1. Chemoprotective effects of inositol hexaphosphate against cyclophosphamide-induced testicular damage in rats.
- Author
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Alkhalaf, Maha I., Alansari, Wafa S., Alshubaily, Fawzia A., Alnajeebi, Afnan M., Eskandrani, Areej A., Tashkandi, Manal A., and Babteen, Nouf A.
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INOSITOL phosphates , *CYCLOPHOSPHAMIDE , *TESTICULAR diseases , *ANTINEOPLASTIC agents , *LABORATORY rats - Abstract
Cyclophosphamide (CP) is commonly used as an anticancer agent but has been associated with high toxicity in several animal organs, including the testes. Inositol hexaphosphate (IP6) is a polyphosphorylated carbohydrate that is present in foods with high fibre contents and has a wide range of essential physiological and pathological activities. Thus, we estimated the defensive effects of IP6 against CP-related testicular toxicity in rats. Sperm counts, motilities, viabilities and abnormalities and levels of testosterone, luteinising hormone and follicle-stimulating hormone were evaluated. Testicle specimens were also processed for histological and biochemical analyses, including determinations of malondialdehyde, nitric oxide, total antioxidant capacity, alkaline phosphatase, acid phosphatase, gamma glutamyl transferase, ß-glucuronidase, c-reactive protein, monocyte chemoattractant protein and leukotriene-4 and in comet assays. CP treatments were associated with deleterious histopathological, biochemical and genetic changes in rat testicles, and these were ameliorated by IP6 supplements in drinking water. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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