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We revisit the construction of quantum Riemannian geometries on graphs starting from a hermitian metric compatible connection, which always exists. We use this method to find quantum Levi-Civita connections on the n-leg star graph for n = 2 , 3 , 4 and find the same phenomenon as recently found for the A n Dynkin graph that the metric length for each inbound arrow has to exceed the length in the other direction by a multiple, here n . We then study quantum geodesics on graphs and construct these on the 4-leg graph and on the integer lattice line Z with a general edge-symmetric metric. [ABSTRACT FROM AUTHOR]

On the basis of current growth trajectories, pasture-based dairies of the future are likely to be bigger, have higher stocking rates and feed more concentrate to cows. This review uses the five-domains framework to consider risks to the welfare of dairy cows in these larger intensified pasture-based production systems. The factors considered in this review can be broadly categorised as (1) emerging welfare risks that can be managed, (2) emerging welfare risks that require research to be managed, or (3) persisting and/or exacerbated welfare risks. First, large herds could be subject to welfare risks associated with more stock per labour unit, longer milking times and longer distances walked to and from the dairy. To counter this, the time that cows in large herds spend off pasture can be reduced by splitting the herd into several more manageable groups, and animal-monitoring technologies can help identify health challenges with a reduced stockperson to animal ratio. Cow body condition and productivity can be maintained at high stocking rates by improving pasture production and feeding a higher proportion of concentrate. The risk of ruminal acidosis may then be reduced by appropriate transition feeding regimes and rumen buffers. Second, ensuring social stability and reducing competition may become difficult as herd sizes increase and feeding becomes more intensive. The resulting variability in feed intake, increased agonistic behaviour and social stress present emerging risks to cow welfare. Research is needed to better understand the social behaviour of cows in large intensive pasture-based herds, and how the design of the pre-milking area, the feeding pad and pasture feeding regimes (i.e. quantity and timing of pasture allocation) can improve accessibility for more vulnerable animals. Finally, intensive pasture-based dairies of the future will continue to face welfare challenges relating to lameness, mastitis and cull-cow management, whereas risks due to environmental exposure may be exacerbated by the removal of shelterbelts to facilitate irrigation. These require continued efforts in research (e.g. ways of incorporating shelter into intensive grazing systems), development (e.g. pathway to market for aged beef) and extension (e.g. improved record keeping and benchmarking of lameness and mastitis). Pasture-based dairies of the future are likely to be bigger, have higher stocking rates and feed more concentrate. This review uses the five-domains framework to consider risks to the welfare of dairy cows in these larger pasture-based systems. Risks to cow welfare are broadly categorised as (1) emerging welfare risks that can be managed, (2) emerging welfare risks that require research to be managed, or (3) persisting and/or exacerbated welfare risks. Suggestions are made for future research, development and extension. [ABSTRACT FROM AUTHOR]

The article discusses the implications of the 28th Conference of the Parties (COP28) of the United Nations Framework Convention on Climate Change (UNFCCC) for lung disease. It highlights the significant impact of climate change on respiratory diseases, such as increased air pollution and extreme weather events, which can exacerbate conditions like asthma and chronic obstructive pulmonary disease (COPD). The article emphasizes the importance of climate change mitigation for respiratory health and the need for global efforts to reduce greenhouse gas emissions. It also mentions the recent COP28 UAE Declaration on Climate and Health, which recognizes the adverse impacts of climate change on health and calls for action to protect respiratory health. However, the article notes that COP28 failed to achieve the necessary level of ambition to mitigate climate change and protect vulnerable populations. It concludes by highlighting the role of healthcare providers, individuals, and leaders in promoting cleaner energy, supporting policies for environmental health, and preparing healthcare systems for the impacts of climate change. [Extracted from the article]

We show that the standard Heisenberg algebra of quantum mechanics admits a noncommutative differential calculus Ω1 depending on the Hamiltonian p2/2m + V(x), and a flat quantum connection ∇ with torsion such that a previous quantum-geometric formulation of flow along autoparallel curves (or "geodesics") is exactly Schrödinger's equation. The connection ∇ preserves a non-symmetric quantum metric given by the canonical symplectic structure lifted to a rank (0, 2) tensor on the extended phase space where we adjoin a time variable. We also apply the same approach to obtain a novel flow generated by the Klein–Gordon operator on Minkowski spacetime with a background electromagnetic field, by formulating quantum "geodesics" on the relativistic Heisenberg algebra with proper time for the external geodesic parameter. Examples include quantum geodesics that look like a relativistic free particle wave packet and a hydrogen-like atom. [ABSTRACT FROM AUTHOR]

Falls are a significant ongoing public health concern for older adults. At present, few studies have concurrently explored the influence of multiple measures when seeking to determine which variables are most predictive of fall risks. As such, this cross-sectional study aimed to identify those functional variables (i.e. balance, gait and clinical measures) and physical characteristics (i.e. strength and body composition) that could best distinguish between older female fallers and non-fallers, using a machine learning approach. Overall, 60 community-dwelling older women (≥65 years), retrospectively classified as fallers (n = 21) or non-fallers (n = 39), attended three data collection sessions. Data (281 variables) collected from tests in five separate domains (balance, gait, clinical measures, strength and body composition) were analysed using random forest (RF) and leave-one-variable-out partial least squares correlation analysis (LOVO PLSCA) to assess variable importance. The strongest discriminators from each domain were then aggregated into a multi-domain dataset, and RF, LOVO PLSCA, and logistic regression models were constructed to identify the important variables in distinguishing between fallers and non-fallers. These models were used to classify participants as either fallers or non-fallers, with their performance evaluated using receiver operating characteristic (ROC) analysis. The study found that it is possible to classify fallers and non-fallers with a high degree of accuracy (e.g. logistic regression: sensitivity = 90%; specificity = 87%; AUC = 0.92; leave-one-out cross-validation accuracy = 63%) using a combination of 18 variables from four domains, with the gait and strength domains being particularly informative for screening programmes aimed at assessing falls risk. [ABSTRACT FROM AUTHOR]

Aim: Phosphorus is a critical constituent of bone as a component of hydroxyapatite. Bone mineral content accrues rapidly early in life necessitating a positive phosphorus balance, which could be established by a combination of increased renal reabsorption and intestinal absorption. Intestinal absorption can occur via a transcellular pathway mediated by the apical sodium‐phosphate cotransporter, Slc34a2/NaPiIIb or via the paracellular pathway. We sought to determine how young mammals increase dietary phosphorus absorption from the small intestine to establish a positive phosphorus balance, a prerequisite for rapid bone growth. Methods: The developmental expression profile of genes mediating phosphate absorption from the small intestine was determined in mice by qPCR and immunohistochemistry. Additionally, Ussing chamber studies were performed on small bowel of young (p7–p14) and older (8‐ to 17‐week‐old) mice to examine developmental changes in paracellular Pi permeability and transcellular Pi transport. Results: Blood and urinary Pi levels were higher in young mice. Intestinal paracellular phosphate permeability of young mice was significantly increased relative to older mice across all intestinal segments. NaPiIIb expression was markedly increased in juvenile mice, in comparison to adult animals. Consistent with this, young mice had increased transcellular phosphate flux across the jejunum and ileum relative to older animals. Moreover, transcellular phosphate transport was attenuated by the NaPiIIb inhibitor NTX1942 in the jejunum and ileum of young mice. Conclusion: Our results are consistent with young mice increasing phosphate absorption via increasing paracellular permeability and the NaPiIIb‐mediated transcellular pathway. [ABSTRACT FROM AUTHOR]

Background: Nursing students and nurse preceptors indicate that a comprehensive orientation is vital to successful work-integrated learning placements in Prison Health Services. The aim of this study was to implement and evaluate a Prison Health Service orientation package that included innovative asynchronous online video simulations with branched decision-making and feedback opportunities to stimulate learning and improve students' feelings of preparedness for a placement in this setting. Methods: A cross-sectional pre and post design was used to evaluate the resource. Students were given access to the package and invited to complete a pre-placement survey evaluating the resource and their feelings of preparedness for placement. Following placement, they re-evaluated the resource in terms of how well it prepared them for the placement and how well prepared they felt. Third year Australian undergraduate nursing students from one university who completed a Prison Health Service work-integrated learning placement in 2018, 2021, and 2022 were invited to participate. Placements were unavailable in 2019 and 2020. Independent t-tests were used to determine differences in scale means and level of preparedness between pre- and post-survey responses. Results: Twenty-three of 40 (57.5%) eligible nursing students completed the pre-placement survey and 13 (32.5%) completed the post placement survey. All respondents to the pre-placement survey indicated that they felt satisfactorily, well, or very well prepared after completing the orientation package prior to their clinical placement. Students were significantly more likely to consider themselves well prepared by the package after they had attended placement (p <.001). All students post placement indicated that overall, the simulation resources and the specific simulation scenario about personal boundaries and management of manipulative behaviours was useful for their placement. The majority of students would recommend the orientation package to other students. Suggestions for improvement included streamlining the resource to reduce the time to complete it. Conclusions: Asynchronous online simulation with the capacity for branched decision making and feedback along with a comprehensive online orientation package were perceived as useful to prepare undergraduate students for placement in the Prison Health Service work-integrated learning setting. [ABSTRACT FROM AUTHOR]

A higher concentration of calcium in breast milk than blood favors paracellular calcium absorption enabling growth during postnatal development. We aimed to determine whether suckling animals have greater intestinal calcium permeability to maximize absorption and to identify the underlying molecular mechanism. We examined intestinal claudin expression at different ages in mice and in human intestinal epithelial (Caco-2) cells in response to hormones or human milk. We also measured intestinal calcium permeability in wildtype, Cldn2 and Cldn12 KO mice and Caco-2 cells in response to hormones or human milk. Bone mineralization in mice was assessed by μCT. Calcium permeability across the jejunum and ileum of mice were 2-fold greater at 2 wk than 2 mo postnatal age. At 2 wk, Cldn2 and Cldn12 expression were greater, but only Cldn2 KO mice had decreased calcium permeability compared to wildtype. This translated to decreased bone volume, cross-sectional thickness, and tissue mineral density of femurs. Weaning from breast milk led to a 50% decrease in Cldn2 expression in the jejunum and ileum. Epidermal growth factor (EGF) in breast milk specifically increased only CLDN2 expression and calcium permeability in Caco-2 cells. These data support intestinal permeability to calcium, conferred by claudin-2, being greater in suckling mice and being driven by EGF in breast milk. Loss of the CLDN2 pathway leads to suboptimal bone mineralization at 2 wk of life. Overall, EGF-mediated control of intestinal claudin-2 expression contributes to maximal intestinal calcium absorption in suckling animals. Graphical Abstract Epidermal growth factor in milk increases the paracellular permeability to calcium across the small intestine via increasing the intestinal claudin-2 abundance in suckling mammals. [ABSTRACT FROM AUTHOR]

Monetary policy differs from other aspects of economic and social policy because it is not directly under the control of the federal government: it is managed by the Reserve Bank of Australia (RBA), which operates on the principle of central bank independence, at 'arm's length' from the government. Although the Bank is operationally independent, its aims and powers are set out in legislation, and interpreted in the Statement on the Conduct of Monetary Policy, all of which can be changed by the government of the day. Moreover, because the monetary policy that the Bank pursues impacts on macroeconomic conditions, it constrains what any government can effectively do in other policy areas. Currently, the wave of inflation over the last two years has loomed large among the economic challenges facing both the Bank and the Albanese government. This ongoing inflation - together with the report of the review of the Bank established by Treasurer Jim Chalmers - make it opportune now to assess the role of monetary policy in Australia. [ABSTRACT FROM AUTHOR]

This study has evaluated five years (2016–2020) of Himawari-8 (H8) Sea Surface Temperature (SST) Level 2 Pre-processed (L2P) data produced by the Australian Bureau of Meteorology (Bureau) against shipborne radiometer SST measurements obtained from the Infrared SST Autonomous Radiometer (ISAR) onboard research vessel RV Investigator. Before being used, all data sets employed in this study have gone through careful quality control, and only the most trustworthy measurements are retained. With a large matchup database (31,871 collocations in total, including 16,418 during daytime and 15,453 during night-time), it is found that the Bureau H8 SST product is of good quality, with a mean bias ± standard deviation (SD) of −0.12 °C ± 0.47 °C for the daytime and −0.04 °C ± 0.37 °C for the night-time. The performance of the H8 data under different environmental conditions, determined by the observations obtained concurrently from RV Investigator, is examined. Daytime and night-time satellite data behave slightly differently. During the daytime, a cold bias can be seen under almost all environmental conditions, including for most values of wind speed, SST, and relative humidity. On the other hand, the performance of the night-time H8 SST product is consistently more stable under most meteorological conditions with the mean bias usually close to zero. [ABSTRACT FROM AUTHOR]

A longer pollen season and higher pollen concentrations may also augment the severity of symptoms.[44] Future global climate change is anticipated to lengthen and intensify pollen seasons and potentially increase the incidence of allergic disease. Google Scholar Crossref Search ADS PubMed WorldCat 30 Anderegg WRL, Abatzoglou JT, Anderegg LDL, Bielory L, Kinney P, Ziska L. Anthropogenic climate change is worsening North American pollen seasons. Google Scholar Crossref Search ADS PubMed WorldCat 51 Demain JG, Choi Y-J, Oh J-W. The impact of climate change on the pollen allergy and sporulation of allergic fungi. Keywords: Allergic disease; biodiversity loss; climate change; compound impacts; urbanization EN Allergic disease biodiversity loss climate change compound impacts urbanization 655 663 9 06/20/23 20230601 NES 230601 Introduction Atmospheric concentrations of carbon dioxide, methane and other greenhouse gases have been rising rapidly due largely to human activities, which have altered our climate system. [Extracted from the article]

We study geodesics flows on curved quantum Riemannian geometries using a recent formulation in terms of bimodule connections and completely positive maps. We complete this formalism with a canonical ∗ operation on noncommutative vector fields. We show on a classical manifold how the Ricci tensor arises naturally in our approach as a term in the convective derivative of the divergence of the geodesic velocity field and use this to propose a similar object in the noncommutative case. Examples include quantum geodesic flows on the algebra of 2 × 2 matrices, fuzzy spheres and the q-sphere. [ABSTRACT FROM AUTHOR]

This paper examines the trends in hot summer days for the Pacific Northwest in observations and a regional climate model ensemble. Hot days are identified by the temperature threshold for several percentile values computed over 10-yr intervals (85th, 90th, and 95th percentiles and absolute maximum) to differentiate heat events of different intensities and are compared to the median temperature (50th percentile). For the stations analyzed, the observed rate of warming during hot days is not statistically different from the warming rate of median days since the 1950s. However, for projections to 2100, hot days show a statistically significant increase in the warming rate of the hottest days compared to the warming rate for median days. Depending on location, the 95th-percentile daily maximum temperature shows a warming rate of up to 0.2°C decade−1 above the median warming rate. The divergence in the trends of median and extreme temperature shows substantial regional variation depending on local terrain and coastlines. The warming trend during hot days is related to the unique circulation patterns during heat events, which respond to different feedbacks and amplifying effects in the land–atmosphere system from those that prevail during typical days. The regional climate model simulations are taken from an ensemble of the Weather Research and Forecasting (WRF) Model simulations forced by 12 global climate model simulations from phase 5 of the Climate Model Intercomparison Project (CMIP5) using the RCP8.5 emissions scenario and 12-km grid spacing. Significance Statement: The heatwave of June 2021 had substantial societal and ecological impacts, illustrating vulnerability to record-shattering events. This paper addresses whether climate change can cause heat events in the Pacific Northwest to warm at a more rapid rate than typical days. Based on observations, in the recent past, the hottest days warmed at about the same rate as typical days in the recent past. However, results from a high-resolution climate model show a higher rate of warming during the warmest days relative to median days under the most aggressive future emissions scenario. This effect could cause heatwaves to become more intense relative to typical days by 2100, making adaptation to extreme events more difficult. [ABSTRACT FROM AUTHOR]

There is increasing evidence in a range of cancer types that the microbiome plays a direct role in modulating the anti-cancer immune response both at the gut level and systemically. Differences in the gut microbiota have been shown to correlate with differences in immunotherapy responses in a range of non-gastrointestinal tract cancers. DNA mismatch repair-deficient (dMMR) colorectal cancer (CRC) is radically different to DNA mismatch repair-proficient (pMMR) CRC in clinical phenotype and in its very good responses to immunotherapy. While this has usually been thought to be due to the high mutational burden in dMMR CRC, the gut microbiome is radically different in dMMR and pMMR CRC in terms of both composition and diversity. It is probable that differences in the gut microbiota contribute to the varied responses to immunotherapy in dMMR versus pMMR CRC. Targeting the microbiome offers a way to boost the response and increase the selection of patients who might benefit from this therapy. This paper reviews the available literature on the role of the microbiome in the response to immunotherapy in dMMR and pMMR CRC, explores the potential causal relationship and discusses future directions for study in this exciting and rapidly changing field. [ABSTRACT FROM AUTHOR]

The pure state evaluation map from M n (C) to C (C P n − 1) is a completely positive map of C * -algebras intertwining the U n symmetries on the two algebras. We show that it extends to a cochain map from the universal calculus on M n (C) to the holomorphic ∂ ¯ calculus on C P n − 1 . The method uses connections on Hilbert C * -bimodules. [ABSTRACT FROM AUTHOR]

Ranking sports teams generally relies on supervised techniques, requiring either prior knowledge or arbitrary metrics. In this paper, we offer a purely unsupervised technique. We apply this to operational decision-making, specifically, the controversial European Super League for association football, demonstrating how this approach can select dominant teams to form the new league. We first use random forest regression to select important variables predicting goal difference, which we use to calculate the Euclidian distances between teams. Creating a Laplacian eigenmap, we bisect the Fiedler vector to identify the natural clusters in five major European football leagues. Our results show how an unsupervised approach could identify four clusters based on five basic performance metrics: shots, shots on target, shots conceded, possession, and pass success. The top two clusters identify teams that dominate their respective leagues and are the best candidates to create the most competitive elite super league. [ABSTRACT FROM AUTHOR]

X-linked myotubular myopathy (XL-MTM) is a rare life-threatening congenital myopathy caused by mutations in the MTM1 gene that encodes myotubularin, a ubiquitous enzyme required for normal development and function of skeletal muscle. The incidence of XLMTM in newborn males is 1:50,000. Recent evidence has revealed a previously unrecognized cholestatic tendency in patients with XL-MTM. EXCEL is a 48-week, prospective, observational, multicenter study to evaluate hepatobiliary health in patients with XLMTM. Approximately 50 male participants <18 years of age (up to half <5 years of age) with genetically confirmed XLMTM will be enrolled at 15–25 specialist sites in Canada, UK, and USA. The primary objective is to assess hepatobiliary health by estimating the incidence and prevalence of cholestatic complications in participants with XL-MTM. Secondary objectives are to evaluate the: (1) association between genetic variants of MTM1 and cholestasis; (2) association between environmental modifiers and cholestasis; and (3) healthcare utilization related to hepatobiliary and cholestatic complications. Participant assessments will be performed at the investigator's discretion based on standard of care at the site. A recommended schedule of assessments includes liver function tests (including serum bile acids), blood clotting parameters, creatinine, triglycerides and total cholesterol, and vitamin panel. Further clinical evaluation including liver ultrasound and Fibroscan will be used where appropriate. To reduce patient and caregiver burden, home healthcare services will collect laboratory tests when possible. Remote data collection may be used for healthcare resource utilization and patient medical history. Findings are expected to improve our understanding of cholestatic tendencies in participants with XL-MTM and provide critical information to improve the current management and treatment of XL-MTM, as well as future clinical trial designs. *Co-first authors. [ABSTRACT FROM AUTHOR]

Artificial water bodies in agricultural landscapes (hereafter 'farm dams') are established primarily to support livestock and crop production but also provide habitats for a wide range of native species. Managing water quality in farm dams is essential to animal production and biodiversity. Farm dam enhancement, which includes restricting direct access of stock to dams, can improve water quality in farm dams, by reducing soil erosion and direct faecal contamination, as well as reducing the trampling, grazing, and browsing of vegetation in the immediate catchment. We tested farm dam enhancement as a tool to improve and maintain water quality in 109 farm dams across 34 farms over three years in the sheep-wheat belt of southeast Australia. Using Bayesian Linear Mixed Models, we found that farm dam enhancement significantly reduced levels of phosphorus, nitrogen, turbidity, thermotolerant coliforms, Escherichia coli , and pH. Furthermore, our study revealed links between dam enhancement, increases in vegetation cover, and improved water quality. Our results show that restoration efforts in the surrounds of dams can have positive results on water quality. They highlight the importance of restoration in agricultural landscapes to both agricultural production and biodiversity. • Managing water quality in farms dams is essential to production and biodiversity. • Dams can be enhanced by restoring vegetation and reducing direct stock access. • Dam enhancement significantly reduced levels of phosphorus and nitrogen. • It also reduced turbidity, thermotolerant coliforms, and Escherichia coli. [ABSTRACT FROM AUTHOR]

Phages have wide influence on bacterial physiology, and likewise, bacterial processes impinge on phage biology. Key to these interactions are phage small proteins (<100 aa). Long underappreciated, recent work has revealed millions of phage small proteins, and increasingly, mechanisms by which they function to dictate phage and/or bacterial behavior and evolution. Here, we describe select phage small proteins that mediate phage–bacterial interactions by modulating phage lifestyle decision-making components or by altering host gene expression. • Phage small proteins play central roles in phage and bacterial physiology. • Phage small proteins can direct phage lifestyle decision-making. • Phage small proteins can alter bacterial host gene expression. • Mechanistic studies of phage small proteins are essential to define functions. [ABSTRACT FROM AUTHOR]

Desmosomes are macromolecular cell-cell junctions critical for maintaining adhesion and resisting mechanical stress in epithelial tissue. Desmosome assembly and the relationship between maturity and molecular architecture are not well understood. To address this, we employed a calcium switch assay to synchronize assembly followed by quantification of desmosome nanoscale organization using direct Stochastic Optical Reconstruction Microscopy (dSTORM). We found that the organization of the desmoplakin rod/C-terminal junction changed over the course of maturation, as indicated by a decrease in the plaque-to-plaque distance, while the plaque length increased. In contrast, the desmoplakin N-terminal domain and plakoglobin organization (plaque-to-plaque distance) were constant throughout maturation. This structural rearrangement of desmoplakin was concurrent with desmosome maturation measured by E-cadherin exclusion and increased adhesive strength. Using two-color dSTORM, we showed that while the number of individual E-cadherin containing junctions went down with the increasing time in high Ca2+, they maintained a wider desmoplakin rod/C-terminal plaque-to-plaque distance. This indicates that the maturation state of individual desmosomes can be identified by their architectural organization. We confirmed these architectural changes in another model of desmosome assembly, cell migration. Desmosomes in migrating cells, closest to the scratch where they are assembling, were shorter, E-cadherin enriched, and had wider desmoplakin rod/C-terminal plaque-to-plaque distances compared to desmosomes away from the wound edge. Key results were demonstrated in three cell lines representing simple, transitional, and stratified epithelia. Together, these data suggest that there is a set of architectural programs for desmosome maturation, and we hypothesize that desmoplakin architecture may be a contributing mechanism to regulating adhesive strength. [ABSTRACT FROM AUTHOR]

The democratic firm is at the heart of many models of market socialism. But a promotion of democracy within the firm calls for very specific institutional adjustments outside it, because its internal structure can be at odds with other goals of market socialism, like a desirable rate of growth and economic equality between workers. This paper lays out a model that seeks to marry firm-level democracy with macroeconomic growth and solidaristic wage policy. [ABSTRACT FROM AUTHOR]

This JAMA Insights in the Climate Change and Health Series defines thunderstorm asthma, describes its effects and increased rate of occurrence, and highlights recommendations for improved response during future events. [ABSTRACT FROM AUTHOR]

Infants born preterm or low birth weight are at risk for morbidity, mortality and later neuroimpairment. Appropriate early post‐natal growth is associated with better outcomes in‐hospital and post‐discharge. Therefore, nutritional strategies that support growth may improve the long‐term health of this population. Mother's milk with donor milk as a supplement are preferred sources of nutrition for these infants but may not always support growth, especially amongst infants born of very low birth weight (<1500 g) and or those with a major morbidity. Systematic reviews of randomised controlled trials to date demonstrate that multi‐nutrient fortification of human milk improves in‐hospital growth of preterm infants although data on long‐term neurodevelopment are lacking. Further, individualised approaches to fortification based on milk analysis or the infant's metabolic response may improve growth over standard fortification. The evidence is insufficient to inform the timing of introducing fortifier, routine fortification of feeds post‐discharge or routine use of fortifiers made from human instead of bovine milk. Importantly, there is insufficient data to determine if these fortification practices improve relevant clinical or neurodevelopmental outcomes. In sum, there is an urgent need for well‐designed clinical trials to assess potential benefits and risks of fortification practices and at what cost. [ABSTRACT FROM AUTHOR]

Recruiting, training and retaining scientists in computational biology is necessary to develop a workforce that can lead the quantitative biology revolution. Yet, African-American/Black, Hispanic/Latinx, Native Americans, and women are severely underrepresented in computational biosciences. We established the UCLA Bruins-in-Genomics Summer Research Program to provide training and research experiences in quantitative biology and bioinformatics to undergraduate students with an emphasis on students from backgrounds underrepresented in computational biology. Program assessment was based on number of applicants, alumni surveys and comparison of post-graduate educational choices for participants and a control group of students who were accepted but declined to participate. We hypothesized that participation in the Bruins-in-Genomics program would increase the likelihood that students would pursue post-graduate education in a related field. Our surveys revealed that 75% of Bruins-in-Genomics Summer participants were enrolled in graduate school. Logistic regression analysis revealed that women who participated in the program were significantly more likely to pursue a Ph.D. than a matched control group (group x woman interaction term of p = 0.005). The Bruins-in-Genomics Summer program represents an example of how a combined didactic-research program structure can make computational biology accessible to a wide range of undergraduates and increase participation in quantitative biosciences. [ABSTRACT FROM AUTHOR]

Heterogeneity within the glycocalyx influences cell adhesion mechanics and signaling. However, the role of specific glycosylation subtypes in influencing cell mechanics via alterations of receptor function remains unexplored. It has been shown that the addition of sialic acid to terminal glycans impacts growth, development, and cancer progression. In addition, the sialyltransferase ST6Gal-I promotes epidermal growth factor receptor (EGFR) activity, and we have shown EGFR is an 'allosteric mechano-organizer' of integrin tension. Here, we investigated the impact of ST6Gal-I on cell mechanics. Using DNA-based tension gauge tether probes of variable thresholds, we found that high ST6Gal-I activity promotes increased integrin forces and spreading in Cos-7 and OVCAR3, OVCAR5, and OV4 cancer cells. Further, employing inhibitors and function-blocking antibodies against β1, β3, and β5 integrins and ST6Gal-I targets EGFR, tumor necrosis factor receptor, and Fas cell surface death receptor, we validated that the observed phenotypes are EGFR-specific. We found that while tension, contractility, and adhesion are extracellular-signal-regulated kinase pathway-dependent, spreading, proliferation, and invasion are phosphoinositide 3-kinase-Akt serine/threonine kinase dependent. Using total internal reflection fluorescence microscopy and flow cytometry, we also show that high ST6Gal-I activity leads to sustained EGFR membrane retention, making it a key regulator of cell mechanics. Our findings suggest a novel sialylation-dependent mechanism orchestrating cellular mechanics and enhancing cell motility via EGFR signaling. [ABSTRACT FROM AUTHOR]

The Jardin des Plantes Ménagerie, a public zoo formed during the French Revolution, reflected French rationalist thought and policy through its display of new and foreign animals. Established in 1795 on the grounds of the Parisian botanical gardens that once belonged to King Louis XVI, it not only reflected the power of the new state, it made the state's goals of scientific advancement relatable to the public. The best scholarly minds of the period conducted their research at the Menagerie, contributing to the Menagerie's reputation as a site of learning. As a public, state-run site, the location also housed the living diplomatic gifts from foreign rulers and the animalian wartime spoils from Napoleonic conquests. This display of French power and scientific prowess was done so as to inspire public imagination in art and culture through novel animals such as the giraffe. In later decades, the Menagerie declined in prominence, particularly during the Prussian siege of Paris from 1870 to 1871, when many of the animals were killed to provide food to the people. Some of the decline, however, could also be attributed to the rise of other scientific zoos around Europe modeled after the Jardin des Plantes Ménagerie. [ABSTRACT FROM AUTHOR]

Calcium (Ca2+) homeostasis is maintained through coordination between intestinal absorption, renal reabsorption, and bone remodeling. Intestinal and renal (re)absorption occurs via transcellular and paracellular pathways. The latter contributes the bulk of (re)absorption under conditions of adequate intake. Epithelial paracellular permeability is conferred by tight-junction proteins called claudins. However, the molecular identity of the paracellular Ca2+ pore remains to be delineated. Claudins (Cldn)-2 and -12 confer Ca2+ permeability, but deletion of either claudin does not result in a negative Ca2+ balance or increased calciotropic hormone levels, suggesting the existence of additional transport pathways or parallel roles for the two claudins. To test this, we generated a Cldn2/12 double knockout mouse (DKO). These animals have reduced intestinal Ca2+ absorption. Colonic Ca2+ permeability is also reduced in DKO mice and significantly lower than single-null animals, while small intestine Ca2+ permeability is unaltered. The DKO mice display significantly greater urinary Ca2+ wasting than Cldn2 null animals. These perturbations lead to hypocalcemia and reduced bone mineral density, which was not observed in single- KO animals. Both claudins were localized to colonic epithelial crypts and renal proximal tubule cells, but they do not physically interact in vitro. Overexpression of either claudin increased Ca2+ permeability in cell models with endogenous expression of the other claudin. We find claudin-2 and claudin-12 form partially redundant, independent Ca2+ permeable pores in renal and colonic epithelia that enable paracellular Ca2+ (re)absorption in these segments, with either one sufficient to maintain Ca2+ balance. [ABSTRACT FROM AUTHOR]

Background: Despite public health efforts to promote breastfeeding, global rates of breastfeeding continue to trail behind the goals identified by the World Health Organization. While the literature exploring breastfeeding beliefs and practices is growing, it offers various and sometimes conflicting explanations regarding women's attitudes towards and experiences of breastfeeding. This research explores existing empirical literature regarding women's perceptions about and experiences with breastfeeding. The overall goal of this research is to identify what barriers mothers face when attempting to breastfeed and what supports they need to guide their breastfeeding choices.Methods: This paper uses a scoping review methodology developed by Arksey and O'Malley. PubMed, CINAHL, Sociological Abstracts, and PsychInfo databases were searched utilizing a predetermined string of keywords. After removing duplicates, papers published in 2010-2020 in English were screened for eligibility. A literature extraction tool and thematic analysis were used to code and analyze the data.Results: In total, 59 papers were included in the review. Thematic analysis showed that mothers tend to assume that breastfeeding will be easy and find it difficult to cope with breastfeeding challenges. A lack of partner support and social networks, as well as advice from health care professionals, play critical roles in women's decision to breastfeed.Conclusion: While breastfeeding mothers are generally aware of the benefits of breastfeeding, they experience barriers at individual, interpersonal, and organizational levels. It is important to acknowledge that breastfeeding is associated with challenges and provide adequate supports for mothers so that their experiences can be improved, and breastfeeding rates can reach those identified by the World Health Organization. [ABSTRACT FROM AUTHOR]

This paper studies games when agents have second-order expected utility. It examines the theoretical predictions of the model and compares its performance in explaining behavior in experimental data on games with that of quantal response equilibrium. [ABSTRACT FROM AUTHOR]

The present study examined the discrimination and calibration properties of Violence Risk Scale–Sexual Offense version (VRS-SO) risk and change scores for sexual and violent recidivism as a function of age at release, on a combined sample of 1,287 men who had attended sexual offense-specific treatment services. The key aim was to examine to what extent VRS-SO scores can accurately discriminate recidivists from nonrecidivists among older cohorts, and if the existing age-related adjustments in the instrument adequately correct for increasing age. VRS-SO risk and change scores showed consistent properties of discrimination for sexual recidivism across the age cohorts, via area under the curve and Cox regression survival analysis, as demonstrated through fixed effects meta-analysis. Calibration analyses, employing logistic regression, demonstrated that age at release was consistently incrementally predictive of violent, but not sexual, recidivism after controlling for individual differences on static and dynamic risk factors. E/O index analyses demonstrated that predicted rates of sexual recidivism from VRS-SO scores, particularly when employed with Static-99R, were not significantly different from those observed among age cohorts; however, calibration was weaker for general violence. Implications for use of the VRS-SO in sexual recidivism risk assessment with older offenders are discussed. [ABSTRACT FROM AUTHOR]

Patients remain at high risk of recurrent ischaemic events following a myocardial infarction (MI), and the goal of secondary prevention therapy is to reduce the risk of cardiovascular events while reducing symptom burden and extending life expectancy. This article provides an overview of the recommended secondary prevention strategies post‐MI, focusing on pharmacological therapy. [ABSTRACT FROM AUTHOR]

Drought is a normal part of the variable Australian climate, occurring on average every thirteen years since 1870. Changes in agricultural policy since the 1980s have attempted to shift more of the drought risk from the state to the producer. During drought, however, governments feel political pressure to support the industry financially. The iconography of rural hardship and representation of drought as crisis in media discourse are key factors in forcing government intervention and ensuring public support. We analysed the content of eighty news articles during six months of the drought which began in 2018. In line with previous research, we found that drought was represented primarily through its effects on the agricultural industry. Implicit disaster narratives persisted, but in contrast to past studies, a recognition of drought as normal was more salient than drought as exceptional. Agrarian narratives emphasising the exceptional cultural value of the agricultural industry persisted and were presented as justification for continued government support. Scientifically informed discourses, recognising the effects of climate change on future drought risk and acknowledging the role of the agricultural industry in current and historical environmental degradation, were scarce or absent. [ABSTRACT FROM AUTHOR]

In this proof-of-concept study the impact of central venous pressure (CVP) on internal jugular veins cross-sectional area (CSA) and blood flow time-average velocity (TAV) was evaluated in eight subjects, with the aim of understanding the drivers of the jugular venous pulse. CVP was measured using a central venous catheter while CSA variation and TAV along a cardiac cycle were acquired using ultrasound. Analysis of CVP, CSA and TAV time-series signals revealed TAV and CSA to lag behind CVP by on average 0.129 s and 0.138 s, with an inverse correlation between CSA and TAV (r= -0.316). The respective autocorrelation signals were strongly correlated (mean r=0.729-0.764), with mean CSA periodicity being 1.062 Hz. Fourier analysis revealed the frequency spectrums of CVP, TAV and CSA signals to be dominated by frequencies at approximately 1 and 2 Hz, with those >1 Hz greatly attenuated in the CSA signal. Because the autocorrelograms and periodograms of the respective signals were aligned and dominated by the same underlying frequencies, this suggested that they are more easily interpreted in the frequency domain rather than the time domain. [ABSTRACT FROM AUTHOR]

Background: Intervention differential effects (IDEs) occur where changes in an outcome depend upon the initial values of that outcome. Although methods to identify IDEs are well documented, there remains a lack of understanding about the circumstances under which these methods are robust. One context that has not been explored is the identification of intervention differential effect in studies where sample selection is based on the initial value of the outcome being evaluated. We hypothesise that, in such settings, established methods for detecting IDEs will struggle to discriminate these from regression to the mean. Methods: Using simulated datasets of weight-loss intervention programmes that recruit according to initial body mass index, we explore the reliability of Oldham's method and multilevel modelling (MLM) to detect IDEs. Results: In datasets simulated with no IDE, Oldham's method and MLM yield Type I error rates >90%, confirming that threshold selection/truncation leads to bias due to regression to the mean. Type I error rates return close to 5% for both methods when a control group is introduced. Conclusions: Oldham's method and MLM can robustly detect IDEs in this setting, but only if analyses incorporate a control group for comparison. [ABSTRACT FROM AUTHOR]

Muscle strains occur frequently in recreational and professional sports. This article considers various treatment options in a biological context and reviews evidence of their efficacy. Treatments reviewed include the PRICE principle (P: rotection, R: est, I: ce, C: ompression, E: levation), early mobilization, physical therapy, hematoma aspiration, platelet-rich plasma injections, use of nonsteroidal anti-inflammatory drugs, corticosteroids, and local anesthetics, cellular therapies, and surgery. [ABSTRACT FROM AUTHOR]

Using in-depth interviews with twenty-six teen fathers, I explore how these young men negotiate the absent-father discourse in making sense of their identities as young dads. I find that teen fathers draw on culturally available notions of gender and age in their attempts to construct and maintain good-dad identities. Teen fathers deploy the expectation that "most dad's aren't around" to "lower the bar" and elevate their own performance by comparison. Teen fathers also feel the need to defend themselves from the discourse's assumptions by invoking tropes of adult masculinity—insisting that "fatherhood means stepping up" and "being a man." Because the fathers are unable to meet all the expectations of adult manhood, they create an escape hatch for themselves by citing their own adolescence and claiming a need for youthful freedom. Ironically, by invoking gendered and aged norms of adulthood, the fathers reify those norms into something harder to escape. [ABSTRACT FROM AUTHOR]

The nighttime ocean cool skin signal ΔT [defined as skin sea surface temperature (SSTskin) minus depth SST (SSTdepth)] is investigated using 103 days of matchups between shipborne Infrared SST Autonomous Radiometer (ISAR) SSTskin and water intake SSTdepth at ~7.1–9.9-m depths, in oceans around Australia. Before data analysis, strict quality control of ISAR SSTskin data is conducted and possible diurnal warming contamination is carefully minimized. The statistical distribution of ΔT, and its dependencies on wind speed, heat flux, etc., are consistent with previous findings. The overall average ΔT value is −0.23 K. It is observed that the magnitude of the cool skin signal increases after midnight and a coolest skin offset (with an average value of −0.36 K) is found at around dawn. The dependency of ΔT on SST conditions is observed. Direct warm skin events are discovered when the net heat flux direction is from the atmosphere to the ocean, which is more likely to occur at high latitudes when the air is very humid and warmer than the SST. In addition, several cool skin models are validated: one widely used physical model performs best and can capture most skin-effect trends and details; the empirical models only reflect the basic features of the observed ΔT values. If the user cannot apply the physical model (due to, e.g., the algorithm complexity or missing inputs), then the empirical parameterization in the form proposed in a 2002 study can be used. However, we recommend using a new set of parameters, calculated in this study, based on much more representative dataset, and with more rigorous quality control. [ABSTRACT FROM AUTHOR]

Interspecific competition is an essential element of the evolution of species and can strongly influence the abundance and distribution of species. Where competition interacts with anthropogenic habitat modification, this natural ecosystem process can become a threatening process. Understanding the mechanisms behind competition in such cases is essential for the formulation of cost‐effective management responses for biodiversity conservation. According to the resource availability hypothesis of competition, interference competition limits access to resources by species vulnerable to such aggression and wastes energy in evasive responses. Studying competition is notoriously difficult, however, empirical evidence of the resource availability theory is limited, and there are few published experimental studies showing such an effect at larger scales. We present the results of a controlled and replicated empirical study of interference competition at a landscape scale. We removed an aggressive, overabundant native bird, Manorina melanocephala (noisy miner), whose interference competition is a threatening process for small woodland birds in the highly modified agricultural landscapes of eastern Australia. We monitored foraging and harassment rates of small woodland birds before and after removal to indicate if levels of interference competition changed. Due to unexpected immediate recolonisation, abundance of M. melanocephala in treatment sites declined by only 34% relative to control sites. Twenty‐four bird species displayed aggressive behaviour towards other birds and 41 bird species were victims of aggression. Manorina melanocephala was responsible for 66% of all aggressive interactions. After removal, we recorded a doubling in foraging rate of small woodland birds in treatment compared to control sites. This appears to confirm the resource availability hypothesis of competition. Paradoxically, however, increased foraging was not accompanied by a decline in harassment. Low detection rates of harassment of small woodland birds, combined with the modest reduction in abundance of M. melanocephala, make it difficult to draw firm conclusions about the relationship between rates of harassment and rates of foraging. [ABSTRACT FROM AUTHOR]

Objectives: Soccer leagues reflect the partial standings of the teams involved after each round of competition. However, the ability of partial league standings to predict end-of-season position has largely been ignored. Here we analyze historical partial standings from English soccer to understand the mathematics underpinning league performance and evaluate the predictive 'power' of partial standings. Methods: Match data (1995–2017) from the four senior English leagues was analyzed, together with random match scores generated for hypothetical leagues of equivalent size. For each season the partial standings were computed and Kendall's normalized tau-distance and Spearman r-values determined. Best-fit power-law and logarithmic functions were applied to the respective tau-distance and Spearman curves, with the 'goodness-of-fit' assessed using the R2 value. The predictive ability of the partial standings was evaluated by computing the transition probabilities between the standings at rounds 10, 20 and 30 and the final end-of-season standings for the 22 seasons. The impact of reordering match fixtures was also evaluated. Results: All four English leagues behaved similarly, irrespective of the teams involved, with the tau-distance conforming closely to a power law (R2>0.80) and the Spearman r-value obeying a logarithmic function (R2>0.87). The randomized leagues also conformed to a power-law, but had a different shape. In the English leagues, team position relative to end-of-season standing became 'fixed' much earlier in the season than was the case with the randomized leagues. In the Premier League, 76.9% of the variance in the final standings was explained by round-10, 87.0% by round-20, and 93.9% by round-30. Reordering of match fixtures appeared to alter the shape of the tau-distance curves. Conclusions: All soccer leagues appear to conform to mathematical laws, which constrain the league standings as the season progresses. This means that partial standings can be used to predict end-of-season league position with reasonable accuracy. [ABSTRACT FROM AUTHOR]

This study explored the viability of preventive treatment services for individuals with sexual interest in children, in jurisdictions without mandatory reporting but where risk-related disclosures to authorities are permitted at therapists' discretion. Health professionals (N = 112) were surveyed regarding their comfort, confidence, knowledge of relevant legal provisions, and personal disclosure thresholds, in relation to a hypothetical scenario of a client confiding pedophilic interest to seek help. Findings were mixed regarding implications for prevention service viability. Despite the complexities of the legal and ethical context of the study setting (New Zealand), predictions regarding professionals' uncertainty in relation to their legal and ethical duties, and displaying a bias toward disclosing information to authorities when permitted, were not fully borne out, although pervasive knowledge inaccuracies and associated training needs were revealed. Instead, general tendencies among respondents were toward comfort, confidence, and the inclination toward maintaining client confidentiality. Yet, widespread variance within the sample, and individuals' thresholds appearing rather unpredictable on the basis of demographic or professional variables, highlights likely barriers for potential clients in feeling safe enough to come forward. Given that preventive treatment viability in this context relies on self-referral, it is suggested that a purpose-designed preventive treatment service, with clear accessible confidentiality and reporting policies that are well within the law, could be the best way forward for viable preventive treatment in discretionary reporting contexts. [ABSTRACT FROM AUTHOR]

Globally, there is growing recognition of the benefits that indigenous peoples can bring to ecology and conservation, drawing on deep spiritual and cultural ties to the environment. The contribution of indigenous peoples and their knowledges is now widely acknowledged as critical to successful efforts to mitigate anthropogenic impacts. In New Zealand, matauranga spans all aspects of indigenous Maori knowledge and is conceptualised, developed and maintained through practice and connection. We searched all issues of the Proceedings of the New Zealand Ecological Society and the New Zealand Journal of Ecology from 1953 to 2018 to identify and highlight papers that feature research partnerships with Maori and/or acknowledge and explore matauranga Maori in a meaningful way. There were only three, republished here in this virtual issue. Although there has been a recent increase in studies that incorporate matauranga Maori published in other journals, we argue that substantive commitment to community partnerships and bicultural research has not been realized in ecological research. Working with interdisciplinary knowledge including matauranga will be critical to halt further biodiversity loss and improve outcomes for the environment and people, in New Zealand and worldwide. Matauranga Maori has much to contribute to positive biodiversity and ecological outcomes, but it will require institutional and systemic support of scientific researchers to develop authentic partnerships with Maori communities to transform research practices. [ABSTRACT FROM AUTHOR]

What is known and objective: Fever, one of the most common symptoms of illness experienced by children, often creates undue parental anxiety about the consequences of fever, which can lead to overtreatment. The full extent of this problem in Australia is not known. This study aimed to describe parents' knowledge, beliefs and perceptions about childhood fever and its management, and identify any predictors of the burden on parents when children are febrile. Methods: This was a cross‐sectional web‐based survey of parents living in Australia. Parents with at least 1 child <6 years were recruited via Facebook. Demographic information, parental fever knowledge and beliefs and responses to the Parent Fever Management Scale, a measure of parental burden, were collected and analysed. Results and discussion: Of the 12 179 parents who completed the survey, 42.0% knew that a temperature above 38°C constitutes a fever, with 33.4% underestimating the temperature of a fever. Parents believed that there were many harms associated with untreated fever, namely seizures (71.8%), dehydration (63.6%), serious illness (43.0%) and brain damage (36.8%). Phobic beliefs were more common among parents who underestimated the temperature of a fever. Identification of health professionals as a main information source about fever did not significantly improve knowledge or reduce fears. Up to 65.0% of respondents indicated that they practice non–evidence‐based strategies to reduce temperature. The belief that 'every child with a fever should be treated with medication to lower temperature' was the strongest predictor of parental burden (ß = 0.245, P < 0.001). What is new and conclusion: Poor parental knowledge and misconceptions surrounding fever and its management are still common among parents throughout Australia. Large‐scale, sustainable educational interventions are needed to dispel misconceptions and concerns about fever, encourage appropriate and safe care of febrile children. [ABSTRACT FROM AUTHOR]