3 results on '"Anderies, Barrett"'
Search Results
2. Image-localized biopsy mapping of brain tumor heterogeneity: A single-center study protocol.
- Author
-
Urcuyo, Javier C, Curtin, Lee, Langworthy, Jazlynn M., De Leon, Gustavo, Anderies, Barrett, Singleton, Kyle W., Hawkins-Daarud, Andrea, Jackson, Pamela R., Bond, Kamila M., Ranjbar, Sara, Lassiter-Morris, Yvette, Clark-Swanson, Kamala R., Paulson, Lisa E., Sereduk, Chris, Mrugala, Maciej M., Porter, Alyx B., Baxter, Leslie, Salomao, Marcela, Donev, Kliment, and Hudson, Miles
- Subjects
- *
BRAIN tumors , *BRAIN mapping , *DIFFUSION tensor imaging , *DIFFUSION magnetic resonance imaging , *MAGNETIC resonance imaging , *PORTAL vein - Abstract
Brain cancers pose a novel set of difficulties due to the limited accessibility of human brain tumor tissue. For this reason, clinical decision-making relies heavily on MR imaging interpretation, yet the mapping between MRI features and underlying biology remains ambiguous. Standard (clinical) tissue sampling fails to capture the full heterogeneity of the disease. Biopsies are required to obtain a pathological diagnosis and are predominantly taken from the tumor core, which often has different traits to the surrounding invasive tumor that typically leads to recurrent disease. One approach to solving this issue is to characterize the spatial heterogeneity of molecular, genetic, and cellular features of glioma through the intraoperative collection of multiple image-localized biopsy samples paired with multi-parametric MRIs. We have adopted this approach and are currently actively enrolling patients for our 'Image-Based Mapping of Brain Tumors' study. Patients are eligible for this research study (IRB #16–002424) if they are 18 years or older and undergoing surgical intervention for a brain lesion. Once identified, candidate patients receive dynamic susceptibility contrast (DSC) perfusion MRI and diffusion tensor imaging (DTI), in addition to standard sequences (T1, T1Gd, T2, T2-FLAIR) at their presurgical scan. During surgery, sample anatomical locations are tracked using neuronavigation. The collected specimens from this research study are used to capture the intra-tumoral heterogeneity across brain tumors including quantification of genetic aberrations through whole-exome and RNA sequencing as well as other tissue analysis techniques. To date, these data (made available through a public portal) have been used to generate, test, and validate predictive regional maps of the spatial distribution of tumor cell density and/or treatment-related key genetic marker status to identify biopsy and/or treatment targets based on insight from the entire tumor makeup. This type of methodology, when delivered within clinically feasible time frames, has the potential to further inform medical decision-making by improving surgical intervention, radiation, and targeted drug therapy for patients with glioma. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
3. Awake Surgery for Brain Vascular Malformations and Moyamoya Disease.
- Author
-
Aoun, Rami James N., Sattur, Mithun G., Krishna, Chandan, Gupta, Amen, Welz, Matthew E., IIINanney, Allan D., Koht, Antoun H., Tate, Matthew C., Noe, Katherine H., Sirven, Joseph I., Anderies, Barrett J., Bolton, Patrick B., Trentman, Terry L., Zimmerman, Richard S., Swanson, Kristin R., and Bendok, Bernard R.
- Subjects
- *
MOYAMOYA disease , *BRAIN surgery , *FUNCTIONAL magnetic resonance imaging , *TRANSIENT ischemic attack , *NEUROVASCULAR surgery , *FETAL surgery , *NEUROPHYSIOLOGIC monitoring - Abstract
Objective Although a significant amount of experience has accumulated for awake procedures for brain tumor, epilepsy, and carotid surgery, its utility for intracranial neurovascular indications remains largely undefined. Awake surgery for select neurovascular cases offers the advantage of precise brain mapping and robust neurologic monitoring during surgery for lesions in eloquent areas, avoidance of potential hemodynamic instability, and possible faster recovery. It also opens the window for perilesional epileptogenic tissue resection with potentially less risk for iatrogenic injury. Methods Institutional review board approval was obtained for a retrospective review of awake surgeries for intracranial neurovascular indications over the past 36 months from a prospectively maintained quality database. We reviewed patients' clinical indications, clinical and imaging parameters, and postoperative outcomes. Results Eight consecutive patients underwent 9 intracranial neurovascular awake procedures conducted by the senior author. A standardized “sedated–awake–sedated” protocol was used in all 8 patients. For the 2 patients with arteriovenous malformations and the 3 patients with cavernoma, awake brain surface and white matter mapping was performed before and during microsurgical resection. A neurological examination was obtained periodically throughout all 5 procedures. There were no intraoperative or perioperative complications. Hypotension was avoided during the 2 Moyamoya revascularization procedures in the patient with a history of labile blood pressure. Postoperative imaging confirmed complete arteriovenous malformation and cavernoma resections. No new neurologic deficits or new-onset seizures were noted on 3-month follow-up. Conclusions Awake surgery appears to be safe for select patients with intracranial neurovascular pathologies. Potential advantages include greater safety, shorter length of stay, and reduced cost. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.