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The ionic conductivity at the grain boundaries (GBs) in oxide ceramics is typically several orders of magnitude lower than that within the grain interior. This detrimental GB effect is the main bottleneck for designing high-performance ceramic electrolytes intended for use in solid-state lithium-ion batteries, fuel cells, and electrolyzer cells. The macroscopic ionic conductivity in oxide ceramics is essentially governed by the underlying polycrystalline microstructures where GBs and grain morphology go hand in hand. This provides the possibility to enhance the ion conductivity by microstructure engineering. To this end, a thorough understanding of microstructure–property correlation is highly desirable. In this work, we investigate numerous polycrystalline microstructure samples with varying grain and grain boundary features. Their macroscopic ionic conductivities are numerically evaluated by the finite element homogenization method, whereby the GB resistance is explicitly regarded. The influence of different microstructural features on the effective ionic conductivity is systematically studied. The microstructure–property relationships are revealed. Additionally, a graph neural network-based machine learning model is constructed and trained. It can accurately predict the effective ionic conductivity for a given polycrystalline microstructure. This work provides crucial quantitative guidelines for optimizing the ionic conducting performance of oxide ceramics by tailoring microstructures. [ABSTRACT FROM AUTHOR]

It is highly demanded to understand the confinement effect on nanoconfined polymers. Recent studies reported a strong perturbation of local dynamics and substantial alteration of glass transition temperature Tg at nanoscale. However, how confinement affects the mechanical properties of polymers is not fully understood. Here, we show that the modulus of thin polymer films could be remarkedly altered through a polymer–polymer interface. The modulus of a thin polystyrene (PS) film next to a polydimethylsiloxane (PDMS) was determined from the PS–PDMS bilayer bulging test. A series of experiments show that the modulus of PS can be increased up to 37%, when the modulus of the neighboring PDMS varies from 1.04 to 4.88 MPa. The results demonstrate a strong sensitivity of mechanical properties of thin polymers to the hard/soft environment, which we attribute to the change of high-mobility layer by the polymer–polymer interface. [ABSTRACT FROM AUTHOR]

Understanding the ignition and dynamic processes for the combustion of hydrate is crucial for efficient energy utilization. Through reactive force field molecular dynamics simulations, we studied the high-temperature decomposition and combustion processes of methane hydrates in a pure oxygen environment. We found that at an ignition temperature of 2800 K, hydrates decomposed from the interface to the interior, but the layer-by-layer manner was no longer strictly satisfied. At the beginning of combustion, water molecules reacted first to generate OH•, followed by methane oxidation. The combustion pathway of methane is C H 4 → CH 3 • → C H 3 O • → C H 2 O → H C • O → HCO O • → CO (C O 2 ). During the combustion process, a liquid water layer was formed between melted methane and oxygen, which hindered the reaction's progress. When there is no heat resistance, oxygen will transform into radicals such as OH• and O•, which have faster diffusion rates, allowing oxygen to conveniently cross the mass transfer barrier of the liquid water layer and participate in the combustion process. Increasing the amount of OH• may cause a surge in the reaction. On the other hand, when significant heat resistance exists, OH• is difficult to react with low-temperature hydrate components, but it can transform into O• to trigger the oxidation of methane. The H• generated has a sufficient lifetime to contact high-temperature oxygen molecules, converting oxygen into radicals that easily cross the water layer to achieve mass transfer. Therefore, finding ways to convert oxygen into various radicals is the key to solving the incomplete combustion of hydrates. Finally, the reaction pathways and microscopic reaction mechanisms of each species are proposed. [ABSTRACT FROM AUTHOR]

Lithium‐sulfur batteries face challenges like polysulfide shuttle and slow conversion kinetics, hindering their practical applications in renewable energy storage and electric vehicles. Herein, a solution to solve this issue is reported by using a cation vacancy engineering strategy with rational synthesis of La‐deficient LaCoO3 (LCO‐VLa). The introduction of cation vacancies in LCO‐VLa modifies the geometric structure of coordinating atoms, exposing Co‐rich surface with more catalytically active surfaces. Meanwhile, the d‐band center of LCO‐VLa shifts toward the Fermi level, enhancing polysulfide adsorption. Furthermore, multivalent cobalt ions (Co3+/Co4+) induced by charge compensation enhance the electrical conductivity of LCO‐VLa, accelerating electron transfer processes and improving catalytic performance. Theoretical calculations and experimental characterizations demonstrate that La‐deficient LCO‐VLa effectively suppresses the polysulfide shuttle, reduces the energy barrier for polysulfide conversion, and accelerates redox reaction kinetics. LCO‐VLa‐based batteries demonstrate exceptional rate performance and cycling stability, retaining 70% capacity after nearly 500 cycles at 1.0 C, with a minimal decay rate of 0.055% per cycle. These findings highlight the significance of cation vacancy engineering for exploring precise structure‐activity relationships during polysulfides conversion, facilitating the rational design of catalysts at the atomic level for lithium‐sulfur batteries. [ABSTRACT FROM AUTHOR]

Senescence of bone marrow mesenchymal stem cells (BMSCs) impairs their stemness and osteogenic differentiation, which is the principal cause of senile osteoporosis (SOP). Imbalances in nicotinamide phosphoribosyltransferase (NAMPT) homeostasis have been linked to aging and various diseases. Herein, reduction of NAMPT and impaired osteogenesis were observed in BMSCs from aged human and mouse. Knockdown of Nampt in BMSCs promotes lipogenic differentiation and increases age‐related bone loss. Overexpression of Nampt ameliorates the senescence‐associated (SA) phenotypes in BMSCs derived from aged mice, as well as promoting osteogenic potential. Mechanistically, NAMPT inhibits BMSCs senescence by facilitating OPA1 expression, which is essential for mitochondrial dynamics. The defect of NAMPT reduced mitochondrial membrane potential, interfered with mitochondrial fusion，and increased SA protein and phenotypes. More importantly, we have confirmed that P7C3, the NAMPT activator, is a novel strategy for reducing SOP bone loss. P7C3 treatment significantly prevents BMSCs senescence by improving mitochondrial function through the NAMPT‐OPA1 signaling axis. Taken together, these results reveal that NAMPT is a regulator of BMSCs senescence and osteogenic differentiation. P7C3 is a novel molecule drug to prevent the pathological progression of SOP. [ABSTRACT FROM AUTHOR]

Poultry and livestock meat are important parts of the human diet. As living standards have improved, food taste has become a major influence on consumer quality assessment and meat purchasing choices. There is increasing research interest in meat taste and meat taste‐active compounds, which include free amino acids, flavor nucleotides, taste‐active peptides, organic acids, soluble sugars, and inorganic ions. Taste component research is also an important part of sensory science. A deeper understanding of the meat taste perception mechanism and interactions among different taste compounds will promote the development of meat science and sensory evaluation. This article reviews the main taste compounds in meat, factors influencing their concentrations, and the identification and measurement of taste‐active compounds, as well as summarizing the mechanisms of taste sensing and perception. Finally, the future of scientific taste component evaluation is discussed. This review provides a theoretical basis for research on meat taste and an important reference for the development of the meat industry. [ABSTRACT FROM AUTHOR]

Summary Populations of Polypogon fugax have developed resistance to many acetyl‐CoA carboxylase (ACCase)‐inhibiting herbicides. This resistance threats the effectiveness and sustainability of herbicide use. In our previous research, a field P. fugax population exhibited GST‐based metabolic resistance to the widely used ACCase‐inhibiting herbicide quizalofop‐p‐ethyl. Here, in this current study, we identified and characterized two GST genes (named as PfGSTF2 and PfGSTF58) that showed higher expression levels in the resistant than the susceptible population. Transgenic rice calli overexpressing PfGSTF2, but not PfGSTF58, became resistant to quizalofop‐p‐ethyl and haloxyfop‐R‐methyl. This reflects similar cross‐resistance pattern to what was observed in the resistant P. fugax population. Transgenic rice seedlings overexpressing PfGSTF2 also exhibited resistance to quizalofop‐p‐ethyl. In contrast, CRISPR/Cas9 knockout of the orthologue gene in rice seedlings increased their sensitivity to quizalofop‐p‐ethyl. LC–MS analysis of in vitro herbicide metabolism by Escherichia coli‐expressed recombinant PfGSTF2 revealed that quizalofop (but not haloxyfop) was detoxified at the ether bond, generating the GSH‐quizalofop conjugate and a propanoic acid derivative with greatly reduced herbicidal activity. Equally, these two metabolites accumulated at higher levels in the resistant population than the susceptible population. In addition, both recombinant PfGSTF2 and PfGSTF58 can attenuate cytotoxicity by reactive oxygen species (ROS), suggesting a role in plant defence against ROS generated by herbicides. Furthermore, the GST inhibitor (NBD‐Cl) reversed resistance in the resistant population, and PfGSTF2 (but not PfGSTF58) responded to NBD‐Cl inhibition. All these suggest that PfGSTF2 plays a significant role in the evolution of quizalofop resistance through enhanced herbicide metabolism in P. fugax. [ABSTRACT FROM AUTHOR]

Background: Multiple system atrophy (MSA) is recognized as an atypical Parkinsonian syndrome, distinguished by a more rapid progression than that observed in Parkinson's disease. Unfortunately, the prognosis for MSA remains poor, with a notable absence of globally recognized effective treatments. Although preliminary studies suggest that transcranial magnetic stimulation (TMS) could potentially alleviate clinical symptoms in MSA patients, there is a significant gap in the literature regarding the optimal stimulation parameters. Furthermore, the field lacks consensus due to the paucity of robust, large-scale, multicenter trials. Methods: This investigation is a multi-center, randomized, double-blind, sham-controlled trial. We aim to enroll 96 individuals diagnosed with MSA, categorized into Parkinsonian type (MSA-P) and cerebellar type (MSA-C) according to their predominant clinical features. Participants will be randomly allocated in a 1:1 ratio to either the TMS or sham stimulation group. Utilizing advanced navigation techniques, we will ensure precise targeting for the intervention, applying theta burst stimulation (TBS). To assess the efficacy of TBS on both motor and non-motor functions, a comprehensive evaluation will be conducted using internationally recognized clinical scales and gait analysis. To objectively assess changes in brain connectivity, functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) will be employed as sensitive indicators before and after the intervention. Discussion: The primary aim of this study is to ascertain whether TBS can alleviate both motor and non-motor symptoms in patients with MSA. Additionally, a critical component of our research involves elucidating the underlying mechanisms through which TBS exerts its potential therapeutic effects. Ethics and dissemination: All study protocols have been reviewed and approved by the First Affiliated Medical Ethics Committee of the Air Force Military Medical University (KY20232118-F-1). Trial registration: Chinese Clinical Trial Registry ChiCTR2300072658. Registered on 20 June 2023. [ABSTRACT FROM AUTHOR]

This paper introduces a model reference adaptive system observer based on the non‐singular fast terminal sliding mode (NFSM‐MRASO) for the purpose of sensorless control of permanent magnet synchronous motors (PMSMs) in electric vehicle applications. Firstly, a non‐singular fast terminal sliding surface is constructed based on the output errors of the reference model and the adjustable model. This ensures that the output errors between the two models converge to zero in a finite time and effectively avoids the singularity problem in the terminal sliding mode control. In addition, a novel reaching law (NRL) is designed to replace the traditional exponential reaching law (TRL) to suppress the chattering phenomenon in the sliding mode control. Finally, the feasibility and effectiveness of the NFSM‐MRASO strategy are demonstrated through simulation results. [ABSTRACT FROM AUTHOR]

Large, immovable rammed earth buildings in UNESCO World Cultural Heritage sites are at serious risk of disaster due to environmental changes. In this study, the rammed earth city walls (REWs) located in the Ancient City of Ping Yao, a World Cultural Heritage site, affected by heavy precipitation in early October 2021, were used as the research object. The study aimed to specify the details of deterioration through multiple indicator data collection, semi-quantitatively evaluate the degree of deterioration of REWs, and investigate the causes of typical deterioration in REWs with different spatial distributions under the influence of heavy precipitation. Based on the current research and experimental data, and considering the mode of action and form of deterioration, a classification system for the landslide-like collapses of REWs under the influence of precipitation was constructed. Factors such as the influence of heavy precipitation and the REWs' intrinsic features resulted in significant variations in structural properties and deterioration development of REWs with different spatial distribution characteristics. Finally, based on the research in this paper and the conservation ideology of cultural relics that respects the original and minimizes intervention, we propose protection recommendations for the daily management and conservation of the REWs to provide guidance for future research. [ABSTRACT FROM AUTHOR]

Aim: This study aimed to investigate the association of personal strength use with job satisfaction among Chinese nurses and to examine the mediating roles of basic psychological needs satisfaction and resilience in this association. Background: The topic of nurses' job satisfaction has been extensively studied worldwide because of its significant effects on nurse turnover, recruitment, and quality of care. Methods: A sample of 417 nurses completed a multi‐section questionnaire that included established scales to measure personal strength use, basic psychological needs satisfaction, resilience, and job satisfaction. Results: The results revealed that personal strength use was positively linked to nurses' job satisfaction. Additionally, basic psychological needs satisfaction and resilience mediated the association of personal strength use with job satisfaction both independently and serially. Conclusion: Personal strength use increases nurses' job satisfaction by satisfying their basic psychological needs and improving their resilience. Implications for nursing and health policy: Creating a culture that supports the use of personal strengths among nurses is a promising strategy that hospital managers could consider to enhance nurses' job satisfaction. Furthermore, implementing programs and interventions to improve nurses' basic psychological needs satisfaction and resilience could further boost their job satisfaction. [ABSTRACT FROM AUTHOR]

The phase transformation and vanadium leaching mechanism of stone coal during two blank calcined stages are systematically studied. Composition, structure, and morphology of the materials are analyzed by ICP‐AES, BPMA, XRD, FTIR, and SEM. The results show that the main components of stone coal are SiO2, C, aluminosilicate and FeS2, V2O5 is 0.70%. Two‐stage roasting is a process of deformation, melting, and reconstruction of stone coal, the oxidation of pyrite, decomposition of aluminosilicate, sulfation of calcite, combustion of carbon and the formation of calcium vanadate occur in the first stage, the oxidation of low‐price vanadium occurs in the second stage. At −0.074 mm ≥90%, liquid solid ratio 1.5:1, 10% sulfuric acid reaction at room temperature for 3 h, the vanadium leaching rate in each material is in the order of roasting slag>decarbonized slag>stone coal. [ABSTRACT FROM AUTHOR]

Fine-grained 3D shape recognition (FGSR) is crucial for real-world applications. Existing methods face challenges in achieving high accuracy for FGSR due to high similarity within sub-categories and low dissimilarity between them, especially in the absence of part location or attribute annotations. In this paper, we propose V 2 MLP, a multi-view representation-oriented MLP network dedicated to FGSR, using only class labels as supervision. V 2 MLP comprises two key modules: the cross-view interaction MLP (CVI-MLP) and the cross-view fusion MLP (CVF-MLP). The CVI-MLP module captures contextual information, including local and global contexts through cross-view interactions, to extract discriminative view features that reinforce subtle differences between sub-categories. Meanwhile, the CVF-MLP module performs cross-view aggregation from space and view dimensions to obtain the final 3D shape features, minimizing information loss during the view feature fusion process. Extensive experiments on three categories from the FG3D dataset demonstrate the effectiveness of V 2 MLP in learning discriminative features for 3D shapes, achieving state-of-the-art accuracy for FGSR. Additionally, V 2 MLP performs competitively for meta-category recognition on the ModelNet40 dataset. [ABSTRACT FROM AUTHOR]

Nurses are at increased risk for developing depressive symptoms. While previous research has suggested that strength use may be inversely related to these symptoms, the longitudinal impact of strength use on nurses' depressive symptoms remains under-explored. This study sought to examine the longitudinal relationship between strength use and depressive symptoms among Chinese nurses. Using a two-wave cross-lagged design from 2020 to 2023, 321 nurses participated in an online questionnaire survey. Using structural equation modeling, our results supported the hypothesized reciprocal model, indicating that strength use can significantly predict a reduction in depressive symptoms and vice versa. Given these findings, there's an urgent need for nurse leaders to emphasize the importance of using nurses' strengths as a strategy to alleviate depressive symptoms. [ABSTRACT FROM AUTHOR]

The recent development of accurate and efficient semilocal density functionals on the third rung of Jacob's ladder of density functional theory, such as the revised regularized strongly constrained and appropriately normed (r2SCAN) density functional, could enable rapid and highly reliable prediction of the elasticity and temperature dependence of thermophysical parameters of refractory elements and their intermetallic compounds using the quasi-harmonic approximation (QHA). Here, we present a comparative evaluation of equilibrium cell volumes, cohesive energy, mechanical moduli, and thermophysical properties (Debye temperature and thermal expansion coefficient) for 22 transition metals using semilocal density functionals, including the local density approximation (LDA), Perdew–Burke–Ernzerhof (PBE) and PBEsol generalized gradient approximations (GGAs), and the r2SCAN meta-GGA. PBEsol and r2SCAN deliver the same level of accuracies for structural, mechanical, and thermophysical properties. PBE and r2SCAN perform better than LDA and PBEsol for calculating cohesive energies of transition metals. Among the tested density functionals, r2SCAN provides an overall well-balanced performance for reliably computing cell volumes, cohesive energies, mechanical properties, and thermophysical properties of various 3d, 4d, and 5d transition metals using QHA. Therefore, we recommend that r2SCAN could be employed as a workhorse method to evaluate thermophysical properties of transition metal compounds and alloys in high throughput workflows. [ABSTRACT FROM AUTHOR]

The targeted concentration of acoustic waves has significant implications for industrial nondestructive testing, ultrasound diagnosis, and medical treatment. Most conventional sound-focusing metasurfaces suffer from an untunable focus, narrow bandwidth, and fixed geometric configurations, which severely constrain their practical utility. In this paper, we propose a reconfigurable acoustic coding metasurface composed of two coding units with high transmittance and transmitted phases of 0 and π for realizing tunable and broadband sound focusing. Through the straightforward manipulation of each unit structure and alterations in the coding sequences, precise control of the focus position across the entire working plane is attainable, enabling both tunable axial-axis and off-axis sound-focusing effects. Moreover, the sound-focusing performance of the proposed metasurface is excellent within a broad frequency range from 3000 to 5500 Hz. The experimental results are consistent with theoretical expectations and numerical simulations. This work lays a practical foundation for the design of acoustic devices for tunable and broadband sound focusing. [ABSTRACT FROM AUTHOR]

The demand for applications, such as coatings, separation filters, and electronic packaging, has greatly driven the research of polymer films. At nanometer scale, mechanical properties of thin polymer films can significantly deviate from bulk. Despite outstanding progresses, there still lack deep discussions on nonlinear viscoelastic–viscoplastic response and their interactions under nanoconfinement. In this work, by conducting measurements via the bubble inflation method and modelling using Schapery and Perzyna equations, we demonstrate nonlinear viscoelastic–viscoplastic properties of freely standing thin polystyrene (PS) films. The results show the unchanged glassy compliance and the rubbery stiffening phenomenon for thin PS films, where the lower rubbery plateau in rubbery stiffening may originate from the induced molecular orientation by plastic deformation. With decreasing film thickness, viscosity and yield stress in viscoplasticity increase in an exponential and a linear trend, respectively, indicating the significant role of nanoconfinement effect on viscoplastic properties. These findings may reveal that there are many properties from linear viscoelasticity to nonlinear viscoelasticity–viscoplasticity that need to be explored and unveiled for sufficient understanding of the nanoconfinement effect on altering mechanical behavior of polymers. [ABSTRACT FROM AUTHOR]

Remote Sensing Image Object Detection (RSIOD) faces the challenges of multi-scale objects, dense overlap of objects and uneven data distribution in practical applications. In order to solve these problems, this paper proposes a YOLO-ACPHD RSIOD algorithm. The algorithm adopts Adaptive Condition Awareness Technology (ACAT), which can dynamically adjust the parameters of the convolution kernel, so as to adapt to the objects of different scales and positions. Compared with the traditional fixed convolution kernel, this dynamic adjustment can better adapt to the diversity of scale, direction and shape of the object, thus improving the accuracy and robustness of Object Detection (OD). In addition, a High-Dimensional Decoupling Technology (HDDT) is used to reduce the amount of calculation to 1/N by performing deep convolution on the input data and then performing spatial convolution on each channel. When dealing with large-scale Remote Sensing Image (RSI) data, this reduction in computation can significantly improve the efficiency of the algorithm and accelerate the speed of OD, so as to better adapt to the needs of practical application scenarios. Through the experimental verification of the RSOD RSI data set, the YOLO-ACPHD model in this paper shows very satisfactory performance. The F1 value reaches 0.99, the Precision value reaches 1, the Precision-Recall value reaches 0.994, the Recall value reaches 1, and the mAP value reaches 99.36 % , which indicates that the model shows the highest level in the accuracy and comprehensiveness of OD. [ABSTRACT FROM AUTHOR]

The purpose of this study was to examine the relationship between control beliefs about stress and post‐traumatic growth among Chinese nurses during the COVID‐19 pandemic and to examine the mediating role of basic psychological needs satisfaction and optimism in this relationship. A total of 692 Chinese nurses participated in this online study, who completed the Beliefs about Stress Scale, Post‐Traumatic Growth Inventory, Positive Psychological Capital Questionnaire, Basic Psychological Needs Satisfaction Scale and demographic variables between September and October 2020. Results indicate that 48.8% (N = 388) of nurses reported significant post‐traumatic growth related to the COVID‐19 pandemic. Moreover, control beliefs about stress were positively related to post‐traumatic growth (r = 0.38, p < 0.001), basic psychological needs satisfaction (r = 0.44, p < 0.001) and optimism (r = 0.47, p < 0.001). In addition, basic psychological needs satisfaction and optimism were both independent and serial mediators of the relationship between control beliefs about stress and post‐traumatic growth. Nurses and hospital administrators should focus on increasing nurses' control beliefs about stress and thereby enhancing their post‐traumatic growth after experiencing events such as the COVID‐19 pandemic. To support this process, programs should be designed to meet nurses' basic psychological needs and increase their optimism. [ABSTRACT FROM AUTHOR]

This article discusses the establishment of a genetic transformation system and gene editing platform for broomcorn millet using CRISPR/Cas12i.3 technology. Broomcorn millet is an ancient crop with desirable traits such as short life cycle, high photosynthetic efficiency, and tolerance to arid and saline-alkali soil. The researchers successfully developed a method for genetic transformation of broomcorn millet using Agrobacterium-mediated techniques. They also used the CRISPR/Cas12i.3 system to edit the BRACHYTIC2 (BR2) gene in broomcorn millet, resulting in dwarf plants with shorter internodes. This research has important implications for improving agronomic traits and developing new varieties of broomcorn millet. [Extracted from the article]

[Display omitted] • The Conyza Canadensis SHMT1 (CcSHMT1) structure was firstly resolved and a typical α-class PLP-dependent enzyme. • The dimethyl 2-acetamido terephthalate containing compounds had excellent herbicidal activity through virtual screening and biological assays. • The compound 9ay (IC 50 =193.8 g a.i./ha) exhibited the highest herbicidal efficiency and had no obvious side-effect on maize. • The first-in-class Cc SHMT1 inhibitor that could be developed as a potent herbicide with a new mode-of-action. Herbicide application is a highly efficiency method of weed control that boots agricultural output and assures food security. The development of novel herbicides focuses on improved bioactivity and new modes of action. The amino acid biosynthesis was validated as a promising novel mode of action for herbicidal compounds. However, the amino acid biosynthesis enzyme remains largely unexplored for herbicidal targets. Serine hydroxymethyl transferase (SHMT) is an essential enzyme in the photorespiratory cycle. The study aims to explore Conyza canadensis SHMT1 (Cc SHMT1) as a promising target for herbicide discovery. Structure determination of Cc SHMT1 was resolved by X-ray crystallography. Virtual screening docking experiments were performed with Glide version 5.5. Novel derivatives of dimethyl 2-acetamido terephthalate were further designed, synthesized, and bioassay. The druggability of the inhibitor was evidenced by ultrastructural changes in mitochondria, in vivo and vitro enzyme activity assays, and genetics analysis. Cc SHMT1 has a typical PLP-dependent enzyme 3D structure. The dimethyl 2-acetamido terephthalate-containing compounds had herbicidal activity. Dimethyl 2-(2-(4-(2-(4-bromo-2-chlorophenoxy) acetyl)piperazin-1-yl)acetamido) terephthalate (Compound 9ay , EC 50 = 193.8 g a.i./ ha) exhibited the highest herbicidal activity on tested weed among the synthesized compounds. Compound 9ay had no obvious adverse effect on the growth of maize and honeybees. Compound 9ay was verified to target Cc SHMT1 as an herbicide candidate. A first-in-class Cc SHMT1 inhibitor that could be developed as a potent herbicide with a new mode of action and provide an avenue for discovering novel inhibitors of pyridoxal-5-phosphate-dependent enzymes. [ABSTRACT FROM AUTHOR]

The rich and unique energy level structure arising from 4fn inner shell configuration of trivalent lanthanide ions (Ln3+) renders them highly attractive for light‐emitting applications. Currently, research primarily focuses on Ln3+ doping in either traditional garnets or the recently developed perovskite phosphors. However, there have been few reports on stable phosphors crystallized with pure lanthanide elements. Herein, a universal solution‐based route to eight Ln3+‐based metal halides from the organic‐inorganic A4LnX7 family is described, where A+ = 4,4‐difluoropiperidinium (DFPD+), Ln3+ = Nd3+, Eu3+, Ho3+, Sm3+, Tm3+, Tb3+, Yb3+, Er3+, and X− = Cl−, Br−. Visible photoluminescence (PL) is observed from Tb3+‐, Eu3+‐, Ho3+‐, and Sm3+‐based compounds with Tb and Eu compositions exhibiting high PL quantum yields of 90–100%; Nd3+‐, Tm3+‐, Yb3+‐, and Er3+‐based crystals show fascinating near‐infrared emission. Light‐emitting diodes (LEDs) fabricated with (DFPD)4TbCl7 yield characteristic emission of Tb3+, representing the first demonstration of electroluminescence from these organic‐inorganic Ln3+‐based metal halides. Moreover, these materials exhibit distinct excitation wavelength‐dependent emission after alloying with different Ln3+ ions, making them interesting for multicolor display and multilevel information encryption applications. It is foreseen that this study will open up the way to a possible design of robust optoelectronic devices based on lanthanide metal halides. [ABSTRACT FROM AUTHOR]

A series of novel (3,5-dinitrophenyl)-4-(benzyloxymethyl)oxazole derivatives was designed, synthesized and characterized by 1H, 13C NMR and HRMS data. The spatial structure of 4-[(2-chlorophenoxy)methyl]-2-(3,5-dinitrophenyl)oxazole was determined by single crystal X-ray diffraction method. Herbicidal activity of the target compounds was evaluated using Echinochloa crusgalli, Lolium perenne, Lactuca sativa, and Medicago sativa as tested species. According to the experimental results, most compounds demonstrated good pre-emergence herbicidal activity. 4-[(3-Bromo-5-chlorophenoxy)methyl]-2-(3,5-dinitrophenyl)oxazole exhibited relatively better pre-emergence efficacy against the four tested weeds when considering the overall control effect. It reveals that 4-[(3-bromo-5-chlorophenoxy)methyl]-2-(3,5-dinitrophenyl)oxazole could serve as a pre-emergence herbicide lead, and the need for further structural optimization and adjustment of the herbicide. [ABSTRACT FROM AUTHOR]

Alumina (Al2O3) particles, the primary combustion products of solid rockets, can accumulate in the stratosphere, changing the global radiative balance. These Al2O3 particles were usually treated as homogeneous spheres. However, they contain impurities and may form clusters during the combustion process. Models representing Al-containing and C-containing Al2O3 clusters were developed, denoted as Al2O3 shell model (ASM) and Al2O3 core model (ACM), respectively. The superposition T-matrix method (STMM) was applied to examine their optical characteristics. Subsequently, a method to obtain the top-of-atmosphere flux was proposed by integrating the models with the moderate resolution atmospheric transmission code (MODTRAN). With the addition of Al/C, the absorption cross-section enhances by several orders of magnitude at 0.55 μm and increases slightly at 10 μm. The equivalent sphere models will weaken their scattering ability. A 4Tg mass burden of Al2O3 produces radiative forcing of −0.439 Wm−2. However, the addition of Al and C reduces the forcing by up to 15% and 12%, respectively. In summary, the optical characteristics and radiative forcing of Al2O3 clusters are sensitive to Al/C and morphology models. While our findings are impacted by various uncertainties, they contribute valuable insights into the radiative forcing of Al2O3 particles, potential climatic changes by space activities. [ABSTRACT FROM AUTHOR]

YOLOv7 is one of the most effective algorithms for one‐stage detectors. However, when it is applied to pedestrian detection tasks in the industrial scene, it is still challenging for complex environments and multi‐scale changes of pedestrians. This paper proposes a new pedestrian detector for the industrial scene based on improved YOLOv7‐tiny and named as GP‐YOLO. First, the neck of YOLOv7‐tiny is replaced by RepGFPN structure, make full use of multi‐scale features to enhance the detection accuracy of objects with large‐scale changes. Second, a new gnconv branch is added to the feature fusion module, and the high‐order spatial interaction capability is introduced to further enhance the target detection accuracy. Finally, a lightweight method based on PModule is proposed, on this basis, a PConv bottleneck is designed to reduce the FLOPs and enhance the feature extraction. Experiments on a self‐made Industrial Pedestrian Data set show that before lightweight, the proposed algorithm achieves a 3.2% improvement in mAP@0.5:0.95 and a 3.7% improvement in Recall compared to the baseline YOLOv7‐tiny. After lightweight GP‐YOLO, compared to non‐lightweight, parameters and FLOPs are decreased by 26% and 23%, respectively, the mAP@0.5:0.95 is decreased by only 1.1% and the Recall is decreased by only 1.3%, which remains at a high level. Compared with baseline YOLOv7‐tiny, the lightweight GP‐YOLO has similar parameters and FLOPs, but the mAP@0.5:0.95 is increased by 2.1%, and the Recall is increased by 2.4%. © 2024 Institute of Electrical Engineers of Japan and Wiley Periodicals LLC. [ABSTRACT FROM AUTHOR]

Self-aerated open channel flows have been extensively investigated in various physical scales, but comprehensive depiction of air entrainment and air–water flow properties for various invert roughness conditions is limited, sometimes due to the insufficient chute length to reach fully developed aeration. In the present work, an 18 m-long chute was built on a 21.8° sloping river bank, and the aerated flow hydraulics and two-phase flow properties were experimentally measured to the fully aerated region. Three types of bottom roughness were tested, and their effects on flow aeration were discussed. The investigated flow characteristics, including the inception of air entrainment, characteristic flow depths, distributions of air concentration and bubble frequency, flow resistance modification, water level fluctuations, and splash height, were compared with existing model and prototype data and empirical expressions. The results revealed different roles of the uniformly distributed bottom roughness in modifying the two-phase and hydraulic processes and highlighted the importance of flow Reynolds number especially for a mass transfer consideration. [ABSTRACT FROM AUTHOR]

Echinochloa crus-galli is a serious weed species in rice paddies. To obtain a new potential bioherbicide, we evaluated the inhibitory activities of 13 essential oils and their active substances against E. crus-galli. Essential oil from Syzygium aromaticum (L.) Merr. & L. M. Perry (SAEO) exhibited the highest herbicidal activity (EC50 = 3.87 mg mL-1) among the 13 essential oils evaluated. The SAEO was isolated at six different temperatures by vacuum fractional distillation, including 164°C, 165°C (SAEO—165), 169°C, 170°C 175°C and 180°C. The SAEO—165 had the highest inhibitory rate against E. crus-galli. Gas chromatography-mass spectrometry and high phase liquid chromatography identified eugenol (EC50 = 4.07 mg mL-1), α-caryophyllene (EC50 = 17.34 mg mL-1) and β-caryophyllene (EC50 = 96.66 mg mL-1) as the three compounds in SAEO. Results from a safety bioassay showed that the tolerance of rice seedling (~ 20% inhibition) was higher than that of E. crus-galli (~ 70% inhibition) under SAEO stress. SAEO induced excessive generation of reactive oxygen species leading to oxidative stress and ultimately tissue damage in E. crus-galli. Our results indicate that SAEO has a potential for development into a new selective bio-herbicide. They also provide an example of a sustainable management strategy for E. crus-galli in rice paddies. [ABSTRACT FROM AUTHOR]

Herein, a CuPc/Bi-MOF cascade heterojunction is synthesized exhibiting an excellent NH3 yield (7.13 μg h−1 cm−2) and stability. Characterization studies show that the cascade heterostructure with a unique morphology and oxygen vacancies offers new insights into future photoelectrocatalytic material design. [ABSTRACT FROM AUTHOR]

Background: Multiple system atrophy (MSA) is a disease with diverse symptoms and the commonly used classifications, MSA-P and MSA-C, do not cover all the different symptoms seen in MSA patients. Additionally, these classifications do not provide information about how the disease progresses over time or the expected outcome for patients. Objective: To explore clinical subtypes of MSA with a natural disease course through a data-driven approach to assist in the diagnosis and treatment of MSA. Methods: We followed 122 cases of MSA collected from 3 hospitals for 3 years. Demographic characteristics, age of onset, clinical signs, scale assessment scores, and auxiliary examination were collected. Age at onset; time from onset to assisted ambulation; and UMSARS I, II, and IV, COMPASS-31, ICARS, and UPDRS III scores were selected as clustering elements. K-means, partitioning around medoids, and self-organizing maps were used to analyze the clusters. Results: The results of all three clustering methods supported the classification of three MSA subtypes: The aggressive progression subtype (MSA-AP), characterized by mid-to-late onset, rapid progression and severe clinical symptoms; the typical subtype (MSA-T), characterized by mid-to-late onset, moderate progression and moderate severity of clinical symptoms; and the early-onset slow progression subtype (MSA-ESP), characterized by early-to-mid onset, slow progression and mild clinical symptoms. Conclusions: We divided MSA into three subtypes and summarized the characteristics of each subtype. According to the clustering results, MSA patients were divided into three completely different types according to the severity of symptoms, the speed of disease progression, and the age of onset. [ABSTRACT FROM AUTHOR]

We report the experimental measurements of the decay rate of polar cesium nD5/2 − 6S1/2 Rydberg-ground molecules with a large principal quantum number range of 35 ≤ n ≤ 40. Rydberg molecules are prepared employing the method of two-photon photoassociation and the molecular (atomic) ions, due to autoionization (blackbody photoionization), are detected with a microchannel plate detector. The decay rate Γ of the vibrational ground state of the deep and shadow bound molecules for triplet (TΣ) and mixed singlet-triplet (S,TΣ) are measured by fitting the molecular population with the exponential function. Comparing with the parent atom, the decay rate of the polar Rydberg-ground molecule shows an obvious increase with a magnitude of a few μs. The possible dissociation mechanism of polar Rydberg-ground molecules including a collisional decay, blackbody induced decay, and coupling of adjacent Rydberg states and tunneling decay are discussed in detail. The theoretical model is induced to simulate the measurements, showing agreement. [ABSTRACT FROM AUTHOR]

In order to explore the interplay among heat, charge, and spin, we investigate the spin-related thermoelectricity of a hybrid double quantum dot Aharonov–Bohm interferometer with Rashba spin–orbit coupling (RSOC). Interestingly, the nonzero RSOC phase difference can induce significant spin-dependent thermoelectric transport. Not only can the strong violation of the Wiedemann-Franz law be obtained, but also a pure spin-Seebeck effect can be produced, which may serve as a pure spin-current generator. The influence of system parameters on thermoelectric coefficients (especially for spin counterparts) are analyzed in detail, and the underlying physics is further elucidated. Furthermore, the spin figure of merit can be much larger than the charge one, which, thus, provides a realistic possibility of engineering spin thermoelectric devices with high performance. These results obtained may be of interest for developing spin thermoelectric devices in the field of spin caloritronics. [ABSTRACT FROM AUTHOR]

Hf0.5Zr0.5O2 (HZO) is a promising candidate for low-power non-volatile memory due to its nanoscale ferroelectricity and compatibility with silicon-based technologies. Stress and oxygen vacancy (VO) are key factors that impact the ferroelectricity of HZO. However, their combined effects have not been extensively studied. In this study, we investigated the impact of the VO content on HZO thin films' ferroelectricity under different electrode stresses by using TiN and tungsten (W) top electrodes and controlling ozone dose time during HZO deposition. The HZO thin films with W top electrodes exhibit elevated stress levels and a greater abundance of orthorhombic/tetragonal phases, and the HZO thin films with TiN top electrode shows an increase in the monoclinic phase with increasing ozone dose time. The residual polarization (Pr) of the capacitors with TiN and W top electrodes displayed different or even opposing trends with increasing ozone dose time, and the VO content decreases with increasing ozone dose time for both sets of capacitor samples. We propose a model to explain these observations, considering the combined influence of electrode stresses and VO on the free and formation energy of the crystalline phase. Increasing the VO content promotes the transformation of the tetragonal phase to the orthorhombic phase in HZO films with TiN top electrodes, and with W top electrodes, a higher VO content prevents the tetragonal phase from transforming into the orthorhombic/monoclinic phase. Additionally, an alternative explanation is proposed solely from the perspective of stress. These findings provide valuable insights into the regulation of ferroelectricity in HZO thin films. [ABSTRACT FROM AUTHOR]

Vibration in wind turbine towers poses a significant threat to the service life and structural integrity of wind turbines. Dampers have been identified as a pivotal strategy for alleviating such vibrations. Despite this, the dynamic behavior of large-scale offshore wind turbines is frequently swayed by wind shear, the tower shadow effect, and the Rotor-Nacelle Assembly (RNA) control system, typically manifesting as responses to the blade passing frequency (3P). To mitigate these vibrations, this study introduces a 3P tuning method for tuned mass dampers (TMDs), alongside a sophisticated design approach that targets optimal frequency and damping ratios. The integration of a semi-active variable-tuned mass damper (SA-V-TMD) offers a dual-mode control solution: The “3P tuning mode” adeptly manages vibrations across a spectrum of operating conditions, while the “1st modal frequency tuning mode” stabilizes the structure during parked states. Simulations substantiate the 3P tuning method’s enhanced efficacy over standard methods under operational conditions. Furthermore, the SA-V-TMD demonstrates superior effectiveness and stability in comparison to traditional TMDs, underscoring its potential as a preeminent solution in wind turbine vibration management. [ABSTRACT FROM AUTHOR]

Insufficient surface dynamics and severe carrier recombination limit the photoelectrochemical water splitting (PEC-WS) performance of hematite (α-Fe2O3) photoanodes. The surface/interface engineering as an effective method can improve the above-mentioned problems. In this study, the ZIF-67 and FeCoNi-LDH as cocatalysts formed via in situ hydrolysis are successfully introduced on the surface of the α-Fe2O3 photoanode to improve the photogenerated carrier transport. The Sn@α-Fe2O3/ZIF-67/FeCoNi-LDH photoanode exhibits an excellent photocurrent density of 1.72 mA cm−2 at 1.23 VRHE, which is 1.7 times that of the original α-Fe2O3 photoanode. The detailed studies demonstrate that the introduced ZIF-67/FeCoNi-LDH heterojunction cocatalyst provides more abundant surface active sites and defects and enhances the light absorbance ability and electric conductivity. The synergistic effect between ZIF-67 and FeCoNi-LDH cocatalysts can significantly enhance photogenerated carrier separation and transfer efficiency. [ABSTRACT FROM AUTHOR]

Background: Progressive oxidative stress easily occurs as a result of a gradual increase in the intensity of maternal metabolism due to rapid foetal development and increased intensity of lactation. However, studies on the effects of processive oxidative stress on nutrient transport in the placenta have received little attention. The present study was conducted on sows at 85 days of gestation to study the effects of pterostilbene (PTE) on maternal oxidative stress status and placental nutrient transport. Results: PTE increased the antioxidant capacity and immunoglobulin content in mothers' blood and milk, reduced the level of inflammatory factors, and improved the nutrient content of milk. PTE also reduced sow backfat loss and the number of weak sons, and increased piglet weaning weight and total weaning litter weight. We subsequently found that PTE enhanced placental glucose and fatty acid transport and further affected glycolipid metabolism by increasing the expression of LAL, PYGM, and Gbe-1, which activated the PI3K phosphorylation pathway. Moreover, PTE addition altered the relative abundance of the Firmicutes, Proteobacteria, Parabacillus, and Bacteroidetes-like RF16 groups in sow faeces. PTE increased the levels of acetate, propionate, butyrate and isovalerate in the faeces. Conclusions: These findings reveal that the addition of PTE during pregnancy and lactation mitigates the effects of processive oxidative stress on offspring development by altering maternal microbial and placental nutrient transport capacity. [ABSTRACT FROM AUTHOR]

AbstractLooking for materials from Scutellaria baicalensis to improve oral inflammation and eliminate bad breath led to one new compound, 5,7,2′,5′-tetrahydroxy-6′-methoxyflavone (1) and 32 known ones. Among of them, 3 flavones (11, 17, 18), 2 dihydroflavones (23, 25), 2 flavone glucosides (30, 32), and a chalcone (26) could inhibit oral anaerobic bacteria Fusobacterium nucleatum, Streptococcus mutans, and Porphyromonas gingivalis. Compounds 3, 14, 18 could inhibit oral bacterial Staphylococcus aureus. Compounds 5, 8, 13 and 21 exhibited strong inhibitory NO production. Additionally, 14 and 26 showed good COX-1/2 inhibitory effects. These results indicated S. baicalensis has potential oral health benefits. [ABSTRACT FROM AUTHOR]

Based on the ribbed rebar with direct rolling thread and hot‐forged double‐lock nut mechanical sleeve connection technology, a construction method for prefabricated reinforcement cage‐cast‐in‐situ concrete (PRC‐CISC) column using this connection is proposed. This method contributes to improving the construction efficiency and engineering quality of reinforced concrete columns. Four PRC‐CISC columns and four control specimens were designed with rebar strength, rebar ratio, and rebar connection method as analysis parameters. A comparative study was conducted on their failure modes, axial compression performance, and rebar connector (coupler) working mechanisms. The results show that compared to the control specimens, the crack morphology of PRC‐CISC columns has no significant difference. However, the apparent yielding position of the reinforcement cage may occur on the cross‐sections where the rebar is located on both sides of the sleeve. The partial carrying capacity of the specimens may increase or decrease (≤4.08%), and the maximum deviation of the displacement ductility coefficient is 0.14, indicating that its strength and deformation differences are relatively small. Furthermore, the study reveals the random migration behavior of the control section of PRC‐CISC columns. When the specimens fail, the strain of the sleeve is significantly smaller than the rebar strain in the control specimens, while the concrete strain shows no significant difference. This is because the increase in the effective area of the sleeve shares the vertical load it bears. Finally, based on the test results, sleeve constitutive relationship, and random migration behavior of the control section, the compressive load capacity range of the positive section of PRC‐CISC columns is proposed. This method can effectively estimate their actual carrying capacity and is consistent with the force characteristics. [ABSTRACT FROM AUTHOR]

Objectives: This study aims to fill the gap in understanding the frequency of changing sanitary pads and the key factors associated with this practice among women in China. Methods: Using a convenient sampling approach, a cross-sectional study was conducted with a quota sampling method to survey women from 28 cities in China between October 21 and 31, 2020. Basic demographic characteristics, personal hygiene habits, self-efficacy, health-related quality of life, and disease status were collected. Multiple logistic regression model was used to analyze the factors associated with the frequency of changing sanitary pads. Results: A total of 1682 respondents were included in this study. The condition of frequently changing sanitary pads was divided into three groups: "Not taken" (224 respondents, 13.32%), "Short-term taken" (330 respondents, 19.62%), and "Long-term taken" (1128 respondents, 67.06%). Multiple logistic analysis revealed that women who performed "long-term taken" cleaning up rubbish timely (OR = 22.89, P < 0.05), "long-term taken" regular breast self-examination (OR = 19.46, P < 0.05), "long-term taken" actively obtaining scientific contraception methods (OR = 7.40, P < 0.05), as well as those with higher health-related quality of life (OR = 33.72, P < 0.05), were more likely to perform "long-term taken" frequently changing sanitary pads. Conversely, women with chronic diseases (OR = 0.48, P < 0.05) and those aged 31–40 (OR = 0.44, P < 0.05) were less likely to perform the "long-term taken" frequently changing sanitary pads during menstruation. Conclusions: Most Chinese women practice good menstrual health management and frequently change their sanitary pads. However, there are still some women whose sanitary pad changing practices fall short of expectations. Multiple factors have been found to be associated with the frequency of changing sanitary pads. Based on the research results, healthcare institutions, schools, and the government can more effectively screen, assess, and support women who face menstrual health issues, thereby improving the overall level of menstrual hygiene management. [ABSTRACT FROM AUTHOR]

Objective: To investigate the anti‐inflammatory and bacteriostatic effects of hydrogen‐rich water (HRW) intake on Wistar rats with periodontitis. Methods: The periodontitis model of rats was established by silk ligature and Porphyromonas gingivalis (Pg) solution smearing. The rats were divided into normal control group, model group, and HRW group. The rats in normal control group were given normal feeding without any intervention, while periodontitis was induced in the rats of model group and HRW group, and the rats were given HRW intake and normal saline, respectively, during the whole procedure of the experiments. The antibacterial effect and clinical symptoms (plaque index and gingival sulcus bleeding index (SBI)) were then observed, and peripheral blood (PB), gingival sulcus fluid, and jaw samples were collected to evaluate the changes of inflammatory factors and the curative effect. Results: In the rats of model group, alveolar bone resorption was obvious, which indicated that the rats with periodontitis were successfully constructed, and HRW intake mitigated it. Pg colony number of the rats fed with HRW was significantly lower than that of the model rats. The contents of proinflammatory factors tumor necrosis factor alpha (TNF‐α), interleukin‐1 beta (IL‐1β), and interleukin‐6 (IL‐6) in PB serum and gingival crevicular fluid (GCF) of rats in model group were significantly increased, and HRW intake reversed these and promoted the level of anti‐inflammatory factor interleukin‐10 (IL‐10). Conclusion: HRW can effectively inhibit the growth of periodontal pathogens and reduce inflammation and may be used to prevent or ameliorate periodontitis. [ABSTRACT FROM AUTHOR]

In this work, we predicted two different configurations of fullerene nanoribbons (quasi-hexagonal phase (qHP) and quasi-tetragonal phase (qTP)) based on two-dimensional fullerenes, with widths of 1, 2, and 3 fullerene units, respectively. Based on first-principles calculations and ab-initio molecular dynamics (AIMD), the thermal stability and optical properties of six fullerene nanoribbons were predicted. AIMD studies indicate that wider qHP nanoribbons (qHPs) exhibit better thermal stability, while increased temperatures lead to greater instability. In contrast, qHP-3 shows the best thermal stability among the six structures. Then, the optical gap between the calculated and experimental quasi-hexagonal two-dimensional fullerenes is compared to illustrate the accuracy of the calculation. The absorption spectra of six fullerene nanoribbons were calculated and the anisotropy of light absorption was analyzed. Finally, the charge transfer modes of each excited state were visualized through electron-hole density plots. This work provides an essential theoretical foundation for understanding new all-carbon materials, specifically fullerenes. [ABSTRACT FROM AUTHOR]

To enhance the low-frequency sound absorption capabilities of expansion chamber mufflers, a novel Helmholtz-ring phononic crystal cell was developed. This innovative design integrates ring Helmholtz resonators as the phononic crystal scatterer, which is periodically arranged within the expansion chamber of a muffler to achieve enhanced sound attenuation at deep sub-wavelength scales. The transmission loss characteristics of the phononic crystal muffler were thoroughly examined and found to reveal a pronounced enhancement in sound absorption within the low-frequency bandgap. A critical aspect of this study was the analysis of the influence of defect states on transmission loss of the muffler. The introduction of defect states significantly expanded the sound attenuation bandwidth, effectively compensating for reduced sound absorption performance of the muffler outside the bandgap. The proposed phononic crystal muffler demonstrated a marked improvement in both transmission loss and aerodynamic performance compared to the traditional expansion chamber muffler. Notably, the sound attenuation was further augmented when in defective states. Corresponding experimental investigations were conducted and confirmed the effectiveness of the phononic crystal muffler within its designated bandgap range. This research presents a new way for the development of more efficient noise control solutions. [ABSTRACT FROM AUTHOR]

It has been commonly assumed that an inerter–stiffness–damping isolator mounts on a rigid foundation, however, there exists a strong interaction among the vibration source, isolator, and the base structure for systems with flexible or nonrigid bases. This paper investigates a system consisting of an isolation object, mounted on flexible base plate through an inerter–spring–damping isolator. The steady-state response of the plate-exerted point force excitation can be obtained by using the eigenfunction expansion theorem and expressed by the eigenfunctions and natural frequencies of the system. The four-pole parameter of the inerter can be modeled from the formula calculation or its properties. The transmissibility relation of the proposed system is obtained by using the four-pole parameter theory, which is validated by creating the simulation model in Abaqus software. The power transmission ratio as an isolation performance index is proposed by the mobility relationship among the isolation object, the isolator, and the base. The novelty of this study is that the vibration transmissibility with the flexible base has a much better roll-off rate and anti-resonance peak than that of the rigid base in the high-frequency range, although the resonant peak is generated. A comprehensive parameter analysis shows that the isolation performance can be designed and adjusted by the thickness, material of the plate and the position of the isolator. The effects of feedback control on the resonant peak mitigation of the proposed system are discussed in detail based on Resonant Control, Positive Position Feedback, and Fractional Order Positive Position Feedback. The H2 optimization criterion is employed to obtain the optimal damping parameters of positive position feedback. [ABSTRACT FROM AUTHOR]

Due to their internal gain mechanism, emerging nanomaterial‐based infrared phototransistors show significant promise for highly sensitive detection; however, they usually suffer from high dark current (Idark) and thus high noise, which restricts the actual detection capability of the detector. Here, a semiconducting carbon nanotube (CNT) film‐based phototransistor is proposed with an ultralow Idark and a high response through the adoption of stacked ZnO/PbS colloidal quantum dot heterojunctions as the photogate to absorb the infrared photons and generate a photovoltage. Solution‐derived semiconducting CNTs with diameters ranging from 0.8 to 1.1 nm are utilized to create a network film that serves as the active channel of the transistor and provides an off‐state current as low as ≈50 fA; this enables an ultralow dark current (pA level) in the infrared phototransistor. By tuning the back‐gate bias, the synergistic modulation is demonstrated of the sensor response and electronic noise and achieve a high detectivity of 5.7 × 1013 Jones under an incident power density of 0.81 nW cm−2 and 1300 nm infrared radiation. These findings provide a promising approach for attaining weak light infrared detection based on nanomaterial‐based photodetectors. [ABSTRACT FROM AUTHOR]

Functional nanoparticles (NPs) have gained significant attention as promising applications in various fields, including sensor, smart coating, drug delivery, and more. Here, a novel mechanism assisted by machine‐learning workflow is proposed to accurately predict phase diagram of NPs, which elegantly achieves tunability of shapes and internal structures of NPs using self‐assembly of block‐copolymers (BCP). Unlike most of previous studies, onion‐like and mesoporous NPs in neutral environment and hamburger‐like NPs in selective environment are obtained. Such novel phenomena are obtained only by tailoring the topology of a miktoarm star BCP chain architecture without the need for any further treatment. Moreover, it is demonstrated that the BCP chain architecture can be used as a new strategy for tuning the lamellar asymmetry of NPs. It is shown that the asymmetry between A and B lamellae in striped ellipsoidal and onion‐like particles increases as the volume fraction of the A‐block increases, beyond the level reached by linear BCPs. In addition, an extended region of onion‐like structure is found in the phase diagram of A‐selective environment, as well as the emergence of an inverse onion‐like structure in the B‐selective one. The findings provide a valuable insight into the design and fabrication of nanoscale materials with customized properties, opening up new possibilities for advanced applications in sensing, materials science, and beyond. [ABSTRACT FROM AUTHOR]

Soil erosion is one of the main issues that endangers global ecosystems. This study explored the spatiotemporal distribution of soil erosion and its drivers in the karst plateau mountainous region. A detailed examination of topography, soil, vegetation, land use, and precipitation data from 2000 to 2020 was conducted in Bijie City using the revised universal soil loss equation model. We also explored the driving forces using a geographical detector. The findings show that between 2000 and 2020, soil erosion first decreased, followed by an increase. The southwest, south, and northern regions contained the highest intensity of soil erosion. Land use, slope, and precipitation are the primary factors influencing soil erosion, with slopes having the greatest impact. By improving our understanding of the dynamics of soil erosion and the primary variables that influence it in karst plateau mountainous environments, our findings can assist in the development of strategies and technical support for sustainable soil and water conservation. [ABSTRACT FROM AUTHOR]

Despite remarkable progress in understanding the fundamental bases of itching, its cortical mechanisms remain poorly understood. Herein, the causal contributions of defined anterior cingulate cortex (ACC) neuronal populations to acute itch modulation in mice are established. Using cell type‐specific manipulations, the opposing functions of ACC glutamatergic and GABAergic neurons in regulating acute itching are demonstrated. Photometry studies indicated that ACC glutamatergic neurons are activated during scratching induced by both histamine and chloroquine, whereas the activation pattern of GABAergic neurons is complicated by GABAergic subpopulations and acute itch modalities. By combining cell type‐ and projection‐specific techniques, a thalamocortical circuit is further identified from the mediodorsal thalamus driving the itch‐scratching cycle related to histaminergic and non‐histaminergic itching, which is contingent on the activation of postsynaptic parvalbumin‐expressing neurons in the ACC. These findings reveal a cellular and circuit signature of ACC neurons orchestrating behavioral responses to itching and may provide insights into therapies for itch‐related diseases. [ABSTRACT FROM AUTHOR]

Osteoporosis is characterized by reduced bone mass due to imbalanced bone metabolism. Exosomes derived from bone mesenchymal stem cells (BMSCs) have been shown to play roles in various diseases. This study aimed to clarify the regulatory function and molecular mechanism of BMSCs-derived exosomes in osteogenic differentiation and their potential therapeutic effects on osteoporosis. Exosomes were extracted from BMSCs. Bone marrow-derived macrophages (BMDMs) were cultured and internalized with BMSCs-derived exosomes. Real-time quantitative PCR was used to detect the expression of macrophage surface markers and tripartite motif (TRIM) family genes. BMDMs were co-cultured with human osteoblasts to assess osteogenic differentiation. Western blot was performed to analyze the ubiquitination of triggering receptor expressed on myeloid cell 1 (TREM1) mediated by TRIM25. An ovariectomized mice model was established to evaluate the role of TRIM25 and exosomes in osteoporosis. Exosomes were successfully isolated from BMSCs. BMSCs-derived exosomes upregulated TRIM25 expression, promoting M2 macrophage polarization and osteogenic differentiation. TRIM25 facilitated the ubiquitination and degradation of TREM1. Overexpression of TREM1 reversed the enhanced M2 macrophage polarization and osteogenic differentiation caused by TRIM25 overexpression. TRIM25 enhanced the protective effect of BMSCs-derived exosomes against bone loss in mice. These findings suggested that BMSCs-derived exosomes promoted osteogenic differentiation by regulating M2 macrophage polarization through TRIM25-mediated ubiquitination and degradation of TREM1. This mechanism might provide a novel approach for treating osteoporosis. [ABSTRACT FROM AUTHOR]

Hyponatremia can worsen the outcomes of patients with liver cirrhosis. However, it remains unclear about how to predict the risk of death in cirrhotic patients with hyponatremia. Patients with liver cirrhosis and hyponatremia were screened. Eligible patients were randomly divided into the training (n = 472) and validation (n = 471) cohorts. In the training cohort, the independent predictors for in-hospital death were identified by logistic regression analyses. Odds ratios (ORs) were calculated. An artificial neural network (ANN) model was established in the training cohort. Areas under curve (AUCs) of ANN model, Child-Pugh, model for end-stage liver disease (MELD), and MELD-Na scores were calculated by receiver operating characteristic curve analyses. In multivariate logistic regression analyses, ascites (OR = 2.705, P = 0.042), total bilirubin (OR = 1.004, P = 0.003), serum creatinine (OR = 1.004, P = 0.017), and international normalized ratio (OR = 1.457, P = 0.005) were independently associated with in-hospital death. Based on the four variables, an ANN model was established. Its AUC was 0.865 and 0.810 in the training and validation cohorts, respectively, which was significantly larger than those of Child-Pugh (AUC = 0.757), MELD (AUC = 0.765), and MELD-Na (AUC = 0.769) scores. An ANN model has been developed and validated for the prediction of in-hospital death in patients with liver cirrhosis and hyponatremia. [ABSTRACT FROM AUTHOR]

Background: Triple-negative breast cancer (TNBC) has pronounced stemness that is associated with relapse. N6-methyladenosine (m6A) plays a crucial role in shaping cellular behavior by modulating transcript expression. However, the role of m6A in TNBC stemness, as well as the mechanisms governing its abundance, has yet to be elucidated. Methods: We analyzed proteomic and transcriptomic data derived from breast cancer cohorts, with an emphasis on m6A regulators. To unravel the role of m6A in TNBC, we employed RNA sequencing, methylated RNA immunoprecipitation sequencing, RNA immunoprecipitation, chromatin immunoprecipitation, and luciferase reporter assays with mesenchymal stem-like (MSL) TNBC models. The clinical relevance was validated using human tissue microarrays and publicly accessible databases. Results: Our findings indicate that the global level of m6A modification in MSL TNBC is downregulated primarily due to the loss of methyltransferase-like 14 (METTL14). The diminished m6A modification is crucial for the maintenance of TNBC stemness, as it increases the expression of yes-associated protein 1 (YAP1) by blocking YTH domain-containing family protein 2 (YTHDF2)-mediated transcript decay, thereby promoting the activation of Hippo-independent YAP1 signaling. YAP1 is essential for sustaining the stemness regulated by METTL14. Furthermore, we demonstrated that the loss of METTL14 expression results from lysine-specific demethylase 1 (LSD1)-mediated removal of histone H3 lysine 4 methylation at the promoter region, which is critical for LSD1-driven stemness in TNBC. Conclusion: These findings present an epi-transcriptional mechanism that maintains Hippo-independent YAP1 signaling and plays a role in preserving the undifferentiated state of TNBC, which indicates the potential for targeting the LSD1-METTL14 axis to address TNBC stemness. [ABSTRACT FROM AUTHOR]

Currently, in metal halide perovskite light‐emitting devices, the interface between functional layers is crucial as it determines the injection and distribution of charge carriers. Herein, by inserting a poly[9‐vinylcarbazole] (PVK) layer between the sol–gel ZnO and perovskite layers, excessive electron injection is blocked, thereby improving the distribution of charge carriers in the device. Additionally, the trap density in the perovskite film is reduced. The performance of the device is enhanced, achieving a maximum current efficiency of 17.5 cd A−1, which represents a significant 30% improvement compared to devices without the PVK layer. This new understanding offers important implications for the operational mechanism of quantum light‐emitting diode. [ABSTRACT FROM AUTHOR]