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Breast cancer ranks among the most commonly diagnosed cancers worldwide and bears the highest mortality rate. As an integral component of cancer treatment, mastectomy entails the complete removal of the affected breast. Typically, breast reconstruction, involving the use of silicone implants (augmentation mammaplasty), is employed to address the aftermath of mastectomy. To mitigate postoperative risks associated with mammaplasty, such as capsular contracture or bacterial infections, the functionalization of breast implants with coatings of cyclodextrin polymers as drug delivery systems represents an excellent alternative. In this context, our work focuses on the application of a mathematical model for simulating drug release from breast implants coated with cyclodextrin polymers. The proposed model considers a unidirectional diffusion process following Fick's second law, which was solved using the orthogonal collocation method, a numerical technique employed to approximate solutions for ordinary and partial differential equations. We conducted simulations to obtain release profiles for three therapeutic molecules: pirfenidone, used for preventing capsular contracture; rose Bengal, an anticancer agent; and the antimicrobial peptide KR-12. Furthermore, we calculated the diffusion profiles of these drugs through the cyclodextrin polymers, determining parameters related to diffusivity, solute solid–liquid partition coefficients, and the Sherwood number. Finally, integrating these parameters in COMSOL multiphysics simulations, the unidirectional diffusion mathematical model was validated. [ABSTRACT FROM AUTHOR]

Introduction: Maxillary ameloblastoma is a rare, slow-growing odontogenic tumor that can recur after surgical excision, be locally aggressive, and rarely develop systemic metastases. We describe the course and management of a patient with recurrent maxillary ameloblastoma with orbital invasion and systemic metastases, the fourth case of its kind to be described in the literature. Case Presentation: A 50-year-old female presented with left hyperglobus. A diagnosis of maxillary ameloblastoma was made based on biopsy and neuroimaging with MRI and CT. Surgical management included partial maxillectomy with orbital floor reconstruction, given the orbital invasion. Three years later, left hyperglobus recurred, and the patient was found to have orbital recurrence and lung metastases on PET imaging. The lung and orbital lesions have responded well to chemoradiation therapy without surgical intervention. Conclusion: Maxillary ameloblastoma is a rare tumor that typically arises from odontogenic tissues. Though considered benign, they can recur and in the case of our patient, metastasize. Complete surgical excision with wide surgical margins is associated with a shorter average time to recurrence and a lower incidence of metastasis. Cases of metastasis are managed with chemotherapy with or without adjuvant radiotherapy. Precision medicine may play a role in managing this entity in the future, given the discovery of differing profiles of maxillary ameloblastoma compared to mandibular. Ophthalmologists should be aware of this tumor as it can invade the orbit, resulting in significant ocular morbidity and mortality. [ABSTRACT FROM AUTHOR]

In general, TED-related vertical deviations require' bilateral or unilateral IR recession with or without contralateral superior rectus recession to restore binocular single vision.[47] Finally, IR muscle recession can cause lower eyelid retraction, especially when recession is >4 mm. Orbital decompression, followed by strabismus surgery, followed by eyelid surgery, is the accepted sequence of surgical intervention, as each step may affect the next.[1] Orbital Decompression Indications, Preoperative Considerations Orbital decompression is nuanced and must be tailored to each patient. In that case, decompression surgery could improve the lower eyelid position by reducing axial proptosis and sometimes reducing or even eliminating lower lid retraction without additional surgery.[94] Cho et al[95] investigated the effect of orbital decompression surgery on lid retraction as a function of proptosis reduction. Lockwood's ligament advancement and release of lower eyelid retractors may prevent lower eyelid retraction postoperatively.[63] Graph: Figure 4 Repair of TED-induced right hypertropia with left inferior rectus recession with adjustable sutures. [Extracted from the article]

Despite efforts to generate a unified terminology, obsolete morphological terms are still used in different contexts, such as school textbooks, which are tools widely used by the Chilean school system. The morphological terminology used in texts for elementary school students (grades 1 to 6) proposed by the Chilean Ministry of Education was analyzed. This analysis was carried out by comparing the terms found in the school texts with the morphological terminology proposed by the international federation of anatomical terminology. In addition, a translation into Spanish is proposed for those terms that are found to be erroneous in the texts analyzed. The results show that out of a total of 254 terms, 35.8 % are incorrect. Among the terms with errors, the most mentioned by the texts are: locomotor system, circulatory system, arm, among others. In view of this, we conclude that it is important that the textbooks used in the educational system be reviewed by experts to avoid obstacles in the learning of anatomy. [ABSTRACT FROM AUTHOR]

In this work, a mathematical model to describe drug delivery from polymer coatings on implants is proposed. Release predictability is useful for development and understanding of drug release mechanisms from controlled delivery systems. The proposed model considers a unidirectional recursive diffusion process which follows Fick's second law while considering the convective phenomena from the polymer matrix to the liquid where the drug is delivered and the polymer–liquid drug distribution equilibrium. The resulting model is solved using Laplace transformation for two scenarios: (1) a constant initial condition for a single drug delivery experiment; and (2) a recursive delivery process where the liquid medium is replaced with fresh liquid after a fixed period of time, causing a stepped delivery rate. Finally, the proposed model is validated with experimental data. [ABSTRACT FROM AUTHOR]

The main objective of this study was to construct and validate a scale of self-efficacy at work that is applicable to transversal work contexts. The sample consisted of 332 Chilean workers randomly divided into two subsamples. The study was conducted in four phases: 1) instrument design, 2) content validation, 3) exploratory factor analysis (subsample A), and 4) confirmatory factor analysis (subsample B). The results for the full scale showed adequate adjustment indicators (CFI = 0.97; TLI = 0.97; RMSEA = 0.05; Cronbach's alpha = 0.948). The scale was conformed into five dimensions: self-management, transfer, metacognition, meta-learning, and self-care. Their respective Cronbach's alphas (0.858; 0.869; 0.808; 0.826 and 0.854) certified adequate internal consistency. In conclusion, the self-efficacy at work scale generated here showed adequate psychometric characteristics for its use, both at the level of the entire scale and at level of each of its dimensions. [ABSTRACT FROM AUTHOR]

The objective of the present study was to adapt and validate the Collective Teacher Efficacy scale to transversal work contexts. The sample was composed of 332 workers from mining, education, health, and other sectors, randomly divided into two subsamples. Two confirmatory factors were analyzed by using the multivariate weighted least squares analysis method. The first analysis revealed adequate adjustment in the CFI (comparative fix index) and TLI (Tucker-Lewis index) parameters, but not for RMSEA (root mean square error of approximation). The second analysis yielded a new measurement model with adequate adjustment for all parameters (CFI, TLI, and RMSEA) and consisted of the following dimensions: positive and negative group competencies and analysis of positive and negative elements influencing tasks. It is concluded that the Collective Teacher Efficacy scale meets the psychometric properties required for its application in the psychology of work and organizations. [ABSTRACT FROM AUTHOR]

The objective of the present study was to adapt and validate the Keyes social well being scale in the work context. This is a quantitative research study with a sample of 332 workers randomly assigned into two subsamples (A and B). An exploratory factorial analysis was performed using generalized least squares (subsample A). A confirmatory factorial analysis was performed with the multivariate weighted least squares estimation method (subsample B). The results showed a social well being scale in the work environment with adequate adjustment indicators: CFI (0.984), TLI (0.98), and RMSEA (0.091). The scale consists of three factors: 1) social belonging, 2) social interaction, and 3) social understanding at work. Their omega values certify internal consistency. It is concluded that the social welfare scale in the work context presents psychometric characteristics suitable for its use, making it a contribution to work and organizational psychology. [ABSTRACT FROM AUTHOR]