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To observe the effects of hip bath fumigation with tongyangxiao lotion on wound healing, anal function and serum inflammatory factors after operation of perianal abscess. All 136 patients with perianal abscess after operation were from our hospital from September 2019 to July 2021. According to the two-color ball method, the patients were divided into control group (68 cases) and study group (68 cases). The patients in the control group received routine treatment, and the study group received the hip bath fumigation with tongyangxiao lotion on the basis of the control group. The curative effect, wound healing situation, anal function and changes of serum inflammatory factors in the two groups were observed, and the adverse reactions in the two groups during the treatment were recorded. The total clinical effective rate of the study group was better than that of the control group (P<0.05). 7 d after treatment, the wound reduction rate of the study group was higher than that of the control group, and the surgical wound granulation growth score and wound pain score were lower than those of the control group (P<0.05). 3 months after treatment, the maximum anal systolic pressure and anal resting pressure of the study group were higher than those of the control group (P<0.05). 7 d after treatment, the levels of serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α ), interleukin-1β (IL-1β) and interleukin-8 (IL-8) in the study group were lower than those of the control group (P<0.05). There were no obvious adverse reactions in both groups. After the operation of perianal abscess, the application of tongyangxiao lotion fumigation hip bath can promote wound healing and reduce the damage to anal function, which may be related to the fact that tongyangxiao lotion fumigation hip bath can effectively reduce the levels of serum inflammatory factors. [ABSTRACT FROM AUTHOR]

Objective To establish the reference intervals (RIs) of the four biochemical parameters for liver function [aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT), and alkaline phosphatase (ALP)] in adults by using the indirect method based on the data of subjects undergoing physical examination in laboratory information system (LIS). Methods With the help of the LIS, related data were collected from the healthy adults who underwent physical examination in Physical Examination Center of The First Hospital of Jilin University from October 2019 to October 2020. The Kolmogorov-Smirnov test was used to check the normal distribution of the original data; data with skewed distribution were transformed into data with approximate normal distribution using the BOX-COX method; the Turkey method was used to remove outliers; the Mann-Whitney U test or the Z-test was used for comparison between groups; the non-parametric method was used to calculate RIs. Results A total of 27 218 subjects were included after the removal of outliers. All four parameters showed age and sex differences. The RIs of AST were 14-39 U/L for male individuals aged 20-79 years, 12-32 U/L for female individuals aged 20-49 years, and 14-39 U/L for female individuals aged 50-79 years; the RIs of ALT were 10-71 U/L for male individuals aged 20-54 years, 10-49 U/L for male individuals aged 55-79 years, 7-43 U/L for female individuals aged 20-49 years, and 9-49 U/L for female individuals aged 50-79 years; the RIs of GGT were 11-70 U/L for male individuals aged 20-64 years, 10-64 U/L for male individuals aged 65-79 years, 6-45 U/L for female individuals aged 20-49 years, and 7-54 U/L for female individuals aged 50-79 years; the RIs of ALP were 38-96 U/L for male individuals aged 20-79 years, 33-89 U/L for female individuals aged 20-49 years, and 40-106 U/L for female individuals aged 50-79 years. The RIs of AST, ALT, and GGT established in this study were similar to those in the industry standards of China (relative deviation < reference change value), and the RIs of all four biochemical parameters were verified by applicability. Conclusion The RIs of the four biochemical parameters for liver function established by the indirect method are relatively consistent with those established by the direct method, which holds promise for application in clinical laboratory. [ABSTRACT FROM AUTHOR]

Objective To investigate whether the reference intervals for serum alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA) in WS/T 645.2-2018 are applicable to the adults in Changchun, China. Methods According to the validation method for the reference intervals in WS/T 645.2-2018, 5420 subjects, aged from 20-79 years, who underwent physical examination from January 2016 to April 2019 were enrolled and divided into 12 subgroups based on age and sex. Each subgroup was analyzed in terms of whether more than 90% of the measured values fell into the reference intervals, and the changing trend of AFP and CEA with age and sex was analyzed. The Mann-Whitney U test was used for comparison between two groups. Results More than 90% of the measured values of serum AFP and CEA fell into the reference intervals, which passed the validation test. There was a significant difference in serum AFP between male and female subjects aged 30-39 years (Z=-4.51, P＜0.05), and there was a significant difference in serum CEA between male and female subjects aged 20-29, 30-39, 40-49, 50-59, and 60-69 years (Z=-13.45, -18.15, -17.34, -10.82, and -3.65, all P＜0.05). Serum AFP increased slowly with age in female subjects aged 20-69 years and decreased with age in male and female subjects aged 70-79 years. Serum CEA increased with age in male and female subjects aged 20-79 years, and male subjects had a higher measured value than female subjects. Conclusion Reference intervals for serum AFP and CEA in WS/T 645.2-2018 issued by National Health Commission are applicable to the adults in Changchun. [ABSTRACT FROM AUTHOR]