Search

To study the effect of immediate intravesical instillation of different concentration of pipirubicin on immune function and quality of life in patients with superficial bladder cancer (SBC) after transurethral resection of bladder tumor (TURBT). 126 patients with SBC who were treated in our hospital from June 2015 to June 2018 were selected as the object of the study. According to the random number method, the patients were divided into the observation group and the control group with 63 cases in each group. The two groups were routinely treated with TURBT. Immediately after operation, the patients in the observation group were given infusion chemotherapy with 30 mg's pirarubicin and 30 mL of 5% of the glucose solution, and the patients in the control group were given infusion chemotherapy with 30 mg's pirarubicin and 50 mL of 5% of the glucose solution. 1 years after treatment, the recurrence, immune function, quality of life and adverse reactions were compared between the two groups. The recurrence rate of the observation group was significantly lower than the control group, and the recurrence time was significantly longer than that of the control group (P<0.05). The levels of CD3+, CD4+, CD8+ and the scores of quality of life in the two groups were significantly higher than those before treatment, and the difference was statistically significant (P<0.05). There was no significant difference in the levels of CD3+, CD4+, CD8+ and the scores of quality of life between the two groups before and after treatment (P>0.05). There was no significant difference in the adverse reactions and the total incidence of the observation group compared with the control group (P>0.05). Immediate intravesical instillation of pirarubicin can improve the immune function and quality of life in patients with SBC after TURBT. However, intravesical instillation of 30 mg's pirarubicin and 30 mL of 5% of the glucose solution can achieve lower postoperative recurrence rate, the recurrence time is also prolonged [ABSTRACT FROM AUTHOR]