rats and protect the ovary by activating Nr£2 / HO-1 signaling pathway. [ABSTRACT FROM AUTHOR]

Objective To observe symptoms and changes in sleep quality before and after moxibustion on Xinshu (BL15), Neiguan (PC6), Danzhong (RN17), Zhongwan (RN12), Zusanli (ST36) in clopidogrel-resistant patients with coronary heart disease (CHD). Methods The project planned to enroll 100 patients in total. In this trial study, 30 CHD patients with clopidogrel resistance and insomnia have been enrolled. All patients filled in the Pittsburgh Sleep Quality Index (PSQI) scale by themselves and recorded accompanying symptoms of coronary heart disease that caused physical discomfort during the past one month. For each treatment session, the operation sequence of"back to belly, top to bottom" was followed. Moxibustion was perforned first on the bilateral Xinshu (BL75) points, then on the Neiguan (PC6) points and Danzhong (RN17) points, and then on Zhongwan (RN12) points, finally on bilateral Zusanli (ST36) acupoints. PSQI scores before and after the treatment were collected. Complications of coronary heart disease were also evaluated. Results PSQI scores significantly improved (P<0.05) both at 2 weeks and 4 weeks after the treatment. CHD related symptoms were also alleviated. Conclusion Moxibustion can significantly improve insomnia and relieve the symptoms of coronary heart disease. It could benefit the prognosis and recovery of CHD patients. [ABSTRACT FROM AUTHOR]

Objective　To explore the clinical efficacy of acupuncture combined with SSRIs in the treatment of patients with depression. Methods　A total of 83 patients with depression admitted to our hospital between January 2019 and January 2020 were selected as the research objects. Patients in the control group were treated with SSRIs, and the combined treatment (observation) group was treated with acupuncture on the basis of the control group. The clinical efficacy, anxiety (HAMD) and depression scale (HAMD) of patients in the two groups were compared. Results　After treatment, the clinical efficacy of depression patients in the observation group was significantly higher than that in the control group (P<0.05). HAMA and HAMD scores showed statistical difference between the two groups. HAMA and HAMD scores of patients in the observation group were lower than those in the control group (P<0.05). Conclusion　Acupuncture combined with SSRIs in the treatment of depression can significantly improve the patient's condition, reduce the patient's anxiety and depression, and has a positive significance for the treatment of the patients. [ABSTRACT FROM AUTHOR]

Objective To observe the effects of moxibustion at GV16 (Fengfu), CV4 (Guanyuan) ST36 (Zusanli) on the expression of E3 ubiquitinase Parkin and unique mitochondrial deubiquitinase USP30 in substantia nigra of Parkinson's disease (PD) model rats, and to explore the mechanism of moxibustion at GV16, C V 4 and ST36 in preventing and treating PD. M e thods Forty healthy male SD rats of SPF grade were randomly divided into normal group (n=8), s ham operation group (n=8), and model group (n=24). The rat PD model was made with subcutaneous injection of rotenone (1 mg/kg, dissolved in dimethyl sulfoxide and 0.9% NaCI solution). Thesham operation group was made by subcutaneous injection of DMS O and 0.9% NaCI solution without rotenone. Forty days after the establishment of the model, 14 rats with a high score of 2 -- 8 were selected. Then two rats were randomly selected from each group. The expression of tyrosine hydroxylase (T H) and alpha-synuclein (a-syn) in substantia nigra of rats was measured with immunohistochemical method to identify the success of the establishment of the model. After model identification, the model group (n=12) was randomly divided into model group and moxibustion treatment group, 6 in each group. In the moxibustion treatment group, acupoints GV16(Fengfu), CV4 (Guanyuan) and ST36 (Zusanli) were selected, and moxibustion was applied at the sametime once a day, 15 minutes for each acupoint, for 14 consecutive days (7 days is a course of treatment, a total of two courses of treatment). Normal group, shamoperation group and model group received no treatment intervention except wearing fixed rat clothes as in with moxibustion group. After moxibustion treatment, the rats in each group were graded for their behavior, and the relative expressions of Parkin and USP30 in substantia nigra of rats were detected by using Western blotting assay. Results Immunohistochemical assay showed that TH staining was significantly lost and unevenly distributed in model group and moxibustion treatment group compared with the normal group and the sham operation group, while the(a-syn) staining was rich and dense in the model group and moxibustion treatment group compared with the normal group and the sham operation group. At the end of moxibustion treatment, the behavioral score of moxibustion treatment group was lower than that of model group (P<0.01); The relative expression of Parkin in substantia nigra of rats in model group decreased (P<0.05) and U SP30 increased (P<0.05) compared with normal group and sham operation group; while the relative expression of Parkin in substantia nigra of rats in moxibustion treatment group increased (P<0.05) and USP30 decreased (P<0.05) compared with those in model group. Conclusion Parkin-mediated mitochondrial autophagy in substantia nigra of Parkinson, s disease model rats was elevated by moxibustion treatment, thus degrading and clearing over-expressed USP30, which may be one of the mechanisms of moxibustion in the treatment of Parkinsondisease. [ABSTRACT FROM AUTHOR]

Objective To investigate the effect of moxibustion on the expression of Caveolin-1, p38MAPK, and pp38MAPK in the articular cartilage of knee osteoarthritis (KOA) rabbits. Methods Forty rabbits were randomly divided into the control group, model group, moxibustion group, and blocker group. Except the control group, KOA models were established by injecting papain into articular cavities of rabbits in the other three groups. Moxibustion was carried out at Dubi point and Zusanli point in the moxibustion group, and p38 blocker S8203580 was injected into articular cavities of rabbits in the blocker group. Rabbits were sacrificed after 3 weeks of treatment to obtain the cartilage tissues, while the rabbits in the control group and model group were not treated. The expression levels of Caveolin-1, p38 MAPK, and p38 MAPK were detected by Western blotting. Results The relative expression levels of Caveolin-1 were 2. 09 ± 0. 07, 1. 45 ± 0. 05, and 1. 09 ± 0. 07, respectively, and the relative expression levels of p-p38 MAPK/p38 MAPK were 3. 25 ± 0. 08, 2. 52 ± 0. 17, and 2. 07 ± 0. 14, respectively, in the model group, moxibustion group and inhibitor group, which were higher than those of the control group (1. 00 ± 0. 05) (all P < 0. 05). Compared with the model group, the expression levels of Caveolin-1 protein and p38 MAPK protein activity in the cartilage of the moxibustion group and blocker group decreased (both P < 0. 05). Compared with the blocker group, the expression levels of Caveolin-1 protein and p38 MAPK protein activity in the cartilage of moxibustion group increased (both P < 0. 05). Conclusions The expression levels of Caveolin-1 and the activity of p38 MAPK protein decrease in the cartilage of KOA rabbits after moxibustion treatment. Inhibition of abnormal activation of Caveolin-1/p38 MAPK signal pathway may be one of the molecular mechanisms of moxibustion. [ABSTRACT FROM AUTHOR]

Objective To investigate the effect of mild moxibustion on pathological morphology of skeletal muscle trigger point of myofascial pain rats as well as the influence on the changes of cyclooxygenase-2( COX-2),prostaglandin E2( PGE-2),interleukin-6( IL-6) and tumor necrosis factor-α( TNF-α). Methods Sixty-four SD rats were randomly divided into the control group( n = 24),model group( n = 24),and mild moxibustion group( n = 16). In the model group and moxibustion group,we adopted the method of beating combined with centrifugal movement to establish the myofascial pain trigger point models. The rats in the control group were fed normally. In the moxibustion group,after the end of the modeling,the rats began to receive moxibustion treatment for 7 days after routine feeding for 7 days. The control group and the model group were not treated with moxibustion. Eight rats were randomly selected from the three groups on the 1st day before moxibustion treatment and the 2nd and 14th days after moxibustion treatment. Tissues of myofascial trigger point or tissues in the same area were taken,stained with HE,and pathological morphology of tissues was observed under light microscope. The expression of COX-2,PGE2,IL-6,and TNF-α in the myofascial trigger point was detected by immunohistochemistry. Results In the control group,the muscle fibers in the myofascial trigger point were arranged regularly and uniformly,and the muscle spaces were consistent. No muscle fibers were twisted,broken,dissolved and necrotic,and with a little inflammatory cell infiltration. In the model group,the muscle fibers were disordered,broken and twisted at each stage. The myofascial trigger points were dissolved and necrotic before mild moxibustion treatment. At the end of mild moxibustion treatment,the muscle fibers were thickened,the size of the muscle gap was different,and there were a large number of inflammatory cells infiltrating. At the 14th day after mild moxibustion treatment,in the myofascial trigger point,partial fibers twisted to form nodules,and inflammatory cell infiltration was significantly reduced on the third day after treatment. The relative expression of COX-2,PGE2,IL-6,and TNF-α in each myofascial trigger point of the model group was significantly higher than that in the control group at the same time( all P < 0. 05),while COX-2,PGE2,IL-6,and TNF-α in the moxibustion group was significantly lower than that in the model group at the same time( all P < 0. 05),and the relative expression of COX-2,PGE2,IL-6,TNF-α in the myofascial trigger point on the 14th day after moxibustion treatment was significantly lower than that on the 3nd day after treatment( all P < 0. 05); no significant change was found in the expression of COX-2,PGE2,IL-6,and TNF-α in the myofascial trigger point of the model group and control group( all P> 0. 05). Conclusion Local mild moxibustion intervention can promote the repair of fibers of myofascial trigger point by reducing the recruitment of inflammatory cytokines in myofascial trigger point and then alleviating the inflammatory reaction. [ABSTRACT FROM AUTHOR]

This article has analyzed the source and clinical significance of statement of "if keeping health, Zusanli (ST36) frequently being given moxibustion" based on philology and medical principles. The statement was recorded in Suosuilu (Trivial Details of Traditional Chinese Medicine) written in early Southern Song Dynasty, which was originally designed for preventing and curing wind diseases. The moxibustion on ST36 is to diffuse and unblock qi and blood of zang-fu organs, but is not to give festering moxibustion. If the statement is explained as repeated festering moxibustion, Yubaizhuang moxibution recorded in Beijiqianjinyaofang (Essential Prescriptions Worth a Thousand Gold for Emergencies) and Bao moxibution recorded in Zhenjiuzishengjing (Classic of Nourishing Life with Acupuncture and Moxibustion) used only in the condition of excessive yang deficiency will be misunderstood. Acupressure, frottage and foot bath can be selected in ST36 healthcare. Considering safety, some mild moxibustion therapies are recommended, such as suspended moxibustion and sandwiched moxibustion, in patients with obvious cold symptoms. [ABSTRACT FROM AUTHOR]

Moxibustion played a role in warming channel and expelling cold,promoting qi to activate blood,clearing and activating the meridians and collaterals as well as dissipating blood stasis and circulating stagnation.It was effective in the treatment of bedsore.However,the molecular mechanism of moxibustion in the treatment of pressure ulcer was still unclear.The angiogenesis played an important part in the repairment and healing process of pressure ulcer,which could provide oxygen and nutrients to the newborn tissue.The molecular mechanism of modern medicine on pressure ulcer which was involved in the angiogenesis constantly went deeper,but it was lack of effective treatment.In addition,great importance should be attached to adjusting the type of moxa stick and moxibustion operation as well as moxibustion mechanism,aiming at optimizing the affecting factors of curative effect of moxibustion in the treatment of pressure ulcer.Accordingly,how to combine the moxibustion therapy which belonged to the original features of Traditional Chinese Medicine with thorough molecular mechanism of angiogenesis study of modern medicine was a significant question worthy of consideration. [ABSTRACT FROM AUTHOR]

Moxibustion played a role in warming channel and expelling cold, promoting qi to activate blood, clearing and activating the meridians and collaterals as well as dissipating blood stasis and circulating stagnation. It was effective in the treatment of bedsore. However, the molecular mechanism of moxibustion in the treatment of pressure ulcer was still unclear. The angiogenesis played an important part in the repairment and healing process of pressure ulcer, which could provide oxygen and nutrients to the newborn tissue. The molecular mechanism of modern medicine on pressure ulcer which was involved in the angiogenesis constantly went deeper, but it was lack of effective treatment. In addition, great importance should be attached to adjusting the type of moxa stick and moxibustion operation as well as moxibustion mechanism, aiming at optimizing the affecting factors of curative effect of moxibustion in the treatment of pressure ulcer. Accordingly, how to combine the moxibustion therapy which belonged to the original features of Traditional Chinese Medicine with thorough molecular mechanism of angiogenesis study of modern medicine was a significant question worthy of consideration. [ABSTRACT FROM AUTHOR]

This paper puts forward the eoneept of "original moxa-moxibustion" from the perspeetive of natural cognition. Based on the ancient unique views on the traditional cultural traits of Nature, Asiatic wormwood, lives and diseases, original moxa-moxibustion was the perfeet combination of mysterious phenomena with magical strength guided by ancient natural philosophy, and was shared with soreery, medicine and Taoism. Then the use of fire accompanied by labor practice pushed the popularization of original moxa-moxibustion which transformed into moxa-moxibustion therapy of traditional Chinese medicine, after integrating with traditional medicines on human physiology, pathology and pharmacology, and learning from the technique of stone needles. Original moxa-moxibustion was earlier than moxibustion therapy, because use of fire was earlier than use of medicines. Development and innovation of moxibustion need deep understanding its origin and characteristics, as well as studying traditional culture and modem technology on thinking, techniques, methods and tools. [ABSTRACT FROM AUTHOR]

Objective: To study the short-term and long-term curative effect of acupuncture plus moxibustion in the treatment of rheumatoid arthritis. Method: 74 cases of patients with rheumatoid arthritis from April 2013 to January 2014 were selected as the research objects, and divided into two groups by the method of random Numbers table, 37 cases each group. The patients in control group were given western medicine therapy, and the patients in observation group were treated with acupuncture with moxibustion on the basis of the control group. The short-term and long-term curative effect of the two groups were analyzed and compared. Result: The effective rate was 89.19 % in the observation group and 70.27 % in control group after 1 month of treatment with significant difference between two groups (P<0.05); the effective rate was 59.46 %in control group and 94.59 % in observation group after 1 year, and the difference between the two groups was statistically significant (P < 0.05). The time of morning stiffness, joint tenderness index, the index of joint swelling, joint function score, grip strength had no significant difference in the two groups of patients before treatment, and after the treatment, these indicators were greatly improved in two groups, and the level of above indexes was better in observation group than that of control group, and the difference between the two groups was statistically significant (P<0.05). After treatment, the incidence of adverse reactions was 16.22%in control group and 2.70%in observation group, and the difference between the two groups was statistically significant Conclusion: (P<0.05). The efficacy of acupuncture and moxibustion for the treatment of rheumatoid arthritis can obtain good short-term and long-term curative effect, improve the patient's joint function and grip strength, alleviate the symptoms such as morning stiffness, joint pain and swelling. [ABSTRACT FROM AUTHOR]

Objective To study the role of nucleus tractus solitarii (NTS) on the protective effects of moxibustion on gastric mucosa lesion in the nervous pathway by investigating the effects of moxibustion at "Zusanli" (ST 36) on endogenous protective factors and gap-associated protein expression of gastric mucosal lesion rats after damaging their nucleus tractus solitarii (NTS). Methods 48 healthy SD rats, SPF grade, were divided into four groups using random number table(each n=12): normal group, model group, moxibustion group, moxibustion + NTS damaged group. Three days after bilateral NTS damaged in moxibustion + NTS damaged group, gastric mucosal lesion rat model was induced by intragastrical (i.g.) administration of anhydrous ethanol at dose of 6 mL/kg and aspirin mixed suspension at dose of 200 mg/kg for consecutive three days. The next day, rats in moxibustion group and moxibustion + NTS damaged group were treated by moxibustion at Zusanli (ST 36) twice daily for consecutive three days. All rats were sacrificed, then their serum and gastric tissue were collected. Ulcer index (UI) was calculated, and the expressions of epidermal growth factor (EGF), nitric oxide (NO), Bcl-2 anti-apoptotic proteins (Bcl-2) and pro-apoptotic protein (Bax) were detected. Results Compared with normal group, UI in model group increased significantly(P<0.05), decreased in moxibustion group(P<0.05). Compared with model group, content of EGF and NO in serum and gastric tissue increased remarkably in moxibustion group(P<0.05)which were higher than those in moxibustion + NTS damaged group(P<0.05). Protein expression of Bcl-2 increased significantly in moxibustion group and moxibustion + NTS damage group compared with model group, while expression of Bax protein decreased with increasing of AI (P<0.05). Conclusion Treatment of moxibustion at Zusanli (ST 36) can regulate the expression of endogenous protective factors and proteins to protect rats' gastric mucosa, which was affected by damaging NTS. It is suggested that NTS be the important regulatory location in the signaling pathway of protective effects of moxibustion at Zusanli on gastric mucosal. [ABSTRACT FROM AUTHOR]

Objective To develop a pottery frame to facilitate warm acupuncture moxibustion. Methods The frame was made of clay, and was composed of a moxa wool retaining table, a handle, a base and a support. The moxa wool holding table had a hollow structure wide at the top and narrow at the bottom, and there was a slot at its middle to hold the needle; while the base had a hollow structure narrow at the top and wide at the bottom, and there were several air vents at its inner wall to accelerate the full combustion of the moxa wool. Results The frame avoided patient burn due to dropped spark or overweight moxa cone during traditional warm acupuncture moxibustion therapy, and relieved the patients' pain and medical staffs' workload. Conclusion The frame has simple structure, easy operation, high safety, high patient satisfaction and high practicability. [ABSTRACT FROM AUTHOR]

目的观察艾灸治疗对帕金森病大鼠黑质磷酸化雷帕霉素靶蛋白(p-mtor)、磷酸化真核细胞起始因子4E结合蛋白1(p-4EBP1)及α-突触核蛋白(α-syn)表达的影响,探讨艾灸治疗帕金森病的作用机制。方法健康雄性SD大鼠60只,随机分为正常组、假手术组、帕金森病组、帕金森病艾灸组,每组15只。帕金森病组、帕金森病艾灸组采用颈背部皮下注射鱼藤酮法制备帕金森病模型,假手术组注射等浓度不含鱼藤酮的葵花油乳液,正常组不做处理。正常组、假手术组、帕金森病组不予艾灸;帕金森病艾灸组造模成功后选取足三里(双侧)、关元、风府穴施予艾灸治疗,1次/d,每次10 min,7 d为1个疗程,连续治疗2个疗程。然后对各组大鼠进行行为学评分;Western blotting检测各组大鼠黑质p-mtor、p-4EBP1,免疫组化法检测各组大鼠黑质α-syn。结果帕金森病组大鼠行为学评分与正常组和假手术组相比明显升高(P均<0.01);帕金森病艾灸组大鼠行为学评分较帕金森病组显著降低(P<0.01)。与正常组、假手术组相比,帕金森病组大鼠黑质p-mtor、p-4EBP1、α-syn表达量明显升高(P均<0.01);与帕金森病组相比,帕金森病艾灸组大鼠黑质p-mtor、p-4EBP1、α-syn表达量明显下降(P均<0.01)。结论艾灸足三里、关元、风府穴治疗帕金森病的作用机制可能是抑制了雷帕霉素靶蛋白/真核细胞起始因子4E结合蛋白通路的过度活化,遏止α-syn的过度表达,从而减轻过度表达的α-syn对多巴胺能神经元的毒性。 [ABSTRACT FROM AUTHOR]

To summarize and explore the academic ideology and characteristics of DOU Cai’s experiences of moxibustion by studying Bian Que Xin Shu written by DOU, a traditional Chinese physician in the Southern Song Dynasty. Before moxibustion, DOU was sure to differentiate meridians and yin-yang. Toni-fying was sure to be applied and strengthening yang was paid much attention, and spleen and kidney were also regarded as important in critical diseases. DOU’s moxibustion worked wonder on most patients, which was characterized by direct moxibustion with less acupoints, more amount and longer duration. DOU’s moxibustion had a wide range of application in internal medicine, surgery, gynecology, pediatrics and ENT. In this book, most of diseases were followed by proved cases which provided important refer-ence to clinical practice. [ABSTRACT FROM AUTHOR]

目的　观察温针灸对类风湿关节炎（ＲＡ）大鼠抗血清抗环瓜氨酸（ＣＣＰ）抗体、类风湿因子（ＲＦ）的影响。方法　将５０只大鼠随机分为５组，每组１０只。Ａ～Ｄ组于左后足跖底部弗氏完全佐剂制作ＲＡ模型，造模成功后Ａ、Ｂ、Ｃ组分别予以温针灸、针刺、艾灸治疗，Ｄ组不予任何治疗；Ｅ组于左后足跖底部注射等量生理盐水，不做任何治疗。治疗３个疗程后，用ＥＬＩＳＡ法检测血清抗ＣＣＰ抗体、ＲＦ，ＨＥ染色观察跖趾关节病理。结果　与Ｅ组比较，Ｄ组血清抗ＣＣＰ抗体、ＲＦ水平均明显增高（Ｐ均＜０．０５）；与Ｄ组比较，Ａ～Ｃ组血清抗ＣＣＰ、ＲＦ水平降低（Ｐ均＜０．０５），Ａ组较Ｂ、Ｃ组降低明显（Ｐ均＜０．０５），Ｂ、Ｃ组无统计学差异。Ａ～Ｃ组跖趾关节滑膜炎症较Ｄ组减轻，Ａ组减轻最明显。结论　温针灸可降低ＲＡ大鼠血清抗ＣＣＰ抗体、ＲＦ水平，从而改善ＲＡ病理发挥治疗作用。 [ABSTRACT FROM AUTHOR]