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In recent years, artificial intelligence (AI) has increasingly made advances across various fields, including ELT. In this article we embrace an egalitarian dialogue framework to explore and understand the role of AI in language education. This format provides a useful backdrop for navigating the dual responses—enthusiasm and scepticism—by which AI's influence in education has often been characterized. We critically assess both the advantages and limitations of AI in ELT, highlighting and praising how AI-powered tools can assist educators in differentiating instruction, promoting learner autonomy, and creating personalized and inclusive learning environments, thus making education more accessible to students with diverse and individual needs. However, the article also addresses the challenges posed by the digital divide, particularly the inequities in access to (AI) technologies in low-socioeconomic-status regions. We also reflect upon how AI can become an obstacle in developing learner autonomy due to the risks associated with overdependence on such technologies and the lack of critical skills. The article concludes that although AI presents exciting opportunities for advancing and facilitating language learning, its integration must be approached with a rational mindset to ensure that it serves to bridge educational gaps rather than intensify them. [ABSTRACT FROM AUTHOR]

Negative posttraumatic cognitions (NPCs) have been linked to symptoms of PTSD and are an important target of cognitive behavioral treatments for PTSD, including Cognitive Processing Therapy (CPT). Yet to be explored are the different change trajectories of NPCs during CPT. Knowledge of such change trajectories could elucidate common NPC change processes within CPT and their relationship to PTSD symptom severity. We examined NPC change trajectories in a group of 443 veterans who completed a 2-week intensive CPT program. We identified four NPC trajectory groups termed start high end high, start high end moderate, start moderate end low, and start low end low. Most of the groups showed an increase in NPCs at the midpoint of treatment before ultimately decreasing. As predicted, baseline PTSD symptom severity predicted change trajectory group membership. Also, NPC change trajectories were associated with PTSD severity at the end of treatment such that individuals in smaller NPC change groups had higher PTSD symptoms at the end of treatment, and vice versa. Clinicians can use this knowledge to make predictions of a particular client's NPC change trajectory and set expectations for what progress in treatment may look like, including normalizing increases in NPCs from the start of treatment. [ABSTRACT FROM AUTHOR]

Melanoma represents a public health issue. One of the biggest goals of current research is to develop new therapeutic options for patients affected by this aggressive tumor. We conducted a retrospective study including 105 patients diagnosed with cutaneous and ocular melanoma, with stages varying from pT1a to pT4b and pT4e, respectively, and we performed immunohistochemistry reactions with the new potential prognostic marker, VISTA (V-domain Ig suppressor of T cell activation). We quantified the expression by applying the H-score adapted for VISTA and divided the patients, based on the median value, into groups that presented high, low, and negative expression. Therefore, we obtained 65 cases with positive expression for cutaneous melanoma and 8 cases with positive expression for ocular melanoma. Forty-one cases presented high expression in cutaneous melanoma and three cases presented high expression in ocular melanoma. In cutaneous melanoma, analytic statistics showed that VISTA expression was associated with a high Breslow index, high mitotic count, high Ki67 expression, and advanced clinicopathological stage. The majority of ocular melanoma cases demonstrating a positive reaction were classified as stage pT3, whereas earlier stages showed a negative reaction. Our findings underscore a significant correlation between VISTA expression and key prognostic factors in melanoma. Looking ahead, the prospect of future randomized studies holds promise in corroborating the clinical relevance of our findings. By further elucidating the intricate relationship between VISTA expression and melanoma progression, new treatment strategies could be found, improving patient outcomes in this challenging neoplasm. [ABSTRACT FROM AUTHOR]

Entangled photon spectroscopy is a nascent field that has important implications for measurement and imaging across chemical, biology, and materials fields. Entangled photon spectroscopy potentially offers improved spatial and temporal-frequency resolutions, increased cross sections for multiphoton and nonlinear measurements, and new abilities in inducing or measuring quantum correlations. A critical step in enabling entangled photon spectroscopies is the creation of high-flux entangled sources that can use conventional detectors as well as provide redundancy for the losses in realistic samples. Here, we report a periodically poled, chirped, lithium tantalate platform that generates entangled photon pairs with ∼10−7 efficiency. For a near watt level diode laser, this results in a near μW-level flux. The single photon per mode limit that is necessary to maintain non-classical photon behavior is still satisfied by distributing this power over up to an octave-spanning bandwidth. The spectral–temporal photon correlations are observed via a Michelson-type interferometer that measures the broadband Hong–Ou–Mandel two-photon interference. A coherence time of 245 fs for a 10 nm bandwidth in the collinear case and a coherence time of 62 fs for a 125 nm bandwidth in the non-collinear case are measured using a CW pump laser and, essentially, collecting the full photon cone. We outline in detail the numerical methods used for designing and tailoring the entangled photons source, such as changing center wavelength or bandwidth, with the ultimate aim of increasing the availability of high-flux UV–Vis entangled photon sources in the optical spectroscopy community. [ABSTRACT FROM AUTHOR]

Caffeine is the most consumed psychoactive substance worldwide. Previous studies suggested higher caffeine consumption in subjects with schizophrenia spectrum disorders (SSD) as well as associations with symptoms, medication and medication side-effects. In a large and well-characterized sample of SSD subjects we explored the association between caffeine consumption and clinical (psychosis related, severity, general health) as well as pharmacological (antipsychotic treatment, sedation potential) variables. Eight hundred four subjects with data on their caffeine (coffee and tea) consumption successively recruited were included in this study. After controlling for potential confounders (demographic variables, smoking) only the negative dimension of psychosis was associated with the amount of caffeine ingested. Less severe negative symptoms were associated with higher caffeine consumption. The effect size of this association was small (partial correlation coefficient = −0.12) but significant. • Higher caffeine consumption was associated with lower negative symptoms. • This association was still significant after adjustment for multiple confounders. • A more sedative treatment was associated with higher caffeine consumption. • Taking into account smoking the association with treatment was no more significant. • Caffeine consumption was not associated with anxiety or quality of sleep. [ABSTRACT FROM AUTHOR]

Flat shaped glucose curves (FC) during oral glucose tolerance test (OGTT) in pregnant women (PW) are a not uncommon finding. We aimed to define the FC incidence in a large PW cohort and to describe the status of insulin and C-peptide secretion in women with FC when compared with a well-matched control group. 1050 PW performing OGTT for gestational diabetes screening were enrolled. An increase <6 % in plasma glucose (PG) during OGTT defined a FC. Serum samples for measuring insulin and C-peptide were also obtained. 61 (5.8 %) women showed a FC. 60 of them, paired to a group of 60 no-FC women matched for age, body mass index and gestational age, were further investigated. C-peptide and insulin concentrations were significantly lower (P < 0.001) in FC in both 1-h and 2-h OGTT samples. When incremental area under the curves (AUC) normalized to PG were estimated, only AUC insulin remained however significantly lower. The insulin sensitivity index was higher in FC. PW with FC showed a hypersensitivity to insulin with normal β-cell function. Moreover, a delayed glucose absorption could be hypothesised because of the slight but continuously increasing shape of insulin curve found in FC group. Both phenomena could occur in parallel and contribute to FC. [ABSTRACT FROM AUTHOR]

In medical laboratories, the appropriateness challenge directly revolves around the laboratory test and its proper selection, data analysis, and result reporting. However, laboratories have also a role in the appropriate management of those phases of total testing process (TTP) that traditionally are not under their direct control. So that, the laboratory obligation to act along the entire TTP is now widely accepted in order to achieve better care management. Because of the large number of variables involved in the overall TTP structure, it is difficult to monitor appropriateness in real time. However, it is possible to retrospectively reconstruct the body of the clinical process involved in the management of a specific laboratory test to track key passages that may be defective or incomplete in terms of appropriateness. Here we proposed an appropriateness check-list scheme along the TTP chain to be potentially applied to any laboratory test. This scheme consists of a series of questions that healthcare professionals should answer to achieve laboratory test appropriateness. In the system, even a single lacking answer may compromise the integrity of all appropriateness evaluation process as the inability to answer may involve a significant deviation from the optimal trajectory, which compromise the test appropriateness and the quality of subsequent steps. Using two examples of the check-list application, we showed that the proposed instrument may offer an objective help to avoid inappropriate use of laboratory tests in an integrated way involving both laboratory professionals and user clinicians. [ABSTRACT FROM AUTHOR]

The primary advancements related to improving the sustainability of concrete continue to focus on the reduction of carbon dioxide associated with the ingredients. The second most significant efforts are focused on the durability and longevity of concrete. While efforts in all these areas are very important, there are other ways to further improve the sustainability of the built environment with concrete, some having more significant long-term environmental benefits than further reductions of carbon dioxide of materials used to produce concrete. These benefits are often overlooked without proper consideration of available concrete systems. Proper consideration requires integrating the concrete system that economically satisfies the overall project requirements at the beginning of the design process. The discussion and examples provide information for designers and owners to consider the sustainability benefits of appropriate concrete system selection and consideration of the multi-attributes of concrete. This information is presented to encourage designers and owners to select concrete systems that minimise negative environmental impacts and improve the understanding of concrete construction compared with construction using other systems. [ABSTRACT FROM AUTHOR]

The mechanisms controlling membrane recognition by proteins with one hydrophobic stretch at their carboxyl terminus (tail anchor, TA) are poorly defined. The Escherichia coli TAs of ElaB and YqjD, which share sequential and structural similarity with the Saccharomyces cerevisiae TA of Fis1, were shown to localize to mitochondria. We show that YqjD and ElaB are directed by their TAs to bacterial cell poles. Fis1(TA) expressed in E. coli localizes like the endogenous TAs. The yeast and bacterial TAs are inserted in the E. coli inner membrane, and they all show affiliation to phosphatidic acid (PA), found in the membrane of the bacterial cell poles and of the yeast mitochondria. Our results suggest a mechanism for TA membrane recognition conserved from bacteria to mitochondria and raise the possibility that through their interaction with PA, and TAs play a role across prokaryotes and eukaryotes in controlling cell/organelle fate. [ABSTRACT FROM AUTHOR]

Pre-analytical plasma glucose (PG) sampling methodology may significantly affect gestational diabetes mellitus (GDM) incidence, but no studies directly examined the impact on perinatal outcomes. We compared the effect on oral glucose tolerance test (OGTT) results of using for blood sampling the traditional sodium fluoride (NaF) tubes, batched at controlled temperature, and the more effective citrate-buffered tubes, in terms of GDM diagnosis and related outcomes. We evaluated 578 pregnant women performing OGTT between 24- and 28-weeks' gestation. Paired NaF and citrate blood samples were drawn and analyzed for PG. GDM diagnosis was made by applying the 'one-step' American Diabetes Association strategy. Data on perinatal outcomes were collected in a subset of 330 women who delivered in our hospital network. Using the standard NaF approach, 69 (11.9%) GDM women were detected. Using citrate PG values, 90 women were additionally identified as GDM, increasing the GDM prevalence to 27.5%. Perinatal outcomes were analyzed according to the different diagnostic allocation (NaF-diagnosed GDM, additional citrate-diagnosed GDM, and no GDM). NaF-diagnosed GDM showed a higher incidence of large for gestational age (LGA) (p=0.034), and of cesarean and preterm delivery (p<0.01) vs. no GDM. The only outcome remaining more frequent in the additional citrate diagnosed GDM when compared with no GDM group was LGA (17.2 vs. 6.8%, p=0.025). If a health care system plans to use citrate tubes for GDM diagnosis, considerations about clinical implications are mandatory by balancing higher sensitivity in detecting a poor glycemic control with effects on outcomes to avoid "overdiagnosis". [ABSTRACT FROM AUTHOR]

There is undoubtedly, and understandably, a growing interest in incorporating generative artificial intelligence (GenAI) technologies into ELT. While advanced AI models have the potential to support language education, offering new tools and resources to enhance learning, their use also raises important questions regarding ethics and responsibility. As we follow the emergence of GenAI as another ELT tool, it is crucial to strike a balance between leveraging the benefits of these technologies and maintaining the core values of effective pedagogy. Educators must develop clear guidelines and best practices for the responsible integration of AI in the classroom, ensuring that it enhances rather than replaces human interaction and critical thinking. In this Special Issue on GenAI and ELT we explore some of the applications, their potential, and the challenges of incorporating GenAI in ELT. [ABSTRACT FROM AUTHOR]

Survivors of intimate partner violence (IPV) experience a vast array of emotional and behavioral consequences, including difficulties in areas related to emotion regulation, and they often qualify for comorbid psychological diagnoses. Although a modified version of DBT has been examined as a treatment for survivors of IPV experiencing emotional dysregulation, there has been little mention of how to treat comorbid disorders among this population. Given that body focused repetitive behaviors (BFRB's), such as trichotillomania, can be conceptualized as poor coping mechanisms to soothe dysregulated emotions, it seems beneficial to understand how to treat these diagnoses in the context of IPV sequelae. To date, there are limited examinations of DBT enhanced cognitive behavioral therapy for those suffering from IPV exposure and trichotillomania. The following case provides a successful example for how and why such therapy can be conducted for the treatment of comorbid diagnoses following IPV exposure. [ABSTRACT FROM AUTHOR]

A new etiological model is proposed for schizophrenia that combines variability‐enhancing nonspecific factors acting during development with more specific risk factors. This model is better suited than the current etiological models of schizophrenia, based on the risk factors paradigm, for predicting and/or explaining several important findings about schizophrenia: high co‐morbidity rates, low specificity of many risk factors, and persistence in the population of the associated genetic polymorphisms. Compared with similar models, e.g., de‐canalization, common psychopathology factor, sexual‐selection, or differential sensitivity to the environment, this proposal is more general and integrative. Recently developed research methods have proven the existence of genetic and environmental factors that enhance developmental variability. Applying such methods to newly collected or already available data can allow for testing the hypotheses upon which this model is built. If validated, this model may change the understanding of the etiology of schizophrenia, the research models, and preventionbrk paradigms. [ABSTRACT FROM AUTHOR]

Language is an essential part of psychotherapy and experts in cultural competence encourage the consideration of language as an element in cultural adaptation to therapy. Providing clients with services in their native language is associated with lower dropout and better outcomes. Therapies such as prolonged exposure therapy (PET) for posttraumatic stress disorder (PTSD) require clients to recount trauma memories to activate and correct overreactive fear networks in the brain. Research shows that the most genuine and detailed recall of these autobiographical memories occurs when people recollect in the same language in which the memory was encoded. Clients are less likely to drop out, tend to see better outcomes, and most closely follow the treatment protocol for PET when speaking in their native language. In an increasingly bilingual world, therapists may share a common language with a client but may be unable to speak the client's native language. A novel solution for PET involves starting therapy in the therapist/client dyad's shared language and then eventually conducting imaginal exposures in the client's native language. The following case provides a successful example for how and why such therapy can be conducted. [ABSTRACT FROM AUTHOR]

Abstract Several groups have demonstrated that induction of heme-oxygenase-1 (HO-1) could protect the myocardium against ischemic events; however, heme accumulation could lead to toxicity. The aim of the present study was to investigate the role of autophagy in heme toxicity. H9c2 cardiomyoblast cells were treated with different dose of hemin or cobalt-protoporphyrin IX (CoPP IX) or vehicle. Cell viability was measured by MTT assay. DCF and MitoSOX staining was employed to detect reactive oxygen species. Western blot analysis was performed to analyse the levels of HO-1, certain autophagy related proteins and pro-caspase-3 as an apoptosis marker. To study the autophagic flux, CytoID staining was carried out and cells were analyzed by fluorescence microscope and flow cytometry. Decreased cell viability was detected at high dose of hemin and CoPP IX treated H9c2 cells in a dose-dependent manner. Furthermore, at concentration of the inducers used in the present study a significantly enhanced level of ROS were detected. As it was expected both treatments induced a robust elevation of HO-1 level. In addition, the Beclin-1- independent autophagy was significantly increased, but caused a defective autophagic flux with triggered activation of caspase-3. In conclusion, these results suggest that overexpression of HO-1 by high dose of hemin and CoPP IX can induce cell toxicity in H9c2 cells via enhanced ROS level and impaired autophagy. Graphical abstract Image 1 Highlights • Hemin and CoPP IX decrease H9c2 cell viability in a dose dependent manner. • High dose of hemin and CoPP IX induce enhanced ROS generation. • High dose of hemin and CoPP IX induce malfunctioning autophagy. [ABSTRACT FROM AUTHOR]

Recent evidence from studies suggests that aged black garlic also has an effect on health. The major aim of the present study is to compare the effect of raw and aged black garlic on postischemic cardiac recovery. Male Sprague Dawley rats were randomly divided into three groups. Animals of the first group were fed with raw garlic, animals of the second group received aged black garlic, while the third group served as vehicle-treated controls. Upon conclusion of the treatment, isolated hearts were undertaken to ischemia/reperfusion. Heart function and infarct size were measured and the level of HO-1 and iNOS were studied. Superior postischemic cardiac function and reduced infarct size in both garlic treated groups compared to the drug-free control group, indicated cardioprotective effects. However, no significant differences between the garlic treated groups were observed. Western blot analysis revealed that raw garlic enhanced the level of HO-1 before ischemia, while in ischemic samples, we found elevated HO-1 expression in both garlic treated groups. The level of iNOS was the same before ischemia in all groups, however, a markedly reduced iNOS level in ischemic/reperfused hearts originating from control and raw garlic treated animals was observed. Samples from aged black garlic treated animals demonstrated that the level of iNOS was not significantly reduced after ischemia/reperfusion. Taken together these results indicate that not only raw but also aged black garlic possess a cardioprotective effect. [ABSTRACT FROM AUTHOR]

Keywords: D-dimer; minimum retesting interval; testing appropriateness EN D-dimer minimum retesting interval testing appropriateness e175 e176 2 06/21/22 20220701 NES 220701 To the Editor, We read with great interest the review by Lang updating the experience about the application of the minimum retesting interval (MRI) concept [[1]]. For evaluating the efficacy and cost-effectiveness of this intervention, we collected data from laboratory information system about numbers of requested D-dimer tests through the same 9 month period (March-November 2017 vs. 2018), before and after the CPOE-based intervention. [Extracted from the article]

Childhood traumas have been extensively associated with the development of psychotic disorders. However, our understanding of processes underlying this relationship remains poor. In order to address this issue, we examined which specific aspects of childhood trauma are significantly associated with a first episode of psychosis. 109 patients with first episode of psychosis and 145 controls representative from general population were recruited in three centers in France. Child experiences of care and abuses allowed obtaining information about types of childhood trauma, age at first exposure, identity of perpetrator, and social support. Odds ratio were calculated for each of these aspects, adjusted for age, sex, and education. Sexual and physical abuses (OR = 2.26 (1.19–4.32)), and separation from one or both parents (OR ranging from 1.94 to 3.17; all significant) are significantly associated with an increased risk to present a first episode of psychosis. Furthermore, separation from mother occurring before age of 4 (OR = 5.96 (1.24–28.77)), and sexual and physical abuses perpetrated by someone other than parents (OR = 4.61 (1.66–12.80)) were also associated with an increased risk of first episode of psychosis. Finally, social support was significantly associated with a decreased risk to develop psychotic disorders (OR ranging from 0.33 to 0.42; all significant). Together, these findings suggest that some but not all aspects of childhood trauma are related to a significant risk to develop a first episode of psychosis. [ABSTRACT FROM AUTHOR]

There is conflicting evidence about the role of folate and B 12 in gestational diabetes mellitus (GDM) onset. The association of vitamin status with GDM was therefore revalued, also measuring the B 12 active form holotranscobalamin. 677 women were evaluated at 24–28 weeks of gestation when OGTT was carried out. The 'one-step' strategy was employed for GDM diagnosis. Odds ratio (OR) of having GDM was estimated to quantify the association with vitamin levels. 180 women (26.6%) had GDM. They were older (median, 34.6 vs. 33.3 years, p = 0.019) and had higher body mass index (BMI) (25.8 vs. 24.1 kg/m2, p < 0.001). Multiparous women had lower levels of all evaluated micronutrients, while overweight lowered both folate and total B 12 , but not holotranscobalamin. Lower total B 12 (270 vs. 290 ng/L, p = 0.005), but not holotranscobalamin, was observed in GDM, being weakly negatively correlated with fasting glycemia (r = −0.11, p = 0.005) and 1-h OGTT serum insulin (r = −0.09, p = 0.014). At multivariate analysis, age, BMI and multiparity remained the strongest GDM predictors, while total B 12 (but not holotranscobalamin and folate) showed a slight protective effect (OR = 0.996, p = 0.038). A weak association between total B 12 levels and GDM risk was shown, but it was not confirmed when holotranscobalamin was measured. [ABSTRACT FROM AUTHOR]

SPEDEN is a computer program that reconstructs the electron density of single particles from their X-ray diffraction patterns, using a single-particle adaptation of the holographic method in crystallography [Szöke, Szöke & Somoza (1997). Acta Cryst. A53, 291-313]. The method, like its parent, is unique because it does not rely on 'back' transformation from the diffraction pattern into real space and on interpolation within measured data. It is designed to deal successfully with sparse, irregular, incomplete and noisy data. It is also designed to use prior information for ensuring sensible results and for reliable convergence. This article describes the theoretical basis for the reconstruction algorithm, its implementation, and quantitative results of tests on synthetic and experimentally obtained data. The program could be used for determining the structures of radiation-tolerant samples and, eventually, of large biological molecular structures without the need for crystallization. [ABSTRACT FROM AUTHOR]

Purpose: We sought to determine whether significant variation in the incidence of clinically relevant psychoses existed at an ecological level in an urban French setting, and to examine possible factors associated with this variation. We aimed to advance the literature by testing this hypothesis in a novel population setting and by comparing a variety of spatial models.Methods: We sought to identify all first episode cases of non-affective and affective psychotic disorders presenting in a defined urban catchment area over a 4 years period, over more than half a million person-years at-risk. Because data from geographic close neighbourhoods usually show spatial autocorrelation, we used for our analyses Bayesian modelling. We included small area neighbourhood measures of deprivation, migrants' density and social fragmentation as putative explanatory variables in the models.Results: Incidence of broad psychotic disorders shows spatial patterning with the best fit for models that included both strong autocorrelation between neighbouring areas and weak autocorrelation between areas further apart. Affective psychotic disorders showed similar spatial patterning and were associated with the proportion of migrants/foreigners in the area (inverse correlation). In contrast, non-affective psychoses did not show spatial patterning.Conclusions: At ecological level, the variation in the number of cases and the factors that influence this variation are different for non-affective and affective psychotic disorders. Important differences in results-compared with previous studies in different settings-point to the importance of the context and the necessity of further studies to understand these differences. [ABSTRACT FROM AUTHOR]

The Marshall Fire on 30 December 2021 became the most destructive wildfire costwise in Colorado history as it evolved into a suburban firestorm in southeastern Boulder County, driven by strong winds and a snow-free and drought-influenced fuel state. The fire was driven by a strong downslope windstorm that maintained its intensity for nearly 11 hours. The southward movement of a large-scale jet axis across Boulder County brought a quick transition that day into a zone of upper-level descent, enhancing the midlevel inversion providing a favorable environment for an amplifying downstream mountain wave. In several aspects, this windstorm did not follow typical downslope windstorm behavior. NOAA rapidly updating numerical weather prediction guidance (including the High-Resolution Rapid Refresh) provided operationally useful forecasts of the windstorm, leading to the issuance of a High-Wind Warning (HWW) for eastern Boulder County. No Red Flag Warning was issued due to a too restrictive relative humidity criterion (already published alternatives are recommended); however, owing to the HWW, a countywide burn ban was issued for that day. Consideration of spatial (vertical and horizontal) and temporal (both valid time and initialization time) neighborhoods allows some quantification of forecast uncertainty from deterministic forecasts—important in real-time use for forecasting and public warnings of extreme events. Essentially, dimensions of the deterministic model were used to roughly estimate an ensemble forecast. These dimensions including run-to-run consistency are also important for subsequent evaluation of forecasts for small-scale features such as downslope windstorms and the tropospheric features responsible for them, similar to forecasts of deep, moist convection and related severe weather. Significance Statement: The Front Range windstorm of 30 December 2021 combined extreme surface winds (>45 m s−1) with fire ignition resulting in an extraordinary and quickly evolving, extremely destructive wildfire–urban interface fire event. This windstorm differed from typical downslope windstorms in several aspects. We describe the observations, model guidance, and decision-making of operational forecasters for this event. In effect, an ensemble forecast was approximated by use of a frequently updated deterministic model by operational forecasters, and this combined use of temporal, spatial (horizontal and vertical), and other forecast dimensions is suggested to better estimate the possibility of such extreme events. [ABSTRACT FROM AUTHOR]

Transitional justice programs traditionally focused on breaches of civil and political rights and violations of bodily integrity, largely ignoring violations of economic and social rights (ESRs) and relegating socioeconomic issues to the category of 'background' or context. This approach is becoming increasingly untenable given that ESRs articulate binding and increasingly justiciable legal obligations. Considering past ESR violations can also provide crucial insight into the causes of past conflict, and addressing socioeconomic grievances can help to reduce the chances of future rights violations or civil unrest. This Article sets out when transitional justice ought concern itself with breaches of ESRs using the 'respect, protect, fulfill' framework of state obligations. Drawing on past examples, the Article argues that failures to respect and protect ESRs are usually discrete enough to be included in the mandates of truth commissions, reparations schemes, and, in some cases, criminal prosecutions. Decentralization programs and the vetting of corrupt economic actors can also effectively address past ESR violations and lead to socioeconomic improvements. Addressing state failures to fulfill ESRs is a more complicated question, although there are occasions where such violations should be included in transitional justice mandates. Ultimately, transitional justice can no longer ignore that ESRs articulate non-negotiable and clearly defined standards, which often hold the key to stable and sustainable political transitions. [ABSTRACT FROM AUTHOR]

This Article focuses on the right to truth and its interaction with the duty to bring perpetrators to justice following a period of gross violations of international human rights law and serious violations of international humanitarian law. It explores how truth-finding and criminal justice programs interact, and how States can most comprehensively satisfy their obligations with regard to the right to truth and the duty to bring perpetrators to justice, given the raft of practical limitations that a State may face in periods of political transition. The Article argues that even when a State is able to carry out prosecutions, it is likely obliged to look for additional strategies, including truth commissions, to more comprehensively fulfill its international human rights obligations. Additionally, where an exhaustive suite of prosecutions is not feasible in the short term, truth commissions and other transitional justice mechanisms can be employed to commence the fulfillment of the right to truth, though these should be implemented with a view to proceeding to thorough criminal justice processes as soon as the State's political context permits. [ABSTRACT FROM AUTHOR]

Abstract: Cannabis consumption can cause abuse and dependence and increase risk of developing psychiatric and somatic disorders. Several literature reviews explored the link between cannabis consumption and schizophrenia but none summarized the rich literature on cannabis and psychometric schizotypy. The aim of our review is to synthesize data from studies that explored the association between cannabis consumption and schizoptypal dimensions. A systematic review of the literature and, when needed, contact with the authors, allowed us to gather data from 29 cross-sectional studies. We compared schizotypy scores between subjects that never used cannabis and subjects that used it at least once (“never vs. ever”) and between current users and subjects that do not use cannabis currently (“current vs. other”). We conducted separate analyses for total schizotypy score and each of the three classical schizotypal dimensions (positive, negative, disorganized). For all eight comparisons, the cannabis group (“ever” or “current”) had higher schizotypy scores. Differences were in the small or medium range and, with the exception of the negative score in the current vs. other comparison, statistically significant. Cannabis consumption is associated with increased schizotypal traits. More research, using different approaches (e.g. longitudinal studies) is needed to explore the cause of this association. [Copyright &y& Elsevier]

Abstract: Bioaugmentation with ammonium oxidizing bacteria (AOB) was tested for 620d. A seeding reactor (R1), two seeded reactors (R2 at 21°C; R3 at 15°C) and an unseeded-control reactor (R4 at 21°C) were operated in parallel (2.4

The sentencing process of the International Criminal Tribunal for Rwanda (ICTR) is deficient. In seeking to distinguish between the gravity of each offender’s conduct and by failing to properly consider the sentencing practices of Rwanda’s domestic courts, the ICTR often inadvertently belittles the suffering caused by offences related to the 1994 genocide. This article addresses the ICTR’s relatively unfettered sentencing discretion and tendency to under-explain its methodology. It then carries out a retributivist critique of ICTR sentencing practices and explores expressivism as a means of addressing current retributive deficiencies. A more expansive use of cumulative sentencing involving a proportionate penalty for the harm caused to each victim, it is argued, would have both symbolic and practical consequences for the offender. [ABSTRACT FROM PUBLISHER]

The purpose of this study was to establish a nomogram in order to predict limb length discrepancies in children with unilateral fibular hemimelia more accurately. In 31 children with unilateral fibular hemimelia the femoral-tibial length and skeletal age were determined an average of seven times per case by sequential radiographs during growth. From the data, a skeletal age nomogram was developed which shows a steeply declining mean skeletal age pattern in unilateral fibular hemimelia (the slope in girls was −0.59 and in boys −0.64). This nomogram crosses the normal mean skeletal age line of the Moseley straight-line graph at 10.5 years in girls and at 12 years in boys, and continues to decline until maturity. The results demonstrate an abnormal skeletal maturation process in patients with unilateral fibular hemimelia. The consistently declining steep skeletal age nomogram in unilateral fibular hemimelia makes prediction of skeletal maturity and limb length discrepancy inaccurate by the standard predictive methods particularly when using early skeletal ages. The skeletal age nomogram from our data determines skeletal maturation in children with unilateral fibular hemimelia more accurately, and allows a correct prediction of limb length discrepancy. [ABSTRACT FROM AUTHOR]

A letter to the editor is presented in response to an article by T. Teodoro-Morrison et al that reported the evaluation of the direct whole blood enzymatic assay for hemoglobin A1c on the Architect c8000 platform.

OBJECTIVE -- To examine the effect of aging on insulin secretion (first- and second-phase insulin release) and insulin sensitivity in people with normal glucose tolerance (NGT) or impaired glucose tolerance (IGT). RESEARCH DESIGN AND METHODS -- First- and second-phase insulin secretion and insulin sensitivity were assessed in hyperglycemic clamp experiments in 266 individuals with NGT and 130 individuals with IGT, ranging in age from ∼20 to ∼70 years. Changes in β-cell function were compared using the disposition index to adjust for differences in insulin sensitivity. RESULTS -- As expected, both phases of insulin release and insulin sensitivity were reduced in individuals with IGT (all P < 0.01). Insulin sensitivity was not independently correlated with age in either group. In people with NGT, the disposition index for first- and second-phase insulin release decreased similarly at a rate of ∼0.7% per year. In people with IGT, the disposition indexes for first- and second-phase insulin release decreased at greater rates (∼2.2 and 1.4% per year, P = 0.002 and 0.009, respectively, vs. NGT), with the decrease in first phase being greater than that of second phase (P = 0.025). CONCLUSIONS -- Insulin secretion (both first and second phase) normally decreases at a rate of ∼0.7% per year with aging; this decrease in β-cell function is accelerated about two-fold in people with impaired glucose tolerance--first phase to a greater extent than second phase. Finally, aging per se has no effect on insulin sensitivity independent of changes in body composition. [ABSTRACT FROM AUTHOR]

Abstract: Objective: Schizoaffective disorder could be considered as a form of schizophrenia, a form of bipolar disorder, an independent disorder or a disorder intermediate between bipolar disorder and schizophrenia, within a psychotic continuum. The study of cognitive deficits in subjects with those diagnoses could help differentiate between these possibilities. Methods: We compared cognitive performances of schizoaffective (SZAff) subjects with those of subjects with schizophrenia (SZ), bipolar disorder with psychotic symptoms (life-time) (BDP), bipolar disorder without life-time occurrence of psychotic symptoms (BD) and normal controls (NC). We used two tests of executive functions – the Wisconsin Card Sorting Test (WCST) and the Trail-making Test (TMT) – that are known to be impaired in those disorders. Results: The number of perseverative errors on WCST was highest in SZ subjects and gradually decreased in SZAff, BDP and, finally in BD subjects. By contrast, SZ and SZAff subjects obtained similar scores in the TMT, as did BD and BDP patients. Conclusions: These results suggest that, for some deficits, there may be a continuum between SZ, SZAff and affective disorders, whereas SZAff patients most closely resemble SZ patients for other deficits. This implies that different conceptual views about schizoaffective disorder should be seen as complementary, rather than mutually exclusive. [Copyright &y& Elsevier]

To assess mechanisms for postprandial hyperglycemia, we used a triple-isotope technique ([\3-³H]glucose and [14C]bicarbonate and oral [6,6-dideutero]glucose iv) and indirect calorimetry to compare components of glucose release and pathways for glucose disposal in 26 subjects with type 2 diabetes and 15 age-, weight-, and sex-matched normal volunteers after a standard meal. The results were as follows: 1) diabetic subjects had greater postprandial glucose release (P < 0.001) because of both increased endogenous and meal-glucose release; 2) the greater endogenous glucose release (P < 0.001) was due to increased gluconeogenesis (P < 0.001) and glycogenolysis (P = 0.01): 3) overall tissue glucose uptake, glycolysis, and storage were comparable in both groups (P > 0.3); 4) glucose clearance (P < 0.001) and oxidation (P = 0.004) were reduced, whereas nonoxidative glycolysis was increased (P = 0.04); and 5) net splanchnic glucose storage was reduced by ∼45% (P = 0.008) because of increased glycogen cycling (P = 0.03). Thus in type 2 diabetes, postprandial hyperglycemia is primarily due to increased glucose release; hyperglycemia overcomes the effects of impaired insulin secretion and sensitivity on glucose transport, but intracellular defects persist so that pathways of glucose metabolism are abnormal and glucose is shunted away from normal sites of storage (e.g., liver and muscle) into other tissues. [ABSTRACT FROM AUTHOR]

OBJECTIVE -- Animal and in vitro studies indicate that a decrease in β-cell insulin secretion, and thus a decrease in tonic α-cell inhibition by intraislet insulin, may be an important factor for the increase in glucagon secretion during hypoglycemia. However, in humans this role of decreased intraislet insulin is still unclear. RESEARCH DESIGN AND METHODS -- We studied glucagon responses to hypoglycemia in 14 nondiabetic subjects on two separate occasions. On both occasions, insulin was infused from 0 to 120 min to induce hypoglycemia. On one occasion, somatostatin was infused from -60 to 60 min to suppress insulin secretion, so that the decrement in intraislet insulin during the final 60 min of hypoglycemia would be reduced. On the other occasion, subjects received an infusion of normal saline instead of the somatostatin. RESULTS -- During the 2nd h of the insulin infusion, when somatostatin or saline was no longer being infused, plasma glucose (∼2.6 mmol/l) and insulin levels (∼570 pmol/l) were comparable in both sets of experiments (both P > 0.4). In the saline experiments, insulin secretion remained unchanged from baseline (-90 to -60 min) before insulin infusion and decreased from 1.20 ± 0.12 to 0.16 ± 0.04 pmol ⋅ kg-1 ⋅ min-1 during insulin infusion (P < 0.001). However, in the somatostatin experiments, insulin secretion decreased from 1.18 ± 0.12 pmol ⋅ kg-1 ⋅ min-1 at baseline to 0.25 ± 0.09 pmol ⋅ kg-1 ⋅ min-1 before insulin infusion so that it did not decrease further during insulin infusion (-0.12 ± 0.10 pmol ⋅ kg-1 ⋅ min-1, P = 0.26) indicating the complete lack of a decrement in intraislet insulin during hypoglycemia. This was associated with ∼30% lower plasma glucagon concentrations (109 ± 7 vs. 136 ± 9 pg/ml, P < 0.006) and increments in plasma glucagon above baseline (41 ± 8 vs. 67 ± 11 pg/ml, P < 0.008) during the last 15 min of the hypoglycemic clamp. In contrast, increases in plasma growth hormone were ∼70% greater during hypoglycemia after somatostatin infusion (P < 0.007), suggesting that to some extent the increases in plasma glucagon might have reflected a rebound in glucagon secretion. CONCLUSIONS -- These results provide direct support for the intraislet insulin hypothesis in humans. However, the exact extent to which a decrement in intraislet insulin accounts for the glucagon responses to hypoglycemia remains to be established. [ABSTRACT FROM AUTHOR]

Since 1988, the Victorian Government has required that any birth resulting from the use of donor gametes or embryos should be registered on a Central Register. Fifteen years of experience of administering these Registers provides some indication of trends in the recruitment of sperm donors, but also the continuing challenge for families of how to tell their children about their birth origins. [Copyright &y& Elsevier]

Objective: Clinical, familial, and, more recently, genetic linkage studies suggest that overlapping genetic susceptibility might contribute to both schizophrenia and bipolar disorder. To identify a potential psychotic dimension common to families of both bipolar and schizophrenia probands, the authors tested if delusional proneness was observed among first-degree relatives of bipolar and schizophrenia probands. Method: The authors included 32 schizophrenia probands and 61 bipolar probands and their respective first-degree relatives (N=63 and N=59). They were all interviewed with the Diagnostic Interview for Genetic Studies, and delusional proneness was assessed with a self-report questionnaire, the Peters et al. Delusions Inventory. Schizophrenia and bipolar probands were subdivided into subgroups according to the intensity of delusional symptoms assessed by Peters et al. Delusions Inventory scores, and the authors compared delusional proneness in their respective first-degree relatives. Results: Familial aggregation of delusional proneness was demonstrated, since Peters et al. Delusions Inventory scores were higher among nonschizophrenic first-degree relatives of schizophrenia probands with productive symptoms and among first-degree relatives of bipolar probands with psychotic features during their affective episodes. The authors also found an intrafamilial correlation of delusional proneness scores in nonaffected siblings of schizophrenia and bipolar probands. Conclusions: Delusional proneness appears to be an inherited predisposition common to both schizophrenia and bipolar disorder. In the future, this dimension might be valuable when used as a quantitative phenotype in linkage and association studies. [ABSTRACT FROM AUTHOR]

Salt rejection and ion selectivity of NF-255 and NF-45 nanofiltration (NF) membranes were investigated. The rejection of two cations (Na+, Ca2+) and two anions (Cl−, SO42−) which are common in natural and in industrial wastewater, were studied as a function of pH at permanent pressure and temperature. The ion rejection of NF membranes were investigated in single salt solutions like NaCl, CaCl2, Na2SO4, CaSO4, and in multicomponent systems that contained all the previous ions. We found that, there is a minimum rejection of the Na+ and Cl− ions between pH 4–5 in NF-255 and between pH 7–8 in NF-45. The rejection of calcium ions were increased in each case at lower pH in both membranes. However the pH value where the ion rejection behaviour of membranes changed, were different: pH 4 in NF-255 and pH 8 in NF-45. In NF-45 the chloride ion has negative rejection which depends on the quality of ions and the pH. We found that below pH values of 4 the selectivity of mono- and multivalent cations considerable increased in NF-255. This phenomena may be used for separation of calcium ions from sodium ions from weakly acidic (hydrochloric and sulfuric acid) solution, e.g. regeneration solution of sodium form softening ion exchangers. [Copyright &y& Elsevier]

This paper proposes a new physical method for the partial solution of the crystallographic phase problem by illuminating the crystal with an X-ray beam of limited coherence. The diffraction spots broaden and, if the coherence length of the incident beam is small enough in all three dimensions, the diffraction pattern becomes continuous. Independent information about the structure is then available both at the Bragg angles and at angles that do not satisfy the Bragg conditions. Under certain conditions, the total information is sufficient to solve the crystal structure ab initio. Two prescriptions for producing X-ray beams with limited coherence are given. [ABSTRACT FROM AUTHOR]

Presents a study that examined the isolation and characterization of a peptide, SNX-482, as a step toward the further study and potential therapeutic modulation of the class E calcium channel. Diversity of calcium channel isoforms and subtypes; Methodology; Results and discussion.

The holographic method solves the crystallographic inverse problem in real space. In addition to the measured structure-factor amplitudes, it uses other available information such as the positivity of the electron density, knowledge of part of the structure as well as MIR and/or MAD data. In the present paper, the range of useful information is extended to include knowledge that is statistical in nature. For example, it is known that the distribution of the structure-factor amplitudes of large molecules is described by Wilson statistics. Bayesian methods are used to optimize the signal-to-noise ratio of experimental measurements, to estimate missing reflections and to extrapolate measured data to higher resolution. In a similar vein, the cost function in the holographic algorithm is modified to account for the uncertainties of the measured structure factors. It is also shown how statistical knowledge about the unsolved part of the molecule may be utilized. [ABSTRACT FROM AUTHOR]

Since the downfall of the dictatorship, Hungary's approach to migration, traditionally a liberal one, is now mainly shaped by the country's intention to be reintegrated into Europe and, to have its migration practice harmonized with that of the Western democracies. Decision, makers in Budapest show no great concern about emigration, which is expected to remain relatively insignificant. Attention is therefore concentrated on the possibility of a massive influx of immigrants, especially from the neighboring states. This could easily undermine Hungary's political stability and economic development. The question of international migration can be addressed only in an all-European framework. Experts are convinced that migratory pressures originating in Eastern and Central Europe could be considerably limited by measures taken to guarantee the rights of ethnic minorities. [ABSTRACT FROM AUTHOR]

This article reports on a study which compared in-use tubes for blood glucose testing, containing sodium fluoride/oxalate and Venosafe tubes with fluoride-citrate mixture (VFC). Topics discussed including the benefit of using a blood collection tube containing a rapidly effective glycolysis inhibitor, the impact of the introduction of such tubes on diagnostic test results when compared with traditionally used approaches, and the potential impact of the tube replacement on population setting.

The article reports on research which was conducted to investigate the measurement of icteric index (II) as an approach to detect abnormal total bilirubin (TB) values. Researchers evaluated all of the measurements of TB requested to their laboratory between January and December 2011 and their corresponding II values. They found that while it was useful to use II to screen for elevated TB concentrations, the accuracy and effectiveness of the approach depended on the employed instrumentation.

Background: Recent international recommendations for the diagnosis of gestational diabetes (GD) were implemented in a university hospital. The aim was to audit the appropriateness of use of the new diagnostic approach. Methods: The same 5-month period, one before [2009, traditional two-step oral glucose tolerance test (OGTT) approach, S1] and one after the implementation of new criteria (2010, S2) were compared. Results: In the two periods, 256 (S1) and 245 (S2) pregnant women were examined and 298 (50 g, n=195; 100 g, n=103) and 252 (75 g) OGTTs were, respectively, executed. In S1, 54 (27.7%) 50 g OGTTs resulted positive and 36 (66.7%) of those performed the 100 g OGTT. In addition, three (1.5% of total) 50 g OGTT negative women were submitted to 100 g OGTT. Sixty-three women did 100 g OGTT only. In total, 14 (13.6%) 100 g OGTTs were positive. In S2, 38 (15.1%) 75 g OGTTs were positive. In women who did the complete protocol in the hospital, 98.3% in S1 and 77.0% in S2 performed the correct protocol (p<0.0001). Conclusions: In this hospital new recommendations for GD diagnosis are not correctly applied in 23% of cases. The main issue seems to be the lack of consideration of the new threshold for fasting glycemia (5.1 mmol/L) as a main decisional driver for performing OGTT. [ABSTRACT FROM AUTHOR]