1. Gold-Catalyzed, SN1-Type Reaction of Alcohols to Afford Ethers and Cbz-Protected Amines.
- Author
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Vinson, Andrew R. S., Davis, Victoria K., Arunasalam, Arunamarie, Jess, Kate A., Hamilton, Rachael E., Shattuck, Morgan A., Hu, Allison C., Iafe, Robert G., and Wenzel, Anna G.
- Subjects
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GOLD catalysts , *ETHER synthesis , *ORGANIC synthesis , *AMINE synthesis , *AMINE derivatives - Abstract
The use of a gold-catalyzed, microwave protocol to activate alcohols through an intermolecular, SN1-type reaction to directly form unsymmetrical ethers and SN-benzyloxy carbamate- (Cbz) protected amines is reported. Results have shown this reaction to be highly reproducible and tolerant of moisture, and moderate to high product yields (53-99%) were obtained. Significantly, the intermolecular catalytic amination of alcohols to directly afford Cbz-protected amines is heretofore unprecedented using gold catalysis. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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